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    • 7. 发明授权
    • System and method for delivering data in an intermittent communication environment
    • 用于在间歇性通信环境中传送数据的系统和方法
    • US09014088B2
    • 2015-04-21
    • US13432561
    • 2012-03-28
    • Hiroshi YamadaYasuo InoueShinichi MatsumotoMasayoshi Kamada
    • Hiroshi YamadaYasuo InoueShinichi MatsumotoMasayoshi Kamada
    • H04W4/00H04W40/02H04W40/24
    • H04W40/026H04W40/246
    • Mobile nodes are allowed to move around within an intermittent communication environment. A mobile node wirelessly communicates with an access node when approaching the access node, and stores data. The access node stores an action history for each mobile node, and generates a forwarder list in association with a destination node, based on action histories of the mobile nodes. The forwarder list stores one or more identifies each identifying a first mobile node in the order of an arrival probability indicating a probability that the first mobile node succeeds in delivering the data to the destination node. The access node selects second mobile nodes that are to carry the data to the destination node, based on the forwarder list, and transfers the data to one of the second mobile nodes when a communication link is established between the access node and the one of the second mobile nodes.
    • 允许移动节点在间歇通信环境内移动。 移动节点在接近接入节点时与接入节点进行无线通信,并存储数据。 访问节点存储每个移动节点的动作历史,并且基于移动节点的动作历史与目的地节点相关联地生成转发器列表。 转发器列表按照指示第一移动节点成功将数据传送到目的地节点的概率的到达概率的顺序存储一个或多个标识每个标识第一移动节点的标识。 接入节点基于转发器列表选择将数据携带到目的节点的第二移动节点,并且当在接入节点和接入节点之间建立通信链路时,将数据传送到第二移动节点之一 第二个移动节点。
    • 8. 发明授权
    • Method of achieving normoglycemia in diabetics by administration of Withaferin A
    • 糖尿病患者血糖异常的方法
    • US08637494B2
    • 2014-01-28
    • US13160334
    • 2011-06-14
    • Bashoo NaziruddinHan PengShinichi MatsumotoMarlon F. Levy
    • Bashoo NaziruddinHan PengShinichi MatsumotoMarlon F. Levy
    • A01N45/00A61K31/56
    • A61K31/58
    • Method and compositions for reducing the inflammation after cytokine exposure of an islet cell transplant without affecting the viability and potency are disclosed herein. The present invention describes a composition comprising Withaferin A (WA), a steroidal lactone derived from Withania somnifera to effectively block NF-kB activation in beta cells, minimize cytokine-induced cell death and improve survival of transplanted islets. The method of the present invention involves identifying a subject having islet cells in need of treatment; and providing a effective amount of a Withaferin A composition disposed in a pharmaceutically acceptable carrier in an amount sufficient to reduce the inflammation after cytokine exposure without affecting the viability and potency of the islet cell population.
    • 本文公开了用于减少细胞因子暴露于胰岛细胞移植而不影响生存力和效力的炎症的方法和组合物。 本发明描述了一种组合物,其包含嗜铬蛋白A(WA),来自嗜睡细菌的甾体内酯,以有效阻断β细胞中的NF-κB活化,使细胞因子诱导的细胞死亡最小化并提高移植胰岛的存活。 本发明的方法涉及鉴定具有需要治疗的胰岛细胞的受试者; 并且以足以减少细胞因子暴露后的炎症而不影响胰岛细胞群体的活力和潜力的量,提供有效量的药物可接受的载体中配置的伴有咖啡因的组合物。
    • 9. 发明申请
    • Inhibition of Pro-Inflammatory Cytokine Induced Response
    • 促炎细胞因子诱导反应的抑制作用
    • US20110305719A1
    • 2011-12-15
    • US13160334
    • 2011-06-14
    • Bashoo NaziruddinHan PengShinichi MatsumotoMarlon F. Levy
    • Bashoo NaziruddinHan PengShinichi MatsumotoMarlon F. Levy
    • A61K39/00A61P29/00A61P41/00A61K35/12A61K31/58
    • A61K31/58
    • Method and compositions for reducing the inflammation after cytokine exposure of an islet cell transplant without affecting the viability and potency are disclosed herein. The present invention describes a composition comprising Withaferin A (WA), a steroidal lactone derived from Withania somnifera to effectively block NF-kB activation in beta cells, minimize cytokine-induced cell death and improve survival of transplanted islets. The method of the present invention involves identifying a subject having islet cells in need of treatment; and providing a effective amount of a Withaferin A composition disposed in a pharmaceutically acceptable carrier in an amount sufficient to reduce the inflammation after cytokine exposure without affecting the viability and potency of the islet cell population.
    • 本文公开了用于减少细胞因子暴露于胰岛细胞移植而不影响生存力和效力的炎症的方法和组合物。 本发明描述了一种组合物,其包含嗜铬蛋白A(WA),来自嗜睡细菌的甾体内酯,以有效阻断β细胞中的NF-κB活化,使细胞因子诱导的细胞死亡最小化并提高移植胰岛的存活。 本发明的方法涉及鉴定具有需要治疗的胰岛细胞的受试者; 并且以足以减少细胞因子暴露后的炎症而不影响胰岛细胞群体的活力和潜力的量,提供有效量的药物可接受的载体中配置的伴有咖啡因的组合物。