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1. 发明授权

US06642375B2 Fluorescent substances 失效
标题翻译：荧光物质
公开(公告)号：US06642375B2
公开(公告)日：2003-11-04
申请号：US09731279
申请日：2000-12-06
申请人： Hiroko Inomata , Hiroshi Shinoki , Masayoshi Kojima , Yukio Sudo , Junji Nishigaki , Osamu Seshimoto
发明人： Hiroko Inomata , Hiroshi Shinoki , Masayoshi Kojima , Yukio Sudo , Junji Nishigaki , Osamu Seshimoto
IPC分类号： C07H1904
CPC分类号： G01N33/582
摘要： The present invention provides a fluorescent substance which is represented by a formula: A-B-C wherein A is a residue of natural or synthetic nucleotide, oligonucleotide, polynucleotide, or derivative thereof, and binds to B at a base moiety in said residue, or A is a residue of avidin or streptavidin; B is a divalent linking group or a single bond; and C is a monovalent group derived from a general formula (I) and binds to B at a reactive group present in R1 or R2: wherein R1 and R2 each independently represent an alkyl group that may be substituted with a reactive group capable of covalently bonding to A-B-; R3, R4, R5, and R6 each independently represent an alkyl group, and R3 and R4, and/or R5 and R6 may bind to each other to form a saturated carbon-ring together with a carbon atom(s) to which they bind; V1, V2, V3, V4, V5, V6, V7, V8, V9 and V10 each independently represent a hydrogen atom or a monovalent substituent, and two adjacent groups thereof may bind to form a ring; L1, L2, and L3 represent a substituted or unsubstituted methine group; each of m, n, s, and t represents 0 or 1, provided that m+n=1 and s+t=1; p represents 1, 2, or 3; M represents a counter ion; and q represents a number required to neutralize the charge of a molecule. The fluorescent substance of the present invention is useful as a labeling substance for nucleic acids, or as a reagent for analyzing biological components such as nucleic acids, proteins or sugars.
摘要翻译：本发明提供一种荧光物质，其由下式表示：AB-C，其中A是天然或合成的核苷酸，寡核苷酸，多核苷酸或其衍生物的残基，并与所述残基中的碱基部分的B结合，或A是抗生物素蛋白或链霉亲和素的残基; B是二价连接基团或单键; 和C是衍生自通式（I）的一价基团，并且在R 1或R 2中存在的反应性基团上与B结合：其中R 1和R 2各自独立地表示烷基，可以被能够与AB-共价结合的反应性基团取代; R 3，R 4，R 5和R 6各自独立地表示烷基，R 3和R 4和/或R 5和R 6独立地表示烷基，可以彼此结合形成饱和碳环与它们所结合的碳原子一起; V 1，V 2，V 3，V 4，V 5，V 6，V 7，V 8，V 9和V 10 独立地表示氢原子或一价取代基，其两个相邻基团可以结合形成环; L 1，L 2和L 3表示取代或未取代的次甲基; m，n，s和t中的每一个表示0或1，条件是m + n = 1且s + t = 1; p表示1,2或3; M表示抗衡离子; q表示中和分子电荷所需的数。本发明的荧光物质可用作核酸的标记物质，或用作分析核酸，蛋白质或糖类等生物成分的试剂。

2. 发明授权

US07087744B2 Fluorescent nucleotides and labeling methods using the same 有权
标题翻译：荧光核苷酸和使用其的标记方法
公开(公告)号：US07087744B2
公开(公告)日：2006-08-08
申请号：US10196223
申请日：2002-07-17
申请人： Junji Nishigaki , Kouki Nakamura , Kazuya Takeuchi , Hiroko Inomata , Masayoshi Kojima
发明人： Junji Nishigaki , Kouki Nakamura , Kazuya Takeuchi , Hiroko Inomata , Masayoshi Kojima
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68 , C12P19/34
CPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C12Q2563/107
摘要： Fluorescent nucleotides useful for labeling nucleic acids which are represented by the formula: X—Y—Z wherein X represents a residue of natural or non-natural nucleotide and the like and binds to Y at a basic moiety of the residue; Y represents a divalent bridging group or a single bond; Z represents a monovalent group derived from a compound represented by the formula (I) wherein R1 to R4 represent an alkyl group; V1 to V6 represent a hydrogen atom or a substituent; L1 to L7 represent a methine group; W represents an oxygen atom, a sulfur atom, —C(R3)(R4)— or —N(R5)— wherein R3 to R5 represents an alkyl group; Q represents a nitrogen atom or —C(V7)— wherein V7 represents a hydrogen atom or a monovalent substituent; M represents a counter ion; m represents a number required to neutralize the charge of the molecule; s, t and u represent 0 or 1 or the like, and binds to Y at a reactive group existing in R1 or R2
摘要翻译：用于标记由式X-Y-Z表示的核酸的荧光核苷酸，其中X表示天然或非天然核苷酸的残基等，并与残基的碱性部分结合; Y表示二价桥基或单键; Z表示由式（I）表示的化合物衍生的单价基团，其中R 1至R 4代表烷基; V 1至V 6表示氢原子或取代基; L 1至L 7表示次甲基; W表示氧原子，硫原子，-C（R 3）（R 4） - 或-N（R 5） - 其中R 3至R 5表示烷基; Q表示氮原子或-C（V-7） - ，其中V 7表示氢原子或一价取代基; M表示抗衡离子; m表示中和分子电荷所需的数量; s，t和u表示0或1等，并且在R 1或R 2中存在的反应性基团与Y结合，

3. 发明申请

US20080032415A1 Fluorescence Detection Method 审中-公开
标题翻译：荧光检测方法
公开(公告)号：US20080032415A1
公开(公告)日：2008-02-07
申请号：US11630199
申请日：2005-06-13
申请人： Junji Nishigaki , Masayoshi Kojima , Hiroyuki Hirai
发明人： Junji Nishigaki , Masayoshi Kojima , Hiroyuki Hirai
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , A61B2090/3941 , A61B2090/395 , G01N2021/6432 , G01N2021/6441
摘要： Two or more target substances are simply and efficiently detected using one type of nanoparticle. Two or more target substances contained in one sample are labeled with two or more fluorescent dyes each capable of binding to the respective target substance and each of which emit light at wavelengths different from each other, combination is made with a phosphor nano-particle capable of binding to each of the two or more fluorescent dyes, subsequently irradiation is undertaken with an excitation light which excites the phosphor nano-particle to emit light, and the two or more fluorescent dyes are caused to emit fluorescence using the light from the phosphor nano-particle as an excitation light.
摘要翻译：使用一种类型的纳米颗粒简单有效地检测两种或更多种靶物质。包含在一个样品中的两种或更多种目标物质用两种或更多种荧光染料标记，每种荧光染料能够结合相应的目标物质，并且每个荧光染料发射彼此不同的波长的光，结合两种或更多种荧光染料中的每种，随后用激发荧光体纳米颗粒发光的激发光进行照射，并且使用来自荧光体纳米颗粒的光使两种或更多种荧光染料发射荧光，颗粒作为激发光。

4. 发明申请

US20080020483A1 Fluorescence Detecting Method 审中-公开
标题翻译：荧光检测方法
公开(公告)号：US20080020483A1
公开(公告)日：2008-01-24
申请号：US11632229
申请日：2005-07-14
申请人： Junji Nishigaki , Masayoshi Kojima , Hiroyuki Hirai , Tatsuya Takahashi
发明人： Junji Nishigaki , Masayoshi Kojima , Hiroyuki Hirai , Tatsuya Takahashi
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , B82Y30/00 , C01G9/02 , C01P2002/54 , C01P2004/64 , C01P2006/22 , C09K11/025 , C09K11/54
摘要： The invention provides a fluorescence detecting method, comprising irradiating an excitation light in the UV range on a sample containing a nanoparticle fluorescent material having an emission half-value width of 50 nm to 200 nm as the fluorescent material and detecting the fluorescence emitted from the sample in the visible range.
摘要翻译：本发明提供一种荧光检测方法，其包括在含有发光半值宽度为50nm至200nm的纳米颗粒荧光材料的样品上照射UV范围内的激发光作为荧光材料，并检测从样品发出的荧光在可见范围内。

5. 发明申请

US20070015226A1 Method for detecting cancer using metal-oxide or metal-sulfide nanoparticle fluorescent material 审中-公开
标题翻译：使用金属氧化物或金属硫化物纳米颗粒荧光材料检测癌症的方法
公开(公告)号：US20070015226A1
公开(公告)日：2007-01-18
申请号：US11483103
申请日：2006-07-10
申请人： Hiroyuki Hirai , Masayoshi Kojima , Junji Nishigaki
发明人： Hiroyuki Hirai , Masayoshi Kojima , Junji Nishigaki
IPC分类号： G01N33/574 , C07K16/46
CPC分类号： C07K16/2863 , C07K2317/55 , G01N33/533 , G01N33/553
摘要： It is an object of the present invention to provide a nanoparticle fluorescent material for detecting cancer with which cancer can be detected with high sensitivity, using highly safe and broad light emission on a simple device. The present invention provides a nanoparticle fluorescent material which comprises a metal-oxide or metal-sulfide nanoparticle fluorescent material whose surface is modified by a surface modifying agent and whose half bandwidth of light emission is between 50 and 200 nm, wherein an antibody that recognizes cancer antigen is bound to the surface modifying agent.
摘要翻译：本发明的目的是提供一种用于检测癌症的纳米颗粒荧光材料，通过在简单的装置上使用高度安全和宽泛的发光，可高灵敏度地检测癌症。本发明提供一种纳米颗粒荧光材料，其包含金属氧化物或金属硫化物纳米颗粒荧光材料，其表面被表面改性剂改性，其半光带宽为50-200nm，其中识别癌症的抗体抗原与表面改性剂结合。

6. 发明申请

US20090130022A1 MRI CONTRAST MEDIUM CONTAINING LIPOSOMES 审中-公开
标题翻译： MRI对比中药含有脂质体
公开(公告)号：US20090130022A1
公开(公告)日：2009-05-21
申请号：US11916391
申请日：2006-06-06
申请人： Junji Nishigaki , Hiroyuki Hirai , Masayoshi Kojima , Kazuhiro Aikawa
发明人： Junji Nishigaki , Hiroyuki Hirai , Masayoshi Kojima , Kazuhiro Aikawa
IPC分类号： A61B5/055 , A61K9/127
CPC分类号： A61K49/1812
摘要： A liposome containing a phosphatidylcholine and a phosphatidylserine in combination as membrane components at a phosphatidylcholine:phosphatidylserine molar ratio of 3:1 to 1:2, and said liposome containing superparamagnetic particles having a mean particle size not less than 1 nm and not more than 50 nm. A means for selectively accumulating an MRI contrast medium in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis and restenosis after PTCA is provided.
摘要翻译：含有磷脂酰胆碱和磷脂酰丝氨酸的磷脂酰丝氨酸组合为磷脂酰胆碱的膜组分：磷脂酰丝氨酸摩尔比为3:1至1:2，所述脂质体含有平均粒度不小于1nm且不大于50的超顺磁性颗粒 nm。用于选择性地累积由血管平滑肌细胞的异常增殖引起的血管疾病的病变中的MRI造影剂的手段，所述血管病变由PTCA提供之后的动脉硬化和再狭窄引起。

7. 发明授权

US08154667B2 Digital planetarium picture-projecting apparatus 有权
标题翻译：数字天文馆图像投影仪
公开(公告)号：US08154667B2
公开(公告)日：2012-04-10
申请号：US11634760
申请日：2006-12-06
申请人： Junji Nishigaki , Kenichi Hyodo
发明人： Junji Nishigaki , Kenichi Hyodo
IPC分类号： H04N5/64
CPC分类号： G09B27/02 , G03B21/00 , H04N5/74
摘要： It is intended to provide a digital planetarium picture-projecting apparatus capable of recording and executing an operation procedure, facilitating recording of the operation procedure, editing the operation procedure, and executing an ad-lib representation when the operation procedure is executed. The digital planetarium picture projecting apparatus comprises an operating portion which accepts an operation by an operator about picture projection, an operation display panel which displays information about picture projection to the operator, a manual process recording portion which records an operation procedure executed to the operating portion, and a control portion which executes picture projection according to the operation procedure recorded in the manual process recording portion, wherein a temporary stop or restart operation by the operator is accepted during recording of the operation procedure by the manual process recording portion. Further, information about a projection screen is displayed on an operation display panel during execution of picture projection according to the operation procedure.
摘要翻译：旨在提供一种能够记录和执行操作过程的数字天文馆图像投影设备，便于在执行操作过程时操作过程的记录，编辑操作过程和执行ad-lib表示。数字天文台图像投影装置包括：操作部，其接受操作者关于图像投影的操作;操作显示面板，其向操作者显示关于图像投影的信息;手动处理记录部，其将执行的操作过程记录到操作部分以及根据记录在手动处理记录部分中的操作过程执行图像投影的控制部分，其中在通过手动处理记录部分记录操作过程期间接受操作者的暂时停止或重新启动操作。此外，根据操作过程，在执行图像投影期间，在操作显示面板上显示关于投影屏幕的信息。

8. 发明授权

US07748852B2 Digital planetarium apparatus 有权
标题翻译：数位天文馆仪器
公开(公告)号：US07748852B2
公开(公告)日：2010-07-06
申请号：US11649681
申请日：2007-01-04
申请人： Junji Nishigaki
发明人： Junji Nishigaki
IPC分类号： G03B21/14
CPC分类号： G03B21/26 , G02B13/06 , G02B13/16 , G03B35/20 , G03B37/04 , G09B27/00
摘要： A digital planetarium apparatus includes an original image generator, an intermediate image generator, and a fish-eye lens. The original image generator is formed of two video projectors and generates semicircular images in display devices inside the respective video projectors. The intermediate image generator optically focuses the two semicircular images generated by the original image generator to thereby generate a circular image. The fish-eye lens projects the circular image generated by the intermediate image generator.
摘要翻译：数字天文馆装置包括原始图像发生器，中间图像发生器和鱼眼镜头。原始图像发生器由两个视频投影仪组成，并在相应的视频放映机内的显示装置中产生半圆形图像。中间图像生成器对由原始图像生成器生成的两个半圆形图像进行光学聚焦，从而生成圆形图像。鱼眼透镜投射由中间图像发生器产生的圆形图像。

9. 发明授权

US07599092B2 Image processing apparatus 有权
标题翻译：图像处理装置
公开(公告)号：US07599092B2
公开(公告)日：2009-10-06
申请号：US11507590
申请日：2006-08-22
申请人： Katsuaki Tajima , Takayuki Nabeshima , Toshio Tsuboi , Junji Nishigaki , Daisetsu Tohyama
发明人： Katsuaki Tajima , Takayuki Nabeshima , Toshio Tsuboi , Junji Nishigaki , Daisetsu Tohyama
IPC分类号： G06F15/00 , H04N1/46
CPC分类号： H04N1/6058
摘要： An image processing apparatus is provided in which the frequency of undesired delay of the image output can be reduced. The image processing apparatus comprises an image processor for performing a process defined by a parameter on the image data of the received job, a decision portion for deciding a state of the image data of the received job, and a controller for setting a parameter in accordance with the state that is decided by the decision portion if an interval between the received job and the previously received job is longer than a predetermined time, and for setting the parameter that was used in the last job despite the state that is decided by the decision portion if the interval is not longer than the predetermined time.
摘要翻译：提供一种图像处理装置，其中可以减少图像输出的不期望延迟的频率。该图像处理装置包括图像处理器，用于执行由接收到的作业的图像数据上的参数定义的处理，用于确定接收到的作业的图像数据的状态的判定部分，以及用于根据接收到的作业设置参数的控制器如果所接收的作业和先前接收到的作业之间的间隔长于预定时间，则由判定部分决定的状态，并且用于设置在最后作业中使用的参数，尽管由该决定决定的状态如果间隔不长于预定时间。

10. 发明申请

US20090246141A1 HIGHER FATTY ACID TRIESTER AND AMIDE DERIVATIVE HAVING DIETHYLENETRIAMINE-TYPE METAL CHELATE STRUCTURE 失效
标题翻译：具有二乙烯胺型金属螯合物结构的高级脂肪酸三羧酸酯和酰胺衍生物
公开(公告)号：US20090246141A1
公开(公告)日：2009-10-01
申请号：US12094862
申请日：2006-12-20
申请人： Atsushi Hirai , Kazunobu Takahashi , Junji Nishigaki , Kazuhiro Aikawa
发明人： Atsushi Hirai , Kazunobu Takahashi , Junji Nishigaki , Kazuhiro Aikawa
IPC分类号： A61K49/04 , C07C229/26 , C07C229/76
CPC分类号： A61K9/127 , A61K47/543 , A61K49/085 , A61K49/10 , A61K49/103 , C07C229/24 , C07C233/36 , C07C311/04 , C07C317/18 , C07C323/12 , C07D317/22 , C07D323/00
摘要： A compound having superior solubility and suitable for a liposome contrast medium selective for a lesion such as vascular diseases is provided which is represented by the following general formula (I) wherein R1 to R3 represent an alkyl group or alkenyl group; X1 and X2 represent a single bond, —O—, or —N(Z1)- (Z1 represents hydrogen atom, or an alkyl group); X3 to X6 represent —O—, or —N(Z2)- (Z2 represents hydrogen atom, or an alkyl group); n represents an integer of 1 to 10; and L represents a divalent bridging group constituted by atoms selected from the group consisting of carbon atom, hydrogen atom, oxygen atom, nitrogen atom, fluorine atom and sulfur atom.
摘要翻译：提供了一种具有优异溶解性并适用于对病变如血管疾病有选择性的脂质体造影剂的化合物，其由以下通式（I）表示，其中R 1至R 3表示烷基或烯基; X 1和X 2表示单键，-O-或-N（Z 1） - （Z 1表示氢原子或烷基）。 X 1〜X 6表示-O-或-N（Z 2） - （Z 2表示氢原子或烷基）。 n表示1〜10的整数， L表示由选自碳原子，氢原子，氧原子，氮原子，氟原子和硫原子的原子构成的二价桥连基团。

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