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1. 发明授权

US07374895B2 Guanosine triphosphate (GTP) binding protein-coupled receptor proteins that bind histamine and are expressed in the brain 失效
标题翻译：使用在脑中表达的A G蛋白偶联的组胺受体的测定
公开(公告)号：US07374895B2
公开(公告)日：2008-05-20
申请号：US11447407
申请日：2006-06-06
申请人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
发明人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
IPC分类号： G01N33/566
CPC分类号： G01N33/502 , C07K14/705 , G01N2333/72
摘要： A full-length cDNA encoding a human-derived G protein-coupled receptor protein is isolated by screening a human hippocampus library. Also, a rat-derived cDNA corresponding to the human-derived cDNA is isolated. Proteins encoded by these cDNAs have an activity of lowering intracellular cAMP concentration under stimulation with histamine. These proteins are usable as tools in screening ligands thereof or in screening candidate compounds for drugs capable of regulating signal transduction from the above proteins.
摘要翻译：通过筛选人海马文库来分离编码人衍生的G蛋白偶联受体蛋白质的全长cDNA。此外，分离与人源cDNA相对应的来自大鼠的cDNA。由这些cDNA编码的蛋白质具有降低组胺刺激下细胞内cAMP浓度的活性。这些蛋白质可用作筛选其配体或筛选能够调节来自上述蛋白质的信号转导的药物的候选化合物的工具。

2. 发明申请

US20070015220A1 Novel guanosine triphosphate (GTP) binding protein-coupled receptor proteins 失效
标题翻译：新型三磷酸鸟苷（GTP）结合蛋白偶联受体蛋白
公开(公告)号：US20070015220A1
公开(公告)日：2007-01-18
申请号：US11447407
申请日：2006-06-06
申请人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
发明人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
IPC分类号： G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： G01N33/502 , C07K14/705 , G01N2333/72
摘要： A full-length cDNA encoding a human-derived G protein-coupled receptor protein is isolated by screening a human hippocampus library. Also, a rat-derived cDNA corresponding to the human-derived cDNA is isolated. Proteins encoded by these cDNAs have an activity of lowering intracellular cAMP concentration under stimulation with histamine. These proteins are usable as tools in screening ligands thereof or in screening candidate compounds for drugs capable of regulating signal transduction from the above proteins.
摘要翻译：通过筛选人海马文库来分离编码人衍生的G蛋白偶联受体蛋白质的全长cDNA。此外，分离与人源cDNA相对应的来自大鼠的cDNA。由这些cDNA编码的蛋白质具有降低组胺刺激下细胞内cAMP浓度的活性。这些蛋白质可用作筛选其配体或筛选能够调节来自上述蛋白质的信号转导的药物的候选化合物的工具。

3. 发明授权

US07074594B2 Guanosine triphosphate (GTP) binding protein-coupled receptor proteins 失效
标题翻译：鸟苷三磷酸（GTP）结合蛋白偶联受体蛋白
公开(公告)号：US07074594B2
公开(公告)日：2006-07-11
申请号：US10759463
申请日：2004-01-16
申请人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
发明人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
IPC分类号： C01K15/12
CPC分类号： G01N33/502 , C07K14/705 , G01N2333/72
摘要： A full-length cDNA encoding a human-derived G protein-coupled receptor protein is isolated by screening a human hippocampus library. Also, a rat-derived cDNA corresponding to the human-derived cDNA is isolated. Proteins encoded by these cDNAs have an activity of lowering intracellular cAMP concentration under stimulation with histamine. These proteins are usable as tools in screening ligands thereof or in screening candidate compounds for drugs capable of regulating signal transduction from the above proteins.
摘要翻译：通过筛选人海马文库来分离编码人衍生的G蛋白偶联受体蛋白质的全长cDNA。此外，分离与人源cDNA相对应的来自大鼠的cDNA。由这些cDNA编码的蛋白质具有降低组胺刺激下细胞内cAMP浓度的活性。这些蛋白质可用作筛选其配体或筛选能够调节来自上述蛋白质的信号转导的药物的候选化合物的工具。

4. 发明申请

US20050048522A1 Novel guanosine triphosphate (GTP) binding protein-coupled receptor proteins 失效
标题翻译：新型三磷酸鸟苷（GTP）结合蛋白偶联受体蛋白
公开(公告)号：US20050048522A1
公开(公告)日：2005-03-03
申请号：US10759463
申请日：2004-01-16
申请人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
发明人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
IPC分类号： C12N15/09 , A61K45/00 , C07D233/64 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , G01N33/15 , G01N33/566 , C12Q1/68 , C07H21/04
CPC分类号： G01N33/502 , C07K14/705 , G01N2333/72
摘要： A full-length cDNA encoding a human-derived G protein-coupled receptor protein is isolated by screening a human hippocampus library. Also, a rat-derived cDNA corresponding to the human-derived cDNA is isolated. Proteins encoded by these cDNAs have an activity of lowering intracellular cAMP concentration under stimulation with histamine. These proteins are usable as tools in screening ligands thereof or in screening candidate compounds for drugs capable of regulating signal transduction from the above proteins.
摘要翻译：通过筛选人海马文库来分离编码人衍生的G蛋白偶联受体蛋白质的全长cDNA。此外，分离与人源cDNA相对应的来自大鼠的cDNA。由这些cDNA编码的蛋白质具有降低组胺刺激下细胞内cAMP浓度的活性。这些蛋白质可用作筛选其配体或筛选能够调节来自上述蛋白质的信号转导的药物的候选化合物的工具。

5. 发明授权

US06750322B2 Guanosine triphosphate (GTP) binding protein-coupled receptor proteins 失效
标题翻译：鸟苷三磷酸（GTP）结合蛋白偶联受体蛋白
公开(公告)号：US06750322B2
公开(公告)日：2004-06-15
申请号：US09891053
申请日：2001-06-25
申请人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
发明人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
IPC分类号： C07K14705
CPC分类号： G01N33/502 , C07K14/705 , G01N2333/72
摘要： The present invention has provided a human-derived novel G protein-coupled receptor protein expressed in the brain, rat-derived protein corresponding to it, and their genes. Use of the receptors makes it possible to screen their ligands and compounds that are candidates for medicines. These ligands and candidate compounds would be useful in the diagnosis and treatment of diseases arising from disorders of signal transduction pathway mediated by the G protein-coupled receptor of the invention.
摘要翻译：通过筛选人海马文库来分离编码人衍生的G蛋白偶联受体蛋白质的全长cDNA。此外，分离与人源cDNA相对应的来自大鼠的cDNA。由这些cDNA编码的蛋白质具有降低组胺刺激下细胞内cAMP浓度的活性。这些蛋白质可用作筛选其配体或筛选能够调节来自上述蛋白质的信号转导的药物的候选化合物的工具。

6. 发明申请

US20100184236A1 GUANOSINE TRIPHOSPHATE (GTP)-BINDING PROTEIN-COUPLED RECEPTOR PROTEIN, BG37 失效
标题翻译：冠状三磷酸（GTP） - 蛋白质偶联受体蛋白BG37
公开(公告)号：US20100184236A1
公开(公告)日：2010-07-22
申请号：US12716906
申请日：2010-03-03
申请人： TAKAHARU MARUYAMA , Takao Nakamura , Hiraku Itadani , Ken-Ichi Tanaka
发明人： TAKAHARU MARUYAMA , Takao Nakamura , Hiraku Itadani , Ken-Ichi Tanaka
IPC分类号： G01N33/566 , C07K14/435
CPC分类号： C07K14/705
摘要： The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”, cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR “BG37” genes from mouse and rat were isolated. Use of the novel GPCR of the present invention enables screening of ligands, compounds inhibiting the binding to a ligand, and candidate compounds of pharmaceuticals which can regulate signal transduction from the “BG37” receptor.
摘要翻译：本发明人对GenBank中已知的G蛋白偶联受体蛋白质的氨基酸序列进行了相似检索，得到新的人GPCR基因“BG37”，克隆了含有该基因的ORF的cDNA，并测定其核苷酸序列。此外，分离了来自小鼠和大鼠的新型GPCR“BG37”基因。使用本发明的新型GPCR能够筛选配体，抑制与配体结合的化合物，以及可调节从“BG37”受体的信号转导的药物的候选化合物。

7. 发明授权

US07198914B2 Guanosine triphosphate (GTP)-binding protein-coupled receptor protein, BG37 失效
标题翻译：鸟苷三磷酸（GTP） - 结合蛋白偶联受体蛋白，BG37
公开(公告)号：US07198914B2
公开(公告)日：2007-04-03
申请号：US10432101
申请日：2001-10-30
申请人： Takaharu Maruyama , Takao Nakamura , Hiraku Itadani , Ken-Ichi Tanaka
发明人： Takaharu Maruyama , Takao Nakamura , Hiraku Itadani , Ken-Ichi Tanaka
IPC分类号： C12P21/06 , C07K5/00
CPC分类号： C07K14/705
摘要： The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”. cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR “BG37” genes from mouse and rat were isolated. Use of the novel GPCR of the present invention enables screening of ligands, compounds inhibiting the binding to a ligand, and candidate compounds of pharmaceuticals which can regulate signal transduction from the “BG37” receptor.
摘要翻译：本发明人对GenBank中已知的G蛋白偶联受体蛋白质的氨基酸序列进行了相似检索，得到了新的人GPCR基因“BG37”。克隆含有该基因ORF的cDNA，测定其核苷酸序列。此外，分离了来自小鼠和大鼠的新型GPCR“BG37”基因。使用本发明的新型GPCR能够筛选配体，抑制与配体结合的化合物，以及可调节从“BG37”受体的信号转导的药物的候选化合物。

8. 发明申请

US20070141642A1 Guanosine triphosphate (GTP)-binding protein-coupled receptor protein, BG37 失效
公开(公告)号：US20070141642A1
公开(公告)日：2007-06-21
申请号：US11704546
申请日：2007-02-08
申请人： Takaharu Maruyama , Takao Nakamura , Hiraku Itadani , Ken-Ichi Tanaka
发明人： Takaharu Maruyama , Takao Nakamura , Hiraku Itadani , Ken-Ichi Tanaka
IPC分类号： G01N33/567 , C07K14/72
CPC分类号： C07K14/705
摘要： The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”. cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR “BG37” genes from mouse and rat were isolated. Use of the novel GPCR of the present invention enables screening of ligands, compounds inhibiting the binding to a ligand, and candidate compounds of pharmaceuticals which can regulate signal transduction from the “BG37” receptor.

9. 发明授权

US5267347A Information processing element 失效
标题翻译：信息处理元件
公开(公告)号：US5267347A
公开(公告)日：1993-11-30
申请号：US946259
申请日：1992-09-16
申请人： Satoru Isoda , Yoshio Hanazato , Satoshi Ueyama , Hiroaki Kawakubo , Ken-Ichi Tanaka , Mitsuo Maeda
发明人： Satoru Isoda , Yoshio Hanazato , Satoshi Ueyama , Hiroaki Kawakubo , Ken-Ichi Tanaka , Mitsuo Maeda
IPC分类号： G06N3/063 , G06G7/16 , H01L31/08
CPC分类号： G06N3/063
摘要： An information processing element for processing information with a function of neural network includes a semiconductor integrated circuit element portion comprising a plurality of neuron circuit regions constituting a neuron function among the neural network function, a molecular film element having a light-electricity function, provided on the circuit element portion, and the combination between the plurality of neurons is realized by utilizing a photoconductivity property of the molecular film element.
摘要翻译：用于处理具有神经网络功能的信息的信息处理元件包括：半导体集成电路元件部分，包括构成神经网络功能的神经元功能的多个神经元电路区域，具有光电功能的分子膜元件电路元件部分和多个神经元之间的组合通过利用分子膜元件的光电导性来实现。

10. 发明授权

US5603995A Snap zipper and bag with the same 失效
标题翻译：扣拉链和袋子一样
公开(公告)号：US5603995A
公开(公告)日：1997-02-18
申请号：US541822
申请日：1995-10-10
申请人： Toyokazu Takubo , Ken-Ichi Tanaka
发明人： Toyokazu Takubo , Ken-Ichi Tanaka
IPC分类号： A44B19/16 , B65D33/25 , B31B1/90
CPC分类号： B65D33/2541 , A44B19/16 , Y10S206/81 , Y10T428/13 , Y10T428/215
摘要： A bag with a snap zipper according to the present invention has a bag body produced to cause the snap zipper to fuse via a portion for fusion to the bag body to a layer composed of a polyester type resin on the bag body. In the present invention, at least a portion in the snap zipper to be fused to the bag body is made of a material mainly composed of a polyester type elastomer or a polybutylene terephthalate (PBT) resin and that the resin of the portion for fusion has a bending modulus of elasticity of 10,000 kg/cm.sup.2 or below. At least its portion for fusion is made of a material having a composition including polyester type elastomer and a polyolefin type resin or polybutylene terephthalate (PBT) resin and a polyolefin type resin and that the content of the polyolefin type resin in the composition is 3 to 50% by weight. When the snap zipper is adapted to have a portion for fusing to the bag body and the male and female members, except the portion for fusion, the portion for fusion may be composed of a copolymer of ethylene and acrylic acid ester or a copolymer of ethylene and methacrylic acid ester.
摘要翻译：根据本发明的具有拉链的袋子具有袋体，该袋体产生使得卡扣拉链经由用于熔融的部分与袋体融合到由袋体上的聚酯型树脂构成的层。在本发明中，要熔合到袋体的卡扣拉链中的至少一部分由主要由聚酯型弹性体或聚对苯二甲酸丁二醇酯（PBT）树脂构成的材料制成，并且熔融部分的树脂弯曲弹性模量为10,000 kg / cm2以下。至少其熔融部分由具有聚酯型弹性体和聚烯烃类树脂或聚对苯二甲酸丁二醇酯（PBT）树脂和聚烯烃类树脂的组合物的材料制成，并且组合物中聚烯烃类树脂的含量为3〜 50重量％。当卡扣拉链适于具有用于熔合到袋体和阳和阴构件的部分，除了熔融部分之外，熔融部分可以由乙烯和丙烯酸酯的共聚物或乙烯的共聚物和甲基丙烯酸酯。

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