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1. 发明授权

US4940062A Guiding member with deflectable tip 失效
标题翻译：引导构件具有偏转尖端
公开(公告)号：US4940062A
公开(公告)日：1990-07-10
申请号：US199099
申请日：1988-05-26
申请人： Hilary J. Hampton , John W. Gaiser , Charles S. Taylor , Timothy R. Machold
发明人： Hilary J. Hampton , John W. Gaiser , Charles S. Taylor , Timothy R. Machold
IPC分类号： A61M25/01 , A61B17/22 , A61M25/09
CPC分类号： A61M25/09033 , A61B2017/22001 , A61M2025/09175 , A61M2025/1079
摘要： The invention is directed to a guiding member for vascular catheters, particularly dilatation catheters for angioplasty procedures having a deflectable tip. The guiding member generally includes an elongated core wire having a tapered distal portion, a coil encasing at least part of the tapered distal portion of a core wire. The coil has an expanded section, and a reference member disposed therein which is secured to the coil proximally and distally of the expanded coil section. The core wire is secured to the coil at a location distally of the expanded section but proximally to the distal tip of the coil. Relative axial movement between the core wire and the coil causes expansion or contraction of the expanded coil section which results in tip deflection.

2. 发明授权

US5588949A Stereoscopic percutaneous visualization system 失效
标题翻译：立体经皮可视化系统
公开(公告)号：US5588949A
公开(公告)日：1996-12-31
申请号：US227366
申请日：1994-04-13
申请人： Charles S. Taylor , Brian S. Donlon , Timothy R. Machold
发明人： Charles S. Taylor , Brian S. Donlon , Timothy R. Machold
IPC分类号： A61B1/00 , A61B1/002 , A61B1/313 , A61B1/317 , A61B17/00 , A61B17/34 , A61B19/00 , G02B21/22 , G02B23/24
CPC分类号： G02B21/22 , A61B1/00193 , A61B1/002 , A61B17/3421 , G02B23/2415 , A61B1/3132 , A61B1/317 , A61B2017/00243 , A61B2017/3492 , A61B2090/3616 , A61B90/361 , A61B90/50
摘要： The invention provides a percutaneous visualization system for direct, stereoscopic visualization of a body cavity during minimally-invasive surgical procedures. The visualization system includes a cannula having a distal end, a proximal end, and a passage extending therebetween. The passage is configured to allow stereoscopic vision therethrough, and is preferably tapered from the proximal end to the distal end. A sleeve is positionable in the passage of the cannula, the sleeve having an optical passage also configured to allow stereoscopic vision, preferably by tapering. A lens may be disposed in the optical passage of the sleeve tier wide-angle viewing. Magnification means may be positioned in optical alignment with the optical passage to provide a magnified image of a surgical site.
摘要翻译：本发明提供了一种经皮可视化系统，用于在微创外科手术过程中直接立体显示体腔。可视化系统包括具有远端，近端和在其间延伸的通道的套管。该通道构造成允许通过其的立体视觉，并且优选地从近端到远端是锥形的。套管可定位在套管的通道中，套筒具有光学通道，其还构造成允许立体视觉，优选通过锥形化。透镜可以设置在袖子层广角视角的光学通道中。放大装置可以定位成与光学通道光学对准以提供手术部位的放大图像。

3. 发明授权

US06508759B1 Stereoscopic percutaneous visualization system 失效
标题翻译：立体经皮可视化系统
公开(公告)号：US06508759B1
公开(公告)日：2003-01-21
申请号：US09429763
申请日：1999-10-28
申请人： Charles S. Taylor , Brian S. Donlon , Timothy R. Machold
发明人： Charles S. Taylor , Brian S. Donlon , Timothy R. Machold
IPC分类号： A61B100
CPC分类号： G02B23/2415 , A61B1/00149 , A61B1/00193 , A61B1/002 , A61B1/3132 , A61B1/317 , A61B17/3421 , A61B90/361 , A61B90/50 , A61B2017/00243 , A61B2017/3492 , A61B2090/3616 , G02B21/22
摘要： A surgical microscope comprising a microscope body, lens means attached to the microscope body for magnifying an object image, an eyepiece attached to the microscope body for viewing the magnified object image, and coupling means attached to the microscope body for retaining a supplementary lens in optical alignment with the lens means, the coupling means being configured for introducing the supplementary lens through a percutaneous penetration into a body cavity, wherein the eyepiece and the lens means are configured to facilitate stereoscopic viewing. In a variation of the surgical microscope, a plurality of binocular eyepieces are attached to the microscope body to allow multiple persons to contemporaneously view the magnified object image.
摘要翻译：一种手术显微镜，包括显微镜主体，附接到显微镜主体上的放大对象图像的透镜装置，附接到显微镜主体以观察放大对象图像的目镜，以及附接到显微镜主体的耦合装置，用于将辅助透镜保持在光学与透镜装置对准，联接装置被配置为将辅助透镜经由经皮穿透引入体腔中，其中目镜和透镜装置构造成便于立体观看。在手术显微镜的变型中，多个双目目镜被附接到显微镜主体，以允许多个人同时观看放大对象图像。

4. 发明授权

US5957832A Stereoscopic percutaneous visualization system 失效
标题翻译：立体经皮可视化系统
公开(公告)号：US5957832A
公开(公告)日：1999-09-28
申请号：US612810
申请日：1996-03-11
申请人： Charles S. Taylor , Timothy R. Machold
发明人： Charles S. Taylor , Timothy R. Machold
IPC分类号： A61B1/00 , A61B1/002 , A61B1/313 , A61B1/317 , A61B17/00 , A61B17/34 , A61B19/00 , G02B21/22 , G02B23/24 , A61B1/012
CPC分类号： G02B23/2415 , A61B1/00149 , A61B1/00193 , A61B1/002 , A61B17/3421 , G02B21/22 , A61B1/3132 , A61B1/317 , A61B2017/00243 , A61B2017/3492 , A61B2090/3616 , A61B90/361 , A61B90/50
摘要： The invention provides a percutaneous visualization system for direct, stereoscopic visualization of a body cavity during minimally-invasive surgical procedures. The visualization system includes a cannula having a distal end, a proximal end, and a passage extending therebetween. The passage is configured to allow stereoscopic vision therethrough, and is preferably tapered from the proximal end to the distal end. A sleeve is positionable in the passage of the cannula, the sleeve having an optical passage also configured to allow stereoscopic vision, preferably by tapering. A lens may be disposed in the optical passage of the sleeve for wide-angle viewing. Magnification means may be positioned in optical alignment with the optical passage to provide a magnified image of a surgical site.
摘要翻译：本发明提供了一种经皮可视化系统，用于在微创外科手术过程中直接立体显示体腔。可视化系统包括具有远端，近端和在其间延伸的通道的套管。该通道构造成允许通过其的立体视觉，并且优选地从近端到远端是锥形的。套管可定位在套管的通道中，套筒具有光学通道，其还构造成允许立体视觉，优选通过锥形化。透镜可以设置在套筒的光学通道中用于广角观看。放大装置可以定位成与光学通道光学对准以提供手术部位的放大图像。

5. 发明授权

US09861475B2 Devices, systems, and methods for reshaping a heart valve annulus 有权
公开(公告)号：US09861475B2
公开(公告)日：2018-01-09
申请号：US12462956
申请日：2009-08-12
申请人： Timothy R. Machold , David A. Rahdert , John A. Macoviak , Robert T. Chang , Rick A. Soss
发明人： Timothy R. Machold , David A. Rahdert , John A. Macoviak , Robert T. Chang , Rick A. Soss
IPC分类号： A61F2/24 , A61B17/00
CPC分类号： A61F2/2418 , A61B2017/00243 , A61F2/2445 , A61F2/2454 , A61F2/2466 , A61F2220/0016
摘要： Devices, systems, and methods employ an implant that is sized and configured to attach to the annulus of a dysfunctional heart valve annulus. In use, the implant extends across the major axis of the annulus above and/or along the valve annulus. The implant reshapes the major axis dimension and/or other surrounding anatomic structures. The implant restores to the heart valve annulus and leaflets a more functional anatomic shape and tension. The more functional anatomic shape and tension are conducive to coaptation of the leaflets during systole, which, in turn, reduces regurgitation. The implant improves function to the valve, without surgically cinching, resecting, and/or fixing in position large portions of a dilated annulus, or without the surgical fixation of ring-like structures.

6. 发明授权

US08568464B2 Method for reducing myocardial infarct by application of intravascular hypothermia 有权
公开(公告)号：US08568464B2
公开(公告)日：2013-10-29
申请号：US12415984
申请日：2009-03-31
申请人： Michael W. Dae , Wade A. Keller , Timothy R. Machold
发明人： Michael W. Dae , Wade A. Keller , Timothy R. Machold
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/0076 , A61F2007/126 , A61M25/1002
摘要： Methods and apparatus for preventing myocardial infarction, or lessening the size/severity of an evolving myocardial infarction, by cooling at least the affected area of the myocardium using an intravascular heat exchange catheter. The heat exchange catheter may be inserted into the vasculature (e.g., a vein) and advanced to a position wherein a heat exchanger on the catheter is located in or near the heart (e.g., within the vena cava near the patient's heart). Thereafter, the heat exchange catheter is used to cool the myocardium (or the entire body of the patient) to a temperature that effectively lessens the metabolic rate and/or oxygen consumption of the ischemic myocardial cells or otherwise protects the ischemic myocardium from undergoing irreversible damage or infarction.

7. 发明授权

US08177824B2 Disposable cassette for intravenous heat exchange catheter 有权
标题翻译：一次性胶囊用于静脉换热导管
公开(公告)号：US08177824B2
公开(公告)日：2012-05-15
申请号：US11781892
申请日：2007-07-23
申请人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , David J. Scott , Jose Alejandro , Edward A. Oliver
发明人： Timothy R. Machold , Nicole Denise Bloom , Alex T. Roth , David J. Scott , Jose Alejandro , Edward A. Oliver
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B2017/00119 , A61B2017/00123 , A61B2017/22051 , A61F7/0085 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M5/44 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/127
摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.
摘要翻译：用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。舱壁包括储存段和泵段。储存器部分设置有用于监测系统中的热交换流体的量的装置。隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。泵部分构造成允许在恒定压力下泵送热交换流体。

8. 发明授权

US08142494B2 Devices, systems, and methods for retaining a native heart valve leaflet 有权
标题翻译：用于保留天然心脏瓣膜小叶的装置，系统和方法
公开(公告)号：US08142494B2
公开(公告)日：2012-03-27
申请号：US12386821
申请日：2009-04-23
申请人： David A. Rahdert , John A. Macoviak , Timothy R. Machold , Robert T. Chang , Rick A. Soss
发明人： David A. Rahdert , John A. Macoviak , Timothy R. Machold , Robert T. Chang , Rick A. Soss
IPC分类号： A61F2/24
CPC分类号： A61F2/2454
摘要： Devices, systems and methods retain a native heart valve leaflet to prevent retrograde flow. The devices, systems, and methods employ an implant that, in use, rests adjacent a valve annulus and includes a retaining structure that is sized and shaped to overlay at least a portion of one or more native valve leaflets. The retaining structure retains the leaflet or leaflets it overlays, to resist leaflet eversion and/or prolapse. In this way, the implant prevents or reduces regurgitation. The implant does not interfere significantly with the opening of and blood flow through the leaflets during periods of antegrade flow.
摘要翻译：装置，系统和方法保留天然心脏瓣膜瓣以防止逆行流动。装置，系统和方法采用植入物，其在使用中邻近瓣膜环并且包括保持结构，该保持结构的尺寸和形状可覆盖一个或多个天然瓣膜的至少一部分。保留结构保留了覆盖的小叶或传单，以抵抗小叶外翻和/或脱垂。以这种方式，植入物防止或减少反流。植入物在顺行流动期间不会明显干扰通过传单的血液流通。

9. 发明授权

US07846193B2 Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权
标题翻译：通过低温抑制血小板活化，聚集和/或粘附
公开(公告)号：US07846193B2
公开(公告)日：2010-12-07
申请号：US11501442
申请日：2006-08-08
申请人： Michael W. Dae , Timothy R. Machold , Wade A. Keller
发明人： Michael W. Dae , Timothy R. Machold , Wade A. Keller
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/126
摘要： A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.
摘要翻译：一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。可以向体温冷却到患者发抖阈值以下（通常约35.5℃）的患者施用抗发抖药物或麻醉。如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制将患者的身体重温为正常体温或接近正常体温。

10. 发明授权

US07691144B2 Devices, systems, and methods for reshaping a heart valve annulus 有权
标题翻译：用于重塑心脏瓣膜环的装置，系统和方法
公开(公告)号：US07691144B2
公开(公告)日：2010-04-06
申请号：US11089940
申请日：2005-03-25
申请人： Robert T. Chang , John A. Macoviak , David A. Rahdert , Timothy R. Machold
发明人： Robert T. Chang , John A. Macoviak , David A. Rahdert , Timothy R. Machold
IPC分类号： A61F2/24
CPC分类号： A61F2/2487 , A61B17/00234 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/00876 , A61B2017/0417 , A61B2017/0453 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61F2/2445 , A61F2/2451 , A61F2/2454 , A61F2/2466 , A61F2210/009 , A61F2230/0093 , A61F2250/0012
摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial retrievability. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize a bridge stop to secure the implant, and the methods of implantation employ various tools.
摘要翻译：植入物或植入物和方法的系统在左心房内或横过左心房施加选定的力向量或力向量的选择组合，这允许二尖瓣小叶更好地适应。植入物和植入物和方法的植入物或系统使得可以快速部署，容易的血管内递送和完全的房内可检索性。植入物或植入物和方法的植入物或系统也利用强荧光检查标志。植入物和植入物和植入物的系统利用可调植入物和固定长度植入物。植入物和植入物的方式的植入物或系统还可以利用桥接止动件来固定植入物，并且植入方法使用各种工具。

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