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1. 发明授权

US09463236B2 RSV mucosal vaccine 有权
标题翻译： RSV粘膜疫苗
公开(公告)号：US09463236B2
公开(公告)日：2016-10-11
申请号：US14241596
申请日：2012-08-29
申请人： Hiroshi Kido , Dai Mizuno , Hirotsugu Ueda , Koji Yoshikawa , Keisuke Ohsumi , Nobuyuki Yamamoto , Kenji Sudo
发明人： Hiroshi Kido , Dai Mizuno , Hirotsugu Ueda , Koji Yoshikawa , Keisuke Ohsumi , Nobuyuki Yamamoto , Kenji Sudo
IPC分类号： A61K39/155 , A61K39/12 , C07K14/005 , C07K14/00 , A61K39/39 , C12N7/00 , A61K39/00
CPC分类号： A61K39/155 , A61K39/12 , A61K39/39 , A61K2039/541 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , A61K2039/55555 , C07K14/001 , C07K14/005 , C12N7/00 , C12N2760/00034 , C12N2760/18522 , C12N2760/18534 , C12N2760/18551
摘要： A composition comprising the following composition: an AD vehicle including a synthetic peptide and a lipid, wherein the synthetic peptide includes the amino acid sequence KnLm (wherein n is 4 to 8 and m is 11 to 20), a carboxylvinyl polymer and an RSV antigen. The composition has an antibody producing ability which is further higher than that of a conventional mucosal vaccine, hence capable of exerting excellent anti-virus antigen-specific IgA antibody- and IgG antibody-inducing effect in the nasal wash and the serum, respectively, even with an extremely small quantity of an RSV antigen.
摘要翻译：包含以下组成的组合物：包含合成肽和脂质的AD载体，其中所述合成肽包括氨基酸序列KnLm（其中n为4至8且m为11至20），羧基乙烯基聚合物和RSV抗原。该组合物具有比常规粘膜疫苗更高的抗体产生能力，因此能够分别在鼻洗液和血清中发挥优异的抗病毒抗原特异性IgA抗体和IgG抗体诱导作用，甚至具有非常少量的RSV抗原。

2. 发明授权

US07465748B2 Amide derivative 有权
标题翻译：酰胺衍生物
公开(公告)号：US07465748B2
公开(公告)日：2008-12-16
申请号：US10567565
申请日：2004-08-05
申请人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Tomoaki Kawano , Akio Kamikawa , Hiroshi Suzuki , Kenji Sudo
发明人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Tomoaki Kawano , Akio Kamikawa , Hiroshi Suzuki , Kenji Sudo
IPC分类号： A61K31/41 , C07D271/06
CPC分类号： C07D335/02 , C07D413/12
摘要： There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection.An N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative, of which phenyl group is substituted at position 4 with a specific 5- or 6-membered heteroaryl group, and a salt thereof have an effective anti-virus activity, and the oral administration thereof at a low dose enabled the therapeutic treatment of the above diseases.
摘要翻译：提供药物，特别是可用于预防或治疗涉及疱疹病毒家族病毒感染的各种疾病的新型化合物，特别是各种疱疹病毒感染如通过水痘带状疱疹病毒的水痘（水痘），水痘带状疱疹经由复发通过HSV-1和生殖器疱疹通过HSV-2感染感染潜伏性水痘带状疱疹病毒，唇疱疹和疱疹脑炎。 N-（2 - [（4-取代苯基）氨基] -2-氧代乙基}四氢-2H-噻喃-4-甲酰胺衍生物，其苯基在4位被特定的5或6元杂芳基取代基团和其盐具有有效的抗病毒活性，并且以低剂量口服给药能够治疗上述疾病。

3. 发明申请

US20090030049A1 MEDICAMENT FOR GENITAL HERPES 审中-公开
标题翻译：一般药物的药物
公开(公告)号：US20090030049A1
公开(公告)日：2009-01-29
申请号：US11815390
申请日：2006-02-01
申请人： Hiroshi Suzuki , Kenji Sudo
发明人： Hiroshi Suzuki , Kenji Sudo
IPC分类号： A61K31/4245 , A61K31/422 , A61P31/22
CPC分类号： C07D413/12 , A61K31/422 , A61K31/4245
摘要： [PROBLEMS] To provide a medicament useful for the treatment of genital herpes after the development of lesions.[MEANS FOR SOLVING PROBLEMS] An N-[2-[(4-substituted phenyl)amino]-2-oxoethyl]tetrahydro-2H-thiopyran-4-carboxamide derivative in which the phenyl group is substituted at position 4 by a specific 5- or 6-membered heteroaryl group has an excellent anti-herpesvirus effect and can exert excellent therapeutic effect on genital herpes after the development of lesions. Therefore, the compound is useful for the treatment of genital herpes after the development of lesions.
摘要翻译： [问题]提供可用于在发展病变后治疗生殖器疱疹的药物。解决问题的方法N-苯并[4 - 取代苯基]氨基] -2-氧代乙基]四氢-2H-噻喃-4-甲酰胺衍生物，其中苯基在4位被特异性5取代 - 或6元杂芳基具有优异的抗疱疹病毒作用，并且可以在病变发展后对生殖器疱疹发挥优异的治疗作用。因此，该化合物在病变发展后可用于治疗生殖器疱疹。

4. 发明申请

US20060229295A1 Amide derivatives 有权
标题翻译：酰胺衍生物
公开(公告)号：US20060229295A1
公开(公告)日：2006-10-12
申请号：US10567565
申请日：2004-08-05
申请人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Tomoaki Kawano , Akio Kamikawa , Hiroshi Suzuki , Kenji Sudo
发明人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Tomoaki Kawano , Akio Kamikawa , Hiroshi Suzuki , Kenji Sudo
IPC分类号： A61K31/55 , A61K31/551 , A61K31/506 , A61K31/5377 , A61K31/4545 , A61K31/4709 , A61K31/4439 , A61K31/433 , A61K31/428 , A61K31/422
CPC分类号： C07D335/02 , C07D413/12
摘要： There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. An N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative, of which phenyl group is substituted at position 4 with a specific 5- or 6-membered heteroaryl group, and a salt thereof have an effective anti-virus activity, and the oral administration thereof at a low dose enabled the therapeutic treatment of the above diseases.
摘要翻译：提供药物，特别是可用于预防或治疗涉及疱疹病毒家族病毒感染的各种疾病的新型化合物，特别是各种疱疹病毒感染如通过水痘带状疱疹病毒的水痘（水痘），水痘带状疱疹经由复发通过HSV-1和生殖器疱疹通过HSV-2感染感染潜伏性水痘带状疱疹病毒，唇疱疹和疱疹脑炎。 N-（2 - [（4-取代苯基）氨基] -2-氧代乙基}四氢-2H-噻喃-4-甲酰胺衍生物，其苯基在4位被特定的5或6元杂芳基取代基团和其盐具有有效的抗病毒活性，并且以低剂量口服给药能够治疗上述疾病。

5. 发明授权

US06903125B2 Tetrahydro-2H-thiopyran-4-carboxamide derivative 有权
标题翻译：四氢-2H-噻喃-4-甲酰胺衍生物
公开(公告)号：US06903125B2
公开(公告)日：2005-06-07
申请号：US10912232
申请日：2004-08-06
申请人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Tomoaki Kawano , Akio Kamikawa , Hiroshi Suzuki , Kenji Sudo
发明人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Tomoaki Kawano , Akio Kamikawa , Hiroshi Suzuki , Kenji Sudo
IPC分类号： A61P31/22 , C07D335/02 , C07D413/12 , A61K31/41 , C07D271/06
CPC分类号： C07D335/02 , C07D413/12
摘要： A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. N-{2-[(4-Substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative where the phenyl group is substituted at position 4 with a specific five-membered or 6-membered heteroaryl group, has such great anti-virus activity that the oral dosing thereof at a low dose enabled the therapeutic treatment of the diseases.
摘要翻译：一种药物，特别是可用于预防或治疗涉及疱疹病毒科家族病毒感染的各种疾病的新型化合物，特别是各种疱疹病毒感染如通过水痘带状疱疹病毒的水痘（水痘），水痘带状疱疹通过潜在的复发性感染水痘带状疱疹病毒，通过HSV-1和生殖器疱疹通过HSV-2感染的唇疱疹和疱疹脑炎。 N- {2 - [（4-取代的苯基）氨基] -2-氧代乙基}四氢-2H-噻喃-4-甲酰胺衍生物，其中苯基在4位被特定的5元或6元杂芳基取代具有如此巨大的抗病毒活性，以低剂量的口服给药能够治疗疾病。

6. 发明申请

US20090048310A1 AGENT FOR PREVENTION/TREATMENT OF DISEASE CAUSED BY ACYCLOVIR-RESISTANT HERPESVIRUS 审中-公开
标题翻译：预防/治疗由抗胆碱性阴道病引起的疾病的药剂
公开(公告)号：US20090048310A1
公开(公告)日：2009-02-19
申请号：US11815365
申请日：2006-02-01
申请人： Hiroshi Suzuki , Koji Chono , Kenji Sudo
发明人： Hiroshi Suzuki , Koji Chono , Kenji Sudo
IPC分类号： A61K31/4245 , A61P31/22 , C07D409/00 , C07D277/62 , C07D277/00 , C07D271/06
CPC分类号： A61K31/422 , A61K31/4245 , C07D413/12
摘要： [Problems] To provide an agent useful for the prevention or treatment of various diseases associated with the infection with acyclovir-resistant viruses of the family Herpesviridae, specifically various infectious caused by herpes viruses, such as varicella associated with varicella-zoster virus infection, herpes zoster associated with recurrent infection with latent varicella-zoster virus, and herpes labialis, herpes encephalitis and genital herpes associated with HSV-1 and HSV-2 infection, and the like.[Means for Solving Problems] An N-[2-[(4-substituted phenyl)amino]-2-oxoethyl]tetrahydro-2H-thiopyran-4-carboxamide derivative in which the phenyl group is substituted at position 4 by a specific 5- or 6-membered heteroaryl group. This derivative has an excellent anti-viral activity against acyclovir-resistant herpes viruses and, therefore, is effective for the treatment of the diseases as mentioned above.
摘要翻译： [问题]提供可用于预防或治疗与疱疹病毒科疱疹病毒的无环鸟苷抗性病毒感染有关的各种疾病的药剂，特别是由疱疹病毒引起的各种感染性疾病，例如与水痘带状疱疹病毒感染相关的水痘，疱疹与潜伏性水痘带状疱疹病毒复发感染的带状疱疹，唇疱疹，与HSV-1和HSV-2感染相关的疱疹性脑炎和生殖器疱疹等。 [解决问题的手段]将苯基在4位被特定5取代的N- [2 - [（4-取代苯基）氨基] -2-氧代乙基]四氢-2H-噻喃-4-甲酰胺衍生物 - 或6-元杂芳基。该衍生物对抗阿昔洛韦抗性疱疹病毒具有优异的抗病毒活性，因此对于如上所述的疾病的治疗是有效的。

7. 发明申请

US20050032855A1 Tetrahydro-2H-thiopyran-4-carboxamide derivative 有权
公开(公告)号：US20050032855A1
公开(公告)日：2005-02-10
申请号：US10912232
申请日：2004-08-06
申请人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Tomoaki Kawano , Akio Kamikawa , Hiroshi Suzuki , Kenji Sudo
发明人： Toru Kontani , Junji Miyata , Wataru Hamaguchi , Tomoaki Kawano , Akio Kamikawa , Hiroshi Suzuki , Kenji Sudo
IPC分类号： A61P31/22 , C07D335/02 , C07D413/12 , A61K31/4245 , A61K31/422 , C07D413/02
CPC分类号： C07D335/02 , C07D413/12
摘要： A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. N-{2-[(4-Substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative where the phenyl group is substituted at position 4 with a specific five-membered or 6-membered heteroaryl group, has such great anti-virus activity that the oral dosing thereof at a low dose enabled the therapeutic treatment of the diseases.

8. 发明授权

US08125963B2 Radio transmission control method, radio receiver apparatus, and radio transmitter apparatus 有权
标题翻译：无线传输控制方法，无线电接收装置和无线电发射装置
公开(公告)号：US08125963B2
公开(公告)日：2012-02-28
申请号：US10567339
申请日：2004-07-29
申请人： Yoshitaka Hara , Akinori Taira , Tomoaki Otsuki , Kenji Sudo
发明人： Yoshitaka Hara , Akinori Taira , Tomoaki Otsuki , Kenji Sudo
IPC分类号： H04W4/00
CPC分类号： H04B7/0639 , H04B7/061 , H04B7/0684 , H04B7/0691 , H04B7/0695 , H04L1/0001 , H04L1/0025 , H04W52/42
摘要： A radio communication method and apparatus generate a plurality of information signals and transmit the signals to a communication partner from a plurality of antennas. A plurality of combination of signals to be transmitted are selected. A transmission evaluation value is determined based on the signal noise ratio of each signal. After all combinations are evaluated, a transmission format suitable for sending a combination of signals is determined based on a highest evaluation value.
摘要翻译：无线电通信方法和装置产生多个信息信号，并将信号从多个天线发送到通信伙伴。选择要发送的信号的多个组合。基于每个信号的信号噪声比来确定传输评估值。在评估所有组合之后，基于最高评估值确定适于发送信号组合的传输格式。

9. 发明申请

US20090042915A1 PREVENTIVE OR THERAPEUTIC AGENT FOR HERPESVIRUS-RELEATED DISEASE 审中-公开
标题翻译：用于治疗病毒性疾病的预防或治疗药物
公开(公告)号：US20090042915A1
公开(公告)日：2009-02-12
申请号：US11815375
申请日：2006-02-01
申请人： Hiroshi Suzuki , Kenji Sudo
发明人： Hiroshi Suzuki , Kenji Sudo
IPC分类号： A61K31/422 , A61K31/4245 , A61K31/522 , A61P31/22
CPC分类号： C07D413/12 , A61K31/422 , A61K31/4245 , A61K31/52 , A61K31/522 , A61K45/06 , A61K2300/00
摘要： [Problems] To provide a medicament, particularly a pharmaceutical composition useful for preventing or treating a variety of diseases caused by infection of a virus of the Herpesviridae family.[Means for Solving Problems] The present invention relates to an anti-herpesvirus agent characterized by combining a helicase-primase inhibitor with a polymerase inhibitor. By combining the polymerase inhibitor with the helicase-primase inhibitor having different functional mechanisms, the anti-herpesvirus agent of the present invention achieves an extremely superior anti-herpesvirus activity compared with conventional administration of a polymerase inhibitor alone. Therefore, it is particularly effective in a case in which a sufficient therapeutic effect cannot be achieved only with a polymerase inhibitor. Further, since the doses of both agents can be kept low, it is also possible to perform treatment by lowering the effect of an adverse reaction to be concerned.
摘要翻译： [问题]提供一种药物，特别是可用于预防或治疗由疱疹病毒科家族病毒感染引起的各种疾病的药物组合物。解决问题的手段本发明涉及抗疱疹病毒药物，其特征在于将解旋酶抑制剂与聚合酶抑制剂组合。通过将聚合酶抑制剂与具有不同功能机制的解旋酶抑制剂相结合，本发明的抗疱疹病毒剂与单独使用聚合酶抑制剂相比，具有非常优异的抗疱疹病毒活性。因此，仅在聚合酶抑制剂不能达到足够的治疗效果的情况下才有效。此外，由于可以将两种药剂的剂量保持在较低水平，所以也可以通过降低所涉及的不良反应的效果来进行治疗。

10. 发明授权

US5698580A Antiviral agent containing benzodithiin derivative as active ingredient 失效
标题翻译：含有苯并二硫杂衍生物作为有效成分的抗病毒剂
公开(公告)号：US5698580A
公开(公告)日：1997-12-16
申请号：US750730
申请日：1996-12-16
申请人： Tsuyoshi Kajiyashiki , Ryu Sato , Tomoyuki Yokota , Kenji Sudo , Wataru Watanabe , Shiro Shigeta
发明人： Tsuyoshi Kajiyashiki , Ryu Sato , Tomoyuki Yokota , Kenji Sudo , Wataru Watanabe , Shiro Shigeta
IPC分类号： A61K31/385 , A61P11/00 , A61P31/12 , C07D339/08
CPC分类号： C07D339/08
摘要： Antiviral agents comprising, as an active ingredient, a 1,4-dihydro-2,3-benzodithiin derivative of the formula ##STR1## wherein each symbol is as defined in the Specification, or a pharmacologically acceptable salt thereof. The antiviral agents of the present invention have superior antiviral activity and are effective for the preventive and therapeutic treatment of viral diseases caused typically by RS virus.
摘要翻译： PCT No.PCT / JP95 / 01107 Sec。 371日期1996年12月16日第 102（e）日期1996年12月16日PCT归档1995年6月6日PCT公布。出版物WO95 / 35292 日期1995年12月28日，含有式“IMAGE”的1,4-二氢-2,3-苯并二硫杂衍生物作为活性成分的抗病毒药物，其中每个符号如本说明书中所定义，或其药理学上可接受的盐。本发明的抗病毒剂具有优异的抗病毒活性，对通常由RS病毒引起的病毒性疾病的预防和治疗有效。

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