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1. 发明申请

US20060189811A1 Process for producing 1,2,4-triazole compound and intermediate therefor 审中-公开
标题翻译：生产1,2,4-三唑化合物及其中间体的方法
公开(公告)号：US20060189811A1
公开(公告)日：2006-08-24
申请号：US10565678
申请日：2004-07-23
申请人： Hiroshi Nakamura , Junichiro Uda , Atsushi Ohno , Takahiro Sato
发明人： Hiroshi Nakamura , Junichiro Uda , Atsushi Ohno , Takahiro Sato
IPC分类号： C07D403/14
CPC分类号： C07D403/14
摘要： Provided is a process for producing 1,2,4-triazole compound (5), or a salt or hydrate thereof which comprises reacting compound (1) with Rc-X (2) to give compound (3), reacting compound (3) with a nitrilization agent to give compound (4), and then removing the group Rc, as shown by the reaction scheme: (Wherein Ra, Rb and Rd represent a group, Rc represents a group which can be removed by an acid) A 1,2,4-triazole compound (5) having an optionally substituted 2-cyanopyridin-4-yl group at 3-position and an optionally substituted aromatic group at 5-position which inhibits a xanthine oxidase and is useful for treatment of gout and hyperuricemia can be obtained from compound (1) in a high yield without requiring isolation of reaction products in the course of reactions.
摘要翻译：本发明提供了使化合物（1）与Rc-X（2）反应得到化合物（3），使化合物（3）与化合物（3）反应的1,2,4-三唑化合物（5）或其盐或水合物的方法，与硝化剂反应得到化合物（4），然后除去Rc基团，如反应方案所示：（其中Ra，Rb和Rd表示基团，Rc表示可被酸除去的基团）A 1 ，3位具有任选取代的2-氰基吡啶-4-基的2,4-三唑化合物（5）和5位上任意取代的芳族基团，其抑制黄嘌呤氧化酶并且可用于治疗痛风和高尿酸血症可以以高产率从化合物（1）获得，而不需要在反应过程中分离反应产物。

2. 发明授权

US08148421B2 Phenylacetic acid derivative 有权
标题翻译：苯乙酸衍生物
公开(公告)号：US08148421B2
公开(公告)日：2012-04-03
申请号：US12440540
申请日：2007-09-10
申请人： Hideo Kato , Osamu Nagata , Yoshiyuki Iwabuchi , Takahiro Sato , Junichiro Uda , Tutomu Inoue , Hiroshi Nakamura , Nobuhide Kawasaki , Ippei Tanaka , Naoki Kurita , Tomohiko Ishikawa
发明人： Hideo Kato , Osamu Nagata , Yoshiyuki Iwabuchi , Takahiro Sato , Junichiro Uda , Tutomu Inoue , Hiroshi Nakamura , Nobuhide Kawasaki , Ippei Tanaka , Naoki Kurita , Tomohiko Ishikawa
IPC分类号： A61K31/382 , C07D335/02
CPC分类号： C07D335/02 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/38 , C07D333/48
摘要： A compound represented by the formula (1) or a salt thereof ( represents a single bond, or a double bond; R1 represents hydrogen atom, or an alkyl group; R2 and R3 represent hydrogen atom, or an alkyl group; R4 and R5 represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R7 represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing action against prostaglandin E2 production and is useful as an active ingredient of medicaments with reduced adverse reactions such as gastrointestinal disorders.
摘要翻译：由式（1）表示的化合物或其盐（表示单键或双键; R1表示氢原子或烷基; R2和R3表示氢原子或烷基; R4和R5表示氢原子，羟基，烷氧基，卤素原子或一或二烷基取代的氨基; R 6表示氢原子，氰基，烷氧基羰基或羧基; R 7表示一个或两个取代基在苯环上（取代基选自氢原子，卤素原子，硝基，氰基，羟基，氨基，烷基和烷氧基）; A表示5元或6元非含有一个或两个相邻硫原子的杂环（硫原子可以独立地形成氧化物）; W表示氧代基，氢原子，烷基，羟基，烷氧基或卤素原子; X表示氧原子，或硫原子）或其盐对前列腺素E2产生的抑制作用较差，并且可用作具有减少的不良反应如胃肠道疾病的药物的活性成分。

3. 发明申请

US20100048666A1 NOVEL PHENYLACETIC ACID DERIVATIVE 有权
标题翻译：新颖的苯甲酸衍生物
公开(公告)号：US20100048666A1
公开(公告)日：2010-02-25
申请号：US12440540
申请日：2007-09-10
申请人： Hideo Kato , Osamu Nagata , Yoshiyuki Iwabuchi , Takahiro Sato , Junichiro Uda , Tutomu Inoue , Hiroshi Nakamura , Nobuhide Kawasaki , Ippei Tanaka , Naoki Kurita , Tomohiko Ishikawa
发明人： Hideo Kato , Osamu Nagata , Yoshiyuki Iwabuchi , Takahiro Sato , Junichiro Uda , Tutomu Inoue , Hiroshi Nakamura , Nobuhide Kawasaki , Ippei Tanaka , Naoki Kurita , Tomohiko Ishikawa
IPC分类号： A61K31/382 , C07D335/02 , A61K31/381 , C07D333/38 , C07D333/32 , A61P13/02 , A61P13/08 , A61P13/10 , A61P3/10 , A61P35/00
CPC分类号： C07D335/02 , C07D333/24 , C07D333/28 , C07D333/32 , C07D333/38 , C07D333/48
摘要： A compound represented by the formula (1) or a salt thereof ( represents a single bond, or a double bond; R1 represents hydrogen atom, or an alkyl group; R2 and R3 represent hydrogen atom, or an alkyl group; R4 and R5 represent hydrogen atom, hydroxy group, an alkoxyl group, a halogen atom, or a mono- or di-alkyl-substituted amino group; R6 represents hydrogen atom, cyano group, an alkoxycarbonyl group, or carboxy group; R7 represents one or two of substituents on the benzene ring (the substituents are selected from hydrogen atom, a halogen atom, nitro group, cyano group, hydroxy group, amino group, an alkyl group, and an alkoxyl group); A represents a 5-membered or 6-membered non-aromatic heterocyclic ring containing one or two contiguous sulfur atoms (the sulfur atoms may independently form oxide); W represents oxo group, hydrogen atom, an alkyl group, hydroxy group, an alkoxyl group, or a halogen atom; and X represents oxygen atom, or sulfur atom), or a salt thereof, which has a superior suppressing action against prostaglandin E2 production and is useful as an active ingredient of medicaments with reduced adverse reactions such as gastrointestinal disorders.
摘要翻译：由式（1）表示的化合物或其盐（表示单键或双键; R1表示氢原子或烷基; R2和R3表示氢原子或烷基; R4和R5表示氢原子，羟基，烷氧基，卤素原子或一或二烷基取代的氨基; R 6表示氢原子，氰基，烷氧基羰基或羧基; R 7表示一个或两个取代基在苯环上（取代基选自氢原子，卤素原子，硝基，氰基，羟基，氨基，烷基和烷氧基）; A表示5元或6元非含有一个或两个相邻硫原子的杂环（硫原子可以独立地形成氧化物）; W表示氧代基，氢原子，烷基，羟基，烷氧基或卤素原子; X表示氧原子，或硫原子）或其盐对前列腺素E2产生的抑制作用较差，并且可用作具有减少的不良反应如胃肠道疾病的药物的活性成分。

4. 发明申请

US20060217556A1 Benzoxepino-11-piperidylidene compounds and process for production thereof 审中-公开
标题翻译：苯并恶灵-11-哌啶基化合物及其制备方法
公开(公告)号：US20060217556A1
公开(公告)日：2006-09-28
申请号：US10553034
申请日：2004-04-14
申请人： Junichiro Uda , Tomomitsu Sasaki , Takahiro Sato , Tsutomu Inoue
发明人： Junichiro Uda , Tomomitsu Sasaki , Takahiro Sato , Tsutomu Inoue
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D491/04 , A61K31/553
摘要： Provided are a process for producing an acid addition salt of a 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic acid alkyl ester by reacting a 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic acid alkyl ester with an acid, and a process for producing 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic acid using the acid addition salt as an intermediate. By using as an intermediate an acid addition salt of a 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic acid alkyl ester to produce 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic acid, the metals used in the synthetic reaction steps and the organic compounds mainly by-produced during production are readily separated from a reaction liquid by a simple procedure, and the by-products are sufficiently removed without using a purification step by chromatography, thereby enabling mass production and enhancing production efficiency.
摘要翻译：提供了制备3- [4-（8-氟-5,11-二氢苯并[b]氧杂环庚烯并[4,3-b]吡啶-11-亚基）哌啶子基]丙酸烷基酯的酸加成盐的方法通过使3- [4-（8-氟-5,11-二氢苯并[b]氧杂环庚烯并[4,3-b]吡啶-11-亚基）哌啶子基]丙酸烷基酯与酸反应，使用酸加成盐作为中间体的3- [4-（8-氟-5,11-二氢苯并[b]氧杂环庚烯并[4,3-b]吡啶-11-亚基）哌啶子基]丙酸。通过使用3- [4-（8-氟-5,11-二氢苯并[b]氧杂环庚烯并[4,3-b]吡啶-11-亚基）哌啶子基]丙酸烷基酯的酸加成盐制备3- [4-（8-氟-5,11-二氢苯并[b]氧杂环庚烯并[4,3-b]吡啶]亚基）哌啶子基]丙酸，合成反应步骤中使用的金属和有机化合物主要通过简单的方法容易地从生产中副产的副产物与反应液分离，并且副产物被充分除去，而不需要通过色谱法的纯化步骤，从而可以批量生产并提高生产效率。

5. 发明授权

US07074816B2 1 2 4-triazole compound 有权
标题翻译： 1 2 4-三唑化合物
公开(公告)号：US07074816B2
公开(公告)日：2006-07-11
申请号：US10495322
申请日：2002-12-03
申请人： Hiroshi Nakamura , Soichi Kaneda , Takahiro Sato , Naoki Ashizawa , Koji Matsumoto , Takashi Iwanaga , Tsutomu Inoue
发明人： Hiroshi Nakamura , Soichi Kaneda , Takahiro Sato , Naoki Ashizawa , Koji Matsumoto , Takashi Iwanaga , Tsutomu Inoue
IPC分类号： C07D249/08 , A61K31/41
CPC分类号： C07D413/10 , C07D311/16 , C07D401/04 , C07D401/14
摘要： A novel 1,2,4-triazole compound which is useful as a therapeutic agent for hyperuricemia and gout due to hyperuricemia is provided. A compound is represented by the following general formula (1): wherein R2 represents an unsubstituted or substituted pyridyl group, R1 represents a similar pyridyl group, a pyridine-N-oxide group corresponding to these pyridyl groups, or a phenyl group, and R3 represents hydrogen or a lower alkyl group substituted with pivaloyloxy group and R3 bonds to a nitrogen atom in the ring. A process for production of a compound by reacting a nitrile and a hydrazide, and a therapeutic agent, particularly a xanthine oxidase inhibitor are also provided.
摘要翻译：提供了一种新颖的1,2,4-三唑化合物，其可用作高尿酸血症和由于高尿酸血症引起的痛风的治疗剂。化合物由以下通式（1）表示：其中R 2代表未取代或取代的吡啶基，R 1代表类似的吡啶基，吡啶-N 对应于这些吡啶基的苯氧基或苯基，R 3表示氢或被三氟甲酰氧基取代的低级烷基和R 3键连接到氮原子上在环中。还提供了通过腈和酰肼反应生产化合物的方法，以及治疗剂，特别是黄嘌呤氧化酶抑制剂。

6. 发明申请

US20050004175A1 Novel 1 2 4-triazole compound 有权
标题翻译：新型1 2 4-三唑化合物
公开(公告)号：US20050004175A1
公开(公告)日：2005-01-06
申请号：US10495322
申请日：2002-12-03
申请人： Hiroshi Nakamura , Soichi Kaneda , Takahiro Sato , Naoki Ashizawa , Koji Matsumoto , Takashi Iwanaga , Tsutomu Inoue
发明人： Hiroshi Nakamura , Soichi Kaneda , Takahiro Sato , Naoki Ashizawa , Koji Matsumoto , Takashi Iwanaga , Tsutomu Inoue
IPC分类号： A61P19/06 , A61P43/00 , C07D311/16 , C07D401/04 , C07D401/14 , C07D413/10 , A61K31/4439 , C07
CPC分类号： C07D413/10 , C07D311/16 , C07D401/04 , C07D401/14
摘要： A novel 1,2,4-triazole compound which is useful as a therapeutic agent for hyperuricemia and gout due to hyperuricemia is provided. A compound is represented by the following general formula (1): wherein R2 represents an unsubstituted or substituted pyridyl group, R1 represents a similar pyridyl group, a pyridine-N-oxide group corresponding to these pyridyl groups, or a phenyl group, and R3 represents hydrogen or a lower alkyl group substituted with pivaloyloxy group and R3 bonds to a nitrogen atom in the ring. A process for production of a compound by reacting a nitrile and a hydrazide, and a therapeutic agent, particularly a xanthine oxidase inhibitor are also provided.
摘要翻译：提供了一种新颖的1,2,4-三唑化合物，其可用作高尿酸血症和由于高尿酸血症引起的痛风的治疗剂。化合物由以下通式（1）表示：其中R2表示未取代或取代的吡啶基，R1表示相似的吡啶基，对应于这些吡啶基的吡啶-N-氧化物基或苯基，R3表示表示氢或被新戊酰氧基取代的低级烷基，并且R 3与环中的氮原子键合。还提供了通过腈和酰肼反应生产化合物的方法，以及治疗剂，特别是黄嘌呤氧化酶抑制剂。

7. 发明授权

US09353310B2 Luminous material using fluorescence amorphous solid 有权
标题翻译：发光材料使用荧光无定形固体
公开(公告)号：US09353310B2
公开(公告)日：2016-05-31
申请号：US12716728
申请日：2010-03-03
申请人： Hiroki Iwanaga , Takahiro Sato
发明人： Hiroki Iwanaga , Takahiro Sato
IPC分类号： C09K11/06 , H01J1/62 , H01J63/04 , H05B33/14
CPC分类号： C09K11/06 , C09K2211/1096 , C09K2211/182 , H05B33/14
摘要： An amorphous luminous material, which is substantially composed of only rare earth complex compounds, wherein the compounds are two or more kinds of rare earth complexes, and rare earth metal ions, which are center ions of the two or more kinds of rare earth complexes, are different ions.
摘要翻译：一种无机发光材料，其基本上仅由稀土配合物组成，其中化合物为两种或多种稀土配合物，稀土金属离子为两种或多种稀土络合物的中心离子，是不同的离子。

8. 发明授权

US09331207B2 Oxide semiconductor device and manufacturing method therof 有权
标题翻译：氧化物半导体器件及其制造方法
公开(公告)号：US09331207B2
公开(公告)日：2016-05-03
申请号：US13937591
申请日：2013-07-09
申请人： Shunpei Yamazaki , Naoya Sakamoto , Takahiro Sato , Shunsuke Koshioka , Takayuki Cho , Yoshitaka Yamamoto , Takuya Matsuo , Hiroshi Matsukizono , Yosuke Kanzaki
发明人： Shunpei Yamazaki , Naoya Sakamoto , Takahiro Sato , Shunsuke Koshioka , Takayuki Cho , Yoshitaka Yamamoto , Takuya Matsuo , Hiroshi Matsukizono , Yosuke Kanzaki
IPC分类号： H01L29/10 , H01L29/786 , H01L29/201
CPC分类号： H01L29/7869 , H01L29/201
摘要： A semiconductor device includes a gate electrode; a gate insulating film over the gate electrode; an oxide semiconductor film in contact with the gate insulating film and including a channel formation region which overlaps with the gate electrode; a source electrode and a drain electrode over the oxide semiconductor film; and an oxide insulating film over the oxide semiconductor film, the source electrode, and the drain electrode. The source electrode and the drain electrode each include a first metal film having an end portion at the end of the channel formation region, a second metal film over the first metal film and containing copper, and a third metal film over the second metal film. The second metal film is formed on the inner side than the end portion of the first metal film.
摘要翻译：半导体器件包括栅电极; 栅电极上的栅极绝缘膜; 与所述栅极绝缘膜接触并且包括与所述栅电极重叠的沟道形成区域的氧化物半导体膜; 氧化物半导体膜上的源电极和漏电极; 以及氧化物半导体膜，源电极和漏电极上的氧化物绝缘膜。源极电极和漏极电极各自包括在沟道形成区域的端部具有端部的第一金属膜，在第一金属膜上的含有铜的第二金属膜和在第二金属膜上的第三金属膜。第二金属膜形成在比第一金属膜的端部的内侧。

9. 发明授权

US09287424B2 Polyimide resin composition for use in forming reverse reflecting layer in photovoltaic cell and method of forming reverse reflecting layer in photovoltaic cell used therewith 有权
标题翻译：用于在光伏电池中形成反向反射层的聚酰亚胺树脂组合物及在其中使用的光伏电池中形成反向反射层的方法
公开(公告)号：US09287424B2
公开(公告)日：2016-03-15
申请号：US13822955
申请日：2011-09-20
申请人： Maw Soe Win , Toshiyuki Goshima , Takahiro Sato , Hidenao Takato , Isao Sakata
发明人： Maw Soe Win , Toshiyuki Goshima , Takahiro Sato , Hidenao Takato , Isao Sakata
IPC分类号： H01L31/0232 , C09D179/08 , H01L31/056 , C08G73/10
CPC分类号： H01L31/02327 , C08G73/1039 , C08G73/1042 , C08G73/1046 , C08G73/106 , C08G73/1064 , C08G73/1067 , C08G73/1071 , C08L2203/204 , C09D179/08 , H01L31/056 , Y02E10/52 , Y02E10/547 , C08K3/22
摘要： Disclosed are a method of forming a back reflection layer in a solar cell, a composition used therefor, and a solar cell having a back reflection layer formed by the method, which layer has superior heat-resistance and various types of durabilities, and can contribute to improving the conversion rate of solar cells and reliability during long-term use, and which method can form a back reflection layer in a solar cell easily and at low cost. The polyimide resin composition for use in forming a back reflection layer in a solar cell includes an organic solvent, a polyimide resin dissolved in the organic solvent, and light-reflecting particles dispersed in the organic solvent.
摘要翻译：公开了一种在太阳能电池中形成背反射层的方法，用于其的组合物和具有通过该方法形成的背面反射层的太阳能电池，该层具有优异的耐热性和各种类型的耐久性，并且可以贡献提高太阳能电池的转换率和长期使用中的可靠性，哪种方法可以容易地且低成本地在太阳能电池中形成背反射层。用于在太阳能电池中形成背反射层的聚酰亚胺树脂组合物包括有机溶剂，溶于有机溶剂中的聚酰亚胺树脂和分散在有机溶剂中的光反射颗粒。

10. 发明授权

US09234263B2 Weldment 有权
标题翻译：焊接
公开(公告)号：US09234263B2
公开(公告)日：2016-01-12
申请号：US13317463
申请日：2011-10-19
申请人： Hiromitsu Kuroda , Toru Sumi , Hideyuki Sagawa , Seigi Aoyama , Masayoshi Goto , Takahiko Hanada , Takahiro Sato , Hidenori Abe
发明人： Hiromitsu Kuroda , Toru Sumi , Hideyuki Sagawa , Seigi Aoyama , Masayoshi Goto , Takahiko Hanada , Takahiro Sato , Hidenori Abe
IPC分类号： B32B15/20 , C22C9/00 , B23K31/00 , C22C1/02 , C22C1/10 , C22F1/00 , C22F1/08
CPC分类号： C22C9/00 , B23K31/00 , B32B15/20 , C22C1/02 , C22C1/1036 , C22F1/00 , C22F1/08 , Y10T428/1266 , Y10T428/12667 , Y10T428/12882 , Y10T428/12903 , Y10T428/1291
摘要： A weldment includes metal materials that are welded to each other. At least one of the metal materials includes pure copper including an inevitable impurity, more than 2 mass ppm of oxygen, and an additive element selected from the group consisting of Mg, Zr, Nb, Fe, Si, Al, Ca, V, Ni, Mn, Ti and Cr. A method of manufacturing a weldment includes melting a dilute copper alloy material by SCR continuous casting and rolling at a molten copper temperature of not less than 1100° C. and not more than 1320° C. to make a molten metal, forming a cast bar from the molten metal, forming a dilute copper alloy member by hot-rolling the cast bar, and welding the dilute copper alloy member to a metal material. The dilute copper alloy material includes the pure copper, more than 2 mass ppm of oxygen, and the additive element,?
摘要翻译：焊件包括彼此焊接的金属材料。至少一种金属材料包括包含不可避免的杂质的纯铜，大于2质量ppm的氧，以及选自Mg，Zr，Nb，Fe，Si，Al，Ca，V，Ni ，Mn，Ti和Cr。一种焊接件的制造方法，其特征在于，以不低于1100℃，不高于1320℃的熔融铜温度，通过SCR连续铸造，熔融稀释的铜合金材料，形成熔融金属从熔融金属中，通过对铸造棒进行热轧而形成稀铜合金构件，并将稀铜合金构件焊接到金属材料上。稀铜合金材料包括纯铜，超过2质量ppm的氧和添加元素，

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