专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08721530B2 Tendon-driven endoscope and methods of use 有权
标题翻译：肌腱驱动内窥镜及使用方法
公开(公告)号：US08721530B2
公开(公告)日：2014-05-13
申请号：US13180501
申请日：2011-07-11
申请人： Robert M. Ohline , Joseph M. Tartaglia , Amir Belson , Alex T. Roth , Wade A. Keller , Scott C. Anderson , Christopher A. Julian
发明人： Robert M. Ohline , Joseph M. Tartaglia , Amir Belson , Alex T. Roth , Wade A. Keller , Scott C. Anderson , Christopher A. Julian
IPC分类号： A61B1/00
CPC分类号： A61B1/00128 , A61B1/00006 , A61B1/00057 , A61B1/0016 , A61B1/0053 , A61B1/0057 , A61B1/0058 , A61B1/01 , A61B1/31 , A61B5/065 , A61B2034/301 , A61B2034/741 , A61B2034/742
摘要： A steerable, tendon-driven endoscope is described herein. The endoscope has an elongated body with a manually or selectively steerable distal portion and an automatically controlled, segmented proximal portion. The steerable distal portion and the segment of the controllable portion are actuated by at least two tendons. As the endoscope is advanced, the user maneuvers the distal portion, and a motion controller actuates tendons in the segmented proximal portion so that the proximal portion assumes the selected curve of the selectively steerable distal portion. By this method the selected curves are propagated along the endoscope body so that the endoscope largely conforms to the pathway selected. When the endoscope is withdrawn proximally, the selected curves can propagate distally along the endoscope body. This allows the endoscope to negotiate tortuous curves along a desired path through or around and between organs within the body.
摘要翻译：这里描述了可操纵的肌腱驱动的内窥镜。内窥镜具有细长主体，其具有手动或选择性可操纵的远侧部分和自动控制的分段近端部分。可操纵的远端部分和可控部分的段由至少两个腱致动。当内窥镜前进时，使用者操纵远侧部分，并且运动控制器致动分段近端部分中的腱，使得近端部分呈现选择性可操纵的远侧部分的选定曲线。通过该方法，所选择的曲线沿着内窥镜主体传播，使得内窥镜大体上符合所选择的路径。当内窥镜向近侧收回时，所选择的曲线可沿内窥镜体向远端传播。这允许内窥镜沿着穿过体内器官之间或之间的所需途径协商曲折曲线。

2. 发明授权

US08425581B2 Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权
标题翻译：通过低温抑制血小板活化，聚集和/或粘附
公开(公告)号：US08425581B2
公开(公告)日：2013-04-23
申请号：US12962487
申请日：2010-12-07
申请人： Michael W. Dae , Timothy R. Machold , Wade A. Keller
发明人： Michael W. Dae , Timothy R. Machold , Wade A. Keller
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/126
摘要： A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient=s vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36_C) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient=s shivering threshold (typically approximately 35.5 C). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient=s body to normothermia or near normothermia.
摘要翻译：一种通过在患者脉管系统中放置热交换装置并使用该热交换装置冷却来治疗人或动物患者的急性冠状动脉综合征（即不稳定心绞痛或非Q波MI）或短暂性脑缺血发作的方法患者达到血小板抑制（即，抑制血小板活化和/或凝集和/或粘附）的温度（例如30-36℃）。可以将抗发炎药物或麻醉剂施用于体温低于该患者发抖阈值（通常约35.5℃）的患者。如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制将患者身体重新加热至正常体温或接近正常体温。

3. 发明申请

US20100030307A1 MULTIPLE LUMEN HEAT EXCHANGE CATHETERS 有权
标题翻译：多功能热交换灯
公开(公告)号：US20100030307A1
公开(公告)日：2010-02-04
申请号：US12511015
申请日：2009-07-28
申请人： Wade A. Keller , Timothy R. Machold
发明人： Wade A. Keller , Timothy R. Machold
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61B18/00 , A61B18/082 , A61B18/245 , A61B2017/00084 , A61B2017/22051 , A61B2018/00095 , A61F7/007 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0056 , A61F2007/0086 , A61F2007/0095 , A61F2007/0096 , A61F2007/126 , A61M25/00 , A61M25/1002 , A61M25/1011 , A61M2025/0078 , A61M2025/1072 , A61M2025/1086 , A61M2205/366 , A61M2206/10 , A61M2230/50
摘要： Catheter devices and methods for intravascular heating and/or cooling of human or veterinary patients. The catheter devices generally comprise catheters having inflow and outflow lumens and at least one curvilinear balloon connected to the inflow and outflow lumens such that heat exchange fluid may be circulated through the balloon(s). The catheter is inserted into the vasculature and heated or cooled fluid is circulated through the balloon(s) to heat or cool blood flowing in heat-exchange proximity to the balloon(s), thereby effecting heating or cooling of all or a portion of the patient's body.
摘要翻译：用于人或兽医患者血管内加热和/或冷却的导管装置和方法。导管装置通常包括具有流入和流出腔的导管和连接到流入和流出腔的至少一个曲线球囊，使得热交换流体可以循环通过球囊。将导管插入脉管系统中，加热或冷却的流体循环通过球囊以加热或冷却在热交换附近流过气球的血液，从而实现加热或冷却全部或一部分病人的身体。

4. 发明授权

US06858005B2 Tendon-driven endoscope and methods of insertion 有权
公开(公告)号：US06858005B2
公开(公告)日：2005-02-22
申请号：US10229577
申请日：2002-08-27
申请人： Robert M. Ohline , Joseph M. Tartaglia , Amir Belson , Alex T. Roth , Wade A. Keller , Scott C. Anderson , Chris A. Julian
发明人： Robert M. Ohline , Joseph M. Tartaglia , Amir Belson , Alex T. Roth , Wade A. Keller , Scott C. Anderson , Chris A. Julian
IPC分类号： G02B23/24 , A61B1/00 , A61B1/005 , A61B1/008 , A61B1/01 , A61B1/04 , A61B1/31 , G02B23/26
CPC分类号： A61B1/00128 , A61B1/00006 , A61B1/00057 , A61B1/0016 , A61B1/0053 , A61B1/0057 , A61B1/0058 , A61B1/01 , A61B1/31 , A61B5/065 , A61B2034/301 , A61B2034/741 , A61B2034/742
摘要： A steerable, tendon-driven endoscope is described herein. The endoscope has an elongated body with a manually or selectively steerable distal portion and an automatically controlled, segmented proximal portion. The steerable distal portion and the segment of the controllable portion are actuated by at least two tendons. As the endoscope is advanced, the user maneuvers the distal portion, and a motion controller actuates tendons in the segmented proximal portion so that the proximal portion assumes the selected curve of the selectively steerable distal portion. By this method the selected curves are propagated along the endoscope body so that the endoscope largely conforms to the pathway selected. When the endoscope is withdrawn proximally, the selected curves can propagate distally along the endoscope body. This allows the endoscope to negotiate tortuous curves along a desired path through or around and between organs within the body.

5. 发明授权

US06695874B2 Method and system for control of a patient's body temperature by way of transluminally insertable heat exchange catheter 有权
标题翻译：通过可插入热交换导管控制患者体温的方法和系统
公开(公告)号：US06695874B2
公开(公告)日：2004-02-24
申请号：US10061692
申请日：2002-02-01
申请人： Timothy R. Machold , Alex T. Roth , Wade A. Keller
发明人： Timothy R. Machold , Alex T. Roth , Wade A. Keller
IPC分类号： A61F700
CPC分类号： A61F7/0085 , A61B2017/00092 , A61B2017/00119 , A61B2017/00123 , A61B2017/00199 , A61B2017/22051 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M25/10 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/12 , A61M2205/127
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including inducing hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette allowing substitution of a smaller, battery-powered unit for a large capacity control once the patient reaches the desired target temperature.
摘要翻译：用于患者温度改变的方法和装置，或其选定的区域，包括诱导低体温。使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。几个公开的变型中的任何一个的热交换盒附接到导管的循环流动管线，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。提供了一种用于使体温上升或下降而没有过冲的温度控制方案。一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。可以提供多于一个的控制单元来接收相同的热交换盒，一旦患者达到期望的目标温度，便可以更换较小的电池供电的单元进行大容量控制。

6. 发明授权

US06582457B2 Method of controlling body temperature while reducing shivering 有权
标题翻译：减少发抖的方法来控制体温
公开(公告)号：US06582457B2
公开(公告)日：2003-06-24
申请号：US09784930
申请日：2001-02-15
申请人： Michael W. Dae , Timothy R. Machold , Wade A. Keller
发明人： Michael W. Dae , Timothy R. Machold , Wade A. Keller
IPC分类号： A61F712
CPC分类号： A61F7/123 , A61F2007/0095 , A61F2007/126 , A61K31/00 , A61K31/137 , A61K31/4174
摘要： A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an &agr;2-adrenoreceptor agonist, a non-opiod analgesic monoamine uptake inhibitor or neuropeptide that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various &agr;2-adrenoreceptor agonist&agr;2-adrenoreceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides are disclosed including dexmedetomidine, nepofam and neurotensin and pharmaceutically acceptable salts thereof. A control system for the control of the patient's temperature is disclosed for controlling the patient'stemperature in conjunction with administering the &agr;2-adrenoreceptor agonist, non-opiod analgesic monoamine uptake inhibitor or neuropeptide.
摘要翻译：一种用于降低患者体温的方法和装置，同时通过使用热交换装置与α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽暂时减轻发抖相结合来减轻发抖。所公开的装置包括具有热交换球囊的导管，其中热交换流体循环通过气囊的内部。将热交换球放置在患者的脉管系统中，并且在脉管系统中除血液温度以外的温度下的热交换流体循环通过气囊的内部以从患者的血液中添加或除去热量。公开了各种α2-肾上腺素受体激动剂α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂和神经肽，其包括右美托咪定，尼美芬和神经降压素及其药学上可接受的盐。公开了一种用于控制患者温度的控制系统，用于与施用α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽一起控制患者的温度。

7. 发明授权

US08568464B2 Method for reducing myocardial infarct by application of intravascular hypothermia 有权
公开(公告)号：US08568464B2
公开(公告)日：2013-10-29
申请号：US12415984
申请日：2009-03-31
申请人： Michael W. Dae , Wade A. Keller , Timothy R. Machold
发明人： Michael W. Dae , Wade A. Keller , Timothy R. Machold
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/0076 , A61F2007/126 , A61M25/1002
摘要： Methods and apparatus for preventing myocardial infarction, or lessening the size/severity of an evolving myocardial infarction, by cooling at least the affected area of the myocardium using an intravascular heat exchange catheter. The heat exchange catheter may be inserted into the vasculature (e.g., a vein) and advanced to a position wherein a heat exchanger on the catheter is located in or near the heart (e.g., within the vena cava near the patient's heart). Thereafter, the heat exchange catheter is used to cool the myocardium (or the entire body of the patient) to a temperature that effectively lessens the metabolic rate and/or oxygen consumption of the ischemic myocardial cells or otherwise protects the ischemic myocardium from undergoing irreversible damage or infarction.

8. 发明授权

US07879077B2 Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
标题翻译：通过可插入热交换导管来控制患者体温的方法和系统
公开(公告)号：US07879077B2
公开(公告)日：2011-02-01
申请号：US11674119
申请日：2007-02-12
申请人： Timothy R. MacHold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
发明人： Timothy R. MacHold , Wade A. Keller , Alex T. Roth , Nicole Denise Bloom
IPC分类号： A61F7/00
CPC分类号： A61F7/0085 , A61B2017/00092 , A61B2017/00119 , A61B2017/00123 , A61B2017/00199 , A61B2017/22051 , A61F7/0097 , A61F7/10 , A61F7/123 , A61F2007/0054 , A61F2007/0096 , A61F2007/126 , A61M25/10 , A61M25/1011 , A61M2025/1072 , A61M2025/1086 , A61M2205/12 , A61M2205/127
摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.
摘要翻译：包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。几个公开的变型中的任何一个的热交换盒附接到导管的循环导管，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和15“冷却。提供了一种用于使体温上升或下降而没有过冲的温度控制方案。一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。可以提供多于一个控制单元以接收相同的热交换盒，使得例如最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元。

9. 发明授权

US07846193B2 Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权
标题翻译：通过低温抑制血小板活化，聚集和/或粘附
公开(公告)号：US07846193B2
公开(公告)日：2010-12-07
申请号：US11501442
申请日：2006-08-08
申请人： Michael W. Dae , Timothy R. Machold , Wade A. Keller
发明人： Michael W. Dae , Timothy R. Machold , Wade A. Keller
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/126
摘要： A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.
摘要翻译：一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。可以向体温冷却到患者发抖阈值以下（通常约35.5℃）的患者施用抗发抖药物或麻醉。如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制将患者的身体重温为正常体温或接近正常体温。

10. 发明授权

US07510569B2 Use of intravascular hypothermia during angioplasty procedures 有权
标题翻译：在血管成形术过程中使用血管内低温
公开(公告)号：US07510569B2
公开(公告)日：2009-03-31
申请号：US10933979
申请日：2004-09-02
申请人： Michael W. Dae , Wade A. Keller , Timothy R. Machold
发明人： Michael W. Dae , Wade A. Keller , Timothy R. Machold
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/0076 , A61F2007/126 , A61M25/1002
摘要： Methods and apparatus for preventing myocardial infarction, or lessening the size/severity of an evolving myocardial infarction, by cooling at least the affected area of the myocardium using an intravascular heat exchange catheter. The heat exchange catheter may be inserted into the vasculature (e.g., a vein) and advanced to a position wherein a heat exchanger on the catheter is located in or near the heart (e.g., within the vena cava near the patient's heart). Thereafter, the heat exchange catheter is used to cool the myocardium (or the entire body of the patient) to a temperature that effectively lessens the metabolic rate and/or oxygen consumption of the ischemic myocardial cells or otherwise protects the ischemic myocardium from undergoing irreversible damage or infarction.
摘要翻译：通过使用血管内热交换导管至少冷却至少心肌的受影响区域来预防心肌梗死或减轻心肌梗死的大小/严重程度的方法和装置。热交换导管可以插入脉管系统（例如静脉）中并且前进到导管上的热交换器位于心脏中或附近（例如在患者心脏附近的腔静脉内）的位置。此后，热交换导管用于将心肌（或患者的整个身体）冷却到有效降低缺血心肌细胞的代谢率和/或氧消耗的温度，或以其它方式保护缺血心肌免受不可逆损伤或梗死。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式