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1. 发明授权

US08663929B2 Method for detection of liver cancer cell using anti-glypican-3 antibody 有权
标题翻译：使用抗磷脂酰肌醇蛋白聚糖-3抗体检测肝癌细胞的方法
公开(公告)号：US08663929B2
公开(公告)日：2014-03-04
申请号：US12736180
申请日：2009-03-16
申请人： Hiroaki Kataoka , Hirotake Takai , Atsuhiko Kato , Masami Suzuki , Masamichi Sugimoto
发明人： Hiroaki Kataoka , Hirotake Takai , Atsuhiko Kato , Masami Suzuki , Masamichi Sugimoto
IPC分类号： G01N33/53
CPC分类号： G01N33/57438 , A61K2039/505 , C07K16/303
摘要： The present invention relates to an in-vitro immunoassay method for detecting the presence of liver cancer cells in a subject. In the method of the present invention, antigen retrieval treatment based on heat-induced epitope retrieval method and antigen retrieval treatment based on protease-induced epitope retrieval method can be combined in the detection of glypican 3 antigen expression in liver cancer tissues to thereby detect the difference in the expression level or expression pattern of the glypican 3 antigen by immunohistochemical staining method. This enables samples, which has been determined by the conventional HIER method as highly expressing glypican 3, to be graded according to the expression level of glypican 3.
摘要翻译：本发明涉及用于检测受试者中肝癌细胞存在的体外免疫测定方法。在本发明的方法中，基于热诱导表位检索方法和基于蛋白酶诱导表位检索方法的抗原恢复处理的抗原恢复处理可以结合在肝癌组织中检测磷脂酰肌醇蛋白聚糖3抗原表达，从而检测通过免疫组织化学染色法观察磷脂酰肌醇蛋白聚糖3抗原的表达水平或表达模式差异。这使得通过常规HIER方法确定的高度表达磷脂酰肌醇蛋白聚糖3的样品根据磷脂酰肌醇蛋白聚糖3的表达水平被分级。

2. 发明申请

US20110091907A1 METHOD FOR DETECTION OF LIVER CANCER CELL USING ANTI-GLYPICAN-3 ANTIBODY 有权
标题翻译：使用抗胰蛋白胨-3抗体检测肝癌细胞的方法
公开(公告)号：US20110091907A1
公开(公告)日：2011-04-21
申请号：US12736180
申请日：2009-03-16
申请人： Hiroaki Kataoka , Hirotake Takai , Atsuhiko Kato , Masami Suzuki , Masamichi Sugimoto
发明人： Hiroaki Kataoka , Hirotake Takai , Atsuhiko Kato , Masami Suzuki , Masamichi Sugimoto
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , A61K2039/505 , C07K16/303
摘要： The present invention relates to an in-vitro immunoassay method for detecting the presence of liver cancer cells in a subject. In the method of the present invention, antigen retrieval treatment based on heat-induced epitope retrieval method and antigen retrieval treatment based on protease-induced epitope retrieval method can be combined in the detection of glypican 3 antigen expression in liver cancer tissues to thereby detect the difference in the expression level or expression pattern of the glypican 3 antigen by immunohistochemical staining method. This enables samples, which has been determined by the conventional HIER method as highly expressing glypican 3, to be graded according to the expression level of glypican 3.
摘要翻译：本发明涉及用于检测受试者中肝癌细胞存在的体外免疫测定方法。在本发明的方法中，基于热诱导表位检索方法和基于蛋白酶诱导表位检索方法的抗原恢复处理的抗原恢复处理可以结合在肝癌组织中检测磷脂酰肌醇蛋白聚糖3抗原表达，从而检测通过免疫组织化学染色法观察磷脂酰肌醇蛋白聚糖3抗原的表达水平或表达模式差异。这使得通过常规HIER方法确定的高度表达磷脂酰肌醇蛋白聚糖3的样品根据磷脂酰肌醇蛋白聚糖3的表达水平被分级。

3. 发明授权

US08896687B2 Lane departure prevention support apparatus, method of displaying a lane boundary line and program 有权
标题翻译：车道离境预防支援装置，显示车道边界线和程序的方法
公开(公告)号：US08896687B2
公开(公告)日：2014-11-25
申请号：US13463431
申请日：2012-05-03
申请人： Hiroaki Kataoka
发明人： Hiroaki Kataoka
IPC分类号： H04N7/00 , G08G1/16
CPC分类号： G08G1/167
摘要： A lane departure prevention support apparatus comprises: imaging means for capturing an image of a lane boundary line which defines a traveling lane; vehicle position detecting means for recognizing the lane boundary line in a recognition area of captured image data to detect a host vehicle position within the traveling lane in a width direction; assisting means for performing driver assist using the recognition result of the lane boundary line; displaying means for displaying the recognition result of the lane boundary line; and recognition result display controlling means for displaying an unrecognized lane boundary line according to the host vehicle position, if one of left and right white lines is not recognized, wherein a display of the unrecognized lane boundary line is not such a display which indicates that the lane boundary line is not recognized.
摘要翻译：车道偏离预防支援装置包括：成像装置，用于捕获限定行驶车道的车道边界线的图像; 车辆位置检测装置，用于识别捕获图像数据的识别区域中的车道边界线，以检测行进车道中宽度方向上的主车辆位置; 用于使用车道边界线的识别结果执行驾驶员辅助的辅助装置; 用于显示车道边界线的识别结果的显示装置; 以及识别结果显示控制装置，用于根据本车辆位置显示无法识别的车道边界线，如果未识别出左和右白线之一，其中未识别的车道边界线的显示不是这样的显示，其指示车道边界线不被识别。

4. 发明授权

US08846751B2 Agent for inhibiting production of hepatitis C virus and its use 有权
标题翻译：用于抑制丙型肝炎病毒生产的药剂及其用途
公开(公告)号：US08846751B2
公开(公告)日：2014-09-30
申请号：US13204219
申请日：2011-08-05
申请人： Masahiko Takeshita , Hirohito Tsubouchi , Hirofumi Uto , Hiroaki Kataoka , Takanori Kai , Hideaki Hirabaru , Miho Sakai , Ena Akamatsu
发明人： Masahiko Takeshita , Hirohito Tsubouchi , Hirofumi Uto , Hiroaki Kataoka , Takanori Kai , Hideaki Hirabaru , Miho Sakai , Ena Akamatsu
IPC分类号： A01N43/16 , C07D311/62 , A61K31/74 , A61K36/45
CPC分类号： A61K31/74 , A61K36/45 , C07D311/62
摘要： This invention provides an agent for inhibiting production of hepatitis C virus with notable anti-HCV activity and without side-effects. The agent comprises a proanthocyanidin polymer composition illustrated in the following the general formula (1), wherein R1 is hydrogen or hydroxyl, R2 is hydroxyl, R3 is hydrogen when R1 is either hydrogen or hydroxyl, but R3 is possibly hydroxyl when R1 is either hydrogen or hydroxyl to the extent that both R1 and R3 being hydroxyl is at most 40 percents in the proanthocyanidin polymer composition said units of flavan-3-ol being bonded each other in any one of three patterns as follows; (i) a bond between carbon at the position 4 and carbon at the position 8, (ii) a bond between carbon at the position 4 and carbon at the position 6, (iii) a bond between carbon at the position 4 and carbon at the position 8, and between carbon, at the position 2 and oxygen at the position 7.
摘要翻译：本发明提供用于抑制具有显着的抗HCV活性并且没有副作用的丙型肝炎病毒生产的药剂。该试剂包含如下通式（1）所示的原花青素聚合物组合物，其中R 1为氢或羟基，R 2为羟基，R 3为氢时，R 1为氢或羟基，但当R 1为氢时，R 3为羟基或羟基，其中R 1和R 3为羟基在原花色素聚合物组合物中至多为40％的程度，所述黄烷-3-醇单元以如下三种模式中的任一种彼此结合; （i）位置4的碳和位置8的碳之间的键，（ii）位置4的碳与位置6的碳之间的键;（iii）位置4的碳与碳之间的键位置8，碳之间，位置2和位置7处的氧。

5. 发明授权

US08392115B2 Road surface division mark recognition apparatus, and lane departure prevention apparatus 有权
标题翻译：路面划痕识别装置，车道偏离防止装置
公开(公告)号：US08392115B2
公开(公告)日：2013-03-05
申请号：US13564078
申请日：2012-08-01
申请人： Hiroaki Kataoka , Shioya Kageyama
发明人： Hiroaki Kataoka , Shioya Kageyama
IPC分类号： B60W30/12
CPC分类号： H04N5/232 , G06K9/00798 , G06K9/00812 , G06K9/209
摘要： A road surface division mark recognition apparatus includes: a vehicle-mounted camera that takes an image of a road surface ahead of a vehicle; an image processing portion which has a plurality of image processing modes that correspond respectively to a plurality of kinds of road surface division marks, and which recognizes a road surface division mark in a selected image processing mode; a temperature measurement portion that measures the temperature of the vehicle-mounted camera; and a restriction portion that restricts the action of the vehicle-mounted camera if the temperature measured by the temperature measurement portion is higher than or equal to a threshold value. The threshold value differs between the image processing modes.
摘要翻译：路面划分标记识别装置包括：车载摄像机，其在车辆前方拍摄路面的图像; 图像处理部分，其具有分别对应于多种路面划分标记的多个图像处理模式，并且识别所选择的图像处理模式中的路面划分标记; 温度测量部，其测量车载摄像机的温度; 以及如果由温度测量部分测量的温度高于或等于阈值则限制车载摄像机的动作的限制部分。阈值在图像处理模式之间不同。

6. 发明申请

US20130024750A1 TRANSMISSION SYSTEM 有权
标题翻译：传输系统
公开(公告)号：US20130024750A1
公开(公告)日：2013-01-24
申请号：US13639675
申请日：2011-03-07
申请人： Hiroaki Kataoka , Shinya Kamada
发明人： Hiroaki Kataoka , Shinya Kamada
IPC分类号： G06F11/10
CPC分类号： H04L1/22 , H04L1/0045 , H04L1/203 , H04L29/04 , H04L49/557 , H04L69/14 , H04L69/40
摘要： When a first communication device receives a predetermined message from a second communication device via a third line (L3) in a state of transmitting frames to a first line (L1) while performing error-correction coding on the frames, the first communication device switches the line used for transmission from L1 to the second line (L2), then transmits a frame of a post-switching message to L1. The second communication device receives frames from L1 and L2 and performs error correction, stores the frames, on which error correction has been performed, in first and second buffers (B1, B2), and when determining that it is necessary to perform line switching based on the status of error correction with respect to the frames received from L1, transmits a predetermined message to L3, and when receiving the frame of the post-switching message from L1, starts reading frames from B2 after reading all frames stored in B1.
摘要翻译：当第一通信设备在对第一线路（L1）发送帧的状态下经由第三线路（L3）从第二通信设备接收到预定消息，同时对帧执行纠错编码时，第一通信设备切换用于从L1传输到第二线路（L2）的线路，然后将切换后消息的帧发送到L1。第二通信装置从L1和L2接收帧并执行纠错，将执行了错误校正的帧存储在第一和第二缓冲器（B1，B2）中，并且当确定需要执行基于线路切换关于从L1接收到的帧的纠错状态，向L3发送预定消息，并且当从L1接收到切换后消息的帧时，在读取存储在B1中的所有帧之后开始从B2读取帧。

7. 发明授权

US08086372B2 Steering support device 有权
标题翻译：转向支撑装置
公开(公告)号：US08086372B2
公开(公告)日：2011-12-27
申请号：US12374755
申请日：2007-08-06
申请人： Yuji Okuda , Seiji Kawakami , Katsuhiko Iwazaki , Hiroaki Kataoka , Chumsamutr Rattapon
发明人： Yuji Okuda , Seiji Kawakami , Katsuhiko Iwazaki , Hiroaki Kataoka , Chumsamutr Rattapon
IPC分类号： G62D6/00 , G06F19/00
CPC分类号： B62D15/025 , B62D5/0466
摘要： The present invention aims at providing a steering assistance apparatus which can accurately detect a curve exit of a running path and perform steering assistance control with an excellent running path following capability. The steering assistance apparatus of the present invention is a steering assistance apparatus 1 for providing a steering mechanism with a steering torque such that a vehicle runs along a running path according to an image capturing the running path in front of the vehicle, which estimates a curve direction of the running path by processing the image, estimates a steering direction of a driver of the vehicle according to a steering operation of the driver, and determines that the vehicle is running through a curve exit according to a fact that the estimated curve direction and steering direction do not coincide with each other. This makes it possible to determine the curve exit of the running path accurately and perform appropriate steering assistance control.
摘要翻译：本发明的目的在于提供一种能够精确地检测行驶路径的曲线出口并且以优异的行驶路径跟随能力执行转向辅助控制的转向辅助装置。本发明的转向辅助装置是一种转向辅助装置1，其用于向转向机构提供转向转矩，使得车辆沿着行驶路径沿着行驶路线行驶，该图像捕获车辆前方的行驶路径，该图像估计曲线通过处理图像来运行路径的方向，根据驾驶员的转向操作来估计车辆的驾驶员的转向方向，并且根据估计的曲线方向和事实上的曲线出口来确定车辆正在行驶转向方向不一致。这使得可以精确地确定运行路径的曲线出口并执行适当的转向辅助控制。

8. 发明申请

US20080117033A1 Driving operation support system and method 有权
标题翻译：驾驶操作支援系统及方法
公开(公告)号：US20080117033A1
公开(公告)日：2008-05-22
申请号：US12007239
申请日：2008-01-08
申请人： Hiroaki Kataoka , Seiji Kawakami , Satoru Niwa , Katsuhiko Iwazaki
发明人： Hiroaki Kataoka , Seiji Kawakami , Satoru Niwa , Katsuhiko Iwazaki
IPC分类号： B62D15/00 , B62D6/00
CPC分类号： B62D15/029 , B60T2201/08 , B60T2201/087 , B60W30/12 , B62D15/025
摘要： In deviation prevention support ECU 10 in driving operation support system 1, an applied torque by steering torque applier 17 is set based on a vehicle speed of a vehicle. The applied torque is set to increase with increase of the vehicle speed. An upper limit according to the vehicle speed is set for this applied torque. Furthermore, in a Start interval in application of the applied torque, a rate of increasing to reach a maximum is determined according to the maximum of the applied torque. In a close interval, the applied torque is decreased at a rate different from that in the Start interval, and the absolute rate of increasing the torque in the Start interval is set to be larger than the absolute rate of decreasing the torque in the close interval.
摘要翻译：在驾驶操作支援系统1的偏离防止支援ECU10中，基于车辆的车速设定转向扭矩施加器17所施加的转矩。施加的转矩设定为随着车速的增加而增加。针对该施加的扭矩设定根据车速的上限。此外，在施加扭矩的起动间隔中，根据所施加的转矩的最大值来确定达到最大值的增加率。在紧密间隔中，施加的转矩以与起动间隔不同的速率减小，并且将起动间隔中的转矩增加的绝对速度设定为大于在闭合间隔中减小转矩的绝对速度。

9. 发明申请

US20070198152A1 Guiding device for guiding vehicle to target place controlling the steering angle 有权
标题翻译：导向装置，用于将车辆引导到控制转向角的目标位置
公开(公告)号：US20070198152A1
公开(公告)日：2007-08-23
申请号：US10565642
申请日：2004-07-15
申请人： Tomohiko Endo , Hisashi Satonaka , Yuichi Kubota , Akira Matsui , Hideyuki Iwakiri , Toru Sugiyama , Seiji Kawakami , Katsuhiko Iwazaki , Hiroaki Kataoka , Yuu Tanaka
发明人： Tomohiko Endo , Hisashi Satonaka , Yuichi Kubota , Akira Matsui , Hideyuki Iwakiri , Toru Sugiyama , Seiji Kawakami , Katsuhiko Iwazaki , Hiroaki Kataoka , Yuu Tanaka
IPC分类号： B62D6/00
CPC分类号： B62D15/0285 , B60T2201/10 , G08G1/161
摘要： A guiding device is disclosed for guiding a vehicle to a target position by controlling the steering angle while estimating the vehicle position at least based on a steering angle value, characterized in that, in estimating the vehicle position, a slowing operation with respect to a change dp in a moving distance of the vehicle is applied to a turning curvature g(Str(p)) estimated based on the steering angle value in order to compensate for the delay due to tire deformation, whereby the delay-compensated turning curvature y(p) is obtained.
摘要翻译：公开了一种引导装置，用于通过控制转向角来引导车辆到目标位置，同时至少基于转向角值来估计车辆位置，其特征在于，在估计车辆位置时，相对于变化的减速操作 dp在车辆的移动距离中被施加到基于转向角值估计的转弯曲率g（Str（p）），以补偿由于轮胎变形引起的延迟，由此延迟补偿的转弯曲率y（p ）。

10. 发明授权

US07233851B2 Driving assist apparatus and method for vehicle 有权
标题翻译：车辆辅助装置和方法
公开(公告)号：US07233851B2
公开(公告)日：2007-06-19
申请号：US10870919
申请日：2004-06-21
申请人： Katsuhiko Iwazaki , Hisashi Satonaka , Yuichi Kubota , Tomohiko Endo , Akira Matsui , Hideyuki Iwakiri , Toru Sugiyama , Seiji Kawakami , Hiroaki Kataoka , Yuu Tanaka , Yoshifumi Iwata
发明人： Katsuhiko Iwazaki , Hisashi Satonaka , Yuichi Kubota , Tomohiko Endo , Akira Matsui , Hideyuki Iwakiri , Toru Sugiyama , Seiji Kawakami , Hiroaki Kataoka , Yuu Tanaka , Yoshifumi Iwata
IPC分类号： G06F19/00
CPC分类号： B62D15/0285 , B60T2201/10
摘要： A vehicle driving assist apparatus for guiding a vehicle to a target position is provided. A basic path that changes the deflection angle θ to 0 is determined, and is subjected to similarity transformation. On the basis of the similarity-transformed path, a path factoring in transition from the initial steering angle is set. Then, a correction is made such that the area in the running distance-curvature graph regarding this path becomes equal to a corresponding area regarding the basic path, thereby setting a corrected path. The corrected path is similarity-transformed, and then is re-corrected in accordance with transition from the initial steering angle. Thus, a final target path is obtained.
摘要翻译：提供了一种用于将车辆引导到目标位置的车辆驾驶辅助装置。确定将偏转角θ改变为0的基本路径，并进行相似变换。在相似变换路径的基础上，设定从初始转向角度转移的路径分解。然后，进行校正，使得关于该路径的行驶距离 - 曲率图的面积等于与基本路径相对应的对应区域，由此设定校正路径。校正路径进行相似变换，然后根据从初始转向角度的转变重新校正。因此，获得最终的目标路径。

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