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1. 发明申请

US20060180734A1 Beads alignment structure, production method thereof, and bead alignment method for capillary beads array 审中-公开
公开(公告)号：US20060180734A1
公开(公告)日：2006-08-17
申请号：US11399409
申请日：2006-04-07
申请人： Osamu Kogi , Hiroshi Kishida
发明人： Osamu Kogi , Hiroshi Kishida
IPC分类号： B29C33/00
CPC分类号： B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B01L3/502707 , B01L3/502753 , B01L3/502761 , B01L2200/0668 , B82Y30/00 , C40B40/06 , Y10T428/2982
摘要： A method for producing a capillary bead array comprises the steps of: dispensing beads into a liquid pool, outside a capillary, having a depth of almost the same length as the particle diameter of a bead; leveling the excessive beads by moving a leveling member which is in contact with and relatively capable of be moved to the liquid pool to remove excessive beads that the liquid pool cannot contain; aligning the beads in the liquid pool one- or two-dimensionally; bonding adjacent individual beads to each other; producing a structure having the plurality of beads bonded and aligned one- or two-dimensionally; removing the structure from the liquid pool; and disposing the structure in the capillary formed of soft resin, so that the beads comprising the plurality of beads retaining the one- or two-dimensional alignment can be introduced simultaneously into the capillary. This method reduces the time and cost necessary for bead array production and retains the bead alignment in the capillary, resulting in improved accuracy and reliability in experiments using the capillary array.

2. 发明申请

US20060024208A1 Apparatus and method for arraying beads 失效
公开(公告)号：US20060024208A1
公开(公告)日：2006-02-02
申请号：US11189931
申请日：2005-07-27
申请人： Noriko Ban , Hiroshi Kishida
发明人： Noriko Ban , Hiroshi Kishida
IPC分类号： B01L3/02
CPC分类号： B01L3/0289 , B01J19/0046 , B01J2219/00463 , B01J2219/005 , B01L2200/0668 , Y10T436/255
摘要： An apparatus and a method for arraying beads that allow a bead array having been difficult in mass production to be manufactured easily and accurately are provided. Beads are once arrayed in a separate container using an inclined bead array apparatus while controlling the number of beads to be inserted simply by the use of a bead control rod. When the whole arraying is completed, the arrayed beads are transferred onto a plate for use in an actual reaction.

3. 发明授权

US06767748B2 Spotting pin, spotting device and method for spotting biomolecules 失效
标题翻译：点针，点样装置和生物分子检测方法
公开(公告)号：US06767748B2
公开(公告)日：2004-07-27
申请号：US10429825
申请日：2003-05-06
申请人： Naoki Yokokawa , Mitsuhiro Tachibana , Hiroshi Kishida
发明人： Naoki Yokokawa , Mitsuhiro Tachibana , Hiroshi Kishida
IPC分类号： G01N128
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00387 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00689 , B01J2219/00698 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N2035/1037 , Y10T436/2575
摘要： The present invention enables the accurate management of the total number of spotting counts for each spotting pin. An IC chip is installed on the spotting pin to allow the IC chip to accumulate spotting-count information, and during each spotting time the information is loaded up and displayed.
摘要翻译：本发明能够精确地管理每个点针的总点数计数。 IC芯片安装在点焊针上，允许IC芯片累积点样数信息，并在每个发光时间内加载和显示信息。

4. 发明申请

US20080312104A1 BIOLOGICAL MATERIAL PREPARATION CHIP AND PREPARATION CHIP SYSTEM 审中-公开
标题翻译：生物材料制备芯片和制备芯片系统
公开(公告)号：US20080312104A1
公开(公告)日：2008-12-18
申请号：US11763471
申请日：2007-06-15
申请人： Yasuhiko Sasaki , Toru Inaba , Hiroshi Kishida , Masaomi Uchida
发明人： Yasuhiko Sasaki , Toru Inaba , Hiroshi Kishida , Masaomi Uchida
IPC分类号： C40B50/00 , C40B60/14
CPC分类号： B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2400/0487 , B01L2400/084
摘要： The present invention is directed to provide a preparation chip system having a simpler configuration and improved reliability while addressing the case where a plurality of reagents have to be fed as in a preparation of extracting DNA from a sample solution. The preparation chip system includes a sample chamber, a dissolving solution chamber, a cleaning solution chamber, an eluting solution chamber, a mixing passage connected to the sample chamber and the dissolving solution chamber and mixing the sample and the dissolving solution with each other, a carrier part connected to the mixing passage, a waste chamber connected to the carrier part via a holding passage, a collection chamber holding the eluting solution passed through the carrier part, and a plurality of resistive materials forming a passage resistor disposed in a first passage connecting the cleaning solution chamber with both the mixing passage and the carrier part. The eluting solution is passed through the carrier part by pressure from a pressure source.
摘要翻译：本发明旨在提供一种制备芯片系统，其具有更简单的结构和改善的可靠性，同时解决了在从样品溶液中提取DNA的制备中必须进料多种试剂的情况。制剂芯片系统包括样品室，溶解溶液室，清洗溶液室，洗脱溶液室，连接到样品室的混合通道和溶解溶液室，并将样品和溶解溶液彼此混合，连接到混合通道的载体部分，经由保持通道连接到载体部分的废物室，保持通过载体部分的洗脱溶液的收集室，以及形成通道电阻器的多个电阻材料，设置在第一通道中，连接所述清洁溶液室具有所述混合通道和所述载体部分。洗脱溶液通过压力源通过载体部分。

5. 发明授权

US07052570B2 Beads alignment structure, production method thereof, and bead alignment method for capillary beads array 有权
标题翻译：珠粒对准结构，其制备方法和毛细管珠阵列的珠粒对准方法
公开(公告)号：US07052570B2
公开(公告)日：2006-05-30
申请号：US10765075
申请日：2004-01-28
申请人： Osamu Kogi , Hiroshi Kishida
发明人： Osamu Kogi , Hiroshi Kishida
IPC分类号： B29C37/00
CPC分类号： B01J19/0046 , B01J2219/00466 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B01L3/502707 , B01L3/502753 , B01L3/502761 , B01L2200/0668 , B82Y30/00 , C40B40/06 , Y10T428/2982
摘要： A method for producing a capillary bead array comprises the steps of: dispensing beads into a liquid pool, outside a capillary, having a depth of almost the same length as the particle diameter of a bead; leveling the excessive beads by moving a leveling member which is in contact with and relatively capable of be moved to the liquid pool to remove excessive beads that the liquid pool cannot contain; aligning the beads in the liquid pool one- or two-dimensionally; bonding adjacent individual beads to each other; producing a structure having the plurality of beads bonded and aligned one- or two-dimensionally; removing the structure from the liquid pool; and disposing the structure in the capillary formed of soft resin, so that the beads comprising the plurality of beads retaining the one- or two-dimensional alignment can be introduced simultaneously into the capillary. This method reduces the time and cost necessary for bead array production and retains the bead alignment in the capillary, resulting in improved accuracy and reliability in experiments using the capillary array.
摘要翻译：用于制备毛细管珠阵列的方法包括以下步骤：将珠子分散到具有与珠的粒径几乎相同长度的深度的毛细管外的液池中; 通过移动与液池接触并相对能够移动到液池的调平构件来调平多余的珠子，以去除液池不能容纳的多余的珠子; 一次或二维地将液体池中的珠子对准; 将相邻的单个珠彼此粘合; 产生具有多个珠粒的结构，其一次或二维地结合并排列; 从液池中取出结构; 并将结构设置在由软树脂形成的毛细管中，使得包含保持一维或二维取向的多个珠的珠可以同时引入毛细管中。该方法减少了珠阵列生产所需的时间和成本，并且保持毛细管中的珠粒对准，从而在使用毛细管阵列的实验中提高了精度和可靠性。

6. 发明申请

US20060008821A1 Biomaterial inspection chip 审中-公开
标题翻译：生物材料检验芯片
公开(公告)号：US20060008821A1
公开(公告)日：2006-01-12
申请号：US11094188
申请日：2005-03-31
申请人： Toru Inaba , Yasuhiko Sasaki , Shigenori Togashi , Hiroshi Kishida , Takashi Shimizu
发明人： Toru Inaba , Yasuhiko Sasaki , Shigenori Togashi , Hiroshi Kishida , Takashi Shimizu
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L9/527 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00576 , B01J2219/00657 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L2200/0647 , B01L2300/0636 , B01L2300/0819 , B01L2300/0883
摘要： Within an inside of a bead chip forming a reactor flow pass therein, rinsing liquid flow passes are also provided in one body. For the purpose of promoting reaction upon a bead array, a turbulence generator or an flow separation stop guide is provided within the reactor flow pass, in which the beads are received. The bead chip is made of a PDMS (Polydimethylsiloxane: (C2H6SiO)n), thereby enabling the reactor flow pass and the rinsing liquid flow passes to be formed freely in the configurations thereof.
摘要翻译：在形成反应器流动通道的珠粒的内部，冲洗液体流动通道也设置在一体中。为了促进珠粒阵列上的反应，在反应器流动通道内提供湍流发生器或流动分离停止引导件，其中容纳珠子。珠芯片由PDMS（聚二甲基硅氧烷：（C 2 H 6 SiO）SiO）N）制成，从而使反应器流过，冲洗液流在其结构中自由形成。

7. 发明授权

US06212038B1 Shutter mechanism for disk cartridge 失效
标题翻译：磁盘盒快门机构
公开(公告)号：US06212038B1
公开(公告)日：2001-04-03
申请号：US09650376
申请日：2000-08-29
申请人： Hiroshi Kishida
发明人： Hiroshi Kishida
IPC分类号： G11B2303
CPC分类号： G11B23/0308
摘要： A slide mechanism for a shutter, installed on a cartridge case of a disk cartridge, which is slidable in both right and left directions relative to the cartridge case from a neutral position at which a head access opening is closed by the shutter, and which is constituted by a smaller number of components and easy to assemble. The case has a groove which forms between a pair of counterparts forming the case itself; the shutter is biased toward a neutral position at which the shutter closes the head access opening; and the shutter has a projecting part which slidably engages the groove. The shutter is divided by a connecting portion of the upper wall side shutter plate and the lower wall side shutter plate, and the shutter is fixed together after the shutter plates are assembled to the cartridge case.
摘要翻译：一种用于快门的滑动机构，其安装在盒式磁盘盒的盒式磁盘盒上，该盒式磁带盒的盒式磁带盒可从相对于盒式磁盘盒的左右方向滑动，从中央位置开始，该中性位置，磁头存取开口由快门关闭，由较少数量的部件组成并易于组装。壳体具有在形成壳体本身的一对对应物之间形成的凹槽; 快门被偏压到快门关闭头部存取开口的中间位置; 并且挡板具有可滑动地接合凹槽的突出部分。快门由上壁侧快门板和下壁侧快门板的连接部分分隔开，并且在快门板组装到盒壳体之后，快门被固定在一起。

8. 发明申请

US20060233665A1 Test chip and test chip system 审中-公开
标题翻译：测试芯片和测试芯片系统
公开(公告)号：US20060233665A1
公开(公告)日：2006-10-19
申请号：US11327481
申请日：2006-01-09
申请人： Yasuhiko Sasaki , Osamu Kogi , Hiroshi Kishida , Toru Inaba , Masaomi Uchida
发明人： Yasuhiko Sasaki , Osamu Kogi , Hiroshi Kishida , Toru Inaba , Masaomi Uchida
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2200/143 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487
摘要： A test chip, which allows a number of solution delivery steps much faster and accurate is provided. The test chip incorporates a sample flow path for containing a sample solution, a reaction flow path for inducing a predetermined reaction with the sample solution, a waste drain path for receiving the used sample, and the washing solution flow paths for containing washing solutions. The reaction flow path contains a plurality of beads having probes of mutually different types fixed thereon. The sample flow path, washing solution flow paths, and sample waste drain path have their respective solution detector units. The solution detector unit detects whether the solution is fed to the path. The detector units adjoiningly provided in the adjacent paths are arranged collinearly.
摘要翻译：提供了一种测试芯片，其允许许多解决方案传送步骤更快速和准确。测试芯片包括用于容纳样品溶液的样品流动路径，用于诱导与样品溶液的预定反应的反应流动路径，用于接收使用的样品的废液排放路径和用于容纳洗涤溶液的洗涤液流路。反应流路包含多个具有固定在其上的相互不同类型的探针的珠。样品流动路径，洗涤液流动路径和样品废物排放路径具有它们各自的溶液检测器单元。溶液检测器单元检测溶液是否被供给到路径。邻接设置在相邻路径中的检测器单元共线布置。

9. 发明授权

US6157517A Shutter mechanism for disk cartridge 失效
标题翻译：磁盘盒快门机构
公开(公告)号：US6157517A
公开(公告)日：2000-12-05
申请号：US958900
申请日：1997-10-28
申请人： Hiroshi Kishida
发明人： Hiroshi Kishida
IPC分类号： G11B23/03
CPC分类号： G11B23/0308
摘要： A slide mechanism for a shutter, installed on a cartridge case of a disk cartridge, which is slidable in both right and left directions relative to the cartridge case from a neutral position at which a head access opening is closed by the shutter, and which is constituted by a smaller number of components and easy to assemble. The case has a groove which forms between a pair of counterparts forming the case itself; the shutter is biased toward a neutral position at which the shutter closes the head access opening; and the shutter has a projecting part which slidably engages the groove. The shutter is divided by a connecting portion of the upper wall side shutter plate and the lower wall side shutter plate, and the shutter is fixed together after the shutter plates are assembled to the cartridge case.
摘要翻译：一种用于快门的滑动机构，其安装在盒式磁盘盒的盒式磁盘盒上，该盒式磁带盒的盒式磁带盒可从相对于盒式磁盘盒的左右方向滑动，从中央位置开始，该中性位置，磁头存取开口由快门关闭，由较少数量的部件组成并易于组装。壳体具有在形成壳体本身的一对对应物之间形成的凹槽; 快门被偏压到快门关闭头部存取开口的中间位置; 并且挡板具有可滑动地接合凹槽的突出部分。快门由上壁侧快门板和下壁侧快门板的连接部分分隔开，并且在快门板组装到盒壳体之后，快门被固定在一起。

10. 发明授权

US6046637A Feedforward amplifier 失效
标题翻译：前馈放大器
公开(公告)号：US6046637A
公开(公告)日：2000-04-04
申请号：US132237
申请日：1998-08-11
申请人： Hiroshi Kishida , Ken Takei , Hiroshi Okabe , Kenji Sekine , Kazuyuki Hori
发明人： Hiroshi Kishida , Ken Takei , Hiroshi Okabe , Kenji Sekine , Kazuyuki Hori
IPC分类号： H03F1/32
CPC分类号： H03F1/3235
摘要： An improved feedforward amplifier capable of enhancing accuracy of extraction of an error signal corresponding to a distortion component while preventing outflow of an pilot signal. A switch is disposed between a pilot signal oscillator and a third power combiner for superimposing the pilot signal on an output signal from a main amplifier, and third control means is connected with the switch so that the switch is opened at the time of error signal extraction and closed at the time of error signal elimination.
摘要翻译：一种改进的前馈放大器，其能够提高对应于失真分量的误差信号的提取精度，同时防止导频信号的流出。在导频信号振荡器和第三功率合成器之间设置开关，用于将导频信号叠加在来自主放大器的输出信号上，第三控制装置与开关连接，使得开关在误差信号提取时打开并在错误信号消除时关闭。

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