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1. 发明授权

US07943351B2 Method for acyltransferase reaction using acyl coenzyme A 有权
标题翻译：使用酰基辅酶A进行酰基转移酶反应的方法
公开(公告)号：US07943351B2
公开(公告)日：2011-05-17
申请号：US12277622
申请日：2008-11-25
申请人： Motoaki Kamachi , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
发明人： Motoaki Kamachi , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
IPC分类号： C12P11/00 , C12P7/64 , C12P7/62
CPC分类号： C12P13/02 , C12N9/1029 , C12P7/625 , C12P13/001
摘要： The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polymers such as polyester.
摘要翻译：本发明涉及一种酰基转移酶反应的方法，其中酰基辅酶A的酰基被转移到酰基基团受体中，其特征在于反应是通过在反应中由辅酶A生产和/或再生酰基辅酶A 系统通过化学硫酯与酰基硫酯交换反应。其中昂贵的酰基CoA在反应体系中非酶原地再生的本发明使得能够仅通过将少量酰基辅酶A与酰基的供体和受体一起投入系统而连续进行酰基转移酶反应。因此，本发明的方法可以应用于包括有用的生物分子和聚合物如聚酯的合成的各种化合物的工业生产方法。

2. 发明申请

US20070219158A1 External Preparation for Skin and Cosmetic Containing Inositol Derivative 审中-公开
标题翻译：包含肌醇衍生物的皮肤和化妆品的外用制剂
公开(公告)号：US20070219158A1
公开(公告)日：2007-09-20
申请号：US10594037
申请日：2005-03-22
申请人： Hirobumi Aoki , Motoaki Kamachi
发明人： Hirobumi Aoki , Motoaki Kamachi
IPC分类号： A61K8/34 , A61K8/60 , A61K8/73 , A61Q19/00
CPC分类号： A61K8/345 , A61K8/602 , A61K8/738 , A61Q19/00
摘要： The present invention discloses a skin external preparation which contains an inositol derivative in which an inositol and a saccharide are combined. The invention aims to provide the external preparation for skin that can be spread over skin without causing grain feeling and has excellent effects of giving sufficient moist feeling and keeping the skin healthy.
摘要翻译：本发明公开了含有肌醇衍生物的皮肤外用剂，其中肌醇和糖被组合。本发明的目的是提供可以分散在皮肤上而不会引起颗粒感的皮肤的外用制剂，并且具有赋予足够的湿感并保持皮肤健康的优异效果。

3. 发明申请

US20070232698A1 Slimming Skin External Preparation and Cosmetic Containing the Same 审中-公开
标题翻译：减肥皮肤外用制剂和化妆品含有它
公开(公告)号：US20070232698A1
公开(公告)日：2007-10-04
申请号：US11597884
申请日：2005-05-31
申请人： Akira Shibuya , Eiko Kato , Motoaki Kamachi , Hirobumi Aoki
发明人： Akira Shibuya , Eiko Kato , Motoaki Kamachi , Hirobumi Aoki
IPC分类号： A61K31/195
CPC分类号： A61K8/365 , A61K8/44 , A61K8/676 , A61K8/678 , A61K31/195 , A61Q19/06
摘要： The invention provides a slimming skin external preparation and a cosmetic that contain a carnitine derivative having excellent skin affinity and percutaneous absorption properties and capable of enhancing the fat metabolism, and that can treat, reduce or prevent the obesity by functioning as a lipolytic agent to enhance the fat metabolism of general or local subcutaneous fat tissues. The slimming skin external preparation contains a particular carnitine derivative and preferably other slimming and skin-care ingredients.
摘要翻译：本发明提供了一种减肥皮肤外用剂和化妆品，其含有具有优异的皮肤亲和性和经皮吸收性能并能够增强脂肪代谢的肉碱衍生物，并且可以通过用作促脂肪分解剂来治疗，减少或预防肥胖症一般或局部皮下脂肪组织的脂肪代谢。减肥皮肤外用制剂含有特定的肉碱衍生物，优选其它减肥和护肤成分。

4. 发明申请

US20060148048A1 Process for acyl-transfer enzyme reactions with acyl-coenzyme a 有权
标题翻译：用酰基辅酶a进行酰基转移酶反应的方法
公开(公告)号：US20060148048A1
公开(公告)日：2006-07-06
申请号：US10542733
申请日：2004-01-21
申请人： Motoaki Kamachi , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
发明人： Motoaki Kamachi , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
IPC分类号： C12P7/64 , C12P7/62
CPC分类号： C12P13/02 , C12N9/1029 , C12P7/625 , C12P13/001
摘要： The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polylmers such as polyester.
摘要翻译：本发明涉及一种酰基转移酶反应的方法，其中酰基辅酶A的酰基被转移到酰基基团受体中，其特征在于反应是通过在反应中由辅酶A生产和/或再生酰基辅酶A 系统通过化学硫酯与酰基硫酯交换反应。其中昂贵的酰基CoA在反应体系中非酶原地再生的本发明使得能够仅通过将少量酰基辅酶A与酰基的供体和受体一起投入系统而连续进行酰基转移酶反应。因此，本发明的方法可以应用于包括有用的生物分子和聚合物如聚酯的合成的各种化合物的工业生产方法。

5. 发明申请

US20090111153A1 METHOD FOR ACYLTRANSFERASE REACTION USING ACYL COENZYME A 有权
标题翻译：使用ACYL COENZYME的ACYLTRANSFERASE反应的方法A
公开(公告)号：US20090111153A1
公开(公告)日：2009-04-30
申请号：US12277622
申请日：2008-11-25
申请人： Motoaki KAMACHI , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
发明人： Motoaki KAMACHI , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
IPC分类号： C12P7/62
CPC分类号： C12P13/02 , C12N9/1029 , C12P7/625 , C12P13/001
摘要： The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polymers such as polyester.
摘要翻译：本发明涉及一种酰基转移酶反应的方法，其中酰基辅酶A的酰基被转移到酰基基团受体中，其特征在于反应是通过在反应中由辅酶A生产和/或再生酰基辅酶A 系统通过化学硫酯与酰基硫酯交换反应。其中昂贵的酰基CoA在反应体系中非酶原地再生的本发明使得能够仅通过将少量酰基辅酶A与酰基的供体和受体一起投入系统而连续进行酰基转移酶反应。因此，本发明的方法可以应用于包括有用的生物分子和聚合物如聚酯的合成的各种化合物的工业生产方法。

6. 发明授权

US07476521B2 Method for acyltransferase reaction using acyl coenzyme A 有权
标题翻译：使用酰基辅酶A进行酰基转移酶反应的方法
公开(公告)号：US07476521B2
公开(公告)日：2009-01-13
申请号：US10542733
申请日：2004-01-21
申请人： Motoaki Kamachi , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
发明人： Motoaki Kamachi , Harumi Kamachi , Hirobumi Aoki , Tomoki Erata , Kenji Tajima
IPC分类号： C12P7/62 , C12P7/64
CPC分类号： C12P13/02 , C12N9/1029 , C12P7/625 , C12P13/001
摘要： The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by a chemical thioester exchange reaction with acylthioester. The present invention, wherein expensive acyl CoA is reproduced nonenzymatically in a reaction system, enables to continuously carry out acyltransferase reaction only by putting a small amount of acyl CoA with a donor and a receptor of an acyl group into a system. Accordingly, the method of the present invention can be applied to an industrial production method of various kinds of compounds including useful biological molecules and synthesis of polylmers such as polyester.
摘要翻译：本发明涉及一种酰基转移酶反应的方法，其中酰基辅酶A的酰基被转移到酰基基团受体中，其特征在于反应是通过在反应中由辅酶A生产和/或再生酰基辅酶A 系统通过化学硫酯与酰基硫酯交换反应。其中昂贵的酰基CoA在反应体系中非酶原地再生的本发明使得能够仅通过将少量酰基辅酶A与酰基的供体和受体一起投入系统而连续进行酰基转移酶反应。因此，本发明的方法可以应用于包括有用的生物分子和聚合物如聚酯的合成的各种化合物的工业生产方法。

7. 发明申请

US20090240070A1 WHITENING DERMATOLOGICAL PREPARATIONS 审中-公开
标题翻译：白化皮肤制剂
公开(公告)号：US20090240070A1
公开(公告)日：2009-09-24
申请号：US12278479
申请日：2007-02-05
申请人： Harumi Kamachi , Hirobumi Aoki , Yohei Kurata , Jiro Takata
发明人： Harumi Kamachi , Hirobumi Aoki , Yohei Kurata , Jiro Takata
IPC分类号： C07D311/72
CPC分类号： A61K31/355 , A61K8/498 , A61K8/678 , A61Q19/02
摘要： Disclosed is a dermatological preparation that are safe and are excellent in inhibiting and removing skin pigmentation and in inhibiting skin roughness. A dermatological preparation comprising a tocopherol aminoalkylcarboxylate and/or a salt thereof, the tocopherol aminoalkylcarboxylate being represented by Formula (I): wherein R1 is a hydrogen atom or a lower alkyl group; R2 and R3 are each independently a hydrogen atom or a methyl group; X is a cycloalkylene group of 3 to 6 carbon atoms; and n is 0 or 1.
摘要翻译：公开了一种安全的皮肤病学制剂，并且在抑制和去除皮肤色素沉着和抑制皮肤粗糙度方面优异。一种包含生育酚氨基烷基羧酸盐和/或其盐的皮肤病学制剂，所述生育酚氨基烷基羧酸盐由式（I）表示：其中R1是氢原子或低级烷基; R2和R3各自独立地为氢原子或甲基; X为3〜6个碳原子的亚环烷基; n为0或1。

8. 发明申请

US20060234331A1 Method of selecting escherichia coli strain overexpressing foreign gene escherichia coli mutant thus selected and process for producing enzyme and compound using the same 失效
标题翻译：选择过表达这样选择的外源基因大肠杆菌突变体的大肠杆菌菌株的方法和使用其制备酶和化合物的方法
公开(公告)号：US20060234331A1
公开(公告)日：2006-10-19
申请号：US10538291
申请日：2003-12-11
申请人： Kazufumi Yazaki , Hirobumi Aoki , Harumi Kamachi
发明人： Kazufumi Yazaki , Hirobumi Aoki , Harumi Kamachi
IPC分类号： C07H21/04 , C12Q1/04 , C12P21/06 , C12P13/04 , C12N9/00 , C12N15/74 , C12N1/21
CPC分类号： C12N9/88 , C12P13/04
摘要： The invention relates to a selection method of an Escherichia coli mutant strain which expresses an exogenous gene at a high level, wherein stress resistance such as hydrogen peroxide decomposition activity is used as an index, the Escherichia coli mutant strain selected thereby and production methods of enzyme using the strain and of useful compounds like amino acids (especially L-amino acid) and the like using the strain. According to the selection method of the invention, an Escherichia coli mutant strain where gene expression amount does not decrease with passage can be obtained, and a compound using a plant-derived ammonia lyase can be efficiently produced.
摘要翻译：本发明涉及高水平表达外源基因的大肠杆菌突变菌株的选择方法，其中使用过氧化氢分解活性等胁迫抗性作为指标，由此选择的大肠杆菌突变株及其生产方法使用菌株和有用化合物如氨基酸（特别是L-氨基酸）等。根据本发明的选择方法，可以获得其中基因表达量不随着通过而降低的大肠杆菌突变菌株，并且可以有效地产生使用植物来源的氨裂解酶的化合物。

9. 发明申请

US20100322887A1 HAIR NOURISHING COSMETIC 审中-公开
标题翻译：头发清新化妆品
公开(公告)号：US20100322887A1
公开(公告)日：2010-12-23
申请号：US12866417
申请日：2009-02-06
申请人： Hirobumi Aoki , Harumi Kamachi
发明人： Hirobumi Aoki , Harumi Kamachi
IPC分类号： A61K8/55 , C07F9/12 , A61Q5/12
CPC分类号： A61K8/55 , A61Q5/02 , A61Q7/00
摘要： It is an object of the present invention to provide a hair nourishing cosmetic which allows an antioxidative action of ubiquinone to contribute to hair nourishment. The hair nourishing cosmetic of the present invention comprises a ubiquinone derivative represented by the following formula (1) and/or its salt, wherein R1 and R2 are each independently a hydrogen atom or a phosphoric acid group, at least one of R1 and R2 is a phosphoric acid group, and n is an integer of 1 to 9.
摘要翻译：本发明的目的是提供一种能够促进泛醌的抗氧化作用促进头发营养的护发美容品。本发明的滋润化妆品包含下式（1）表示的泛醌衍生物和/或其盐，其中R1和R2各自独立地为氢原子或磷酸基，R1和R2中的至少一个为磷酸基，n为1〜9的整数。

10. 发明申请

US20070293577A1 Hydroxycitric Acid Derivatives And Skin External Preparations Using The Same 有权
标题翻译：羟基柠檬酸衍生物和皮肤外用制剂
公开(公告)号：US20070293577A1
公开(公告)日：2007-12-20
申请号：US11663422
申请日：2005-09-22
申请人： Harumi Kamachi , Tsuyoshi Katoh , Hirobumi Aoki
发明人： Harumi Kamachi , Tsuyoshi Katoh , Hirobumi Aoki
IPC分类号： A61K31/191 , A61P3/04 , C07C59/265
CPC分类号： A61K8/0212 , A61K8/365 , A61K8/375 , A61Q19/00 , A61Q19/06 , A61Q19/10 , C07C59/285 , C07C69/28 , C07C69/675
摘要： Hydroxycitric acid derivatives and salts thereof are provided which are useful as active ingredients of skin external preparations and cosmetics. Also provided are processes for production of the hydroxycitric acid derivatives, and skin external preparations and cosmetics containing the hydroxycitric acid derivatives. Specific hydroxycitric acid derivatives or salts thereof are produced wherein at least one of the hydroxyl groups of hydroxycitric acid or least one of the hydroxyl groups and at least one carboxyl group of hydroxycitric acid are modified to linkage moieties breakable by biological enzyme reaction. The hydroxycitric acid derivatives or salts thereof are added in skin external preparations and cosmetics.
摘要翻译：提供羟基柠檬酸衍生物及其盐，其可用作皮肤外用制剂和化妆品的活性成分。还提供了用于生产羟基柠檬酸衍生物的方法，以及含有羟基柠檬酸衍生物的皮肤外用制剂和化妆品。制备特定的羟基柠檬酸衍生物或其盐，其中羟基柠檬酸或至少一个羟基的羟基和羟基柠檬酸的至少一个羧基的羟基中的至少一个被修饰成可通过生物酶反应而破坏的连接部分。将羟基柠檬酸衍生物或其盐加入皮肤外用制剂和化妆品中。

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