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1. 发明授权

US5547848A Immunoassay element containing a pulverized water-insoluble polysaccharide and process for immunoassay 失效
标题翻译：含有粉碎水不溶性多糖的免疫测定元件和免疫测定方法
公开(公告)号：US5547848A
公开(公告)日：1996-08-20
申请号：US393240
申请日：1995-02-23
申请人： Hiroshi Shinoki , Toshikage Hiraoka , Masashi Ogawa
发明人： Hiroshi Shinoki , Toshikage Hiraoka , Masashi Ogawa
IPC分类号： G01N33/542 , G01N33/543 , G01N33/558 , G01N33/535 , G01N33/548
CPC分类号： G01N33/54386 , G01N33/558
摘要： An immunoassay element for quantitatively analyzing a ligand by determining the change in enzymatic activity. When the ligand is a low molecular weight antigen, competitive reactions between the ligand, enzyme-labelled antibody and conjugate of the antigen and high molecular weight compound are utilized. When the ligand is a macromolecular antigen, a reaction between the ligand and an enzyme-labelled antibody is utilized directly. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the enzyme, and a reagent layer for detecting the thus formed diffusible material. The non-diffusible substrate is composed of a pulverized insoluble polysaccharide. The reagent layer may further contain a fragmenting enzyme for further fragmenting the non-diffusible material. Also provided are processes for quantitatively analyzing both of low molecular weight and macromolecular antigens contained in any samples by the use of the immunoassay elements of the invention.
摘要翻译：用于通过确定酶活性的变化定量分析配体的免疫测定元件。当配体是低分子量抗原时，配体，酶标记抗体与抗原结合物和高分子量化合物之间的竞争性反应被利用。当配体是大分子抗原时，直接使用配体和酶标记的抗体之间的反应。免疫测定元件包括含有在酶存在下形成可扩散材料的不扩散基底的基底层和用于检测由此形成的可扩散材料的试剂层。非扩散性基材由粉碎的不溶性多糖组成。试剂层可以进一步包含用于进一步碎裂非扩散材料的碎裂酶。还提供了通过使用本发明的免疫测定元件定量分析任何样品中所含的低分子量和大分子抗原的方法。

2. 发明授权

US06589754B1 Immunoassay element and process for immunoassay 失效
标题翻译：免疫测定元件和免疫测定方法
公开(公告)号：US06589754B1
公开(公告)日：2003-07-08
申请号：US08946685
申请日：1997-10-08
申请人： Toshikage Hiraoka , Tetsuji Tanimoto , Yoshihiko Makino , Tadashi Ninomiya , Hiroshi Shinoki , Yoshihiro Ashihara , Naofumi Hora , Masashi Ogawa
发明人： Toshikage Hiraoka , Tetsuji Tanimoto , Yoshihiko Makino , Tadashi Ninomiya , Hiroshi Shinoki , Yoshihiro Ashihara , Naofumi Hora , Masashi Ogawa
IPC分类号： G01N3353
CPC分类号： G01N33/54386
摘要： An immunoassay element for quantitatively analyzing a macromolecular antigen by determining the change in enzymatic activity caused by a reaction between the macromolecular polymer antigen and an enzyme-labelled antibody. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. Also provided is a process for quantitatively analyzing a macromolecular antigen in a sample by the use of the immunoassay element.
摘要翻译：一种用于通过测定由高分子聚合物抗原和酶标记的抗体之间的反应引起的酶活性的变化来定量分析大分子抗原的免疫测定元件。免疫测定元件包括含有在酶存在下形成可扩散材料的不扩散基底的基底层和含有用于进一步将可扩散材料分解成较低分子量产物的碎裂酶的试剂层。还提供了通过使用免疫测定元件定量分析样品中的大分子抗原的方法。

3. 发明授权

US5882935A Analysis element and method for analyzing glycated hemoglobin content ratio 失效
标题翻译：分析元素及分析糖化血红蛋白含量的方法
公开(公告)号：US5882935A
公开(公告)日：1999-03-16
申请号：US544133
申请日：1995-10-17
申请人： Kikuo Hirai , Hiroshi Shinoki , Masashi Ogawa , Yoshihiko Makino
发明人： Kikuo Hirai , Hiroshi Shinoki , Masashi Ogawa , Yoshihiko Makino
IPC分类号： G01N33/53 , G01N33/52 , G01N33/542 , G01N33/72 , H01L21/302 , H01L21/304 , H01L21/306 , H01L21/76
CPC分类号： G01N33/723 , G01N33/721
摘要： An analysis element for analyzing both amounts of glycated hemoglobin and total hemoglobin in an aqueous liquid sample to determine glycated hemoglobin content ratio in the sample. The element comprises a substrate layer for receiving a reaction mixture after the completion of an immunological reaction between the glycated hemoglobin in the sample and an enzyme-labelled antibody against the glycated hemoglobin, and a reagent layer. The substrate layer contains a non-diffusible substrate which forms a diffusible material in the presence of the enzyme of the enzyme-labelled antibody, the activity of the enzyme being effected relative to the steric hindrance due to the immunological reaction. The reagent layer contains a reagent composition for reacting with the diffusible material to form a dye detectable colorimetrically in a wavelength range which is not effected by an absorption spectrum of the hemoglobin. The total hemoglobin retained in the substrate layer and the dye formed in the reagent layer are colorimetrically analyzed separately, and the glycated hemoglobin content ratio is calculated from respective values. An analysis method using this analysis element is also provided.
摘要翻译：分析元素，用于分析含水液体样品中糖化血红蛋白和总血红蛋白的量，以测定样品中糖化血红蛋白含量的比例。该元件包括用于在样品中的糖化血红蛋白和糖化血红蛋白的酶标记抗体完成后的反应混合物和试剂层的基底层。底物层含有在酶标记抗体的酶存在下形成可扩散材料的非扩散性底物，该酶的活性相对于由于免疫反应引起的空间位阻影响。试剂层含有用于与可扩散材料反应的试剂组合物，以形成可在不受血红蛋白的吸收光谱影响的波长范围内比色测定的染料。分别保留在基材层中的总血红蛋白和形成在试剂层中的染料，并根据各值计算糖化血红蛋白含量比。还提供了使用该分析元素的分析方法。

4. 发明授权

US5447846A Homogeneous Immunoassay process using covalent conjugate of enzyme and plural monoclonal antibodies for different epitopes on analyte 失效
标题翻译：均质免疫测定方法使用酶和多种单克隆抗体的共价缀合物对分析物上的不同表位进行
公开(公告)号：US5447846A
公开(公告)日：1995-09-05
申请号：US91661
申请日：1993-07-14
申请人： Hiroshi Shinoki , Masashi Ogawa
发明人： Hiroshi Shinoki , Masashi Ogawa
IPC分类号： G01N33/542 , G01N33/543 , G01N33/58 , G01N33/68 , G01N33/53
CPC分类号： G01N33/581 , G01N33/542 , G01N33/54386 , G01N33/6857 , Y10S435/964 , Y10S435/969 , Y10S435/97 , Y10S435/972 , Y10S530/866
摘要： An enzyme-labelled antibody adapted for use in a homogeneous immunoassay is provided. The enzyme-labelled antibody is a conjugate of an enzyme with two or more different monoclonal antibodies, each of the monoclonal antibodies being capable of specifically recognizing and binding to a different epitope of the same antigen. By using the enzyme-labelled antibody in the homogeneous enzyme immunoassay process, an analyte can be quantitatively analyzed at a higher sensitivity through a simple operation. Also provided is a dry immunoassay element comprising an immunological reaction layer containing the enzyme-labelled antibody. By the provision of such an immunoassay element, a further simplified quick analysis of an analyte is realized to give an accurate result.
摘要翻译：提供适用于均相免疫测定法的酶标记抗体。酶标记的抗体是酶与两种或更多种不同单克隆抗体的缀合物，每种单克隆抗体能够特异性识别并结合相同抗原的不同表位。通过在均相酶免疫测定法中使用酶标记的抗体，可以通过简单的操作以更高的灵敏度对分析物进行定量分析。还提供了包含含有酶标记抗体的免疫反应层的干免疫测定元件。通过提供这样的免疫测定元件，实现了分析物的进一步简化的快速分析以给出准确的结果。

7. 发明申请

US20120330047A1 COMPOUND 有权
标题翻译：复合
公开(公告)号：US20120330047A1
公开(公告)日：2012-12-27
申请号：US13510207
申请日：2010-11-18
申请人： Seiji Shinkai , Shuichi Haraguchi , Tomohiro Shiraki , Masashi Ogawa , Shuhei Nakatani , Kei Sakanoue , Osamu Goto , Hidenobu Kakimoto
发明人： Seiji Shinkai , Shuichi Haraguchi , Tomohiro Shiraki , Masashi Ogawa , Shuhei Nakatani , Kei Sakanoue , Osamu Goto , Hidenobu Kakimoto
IPC分类号： C07F7/18
CPC分类号： G03F7/027 , C07F7/12 , C07F7/1804 , G03F7/0046 , G03F7/0755 , H01L51/0056 , H01L51/0095
摘要： A problem of the present invention is to prevent a base layer beneath the layer to be irradiated with light from deterioration in property and a functional thin film from deterioration in property as the fine patterning of a functional film is performed with light irradiation. Means for solving the problem is a compound obtained by dimerizing with light irradiation a compound (A) containing a group that has photosensitivity and can be photodimerized and a group having lyophilicity and a compound (B) containing a group that has photosensitivity and can be photodimerized and a group having liquid-repellency.
摘要翻译：本发明的问题在于，通过光照射进行功能性薄膜的精细图案化，可以防止层下面的基底层被特性劣化的光照射，功能性薄膜的性能劣化。用于解决问题的方法是通过光照射包含具有光敏性且可以被光二聚化的基团的化合物（A）和具有亲液性的基团和含有具有光敏性并可以被光二聚化的基团的化合物（B））而获得的化合物和具有拒水性的组。

8. 发明申请

US20080273068A1 Cartridge for ink jet recording and method for producing the same 有权
标题翻译：喷墨记录用墨盒及其制造方法
公开(公告)号：US20080273068A1
公开(公告)日：2008-11-06
申请号：US12153018
申请日：2008-05-13
申请人： Masashi Ogawa , Wataru Takahashi , Hiromasa Anma , Yasuo Kotaki
发明人： Masashi Ogawa , Wataru Takahashi , Hiromasa Anma , Yasuo Kotaki
IPC分类号： B41J2/175
CPC分类号： B41J2/17513
摘要： The present invention provides a method for producing an ink jet recording cartridge provided with a recording element substrate on the bottom surface, wherein the cartridge can be integrated with the recording element substrate precisely without causing any damage on the substrate has a high barrier capacity, and can work with various inks and wherein such characteristics of the cartridge are provided by including the steps of pressing a lid to the upper opening of an ink-holding container made of a resin material including glass fibers to cover the opening, and vibration welding the lid to the container where means for holding the lid is vibrated in the direction along the top surface of the container.
摘要翻译：本发明提供了一种用于制造在底面上设置有记录元件基板的喷墨记录盒的方法，其中盒可以与记录元件基板精确地集成而不会对基板造成任何损坏，具有高阻隔能力，以及可以使用各种油墨，并且通过包括将盖子压到由包括玻璃纤维的树脂材料制成的油墨保持容器的上部开口以覆盖开口的步骤，并且将盖子振动焊接到容器，其中用于保持盖的装置沿着容器的顶表面的方向振动。

9. 发明申请

US20070084904A1 Conductive ball, formation method for electrode of electronic component, electronic component and electronic equipment 审中-公开
标题翻译：导电球，电子部件电极的形成方法，电子部件和电子设备
公开(公告)号：US20070084904A1
公开(公告)日：2007-04-19
申请号：US10557698
申请日：2004-05-24
申请人： Masato Sumikawa , Rina Murayama , Masashi Ogawa , Kiyoto Matsushita
发明人： Masato Sumikawa , Rina Murayama , Masashi Ogawa , Kiyoto Matsushita
IPC分类号： A47J36/02
CPC分类号： H05K3/3436 , H01L2224/05567 , H01L2224/05573 , H01L2224/05655 , H01L2224/11 , H05K3/3463 , H05K2201/10234 , Y02P70/613 , H01L2924/00014
摘要： A conductive ball is formed by coating a generally spherical-shaped core made of a non-metallic material with a coating layer composed of a Cu layer and an Sn-5.5Ag alloy layer of non-eutectic composition. The conductive ball is disposed on a land of an electronic component via flux and reflown at heating temperatures whose peak temperatures reach 250 to 260° C. The Sn-5.5Ag alloy of non-eutectic composition is put in the state in which a solidus portion and a liquidus portion coexist to keep flowability relatively small. The conductive ball is fixed on the land without exposing an SnCu layer formed on the Cu layer. An electrode is formed without exposing the SnCu layer having relatively poor solder wettability. Between the electronic component and a circuit board, a joint section having a good electric conduction property and mechanical strength may be formed.
摘要翻译：通过涂覆由非金属材料制成的大致球形的芯由具有Cu层和非共晶组成的Sn-5.5Ag合金层的涂层形成导电球。导电球通过焊剂置于电子部件的焊盘上，并在峰值温度达到250〜260℃的加热温度下进行退火。将非共晶组合物的Sn-5.5Ag合金置于固体部分并且液相部分共存以保持流动性相对较小。导电球固定在焊盘上，而不暴露形成在Cu层上的SnCu层。形成电极，而不会使焊锡润湿性差的SnCu层露出。在电子部件与电路基板之间，可以形成具有良好的导电性和机械强度的接合部。

10. 发明授权

US07055942B2 Liquid discharge head cartridge 有权
标题翻译：液体排放头盒
公开(公告)号：US07055942B2
公开(公告)日：2006-06-06
申请号：US10806753
申请日：2004-03-22
申请人： Hiromasa Amma , Wataru Takahashi , Hiroki Hayashi , Masashi Ogawa , Yasuo Kotaki
发明人： Hiromasa Amma , Wataru Takahashi , Hiroki Hayashi , Masashi Ogawa , Yasuo Kotaki
IPC分类号： B41J2/175
CPC分类号： B41J2/17513
摘要： A liquid discharge head cartridge can assuredly supply a liquid discharge head with a liquid even when a bubble is generated within a liquid channel, and maintain excellent recording characteristics even in a configuration in which light recovery or no recovery is adopted. The cartridge includes a slit-shaped opening provided at an ink channel facing an ink-jet recording head, a filter provided at an ink introducing unit so as to contact an ink absorber, and ribs for supporting the filter that extend from an inner wall of the ink introducing unit to a substantially central portion of the filter.
摘要翻译：即使当在液体通道内产生气泡时，液体排出头盒也可以确保地提供具有液体的液体排出头，并且即使在采用光回收或不进行回收的构造中也能保持良好的记录特性。墨盒包括设置在面向喷墨记录头的墨水通道处的狭缝状开口，设置在墨水引入单元处以与墨水吸收器接触的过滤器，以及用于支撑过滤器的肋条，墨水引入单元到过滤器的大致中心部分。

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