专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070042947A1 Agents for preventing and/or treating uppper digestive tract disorders 审中-公开
标题翻译：用于预防和/或治疗上消化道疾病的药剂
公开(公告)号：US20070042947A1
公开(公告)日：2007-02-22
申请号：US10548817
申请日：2004-03-11
申请人： Hirokazu Matsumoto , Koh Takagi , Masaaki Mori
发明人： Hirokazu Matsumoto , Koh Takagi , Masaaki Mori
IPC分类号： A61K38/17
CPC分类号： A61K38/177 , A61K38/1709 , C12N2310/11 , G01N2800/06
摘要： A compound or its salts that inhibit the activity of the polypeptide or receptor of the present invention and the antibody of the present invention as well as the antisense DNA of the present invention are useful as, e.g., gastric acid secretion inhibitors, mucosa protectants, mineral absorption promoters, etc., which are less toxic and safe, and can be used as, e.g., agents for preventing/treating upper digestive tract disorders, antibacterial agents to Helicobacter pylori, etc. A compound or its salts that promote the activity of the polypeptide or receptor of the present invention, the polypeptide or receptor of the present invention and the DNA of the present invention can be used as, e.g., gastric acid secretion promoters and can be used as, e.g., agents for preventing/treating dyspepsia, bone metabolism disorders, anemia, etc. A compound or its salts that promote the activity of the polypeptide or receptor of the present invention, the polypeptide of the present invention, etc. can also be used as test agents for gastric secretory function. Furthermore, the polypeptide or receptor of the present invention and the DNA of the present invention are also useful for screening the agents for the prevention/treatment described above.
摘要翻译：抑制本发明的多肽或受体和本发明的抗体以及本发明的反义DNA的活性的化合物或其盐可用于例如胃酸分泌抑制剂，粘膜保护剂，矿物质吸收促进剂等，其毒性和安全性较低，并且可以用作例如用于预防/治疗上消化道疾病的药剂，对幽门螺杆菌等的抗菌剂。促进幽门螺杆菌活性的化合物或其盐本发明的多肽或受体，本发明的多肽或受体和本发明的DNA可以用作例如胃酸分泌促进剂，并且可以用作例如用于预防/治疗消化不良，骨骼的药剂代谢紊乱，贫血等。促进本发明的多肽或受体的活性，本发明的多肽等的化合物或其盐。c 也可用作胃分泌功能的试剂。此外，本发明的多肽或受体和本发明的DNA也可用于筛选用于上述预防/治疗的药剂。

2. 发明申请

US20090227501A1 Agents for preventing and/or treating upper digestive tract disorders 审中-公开
标题翻译：用于预防和/或治疗上消化道疾病的药剂
公开(公告)号：US20090227501A1
公开(公告)日：2009-09-10
申请号：US12214938
申请日：2008-06-24
申请人： Hirokazu Matsumoto , Koh Takagi , Masaaki Mori
发明人： Hirokazu Matsumoto , Koh Takagi , Masaaki Mori
IPC分类号： A61K38/16 , G01N33/68 , A61P1/00
CPC分类号： A61K38/177 , A61K38/1709 , C12N2310/11 , G01N2800/06
摘要： A compound or its salts that inhibit the activity of the polypeptide or receptor of the present invention and the antibody of the present invention as well as the antisense DNA of the present invention are useful as, e.g., gastric acid secretion inhibitors, mucosa protectants, mineral absorption promoters, etc., which are less toxic and safe, and can be used as, e.g., agents for preventing/treating upper digestive tract disorders, antibacterial agents to Helicobacter pylori, etc. A compound or its salts that promote the activity of the polypeptide or receptor of the present invention, the polypeptide or receptor of the present invention and the DNA of the present invention can be used as, e.g., gastric acid secretion promoters and can be used as, e.g., agents for preventing/treating dyspepsia, bone metabolism disorders, anemia, etc. A compound or its salts that promote the activity of the polypeptide or receptor of the present invention, the polypeptide of the present invention, etc. can also be used as test agents for gastric secretory function. Furthermore, the polypeptide or receptor of the present invention and the DNA of the present invention are also useful for screening the agents for the prevention/treatment described above.
摘要翻译：抑制本发明的多肽或受体和本发明的抗体以及本发明的反义DNA的活性的化合物或其盐可用于例如胃酸分泌抑制剂，粘膜保护剂，矿物质吸收促进剂等，其毒性和安全性较低，并且可以用作例如用于预防/治疗上消化道疾病的药剂，对幽门螺杆菌等的抗菌剂。促进幽门螺杆菌活性的化合物或其盐本发明的多肽或受体，本发明的多肽或受体和本发明的DNA可以用作例如胃酸分泌促进剂，并且可以用作例如用于预防/治疗消化不良，骨骼的药剂代谢紊乱，贫血等。促进本发明的多肽或受体的活性，本发明的多肽等的化合物或其盐。c 也可用作胃分泌功能的试剂。此外，本发明的多肽或受体和本发明的DNA也可用于筛选用于上述预防/治疗的药剂。

3. 发明授权

US07323541B2 Polypeptide DNA thereof and use of the same 失效
标题翻译：其多肽DNA及其用途
公开(公告)号：US07323541B2
公开(公告)日：2008-01-29
申请号：US10489537
申请日：2002-09-13
申请人： Masaaki Mori , Kozo Hayashi , Hiroyuki Miya , Shuji Sato , Chieko Kitada , Hirokazu Matsumoto , Toshimi Nagi , Yukio Shimomura
发明人： Masaaki Mori , Kozo Hayashi , Hiroyuki Miya , Shuji Sato , Chieko Kitada , Hirokazu Matsumoto , Toshimi Nagi , Yukio Shimomura
IPC分类号： A61K38/04
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like.The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.
摘要翻译：本发明的目的在于提供新的多肽，受体及其DNA等。具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。

4. 发明授权

US07795267B2 Bicyclic piperazine compound having TGR23 antagonistic activity 失效
标题翻译：具有TGR23拮抗活性的双环哌嗪化合物
公开(公告)号：US07795267B2
公开(公告)日：2010-09-14
申请号：US10570270
申请日：2004-08-26
申请人： Kohji Fukatsu , Yutaka Nakayama , Naoki Tarui , Masaaki Mori , Hirokazu Matsumoto , Osamu Kurasawa , Hiroshi Banno
发明人： Kohji Fukatsu , Yutaka Nakayama , Naoki Tarui , Masaaki Mori , Hirokazu Matsumoto , Osamu Kurasawa , Hiroshi Banno
IPC分类号： A61K31/4965
CPC分类号： C07D487/04 , C07D513/04
摘要： The present invention provides a compound represented by the formula: wherein R1 is —(C═O)—NR7R8 or —(C═O)—OR6, R2 is a hydrocarbon group which may be substituted or the like, R3 is a hydrocarbon group which may be substituted or the like, R4 is a hydrocarbon group which may be substituted or the like, n is from 0 to 4, and X is an oxygen atom, or a salt thereof. The invention also provides a compound which has a TGR23 antagonist activity and thus is useful for prevention and treatment of cancer.
摘要翻译：本发明提供由下式表示的化合物：其中R 1为 - （C = O）-NR 7 R 8或 - （C = O）-OR 6，R 2为可被取代的烃基等，R 3为烃基其可以被取代或类似，R 4是可以被取代的烃基等，n是0-4，X是氧原子或其盐。本发明还提供具有TGR23拮抗剂活性的化合物，因此可用于预防和治疗癌症。

5. 发明授权

US07342105B2 Antibody and use thereof 失效
标题翻译：抗体及其用途
公开(公告)号：US07342105B2
公开(公告)日：2008-03-11
申请号：US10547051
申请日：2004-02-26
申请人： Hirokazu Matsumoto , Eri Hashimoto , Masaaki Mori , Chieko Kitada
发明人： Hirokazu Matsumoto , Eri Hashimoto , Masaaki Mori , Chieko Kitada
IPC分类号： C07K16/00
CPC分类号： C07K7/08 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57407 , G01N33/57419
摘要： The antibody of the present invention, which specifically reacts with the N-terminal or C-terminal partial peptide of TGR23-2 ligand, is useful in detecting and quantifying the TGR23-2 ligand. Moreover, it is useful as a preventing/treating agent and a diagnostic agent for cancer, etc.
摘要翻译：与TGR23-2配体的N末端或C-末端部分肽特异性反应的本发明的抗体可用于检测和定量TGR23-2配体。此外，作为癌症等的预防处理剂和诊断剂是有用的

6. 发明申请

US20070072865A1 Bicyclic piperazine compound and use thereof 失效
标题翻译：双环哌嗪化合物及其用途
公开(公告)号：US20070072865A1
公开(公告)日：2007-03-29
申请号：US10570270
申请日：2004-08-26
申请人： Kohji Fukatsu , Yutaka Nakayama , Naoki Tarui , Masaaki Mori , Hirokazu Matsumoto , Osamu Kurasawa , Hiroshi Banno
发明人： Kohji Fukatsu , Yutaka Nakayama , Naoki Tarui , Masaaki Mori , Hirokazu Matsumoto , Osamu Kurasawa , Hiroshi Banno
IPC分类号： A61K31/498 , C07D498/04 , C07D491/04 , C07D487/04
CPC分类号： C07D487/04 , C07D513/04
摘要： The present invention provides a compound represented by the formula: wherein R1 is an acyl group, R2 is a hydrocarbon group which may be substituted or the like, R3 is a hydrocarbon group which may be substituted or the like, R4 is a hydrocarbon group which may be substituted or the like, n is from 0 to 4, and X is an oxygen atom, a sulfur atom or the like, or a salt thereof. The invention also provides a compound which has a TGR23 antagonist activity and thus is useful for prevention and treatment of cancer.
摘要翻译：本发明提供由下式表示的化合物：其中R 1是酰基，R 2是可以被取代的烃基，等等，R SUP > 3为可以被取代的烃基等，R 4为可以被取代的烃基等，n为0〜4，X为氧原子，硫原子等，或其盐。本发明还提供具有TGR23拮抗剂活性的化合物，因此可用于预防和治疗癌症。

7. 发明申请

US20050048605A1 Novel polypeptide dna thereof and use of the same 失效
标题翻译：新型多肽dna及其用途
公开(公告)号：US20050048605A1
公开(公告)日：2005-03-03
申请号：US10489537
申请日：2002-09-13
申请人： Masaaki Mori , Kozo Hayashi , Hiroyuki Miya , Shuji Sato , Chieko Kitada , Hirokazu Matsumoto , Toshimi Nagi , Yukio Shimomura
发明人： Masaaki Mori , Kozo Hayashi , Hiroyuki Miya , Shuji Sato , Chieko Kitada , Hirokazu Matsumoto , Toshimi Nagi , Yukio Shimomura
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , C12N15/12 , C12P21/08 , C07H21/04 , C07K14/47
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like. The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.
摘要翻译：本发明的目的在于提供新的多肽，受体及其DNA等。具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。

8. 发明申请

US20060177449A1 Antibody and use thereof 失效
标题翻译：抗体及其用途
公开(公告)号：US20060177449A1
公开(公告)日：2006-08-10
申请号：US10547051
申请日：2004-02-26
申请人： Hirokazu Matsumoto , Eri Hashimoto , Masaaki Mori , Chieko Kitada
发明人： Hirokazu Matsumoto , Eri Hashimoto , Masaaki Mori , Chieko Kitada
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： C07K7/08 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57407 , G01N33/57419
摘要： The antibody of the present invention, which is specifically reacting with the N-terminal or C-terminal partial peptide of TGR23-2 ligand, is useful in detecting and quantifying the TGR23-2 ligand. Moreover, it is useful as a preventing/treating agent and a diagnostic agent for cancer, etc.
摘要翻译：与TGR23-2配体的N-末端或C-末端部分肽特异性反应的本发明的抗体可用于检测和定量TGR23-2配体。此外，作为癌症等的预防处理剂和诊断剂是有用的

9. 发明申请

US20120015868A1 Metastin derivatives and use thereof 有权
标题翻译： Metastin衍生物及其用途
公开(公告)号：US20120015868A1
公开(公告)日：2012-01-19
申请号：US13135230
申请日：2011-06-29
申请人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
发明人： Chieko Kitada , Taiji Asami , Naoko Nishizawa , Tetsuya Ohtaki , Naoki Tarui , Hirokazu Matsumoto , Jiro Noguchi , Hisanori Matsui
IPC分类号： A61K38/08 , A61P3/10 , A61P25/28 , A61P15/00 , A61P35/00 , A61P25/00 , A61P3/04 , A61P13/00 , C07K7/06 , A61P9/10
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a metastin derivative in which the amino acids comprising metastin were modified by alternative chemical substituents resulting in metastin derivitives, having excellent blood stability and exhibiting cancer metastasis inhibiting action or cancer growth inhibiting action.
摘要翻译：本发明提供了一种转氨酶衍生物，其中包含转氨酶的氨基酸被替代的化学取代基修饰，导致转移衍生物，具有优异的血液稳定性和显示出癌转移抑制作用或癌生长抑制作用。

10. 发明授权

US07886181B2 Failure recovery method in cluster system 有权
标题翻译：群集系统中的故障恢复方法
公开(公告)号：US07886181B2
公开(公告)日：2011-02-08
申请号：US12041059
申请日：2008-03-03
申请人： Hirokazu Matsumoto , Tsunehiko Baba , Shinji Hamada , Takashi Ichimura , Noriaki Takahashi
发明人： Hirokazu Matsumoto , Tsunehiko Baba , Shinji Hamada , Takashi Ichimura , Noriaki Takahashi
IPC分类号： G06F11/00
CPC分类号： G06F11/2025 , G06F11/0709 , G06F11/0793 , G06F11/1438 , G06F11/2041 , G06F11/2043
摘要： There is provided a method executed in a cluster system comprising a first computer and at least one second computer that stores the data transmitted from the first computer. The method comprising the steps of: judging whether the failure-occurred processing is restarted by the first computer or the failure-occurred processing is switched over by the second computer based on the system information; receiving the stored data from the second computer and re-executing the processing in which the failure has occurred by the first computer, in the case of which it is judged that the processing in which the failure has occurred is restarted by the first computer; and executing, by the second computer, the processing in which the failure has occurred, in the case of which it is judged that the processing in which the failure has occurred is switched over by the at least one second computer.
摘要翻译：提供了一种在包括第一计算机和存储从第一计算机发送的数据的至少一个第二计算机的集群系统中执行的方法。该方法包括以下步骤：基于系统信息，判断第一计算机重新启动故障发生处理或由第二计算机切换故障发生处理; 从所述第二计算机接收所述存储的数据并重新执行由所述第一计算机发生所述故障的处理，在判断已经发生所述故障的处理由所述第一计算机重新启动的情况下; 并且由所述第二计算机执行在所述至少一个第二计算机切换已经发生故障的处理的情况下发生故障的处理。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式