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1. 发明授权

US07326543B2 Gene encoding protein from merozoite of Babesia caballi, recombinant protein obtained with said gene and use thereof 失效
标题翻译：来自Babesia caballi的裂殖子的基因编码蛋白，用该基因获得的重组蛋白及其用途
公开(公告)号：US07326543B2
公开(公告)日：2008-02-05
申请号：US10863338
申请日：2004-06-09
申请人： Hiromi Ikadai , Ikuo Igarashi , Naoyoshi Suzuki , Hideyuki Nagasawa , Kozo Fujisaki , Takeshi Mikami
发明人： Hiromi Ikadai , Ikuo Igarashi , Naoyoshi Suzuki , Hideyuki Nagasawa , Kozo Fujisaki , Takeshi Mikami
IPC分类号： C12N15/09 , C12P21/04 , A61K39/002 , A61K39/015 , C07K1/00
CPC分类号： G01N33/56905 , C07K14/44 , C07K16/20 , Y10S530/822
摘要： The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In accordance with the present invention, it is possible to stably prepare the 48 kDa protein of rhoptry of Babesia caballi and the gene encoding said protein in a large amount with the recombinant DNA technique. The present invention also provides a method for diagnosing equine babesiasis which comprises either specifically detecting anti-Babesia caballi antibody present in equine blood by using the recombinant protein of present invention as an antigen or detecting the presence of Babesia caballi merozoite in equine blood by using the antibody of the present invention.
摘要翻译：本发明提供了编码来自巴贝虫（Babesia caballi）的重组蛋白的巴贝虫（Babesia caballi）的裂殖子的蛋白质和能够特异性结合巴贝虫裂殖子的48kDa蛋白质的抗体的基因。根据本发明，可以通过重组DNA技术稳定地制备巴贝氏菌的48kDa蛋白质和大量编码所述蛋白质的基因。本发明还提供了一种用于诊断马贝氏病的方法，其特征在于，通过使用本发明的重组蛋白作为抗原或者通过使用本发明的马血中的巴贝虫突变体的存在来特异性检测马血中存在的抗巴贝虫抗体本发明的抗体。

2. 发明授权

US06855319B1 Gene encoding merozoite protein of Babesia caballi, recombinant protein obtained therefrom and utilization thereof 失效
标题翻译：基因编码巴贝幼虫的裂殖子蛋白，从其获得的重组蛋白质及其利用
公开(公告)号：US06855319B1
公开(公告)日：2005-02-15
申请号：US09807459
申请日：1999-08-13
申请人： Hiromi Ikadai , Ikuo Igarashi , Naoyoshi Suzuki , Hideyuki Nagasawa , Kozo Fujisaki , Takeshi Mikami
发明人： Hiromi Ikadai , Ikuo Igarashi , Naoyoshi Suzuki , Hideyuki Nagasawa , Kozo Fujisaki , Takeshi Mikami
IPC分类号： C07H21/02 , C07H21/04 , C07K14/44 , C07K16/20 , C12N1/21 , C12N15/30 , G01N33/569 , A61K39/002 , A61K39/015 , C07K1/00
CPC分类号： G01N33/56905 , C07K14/44 , C07K16/20 , Y10S530/822
摘要： The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In accordance with the present invention, it is possible to stably prepare the 48 kDa protein of rhoptry of Babesia caballi and the gene encoding said protein in a large amount with the recombinant DNA technique. The present invention also provides a method for diagnosing equine babesiasis which comprises either specifically detecting anti-Babesia caballi antibody present in equine blood by using the recombinant protein of present invention as an .antigen or detecting the presence of Babesia caballi merozoite in equine blood by using the antibody of the present invention.
摘要翻译：本发明提供了编码来自巴贝虫（Babesia caballi）的重组蛋白的巴贝虫（Babesia caballi）的裂殖子的蛋白质和能够特异性结合巴贝虫裂殖子的48kDa蛋白质的抗体的基因。根据本发明，可以通过重组DNA技术稳定地制备巴贝氏菌的48kDa蛋白质和大量编码所述蛋白质的基因。本发明还提供了一种用于诊断马贝氏病的方法，其包括通过使用本发明的重组蛋白作为抗原特异性检测存在于马血中的抗巴贝虫抗体，或通过使用马血检测胎儿巴马裂殖子的存在本发明的抗体。

3. 发明授权

US4621054A Biologically active substance, process for preparing the substance and immunoactive composition 失效
标题翻译：生物活性物质，制备物质和免疫组合物的方法
公开(公告)号：US4621054A
公开(公告)日：1986-11-04
申请号：US559760
申请日：1983-12-09
申请人： Naoyoshi Suzuki , Tsuneo Hirose , Humio Osaki
发明人： Naoyoshi Suzuki , Tsuneo Hirose , Humio Osaki
IPC分类号： C12P1/00 , A61K35/14 , A61K35/16 , A61K38/00 , A61K38/16 , A61K39/002 , C07G99/00 , C07K14/00 , C07K14/47 , C12P21/00 , C12P21/06 , C12R1/90 , A61K39/00 , A61K37/00
CPC分类号： C07K14/4703 , A61K35/16 , A61K39/002 , C12P21/005 , A61K38/00 , Y10S435/947
摘要： This invention relates to a biologically active substance which is a glycoprotein having a molecular weight of 3,000 to 5,000 and has activity to inhibit toxoplasma multiplication in homologous cells and heterologous cells.This invention also relates to a process for preparing the substance, immunoactive compositions containing the substance and use of the substance as a drug.
摘要翻译：本发明涉及生物活性物质，其是分子量为3,000至5,000的糖蛋白，并且具有抑制同源细胞和异源细胞中的弓形体繁殖的活性。本发明还涉及制备该物质的方法，含有该物质的免疫活性组合物和该物质作为药物的用途。

4. 发明授权

US4362268A Air conditioning system for an automotive vehicle compartment 失效
标题翻译：汽车车厢空调系统
公开(公告)号：US4362268A
公开(公告)日：1982-12-07
申请号：US197678
申请日：1980-10-16
申请人： Yukio Shimada , Naoyoshi Suzuki , Toshio Ohashi , Yasushi Inoshita
发明人： Yukio Shimada , Naoyoshi Suzuki , Toshio Ohashi , Yasushi Inoshita
IPC分类号： B60H1/00 , B60H3/00 , B60S1/54 , G05D23/275 , G05D23/13
CPC分类号： B60H1/00864 , B60S1/54 , G05D23/1925 , G05D23/275
摘要： An air conditioning system particularly mounted in a passenger compartment of an automotive vehicle according to the present invention can be fixed in the maximum heating operation mode to produce a maximum effect of the defrosting function by only pushing a push-button switch engaged with a mode selector for maximizing the air blowing rate of a ventilating fan and also engaged with a three-way vacuum switch for opening a vacuum power servomechanism to the air to fix an air mix door in the maximum heating position.
摘要翻译：根据本发明的特别安装在机动车辆的乘客室中的空调系统可以被固定在最大加热操作模式中，以通过仅按压与模式选择器接合的按钮开关来产生除霜功能的最大效果用于使通气风扇的吹风速度最大化，并且还与用于向空气打开真空动力伺服机构的三通真空开关接合，以将空气混合门固定在最大加热位置。

5. 发明申请

US20050187581A1 Methods of treating disorders with electric fields 审中-公开
标题翻译：用电场治疗疾病的方法
公开(公告)号：US20050187581A1
公开(公告)日：2005-08-25
申请号：US11014461
申请日：2004-12-17
申请人： Akikuni Hara , Hiroyuki Hara , Naoyoshi Suzuki , Shinji Harakawa , Nobuo Uenaka , David Martin , Henry Harris
发明人： Akikuni Hara , Hiroyuki Hara , Naoyoshi Suzuki , Shinji Harakawa , Nobuo Uenaka , David Martin , Henry Harris
IPC分类号： A61N1/00
CPC分类号： A61N1/00
摘要： The invention relates to methods and devices for treating disorders with electric current or electric field therapy. The invention uses applied electric current or current induced by an external electric field to alter ionic concentrations and modulates at least one G-protein-coupled receptor. The invention is useful, for example, for treating hyperproliferative and cardiovascular disorders and for ameliorating the effects of stress.
摘要翻译：本发明涉及用电流或电场治疗来治疗疾病的方法和装置。本发明使用施加的电流或由外部电场引起的电流来改变离子浓度并调节至少一种G蛋白偶联受体。本发明例如用于治疗过度增生和心血管疾病以及改善压力的作用是有用的。

6. 发明授权

US4352452A Emergency controller for an air conditioning system of an automotive vehicle 失效
标题翻译：汽车空调系统应急控制器
公开(公告)号：US4352452A
公开(公告)日：1982-10-05
申请号：US197694
申请日：1980-10-16
申请人： Yukio Shimada , Naoyoshi Suzuki , Toshio Ohashi , Yasushi Inoshita
发明人： Yukio Shimada , Naoyoshi Suzuki , Toshio Ohashi , Yasushi Inoshita
IPC分类号： B60H1/00 , F24F11/02 , G05D23/13
CPC分类号： B60H1/00978
摘要： An emergency controller for an air conditioning system of an automotive vehicle which incorporates an electronic control circuit in the automatic temperature adjusting means to perform a proportional control over an air mixing door by the use of a vacuum power servo is operated to connect a vacuum source to the vacuum power servo or to cause the air to flow into the vacuum power servo so that the maximum cooling or heating operation can be achieved. Consequently, when a trouble occurs in the electronic control circuit during running in a high-temperature region or low-temperature region, the air conditioning system may immediately be fixed in the maximum cooling or heating operation without intervention of electric circuits.
摘要翻译：操作用于汽车空调系统的应急控制器，其中包括电子控制电路在自动温度调节装置中，通过使用真空动力伺服器对空气混合门执行比例控制，以将真空源连接到真空动力伺服或使空气流入真空动力伺服器，从而可实现最大的制冷或制热操作。因此，当在高温区域或低温区域中运行时电子控制电路发生故障时，空调系统可以在没有电路介入的情况下立即在最大的制冷或制热操作中被固定。

7. 发明授权

US4333606A Air intake control system in air conditioning system 失效
标题翻译：空调系统进气控制系统
公开(公告)号：US4333606A
公开(公告)日：1982-06-08
申请号：US204511
申请日：1980-11-06
申请人： Yukio Shimada , Naoyoshi Suzuki , Toshio Ohashi , Yasushi Inoshita
发明人： Yukio Shimada , Naoyoshi Suzuki , Toshio Ohashi , Yasushi Inoshita
IPC分类号： B60H1/00 , F24F11/02 , G05D23/185
CPC分类号： B60H1/00849 , G05D23/185
摘要： An intake control system comprising a mode selector which receives a first control pressure and a second control pressure, and, according to the temperature inside and outside the vehicle, adapted to supply selectively a plurality of different combinations of the first and second control pressures to a pressure activated actuator to switch an air intake system between at least an outside air position and a recirculating air position. An air intake changeover switch receives the pressure output by an air control switch, a first reference pressure and a second reference pressure, and supplies a certain combination thereof as the first and second control pressures, when operated, to the mode selector, thereby causing the actuator to switch the air intake system to the recirculating air position, irrespective of the switching state of the mode selector.
摘要翻译：一种进气控制系统，包括接收第一控制压力和第二控制压力的模式选择器，并且根据车辆内部和外部的温度，适于向第一和第二控制压力选择性地供应多个不同的第一和第二控制压力组合压力激活的致动器以在至少外部空气位置和再循环空气位置之间切换进气系统。进气切换开关接收由空气控制开关输出的压力，第一参考压力和第二参考压力，并且当操作时将其特定组合作为第一和第二控制压力提供给模式选择器，从而使得执行器将进气系统切换到循环空气位置，而与模式选择器的切换状态无关。

8. 发明授权

US4897463A Biologically active peptides which inhibit toxoplasma multiplication 失效
标题翻译：抑制弓形体繁殖的生物活性肽
公开(公告)号：US4897463A
公开(公告)日：1990-01-30
申请号：US291039
申请日：1988-12-28
申请人： Naoyoshi Suzuki , Humio Osaki
发明人： Naoyoshi Suzuki , Humio Osaki
IPC分类号： A61K38/00 , A61P33/02 , A61P37/04 , C07K1/20 , C07K7/06 , C07K14/47
CPC分类号： C07K14/4703 , A61K38/00
摘要： Biologically active peptides each having an activity to inhibit multiplication of toxoplasma and having a structure composed of amino acid sequence by the formula Gly-Glu-Glu-Glu-Glu-Glu; Glu-Glu-Glu-Glu-Glu; Asp-Asp-Asp-Asp-Asp; or Ala-Asp-Asp-Asp-Asp-Asp. These peptides are estimated to form active units or cores of Obioactin. The peptides may be applied in various dosage forms to human being and animals as immunoregulators against attack by toxoplasma, since they exhibit no specie specificity and have Toxo-GIF activities of 10 or more times on weight basis, and 40 or more time on molar basis, of that of the crude Obioactin.

9. 发明授权

US4349177A Push-button type valve 失效
标题翻译：按钮式阀
公开(公告)号：US4349177A
公开(公告)日：1982-09-14
申请号：US185642
申请日：1980-09-09
申请人： Yukio Shimada , Naoyoshi Suzuki , Toshio Ohashi , Yasushi Inoshita
发明人： Yukio Shimada , Naoyoshi Suzuki , Toshio Ohashi , Yasushi Inoshita
IPC分类号： F16K31/44 , B60H1/00 , F16K11/065 , F16K31/528 , F16K31/56 , F16K35/00
CPC分类号： B60H1/00857 , B60H1/00485 , F16K11/065 , F16K31/5286 , F16K35/00 , Y10T137/86405 , Y10T137/8671
摘要： The present invention relates to a two position valve having a cam and a cam follower mechanism for holding the valve element in either of its two operative positions, depending on the operation of a push button switch arrangement cooperating with the valve so that the valve shifts between positions in response to pushing the switch. The cam takes the form of an arrowhead shaped groove having first and second apex portions in which the cam follower, a spring loaded pin, traces. The groove is formed with a step at one apex to prevent the pin from reversing its trace and to ensure its oneway tracing about the groove.
摘要翻译：本发明涉及一种具有凸轮和凸轮从动机构的两位置阀，该凸轮从动机构用于将阀元件保持在其两个操作位置中的任一个中，这取决于与该阀配合的按钮开关装置的操作，响应推动开关的位置。凸轮采取具有第一和第二顶点部分的箭头形凹槽的形式，凸轮从动件，弹簧加载销，跟踪。凹槽在一个顶点处形成有台阶，以防止销反转其迹线并确保其围绕凹槽的单向跟踪。

10. 发明授权

US5464819A Physiologically active peptide having immunoregulatory activities 失效
标题翻译：具有免疫调节活性的生理活性肽
公开(公告)号：US5464819A
公开(公告)日：1995-11-07
申请号：US729353
申请日：1991-07-12
申请人： Naoyoshi Suzuki
发明人： Naoyoshi Suzuki
IPC分类号： A61K38/00 , A61K31/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P33/02 , A61P35/00 , A61P37/00 , A61P37/02 , C07K5/06 , C07K5/062 , C07K5/08 , C07K5/097 , C07K5/10 , C07K5/113 , C07K7/06 , C07K14/44 , C07K14/47 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K7/06 , C07K14/4703 , C07K5/06026 , C07K5/0823 , C07K5/1021 , A61K38/00
摘要： A novel, substantially pure, physiologically active peptide is disclosed, comprising an amino acid sequence selected from Gly-Glu (SEQ ID NO. 5), Pro-Val-Val (SEQ ID NO. 6), Glu-Pro-Val-Val (SEQ ID NO. 7), Glu-Glu-Pro-Val-Val (SEQ ID NO. 8), Ala-Glu-Glu-Pro-Val-Val (SEQ ID NO. 9), and Gly-Ala-Glu-Glu-Pro-Val-Val (SEQ ID NO. 10). This peptide has immunoregulatory activities, including the activity to inhibit multiplication of Toxoplasma gondii inside cells, antibacterial activity, antiviral activity and antitumor activity. A composition comprising at least two peptides selected from the above peptides or comprising at least one peptide selected from the above peptides and at least one additional peptide comprising an amino acid sequence selected from Gly-Glu-Glu-Glu-Glu-Glu (SEQ ID NO. 1), Glu-Glu-Glu-Glu-Glu (SEQ ID NO. 2), Asp-Asp-Asp-Asp-Asp (SEQ ID NO. 3) and Ala-Glu-Glu-Glu-Glu-Glu (SEQ ID NO. 4) is especially useful as an active component for antiprotozoan, antibacterial, antiviral or antitumor agent.
摘要翻译：公开了一种新颖的，基本上纯的生理活性肽，其包含选自Gly-Glu（SEQ ID NO.5），Pro-Val-Val（SEQ ID NO.6），Glu-Pro-Val-Val （SEQ ID NO.7），Glu-Glu-Pro-Val-Val（SEQ ID NO.8），Ala-Glu-Glu-Pro-Val-Val（SEQ ID NO.9）和Gly-Ala-Glu -Glu-Pro-Val-Val（SEQ ID NO.10）。该肽具有免疫调节活性，包括抑制细胞内弓形体增殖的活性，抗菌活性，抗病毒活性和抗肿瘤活性。一种组合物，其包含至少两种选自上述肽的肽或包含至少一种选自上述肽的肽和至少一种另外的肽，其包含选自Gly-Glu-Glu-Glu-Glu-Glu（SEQ ID NO： NO-1），Glu-Glu-Glu-Glu-Glu（SEQ ID NO.2），Asp-Asp-Asp-Asp-Asp（SEQ ID NO.3）和Ala-Glu-Glu-Glu-Glu-Glu （SEQ ID NO.4）特别可用作抗替佐唑，抗细菌剂，抗病毒剂或抗肿瘤剂的活性成分。

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