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1. 发明申请

US20130175131A1 TORQUE CONVERTER 有权
标题翻译：扭矩转换器
公开(公告)号：US20130175131A1
公开(公告)日：2013-07-11
申请号：US13821946
申请日：2011-07-21
申请人： Norio Iwashita , Tokimori Saka , Takashi Ishiyama , Hidetoshi Maeta
发明人： Norio Iwashita , Tokimori Saka , Takashi Ishiyama , Hidetoshi Maeta
IPC分类号： F16D33/18
CPC分类号： F16D33/18 , F16H41/30 , F16H45/02 , F16H2045/021 , F16H2045/0284
摘要： A torque converter includes, in a case coupled to an output shaft of an engine, a torus formed from a pump, a turbine and a stator having a one-way clutch on the inside thereof, and a lock-up clutch. In addition, in this torque converter, a fluid from a pump is introduced from a space between a stator shaft (F2) and a turbine shaft (F1), and discharged from a space between a pump sleeve (23) and the stator shaft (F2) through a space where the lock-up clutch is disposed and the torus. Moreover, this torque converter further includes a seal member (80) which is disposed at a side that is closer to the engine than a spline engagement part (P2) of an inner race (52) and the stator shaft (F2), and seals a space between an inner peripheral face of the inner race (52) and an outer peripheral face of the stator shaft (F2).
摘要翻译：在与发动机的输出轴联接的情况下，变矩器包括由泵，涡轮和在其内部具有单向离合器的定子形成的环形圈，以及锁止离合器。此外，在该液力变矩器中，来自泵的流体从定子轴（F2）和涡轮轴（F1）之间的空间引入，并从泵套（23）与定子轴（ F2）通过设置锁止离合器的空间和环面。此外，该变矩器还具备密封部件（80），该密封部件设置在比内圈（52）和定子轴（F2）的花键接合部（P2）更靠近发动机的一侧，并且密封内座圈（52）的内周面与定子轴（F2）的外周面之间的空间。

2. 发明申请

US20130140123A1 TORQUE CONVERTER 有权
标题翻译：扭矩转换器
公开(公告)号：US20130140123A1
公开(公告)日：2013-06-06
申请号：US13817798
申请日：2011-07-21
申请人： Tokimori Saka , Norio Iwashita , Takashi Ishiyama , Hidetoshi Maeta
发明人： Tokimori Saka , Norio Iwashita , Takashi Ishiyama , Hidetoshi Maeta
IPC分类号： F16D39/00
CPC分类号： F16D39/00 , F16F15/12 , F16H45/02 , F16H2041/246 , F16H2045/0205 , F16H2045/021 , F16H2045/0284 , F16H2045/0294
摘要： Provided is a torque converter (1) which comprises: a casing (10) coupled to an output shaft of an engine; a torus (T) defined by a pump (20), a turbine (30) and a stator (40) each disposed within the casing (10); a multi-plate lockup clutch (60) adapted to directly couple the turbine (30) and the casing (10); and a lockup damper (70) adapted to absorb shock during engagement of the lockup clutch (60). The lockup clutch (60) and the lockup damper (70) are arranged within a space between the torus (T) and a surface of the casing (10) on the side of the engine, in an axially overlapping relation. The lockup clutch (60) is disposed on a radially inner side with respect to a widest region (T1) of the torus (T), and the lockup damper (70) is disposed on a radially outer side with respect to the widest region (T1). This makes it possible to engage the lockup clutch (60) with excellent response while suppressing shock, and shorten an overall length of an automatic transmission.
摘要翻译：提供一种变矩器（1），其包括：联接到发动机的输出轴的壳体（10）每个设置在所述壳体（10）内的由泵（20），涡轮机（30）和定子（40）限定的环面（T）; 适于直接联接所述涡轮机（30）和所述壳体（10）的多板锁止离合器（60）; 以及适于在所述锁止离合器（60）的接合期间吸收冲击的锁止阻尼器（70）。锁止离合器（60）和锁止阻尼器（70）以轴向重叠的关系布置在环形面（T）与壳体（10）的在发动机侧面上的空间之间。锁止离合器（60）相对于环面（T）的最宽区域（T1）设置在径向内侧，锁止阻尼器（70）相对于最宽区域（径向外侧）设置 T1）。这使得可以在抑制冲击的同时使锁止离合器（60）具有优异的响应，并缩短自动变速器的总长度。

3. 发明申请

US20060128685A1 Pyrazole derivative 失效
标题翻译：吡唑衍生物
公开(公告)号：US20060128685A1
公开(公告)日：2006-06-15
申请号：US10543915
申请日：2004-02-06
申请人： Naoaki Kanaya , Hiroaki Ishihara , Youichi Kimura , Takashi Ishiyama , Yuichi Ochiai
发明人： Naoaki Kanaya , Hiroaki Ishihara , Youichi Kimura , Takashi Ishiyama , Yuichi Ochiai
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4178 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： A61K31/551 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K31/541 , C07D231/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07D493/04
摘要： The present invention is directed to a strong platelet aggregation-inhibiting agent which does not inhibit COX-1 or COX-2. The present invention provides compounds represented by formula (I) or formula (II), salts of the compounds, and solvates of the compounds or the salts. Also provided are medicaments containing any of the compounds, salts, or solvates and preventive and/or therapeutic agents for ischemic diseases, containing any of the compounds, salts, or the solvates.
摘要翻译：本发明涉及不抑制COX-1或COX-2的强烈的血小板聚集抑制剂。本发明提供由式（I）或式（II）表示的化合物的盐，化合物的盐和化合物或其盐的溶剂合物。还提供了含有任何化合物，盐或溶剂合物的药物，以及含有任何化合物，盐或溶剂合物的缺血性疾病的预防和/或治疗剂。

4. 发明授权

US06646123B2 Pentacyclic Compound 失效
标题翻译：五环化合物
公开(公告)号：US06646123B2
公开(公告)日：2003-11-11
申请号：US10126653
申请日：2002-04-22
申请人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
发明人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
IPC分类号： C07D49308
CPC分类号： C07D493/08 , C07D305/14
摘要： The present invention relates to a novel taxol derivative having an antitumor activity which is represented by formula (1). [In the formula (I), R1: a phenyl group, R2: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group or an alkoxyl group, R3: a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxyl group, a group —O—R311 an acyloxy group or a group —O—CO—R31, (in which R31: an alkylamino group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group), R4 and R5: a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, Z1: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z2: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z3: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group].
摘要翻译：本发明涉及由式（1）表示的具有抗肿瘤活性的新型紫杉醇衍生物[在式（I）中，R 1：苯基，R 2：烷基，烯基基团，炔基，环烷基或烷氧基，R 3：氢原子，羟基，卤素原子，烷氧基，基团-OR 31，酰氧基或基团， O-CO-R 31（其中R 31：烷基氨基，烯基，炔基，环烷基，芳基或杂环基），R 4和R 5 >：氢原子，烷基，烯基，炔基，芳基或杂环基，Z 1：氢原子，羟基，卤素原子或烷基，Z 2 >：氢原子，羟基，卤素原子或烷基，Z 3：烷基，烯基，炔基，环烷基，芳基或杂环基]。

5. 发明授权

US06211363B1 Pentacyclic compound 有权
标题翻译：五环化合物
公开(公告)号：US06211363B1
公开(公告)日：2001-04-03
申请号：US09513852
申请日：2000-02-25
申请人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
发明人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
IPC分类号： C07D49308
CPC分类号： C07D493/08 , C07D305/14
摘要： The present invention relates to a novel taxol derivative having an antitumor-activity which is represented by formula (1). [In the formula (I), R1: a phenyl group, R2: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group or an alkoxyl group, R3: a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxyl group, a group —O—R31, an acyloxy group or a group —O—CO—R31, (in which R31: an alkylamino group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group), R4 and R5: a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, Z1: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z2: a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z3: an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group].
摘要翻译：本发明涉及由式（1）表示的具有抗肿瘤活性的新型紫杉醇衍生物[式（I）中，R 1为苯基，R 2为烷基，烯基，炔基，环烷基或烷氧基，R3：氢原子，羟基，卤素原子，烷氧基，-O-R31基，酰氧基或-O-CO-R31基（其中 R 31：烷基氨基，烯基，炔基，环烷基，芳基或杂环基），R 4和R 5：氢原子，烷基，烯基，炔基，芳基或杂环基，Z1：氢原子，羟基，卤素原子或烷基，Z2：氢原子，羟基，卤素原子或烷基，Z3：烷基，烯基，炔基，环烷基，芳基或杂环基]。

6. 发明授权

US6075140A Pentacyclic compound 失效
标题翻译：五环化合物
公开(公告)号：US6075140A
公开(公告)日：2000-06-13
申请号：US945276
申请日：1998-02-05
申请人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
发明人： Hirofumi Terasawa , Tsunehiko Soga , Takashi Ishiyama
IPC分类号： C07D305/14 , C07D493/08
CPC分类号： C07D493/08 , C07D305/14
摘要： The present invention relates to a novel taxol derivative having an antitumor activity which is represented by formula (1). ##STR1## [In the formula (I), R.sup.1 : a phenyl group, R.sup.2 : an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group or an alkoxyl group, R.sup.3 : a hydrogen atom, a hydroxyl group, a halogen atom, an alkoxyl group, a group --O--R.sup.31, an acyloxy group or a group --O--CO--R.sup.31, (in which R.sup.31 : an alkylamino group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group), R.sup.4 and R.sup.5 : a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group, Z.sup.1 : a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z.sup.2 : a hydrogen atom, a hydroxyl group, a halogen atom or an alkyl group, Z.sup.3 : an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group].
摘要翻译： PCT No.PCT / JP96 / 01145 Sec。 371日期：1998年2月5日 102（e）1998年2月5日PCT 1996年4月25日PCT PCT。出版物WO96 / 33998 日期：1996年10月31日本发明涉及由式（1）表示的具有抗肿瘤活性的新型紫杉醇衍生物。 [式（I）中，R 1为苯基，R 2为烷基，烯基，炔基，环烷基或烷氧基，R 3为氢原子，羟基，卤素原子，烷氧基，基团-O-R31，酰氧基或基团-O-CO-R31（其中R31：烷基氨基，烯基，炔基，环烷基，芳基或杂环基），R4和R5：氢原子，烷基，烯基，炔基，芳基或杂环基，Z1：氢原子，羟基，卤素原子或烷基， Z2：氢原子，羟基，卤原子或烷基，Z3：烷基，烯基，炔基，环烷基，芳基或杂环基）。

7. 发明授权

US09316273B2 Torque converter 有权
标题翻译：转矩转换器
公开(公告)号：US09316273B2
公开(公告)日：2016-04-19
申请号：US13817798
申请日：2011-07-21
申请人： Tokimori Saka , Norio Iwashita , Takashi Ishiyama , Hidetoshi Maeta
发明人： Tokimori Saka , Norio Iwashita , Takashi Ishiyama , Hidetoshi Maeta
IPC分类号： F16D39/00 , F16H45/02 , F16F15/12
CPC分类号： F16D39/00 , F16F15/12 , F16H45/02 , F16H2041/246 , F16H2045/0205 , F16H2045/021 , F16H2045/0284 , F16H2045/0294
摘要： Provided is a torque converter (1) which comprises: a casing (10) coupled to an output shaft of an engine; a torus (T) defined by a pump (20), a turbine (30) and a stator (40) each disposed within the casing (10); a multi-plate lockup clutch (60) adapted to directly couple the turbine (30) and the casing (10); and a lockup damper (70) adapted to absorb shock during engagement of the lockup clutch (60). The lockup clutch (60) and the lockup damper (70) are arranged within a space between the torus (T) and a surface of the casing (10) on the side of the engine, in an axially overlapping relation. The lockup clutch (60) is disposed on a radially inner side with respect to a widest region (T1) of the torus (T), and the lockup damper (70) is disposed on a radially outer side with respect to the widest region (T1). This makes it possible to engage the lockup clutch (60) with excellent response while suppressing shock, and shorten an overall length of an automatic transmission.
摘要翻译：提供一种变矩器（1），其包括：联接到发动机的输出轴的壳体（10）每个设置在所述壳体（10）内的由泵（20），涡轮机（30）和定子（40）限定的环面（T）; 适于直接联接所述涡轮机（30）和所述壳体（10）的多板锁止离合器（60）; 以及适于在所述锁止离合器（60）的接合期间吸收冲击的锁止阻尼器（70）。锁止离合器（60）和锁止阻尼器（70）以轴向重叠的关系布置在环形面（T）与壳体（10）的在发动机侧面上的空间之间。锁止离合器（60）相对于环面（T）的最宽区域（T1）设置在径向内侧，锁止阻尼器（70）相对于最宽区域（径向外侧）设置 T1）。这使得可以在抑制冲击的同时使锁止离合器（60）具有优异的响应，并缩短自动变速器的总长度。

8. 发明申请

US20070254881A1 Pyrazole Derivative 审中-公开
标题翻译：吡唑衍生物
公开(公告)号：US20070254881A1
公开(公告)日：2007-11-01
申请号：US11573098
申请日：2005-08-08
申请人： Naoaki Kanaya , Takashi Ishiyama , Ryo Muto , Toshiyuki Watanabe , Yuichi Ochiai
发明人： Naoaki Kanaya , Takashi Ishiyama , Ryo Muto , Toshiyuki Watanabe , Yuichi Ochiai
IPC分类号： A61K31/501 , A61K31/444 , A61K31/4545 , A61P7/02 , C07D401/14 , C07D413/14 , C07D403/14 , C07D211/32 , A61K31/5377 , A61K31/497
CPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要： A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.
摘要翻译：由式（I）表示的化合物：其中Ar 1代表式（II）：Ar 2表示可被取代的5或6元芳族杂环基; 并且X表示式（III）：其盐或化合物或其盐的溶剂合物。提供了不抑制COX-1和COX-2的有效的血小板聚集抑制剂。

9. 发明授权

US08939267B2 Torque converter 有权
标题翻译：转矩转换器
公开(公告)号：US08939267B2
公开(公告)日：2015-01-27
申请号：US13821946
申请日：2011-07-21
申请人： Norio Iwashita , Tokimori Saka , Takashi Ishiyama , Hidetoshi Maeta
发明人： Norio Iwashita , Tokimori Saka , Takashi Ishiyama , Hidetoshi Maeta
IPC分类号： F16H45/02 , F16D33/18 , F16H41/30
CPC分类号： F16D33/18 , F16H41/30 , F16H45/02 , F16H2045/021 , F16H2045/0284
摘要： A torque converter includes, in a case coupled to an output shaft of an engine, a torus formed from a pump, a turbine and a stator having a one-way clutch on the inside thereof, and a lock-up clutch. In addition, in this torque converter, a fluid from a pump is introduced from a space between a stator shaft (F2) and a turbine shaft (F1), and discharged from a space between a pump sleeve (23) and the stator shaft (F2) through a space where the lock-up clutch is disposed and the torus. Moreover, this torque converter further includes a seal member (80) which is disposed at a side that is closer to the engine than a spline engagement part (P2) of an inner race (52) and the stator shaft (F2), and seals a space between an inner peripheral face of the inner race (52) and an outer peripheral face of the stator shaft (F2).
摘要翻译：在与发动机的输出轴联接的情况下，变矩器包括由泵，涡轮和在其内部具有单向离合器的定子形成的环形圈，以及锁止离合器。此外，在该液力变矩器中，来自泵的流体从定子轴（F2）和涡轮轴（F1）之间的空间引入，并从泵套（23）与定子轴（ F2）通过设置锁止离合器的空间和环面。此外，该变矩器还具备密封部件（80），该密封部件设置在比内圈（52）和定子轴（F2）的花键接合部（P2）更靠近发动机的一侧，并且密封内座圈（52）的内周面与定子轴（F2）的外周面之间的空间。

10. 发明申请

US20070219210A1 Amidopyrazole Derivative 审中-公开
标题翻译：吡唑衍生物
公开(公告)号：US20070219210A1
公开(公告)日：2007-09-20
申请号：US10584632
申请日：2004-12-27
申请人： Naoaki Kanaya , Takashi Ishiyama , Ryo Muto , Yuichi Ochiai , Toshiyuki Watanabe , Noriko Shima
发明人： Naoaki Kanaya , Takashi Ishiyama , Ryo Muto , Yuichi Ochiai , Toshiyuki Watanabe , Noriko Shima
IPC分类号： A61K31/415 , A61K31/4427 , A61K31/497 , A61K31/501 , C07D231/04 , C07D401/14
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要： A platelet coagulation inhibitor which inhibits neither COX-1 nor COX-2 is provided. The inhibitor is a compound represented by general formula (I): wherein Ar1 and Ar2 independently represent a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents, or a phenyl group optionally substituted with 1 to 3 substituents; R1 represents a lower acyl group, carboxyl group, a lower alkoxy carbonyl group, a lower alkoxy group, a lower alkyl group optionally substituted with 1 or 2 substituents, a carbamoyl group optionally substituted with 1 or 2 substituents, an oxamoyl group optionally substituted with 1 or 2 substituents, an amino group optionally substituted with 1 or 2 substituents, a 4- to 7-membered alicyclic heterocyclic group optionally substituted with 1 or 2 substituents, a phenyl group optionally substituted with 1 to 3 substituents, or a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents; and R2 represents hydrogen atom, a halogeno group, or the like.
摘要翻译：提供了既不抑制COX-1也不抑制COX-2的血小板凝血抑制剂。抑制剂是由通式（I）表示的化合物：其中Ar 1和Ar 2独立地表示任选被1至 3个取代基或任选被1至3个取代基取代的苯基; R 1表示低级酰基，羧基，低级烷氧基羰基，低级烷氧基，任选被1或2个取代基取代的低级烷基，任选被1或2个取代基取代的氨基甲酰基，任选被 1或2个取代基，任选被1或2个取代基取代的氨基，任选被1或2个取代基取代的4-至7-元脂环族杂环基，任选被1至3个取代基取代的苯基，或5-或任选被1至3个取代基取代的6元芳族杂环基; R 2表示氢原子，卤代基等。

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