专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06545151B2 Pentacyclic compound 有权
标题翻译：五环化合物
公开(公告)号：US06545151B2
公开(公告)日：2003-04-08
申请号：US09759378
申请日：2001-01-16
申请人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
发明人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
IPC分类号： C07D49308
CPC分类号： C07D493/08 , C07D305/14
摘要： The present invention relates to a novel taxol derivative having an antitumor-activity which is represented by formula (1). [In the formula (I), R1: a phenyl group, R2: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group or an alkoxyl group, R3: a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxyl group, a group —O—R31, an acyloxy group or a group —O—CO—R31 (in which R31: an alkylamino group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group), R4 and R5: a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, Z1: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z2: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z3: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group].
摘要翻译：本发明涉及由式（1）表示的具有抗肿瘤活性的新型紫杉醇衍生物[式（I）中，R 1为苯基，R 2为烷基，烯基，炔基，环烷基或烷氧基，R3：氢原子，羟基，卤素原子，烷氧基，-O-R31基，酰氧基或-O-CO-R31基（其中R31 ：烷基氨基，烯基，炔基，环烷基，芳基或杂环基），R4和R5：氢原子，烷基，烯基，炔基，芳基或杂环基，Z 1：氢原子，羟基，卤原子或烷基，Z 2：氢原子，羟基，卤素原子或烷基，Z 3：烷基，烯基，炔基，环烷基，芳基或杂环基]。

2. 发明授权

US06646123B2 Pentacyclic Compound 失效
标题翻译：五环化合物
公开(公告)号：US06646123B2
公开(公告)日：2003-11-11
申请号：US10126653
申请日：2002-04-22
申请人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
发明人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
IPC分类号： C07D49308
CPC分类号： C07D493/08 , C07D305/14
摘要： The present invention relates to a novel taxol derivative having an antitumor activity which is represented by formula (1). [In the formula (I), R1: a phenyl group, R2: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group or an alkoxyl group, R3: a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxyl group, a group —O—R311 an acyloxy group or a group —O—CO—R31, (in which R31: an alkylamino group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group), R4 and R5: a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, Z1: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z2: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z3: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group].
摘要翻译：本发明涉及由式（1）表示的具有抗肿瘤活性的新型紫杉醇衍生物[在式（I）中，R 1：苯基，R 2：烷基，烯基基团，炔基，环烷基或烷氧基，R 3：氢原子，羟基，卤素原子，烷氧基，基团-OR 31，酰氧基或基团， O-CO-R 31（其中R 31：烷基氨基，烯基，炔基，环烷基，芳基或杂环基），R 4和R 5 >：氢原子，烷基，烯基，炔基，芳基或杂环基，Z 1：氢原子，羟基，卤素原子或烷基，Z 2 >：氢原子，羟基，卤素原子或烷基，Z 3：烷基，烯基，炔基，环烷基，芳基或杂环基]。

3. 发明授权

US06211363B1 Pentacyclic compound 有权
标题翻译：五环化合物
公开(公告)号：US06211363B1
公开(公告)日：2001-04-03
申请号：US09513852
申请日：2000-02-25
申请人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
发明人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
IPC分类号： C07D49308
CPC分类号： C07D493/08 , C07D305/14
摘要： The present invention relates to a novel taxol derivative having an antitumor-activity which is represented by formula (1). [In the formula (I), R1: a phenyl group, R2: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group or an alkoxyl group, R3: a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxyl group, a group —O—R31, an acyloxy group or a group —O—CO—R31, (in which R31: an alkylamino group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group), R4 and R5: a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, Z1: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z2: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z3: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group].
摘要翻译：本发明涉及由式（1）表示的具有抗肿瘤活性的新型紫杉醇衍生物[式（I）中，R 1为苯基，R 2为烷基，烯基，炔基，环烷基或烷氧基，R3：氢原子，羟基，卤素原子，烷氧基，-O-R31基，酰氧基或-O-CO-R31基（其中 R 31：烷基氨基，烯基，炔基，环烷基，芳基或杂环基），R 4和R 5：氢原子，烷基，烯基，炔基，芳基或杂环基，Z1：氢原子，羟基，卤素原子或烷基，Z2：氢原子，羟基，卤素原子或烷基，Z3：烷基，烯基，炔基，环烷基，芳基或杂环基]。

4. 发明授权

US6075140A Pentacyclic compound 失效
标题翻译：五环化合物
公开(公告)号：US6075140A
公开(公告)日：2000-06-13
申请号：US945276
申请日：1998-02-05
申请人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
发明人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
IPC分类号： C07D305/14 , C07D493/08
CPC分类号： C07D493/08 , C07D305/14
摘要： The present invention relates to a novel taxol derivative having an antitumor activity which is represented by formula (1). ##STR1## [In the formula (I), R.sup.1 : a phenyl group, R.sup.2 : an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group or an alkoxyl group, R.sup.3 : a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxyl group, a group --O--R.sup.31, an acyloxy group or a group --O--CO--R.sup.31, (in which R.sup.31 : an alkylamino group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group), R.sup.4 and R.sup.5 : a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, Z.sup.1 : a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z.sup.2 : a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z.sup.3 : an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group].
摘要翻译： PCT No.PCT / JP96 / 01145 Sec。 371日期：1998年2月5日 102（e）1998年2月5日PCT 1996年4月25日PCT PCT。出版物WO96 / 33998 日期：1996年10月31日本发明涉及由式（1）表示的具有抗肿瘤活性的新型紫杉醇衍生物。 [式（I）中，R 1为苯基，R 2为烷基，烯基，炔基，环烷基或烷氧基，R 3为氢原子，羟基，卤素原子，烷氧基，基团-O-R31，酰氧基或基团-O-CO-R31（其中R31：烷基氨基，烯基，炔基，环烷基，芳基或杂环基），R4和R5：氢原子，烷基，烯基，炔基，芳基或杂环基，Z1：氢原子，羟基，卤素原子或烷基， Z2：氢原子，羟基，卤原子或烷基，Z3：烷基，烯基，炔基，环烷基，芳基或杂环基）。

5. 发明授权

US5767296A Deacetoxytaxol derivatives 失效
标题翻译：脱乙酰氧基紫杉醇衍生物
公开(公告)号：US5767296A
公开(公告)日：1998-06-16
申请号：US750374
申请日：1996-12-06
申请人： Hirofumi Terasawa , Tsunehiko Soga , Kiyoshi Nakayama
发明人： Hirofumi Terasawa , Tsunehiko Soga , Kiyoshi Nakayama
IPC分类号： C07D305/14 , C07D407/12
CPC分类号： C07D407/12 , C07D305/14
摘要： A novel taxol derivative having the formula (I), in which the 10-position is modified to have a carbon-carbon bond, is disclosed. The taxol derivative of the present invention has an antitumor activity. ##STR1##
摘要翻译： PCT No.PCT / JP95 / 01163 Sec。 371日期1996年12月6日第 102（e）日期1996年12月6日PCT Filed 1995年6月9日PCT公布。第WO95 / 33740号公报 1995年12月14日，公开了具有式（I）的新型紫杉醇衍生物，其中10位被改性为具有碳 - 碳键。本发明的紫杉酚衍生物具有抗肿瘤活性。（一）

6. 发明授权

US06407115B1 Hexa-cyclic compound 失效
标题翻译：六环化合物
公开(公告)号：US06407115B1
公开(公告)日：2002-06-18
申请号：US08451993
申请日：1995-05-26
申请人： Hirofumi Terasawa , Akio Ejima , Satoru Ohsuki , Kouichi Uoto
发明人： Hirofumi Terasawa , Akio Ejima , Satoru Ohsuki , Kouichi Uoto
IPC分类号： C07D49122
CPC分类号： C07D491/22 , C07D495/22
摘要： Accordingly, an object of this invention is to provide a hexa-cyclic compound represented by the following general formula: wherein R1 and R2 individually represent a hydrogen atom, a hydroxyl group, a C1-6 alkyl group (“C1-6 alkyl group means an alkyl group having 1 to 6 carbon atoms. Hereinafter defined in the same manner.) The present inventors have conducted extensive studies for the purpose of obtaining camptothecin derivatives with more excellent activity and higher safety, as well as excellent characteristics required for a drug to be administered, and found that hexa-cyclic compounds obtained by the addition of a water-soluble ring to camptothecin had characteristics superior to camptothecin. This finding has led to the completion of this invention.
摘要翻译：因此，本发明的目的是提供由以下通式表示的六环化合物：其中R 1和R 2各自表示氢原子，羟基，C 1-6烷基（“C 1-6烷基” 具有1〜6个碳原子的烷基，以下相同的方式定义。）本发明人为了得到活性更高，安全性更好的喜树碱衍生物进行了广泛的研究，并且发现通过向喜树碱中加入水溶性环获得的六环化合物具有优于喜树碱的特征，这一发现导致本发明的完成。

7. 发明授权

US5658920A Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound 失效
标题翻译：取代的1H，12H-苯并ÄDEÜpyranoÄ3'，4'：6,7H-吲嗪并[1,2-b]喹啉-10,13（9H，15H） - 二酮化合物
公开(公告)号：US5658920A
公开(公告)日：1997-08-19
申请号：US455706
申请日：1995-05-31
申请人： Hirofumi Terasawa , Akio Ejima , Satoru Ohsuki , Kouichi Uoto
发明人： Hirofumi Terasawa , Akio Ejima , Satoru Ohsuki , Kouichi Uoto
IPC分类号： C07D491/22 , C07D495/22 , A61K31/47
CPC分类号： C07D491/22 , C07D495/22
摘要： A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumor activity and a high degree of safety, and can be applied as an antitumor medicine for curing tumors of various kinds.
摘要翻译：一种新颖的六环化合物，喜树碱的衍生物，具有以下通式：该化合物通过缩合闭合反应由氨基酮化合物和吡喃并吲哚化合物制备。水溶性丰富，具有优异的抗肿瘤活性和高度的安全性，可用作治疗各种肿瘤的抗肿瘤药物。

8. 发明授权

US4778891A Certain pyrano (3,4-f)-indolizine derivatives 失效
标题翻译：某些吡喃（3,4-f） - 吲哚啉衍生物
公开(公告)号：US4778891A
公开(公告)日：1988-10-18
申请号：US919388
申请日：1986-10-16
申请人： Hiroaki Tagawa , Hirofumi Terasawa , Akio Ejima
发明人： Hiroaki Tagawa , Hirofumi Terasawa , Akio Ejima
IPC分类号： C07D491/052 , C07D491/147 , C07D491/22 , C07D493/14 , C07D493/20 , C07D493/22 , C07D491/14 , C07D491/20
CPC分类号： C07D493/14
摘要： A pyranoindolizine derivative represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or hydroxyl group and Q denotes >C.dbd.O or ##STR2## with a proviso that Q is other than >C.dbd.O when R is a hydrogen atom. Its preparation process is also described.
摘要翻译：由下列通式（I）表示的吡喃并吲哚衍生物：其中R表示氢原子或羟基，Q表示> C = O或，条件是Q不大于> C = 当R为氢原子时。还描述了其制备过程。

9. 发明授权

US4939255A Hexa-cyclic camptothecin derivatives 失效
标题翻译：六环喜树碱衍生物
公开(公告)号：US4939255A
公开(公告)日：1990-07-03
申请号：US207718
申请日：1988-06-16
申请人： Hiroaki Tagawa , Masamichi Sugimori , Hirofumi Terasawa , Akio Ejima , Satoru Ohsuki
发明人： Hiroaki Tagawa , Masamichi Sugimori , Hirofumi Terasawa , Akio Ejima , Satoru Ohsuki
IPC分类号： C07D471/22 , C07D491/22 , C07D495/22
CPC分类号： C07D495/22 , C07D471/22 , C07D491/22
摘要： A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound through Friedlaender reaction. It has an excellent antitumor activity and a high degree of safety, and can be applied as an antitumor medicine for curing tumors of various kinds.

10. 发明授权

US5637770A Hexa-cyclic compound 失效
标题翻译：六环化合物
公开(公告)号：US5637770A
公开(公告)日：1997-06-10
申请号：US455718
申请日：1995-05-31
申请人： Hirofumi Terasawa , Akio Ejima , Satoru Ohsuki , Kouichi Uoto
发明人： Hirofumi Terasawa , Akio Ejima , Satoru Ohsuki , Kouichi Uoto
IPC分类号： C07D491/22 , C07D495/22 , C07C233/05
CPC分类号： C07D491/22 , C07D495/22
摘要： A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.
摘要翻译：一种新颖的六环化合物，喜树碱的衍生物，具有以下通式：该化合物通过缩合闭合反应由氨基酮化合物和吡喃并吲哚化合物制备。水溶性丰富，抗肿瘤活性优良，安全性高，可用作治疗各种肿瘤的抗肿瘤药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式