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1. 发明授权

US07309710B2 Crystals 失效
标题翻译：晶体
公开(公告)号：US07309710B2
公开(公告)日：2007-12-18
申请号：US10525709
申请日：2003-08-26
申请人： Hirokazu Kubota , Kiyoshi Iwaoka , Sou Yamaguchi , Masaki Yokota
发明人： Hirokazu Kubota , Kiyoshi Iwaoka , Sou Yamaguchi , Masaki Yokota
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D401/12
摘要： Obtaining the crystal of 4,6-dimethyl-4′-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide having excellent activity of inhibiting Ca2+ release-activated Ca2+ channel and suppressing IL-2 production to find that the compound includes the presence of two types of polymorphic crystals and that any of the crystals is preferable as a raw material for producing pharmaceutical compositions.
摘要翻译：获得具有优异的抑制Ca 2+释放激活活性的4,6-二甲基-4' - [3,5-双（三氟甲基）-1H-吡唑-1-基]烟酰苯胺的结晶 Ca 2+通道并抑制IL-2产生，发现该化合物包括两种类型的多晶型晶体的存在，并且任何晶体优选作为制备药物组合物的原料。

2. 发明申请

US20060069130A1 Novel crystals 失效
标题翻译：新颖的水晶
公开(公告)号：US20060069130A1
公开(公告)日：2006-03-30
申请号：US10525709
申请日：2003-08-26
申请人： Hirokazu Kubota , Kiyoshi Iwaoka , Sou Yamaguchi , Masaki Yokota
发明人： Hirokazu Kubota , Kiyoshi Iwaoka , Sou Yamaguchi , Masaki Yokota
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/12
摘要： Obtaining the crystal of 4,6-dimethyl-4′-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide having excellent activity of inhibiting Ca2+ release-activated Ca2+ channel and suppressing IL-2 production to find that the compound includes the presence of two types of polymorphic crystals and that any of the crystals is preferable as a raw material for producing pharmaceutical compositions.
摘要翻译：获得具有优异的抑制Ca 2+释放激活活性的4,6-二甲基-4' - [3,5-双（三氟甲基）-1H-吡唑-1-基]烟酰苯胺的结晶 Ca 2+通道并抑制IL-2产生，发现该化合物包括两种类型的多晶型晶体的存在，并且任何晶体优选作为制备药物组合物的原料。

3. 发明授权

US08390957B2 Head suspension and method of manufacturing head suspension 有权
标题翻译：头悬挂及制造头悬挂方法
公开(公告)号：US08390957B2
公开(公告)日：2013-03-05
申请号：US12836936
申请日：2010-07-15
申请人： Kenichi Takikawa , Hideki Fuchino , Masaki Yokota
发明人： Kenichi Takikawa , Hideki Fuchino , Masaki Yokota
IPC分类号： G11B5/48 , G11B21/16
CPC分类号： G11B5/4833 , Y10T29/49032
摘要： A head suspension 11 includes a load beam 17 having a base plate 13, a hinge part 15 resiliently supported by the base plate, and a rigid part 14 joined with the hinge part, a reinforcing plate 25 joined with the rigid part at a portion proximal to the hinge part, and a bend 17c on the load beam formed by bending the load beam toward the reinforcing plate along an edge 25a of the reinforcing plate. Only by accurately joining the reinforcing plate with the load beam in a sway direction (a widthwise direction of the head suspension), the load beam is easily and properly bent without torsion to form the bend 17c along the edge of the reinforcing plate that defines a bending strength boundary.
摘要翻译：磁头悬架11包括具有基板13的负载梁17，由基板弹性地支撑的铰链部分15和与铰链部分连接的刚性部分14，加强板25与刚性部分接合在近端部分并且通过沿加强板的边缘25a将负载梁向加强板弯曲而形成的负载梁上的弯曲部17c。仅通过将加强板与摆动方向（头部悬架的宽度方向）上的加载板精确地接合，则负载梁容易且适当地弯曲而没有扭转，从而沿加强板的边缘形成弯曲部17c，该加强板限定弯曲强度边界。

4. 发明申请

US20090281072A1 Diaminopyrimidinecarboxamide Derivative 有权
标题翻译：二氨基嘧啶甲酰胺衍生物
公开(公告)号：US20090281072A1
公开(公告)日：2009-11-12
申请号：US12235189
申请日：2008-09-22
申请人： Shinya Nagashima , Hiroshi Nagata , Masashiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
发明人： Shinya Nagashima , Hiroshi Nagata , Masashiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
IPC分类号： A61K31/5377 , A61K31/551 , A61K31/397 , A61P11/06
CPC分类号： C07D403/12 , C07D239/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D453/02 , C07D471/10 , C07D487/08
摘要： A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要翻译：提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物，特别是哮喘，慢性阻塞性肺病等。具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的氨基或4-位上的氨基甲酰基和氨基甲酰基，可以在5位被提供。

5. 发明授权

US5204468A Substituted 4,5,6,7-tetrahydrothiens[2,3-C]pyridine compounds 失效
标题翻译：取代4,5,6,7-四氢噻吩（2,3-C）吡啶化合物
公开(公告)号：US5204468A
公开(公告)日：1993-04-20
申请号：US737883
申请日：1991-07-25
申请人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
发明人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
IPC分类号： C07D217/16 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , C07D217/16 , C07D513/04
摘要： This invention provides the single species (-)-(S)-4-(3,4-dihydroxyphenyl)-7, 8-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride hydrate, which is useful as a nephrovascular dilator.
摘要翻译：本发明提供了可用作肾血管扩张剂的单一（ - ） - （S）-4-（3,4-二羟基苯基）-7,8-二羟基-1,2,3,4-四氢异喹啉盐酸盐水合物。

6. 发明授权

US07612108B2 2-phenylthiophene derivative 失效
标题翻译： 2-苯基噻吩衍生物
公开(公告)号：US07612108B2
公开(公告)日：2009-11-03
申请号：US11661294
申请日：2005-08-26
申请人： Junji Miyata , Masaki Yokota , Ryo Naito , Akio Kamikawa , Masakatsu Kawakami , Kazuyuki Hattori
发明人： Junji Miyata , Masaki Yokota , Ryo Naito , Akio Kamikawa , Masakatsu Kawakami , Kazuyuki Hattori
IPC分类号： A61K31/381 , C07D333/16
CPC分类号： C07D333/40 , C07D409/04 , C07D409/10 , C07D417/10 , C07D417/12
摘要： The present invention relates to a 2-phenylthiophene derivative or a salt thereof, wherein the thiophene ring is substituted with a carboxyl group or the like and the benzene ring has an electron-withdrawing group such as a cyano group and an electron-donating group such as a substituted alkoxy group at the same time. Since the compound of the invention has good xanthine oxidase-inhibitory action and uric acid-lowering action and does not have a structure derived from nucleic acid, the compound has advantages of high safety and excellent effects as compared with conventional compounds and is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy, or the like.
摘要翻译：本发明涉及2-苯基噻吩衍生物或其盐，其中噻吩环被羧基等取代，苯环具有吸电子基如氰基和给电子基团，例如作为取代的烷氧基。由于本发明的化合物具有良好的黄嘌呤氧化酶抑制作用和尿酸降低作用，并且不具有衍生自核酸的结构，与常规化合物相比，该化合物具有安全性高，效果优异的优点，可用作高尿酸血症，痛风，炎性肠病，糖尿病性肾病，糖尿病性视网膜病变等的治疗或预防剂。

7. 发明申请

US20090262463A1 DISK DRIVE SUSPENSION 有权
标题翻译：磁盘驱动器暂停
公开(公告)号：US20090262463A1
公开(公告)日：2009-10-22
申请号：US12419477
申请日：2009-04-07
申请人： Masaki Yokota , Akira Nojima
发明人： Masaki Yokota , Akira Nojima
IPC分类号： G11B5/56
CPC分类号： G11B5/4833 , G11B5/5582
摘要： A suspension is provided with a base plate, load beam, and flexure. The base plate includes a boss portion, a first region situated on a side closer to a slider with respect to a center of the boss portion, and a second region situated on a side more remote from the slider. A pair of first projections are formed in the first region. A pair of second projections are formed in the second region. The projections project in the thickness direction of the base plate. The boss portion is inserted into a hole in an actuator arm, and the projections contact a suspension support portion of the actuator arm. The boss portion is pressurized from inside to be enlarged, whereby the base plate is fixed to the inner peripheral surface of the hole of the actuator arm.
摘要翻译：悬架设有基板，负载梁和挠曲件。基板包括凸台部分，位于相对于凸台部分的中心更靠近滑块的一侧的第一区域和位于更远离滑块的一侧的第二区域。在第一区域中形成一对第一突起。在第二区域中形成一对第二突起。突起在基板的厚度方向上突出。凸台部分插入到致动器臂中的孔中，并且突起接触致动器臂的悬架支撑部分。凸起部分从内部被加压以扩大，由此基板固定到致动器臂的孔的内周表面。

8. 发明授权

US4966904A Substituted tetrahydroisoquinoline compounds, and process for producing them, and composition containing them 失效
标题翻译：取代的四氢异喹啉化合物及其制备方法和含有它们的组合物
公开(公告)号：US4966904A
公开(公告)日：1990-10-30
申请号：US320975
申请日：1989-03-09
申请人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
发明人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
IPC分类号： C07D217/16 , C07D277/44 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , C07D217/16 , C07D513/04
摘要： A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## Wherein ##STR2## represents the formula ##STR3## (wherein R.sup.4 is a hydrogen atom or lower alkylsulfonyl); R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkylsulfonylamino;R.sup.3 is hydrogen, lower alkyl, or hydroxyl;R is hydrogen or halogen;with the proviso that when R.sup.1 is hydroxyl, there is no case that all of R.sup.2, R.sup.3 and R are hydrogens, and further with the proviso that when R is hydrogen, A excludes ##STR4## or a salt therof.
摘要翻译：式（I）化合物或其盐及其制备方法; 该化合物具有扩张新生血管束的作用; （I）其中代表式（IMAGE）（其中R4是氢原子或低级烷基磺酰基）; R1是氢，低级烷基，羟基，卤素，氨基或低级酰基氨基; R2是氢，低级烷基，羟基，氨基或低级烷基磺酰基氨基; R3是氢，低级烷基或羟基; R是氢或卤素; 条件是当R 1是羟基时，不存在所有的R 2，R 3和R都是氢的情况，并且进一步条件是当R是氢时，A不包括囟素或盐。

9. 发明申请

US20110294749A1 DIAMINOPYRIMIDINECARBOXAMIDE DERIVATIVE 审中-公开
公开(公告)号：US20110294749A1
公开(公告)日：2011-12-01
申请号：US13171411
申请日：2011-06-28
申请人： Shinya Nagashima , Hiroshi Nagata , Masahiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
发明人： Shinya Nagashima , Hiroshi Nagata , Masahiro Iwata , Masaki Yokota , Hiroyuki Moritomo , Eiichi Nakai , Sadao Kuromitsu , Keiko Ohga , Makoto Takeuchi
IPC分类号： A61K31/505 , C07D413/12 , A61K31/5377 , C07D413/14 , C07D417/12 , A61K31/541 , C07H15/26 , A61K31/7064 , C07D403/12 , A61K31/551 , A61K31/553 , A61P11/06 , A61P11/00 , A61K31/506 , C07D239/48
CPC分类号： C07D403/12 , C07D239/48 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D453/02 , C07D471/10 , C07D487/08
摘要： A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.
摘要翻译：提供了可用于预防或治疗其中涉及STAT6的呼吸系统疾病的化合物，特别是哮喘，慢性阻塞性肺病等。具有可以被特定取代基取代的芳基氨基或芳基乙氨基的嘧啶衍生物或其盐在2-位被苄基取代的4-氨基甲酰基和氨基甲酰基上，可以在5位被提供。

10. 发明授权

US5623074A Substituted tetrahydroisoquinoline compounds, and process for producing them, and composition containing them 失效
标题翻译：取代的四氢异喹啉化合物及其制备方法和含有它们的组合物
公开(公告)号：US5623074A
公开(公告)日：1997-04-22
申请号：US269733
申请日：1994-06-30
申请人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
发明人： Akihiro Tanaka , Takashi Fujikura , Ryuji Tsuzuki , Masaki Yokota , Takeyuki Yatsu
IPC分类号： C07D217/16 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , C07D217/16 , C07D513/04
摘要： A compound of the formula (I) or its salt and a process for producing the compounds; The compounds have the effect to dilate neophrovascular tracts; ##STR1## Wherein ##STR2## represents the formula ##STR3## (wherein R.sup.4 is a hydrogen atom or lower alkylsulfonyl); R.sup.1 is hydrogen, lower alkyl, hydroxyl, halogen, amino, or lower acylamino;R.sup.2 is hydrogen, lower alkyl, hydroxyl, amino, or lower alkylsulfonylamino;R.sup.3 is hydrogen, lower alkyl, or hydroxyl;R is hydrogen or halogen;with the proviso that when R.sup.1 is hydroxyl, there is no case that all of R.sup.2, R.sup.3 and R are hydrogens, and further with the proviso that when R is hydrogen, A excludes ##STR4## or a salt thereof.
摘要翻译：式（I）化合物或其盐及其制备方法; 该化合物具有扩张新生血管束的作用; 式（IMA）（其中R4是氢原子或低级烷基磺酰基）; R1是氢，低级烷基，羟基，卤素，氨基或低级酰基氨基; R2是氢，低级烷基，羟基，氨基或低级烷基磺酰基氨基; R3是氢，低级烷基或羟基; R是氢或卤素; 条件是当R 1是羟基时，不存在所有的R 2，R 3和R都是氢的情况，并且进一步条件是当R是氢时，A不包括它们或其盐。

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