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1. 发明授权

US06242425B1 Quinolinone glycoside, production process, and anti-allergic agent 失效
标题翻译：喹啉酮糖苷，生产过程和抗过敏剂
公开(公告)号：US06242425B1
公开(公告)日：2001-06-05
申请号：US09231492
申请日：1999-01-14
申请人： Hidetsugu Takagaki , Shigenori Nakanishi , Nobuyuki Kimura , Shinobu Yamaguchi , Yasuo Aoki
发明人： Hidetsugu Takagaki , Shigenori Nakanishi , Nobuyuki Kimura , Shinobu Yamaguchi , Yasuo Aoki
IPC分类号： A01N4304
CPC分类号： C07H17/02 , C07H15/26
摘要： An object is to provide: novel quinolinone glycosides which are useful as medicines; processes for producing the quinolinone glycosides; intermediates for synthesis; and medicines, and particularly anti-allergic agents, which comprise the quinolinone glycoside as an active ingredient. The object is achieved by: a quinolinone glycoside or a physiologically acceptable salt thereof; processes for producing this quinolinone glycosides; intermediates for synthesis; and medicines, and particularly anti-allergic agents, which comprise the quinolinone glycoside as an active ingredient; the quinolinone glycoside being expressed by general formula (I): (wherein, in the formula, each of R1 and R2 is a hydrogen atom or a glycosyl group selected from the group consisting of a glucuronyl group, a glucosyl group, a galactosyl group and a mannosyl group, and at least one of R1 and R2 is a glycosyl group in which a hydroxyl group in the glycosyl group is unprotected or protected with an acyl group having a carbon number of 2 to 7 or a benzyl group).
摘要翻译：目的是提供：作为药物有用的新型喹啉酮糖苷; 制备喹啉酮糖苷的方法; 合成中间体; 以及包含喹啉酮糖苷作为活性成分的药物，特别是抗过敏剂。该目的通过以下方法实现：喹啉酮糖苷或其生理上可接受的盐; 制备该喹啉酮糖苷的方法; 合成中间体; 以及包含喹啉酮糖苷作为活性成分的药物，特别是抗过敏剂; 喹啉酮糖苷由通式（I）表示:(式中，R 1和R 2各自为氢原子或选自葡糖醛酸基，葡糖基，半乳糖基和甘油基，并且R1和R2中的至少一个是其中糖基中的羟基被未被保护或用碳数为2至7的酰基或苄基保护的糖基）。

2. 发明授权

US6136822A Quinolinone derivative, method for preparing the same, and anti-allergic agent 有权
标题翻译：喹啉酮衍生物，其制备方法和抗过敏剂
公开(公告)号：US6136822A
公开(公告)日：2000-10-24
申请号：US201662
申请日：1998-12-01
申请人： Hidetsugu Takagaki , Shinobu Yamaguchi , Masayoshi Abe , Mitsuru Sakai , Osamu Misumi
发明人： Hidetsugu Takagaki , Shinobu Yamaguchi , Masayoshi Abe , Mitsuru Sakai , Osamu Misumi
IPC分类号： C07D215/22 , A61K31/00 , A61K31/47 , A61K31/4704 , A61P37/00 , A61P37/08 , C07C235/16 , C07D215/38 , C07D215/40 , C07D215/48 , C07D401/12 , C07D405/04 , C07D405/06 , C07D215/16 , C07D215/20 , C07D215/36
CPC分类号： C07D215/22 , C07C235/16 , C07D215/38 , C07D215/40 , C07D215/48 , C07D401/12 , C07D405/04 , C07D405/06
摘要： The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method; novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following formula (I), is reacted with a basic agent, followed by intramolecular ring formation: ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group an alkenyl group, or an aryl group; R.sub.2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R.sub.3 represents a reactive carboxyl group; and R.sub.4 to R.sub.7 represent, respectively and independently, a hydrogen atom; a hydroxyl group; an alkyl group; an alkoxy group; an alkenyl group; an alkenyloxy group; an aryl group; an aryloxy group; an aralkyloxy group; a R.sub.8 R.sub.9 N group wherein R.sub.8 and R.sub.9 represent, respectively and independently, a hydrogen atom, an alkyl group, an alkenyl group an aralkyl group, or an acyl group; a nitro group; or a R.sub.10 OOC group wherein R.sub.10 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; ##STR2## wherein R.sub.1, R.sub.2 and R.sub.4 to R.sub.7 represent, respectively, the same constituents as described in formula (I).
摘要翻译：本发明涉及一种制备喹啉酮衍生物的简单方法，其作为药物是有效的，例如用作治疗过敏性疾病等的药剂; 在该方法中作为中间体有效的新型酰胺衍生物; 按照该方法得到的新型喹啉酮衍生物; 以及含有与活性成分相同的喹啉酮衍生物和/或其生理盐的抗过敏剂。喹啉酮衍生物由以下通式（II）表示; 该方法的特征在于将由下式（I）表示的酰胺衍生物与碱性试剂反应，然后分子内环形成：其中R 1表示氢原子，烷基，含有羟基的烷基烯基或芳基; R2表示烷基，烯基，芳基或芳烷基; R3代表活性羧基; 和R 4至R 7分别独立地表示氢原子; 羟基; 烷基; 烷氧基烯基; 烯氧基; 芳基; 芳氧基; 芳烷氧基; R8R9N基，其中R8和R9分别独立地表示氢原子，烷基，烯基，芳烷基或酰基; 硝基; 或R10OOC基，其中R10表示氢原子，烷基，烯基，芳基或芳烷基; 其中R1，R2和R4至R7分别表示与式（I）中所述相同的组分。

3. 发明授权

US06271416B1 Quinolinone derivative, method for preparing the same, and anti-allergic agent 有权
标题翻译：喹啉酮衍生物，其制备方法和抗过敏剂
公开(公告)号：US06271416B1
公开(公告)日：2001-08-07
申请号：US09595909
申请日：2000-06-20
申请人： Hidetsugu Takagaki , Shinobu Yamaguchi , Masayoshi Abe , Mitsuru Sakai , Osamu Misumi
发明人： Hidetsugu Takagaki , Shinobu Yamaguchi , Masayoshi Abe , Mitsuru Sakai , Osamu Misumi
IPC分类号： C07C22900
CPC分类号： C07D215/22 , C07C235/16 , C07D215/38 , C07D215/40 , C07D215/48 , C07D401/12 , C07D405/04 , C07D405/06
摘要： The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method, novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following general formula (I), is reacted with a basic agent, followed by intramolecular ring formation: General Formula (I) [wherein, R1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group, an alkenyl group, or an aryl group; R2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R3 represents a reactive carboxyl group; and R4 to R7 represent, respectively and independently, a hydrogen atom, a hydroxyl group, an alkyl group, an alkoxy group, an alkenyl group, an alkenyloxy group, an aryl group, an aryloxy group, an aralkyloxy group, a R8R9N group (wherein, R8 and R9 represent, respectively and independently, a hydrogen atom, an alkyl group, an alkenyl group, an aralkyl group, or an acyl group), a nitro group, or a R10OOC group (wherein, R10 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group)]. General Formula (II) [wherein, R1, R2 and R4 to R7 represent, respectively, the same constituents as described in general formula (I)].
摘要翻译：本发明涉及一种制备喹啉酮衍生物的简单方法，其作为药物是有效的，例如用作治疗过敏性疾病等的药剂; 该方法中作为中间体有效的新型酰胺衍生物，按照该方法得到的新型喹啉酮衍生物; 以及含有与活性成分相同的喹啉酮衍生物和/或其生理盐的抗过敏剂。喹啉酮衍生物由以下通式（II）表示; 该方法的特征在于将由以下通式（I）表示的酰胺衍生物与碱性试剂反应，然后分子内环形成：通式（I）[其中，R 1表示氢原子，烷基基团，含有羟基，烯基或芳基的烷基; R2表示烷基，烯基，芳基或芳烷基; R3代表活性羧基; R 4〜R 7分别独立地表示氢原子，羟基，烷基，烷氧基，烯基，烯氧基，芳基，芳氧基，芳烷氧基，R8R9N基（其中，R8和R9分别独立地表示氢原子，烷基，烯基，芳烷基或酰基），硝基或R10OOC基（其中，R10表示氢原子，烷基，烯基，芳基或芳烷基）]通式（II）[其中，R1，R2和R4至R7分别表示与通式（I）中所述相同的组分] 。

4. 发明授权

US5392519A Reciprocating saw 失效
标题翻译：往复锯
公开(公告)号：US5392519A
公开(公告)日：1995-02-28
申请号：US113757
申请日：1993-08-31
申请人： Nobuhiro Inoue , Shinobu Yamaguchi
发明人： Nobuhiro Inoue , Shinobu Yamaguchi
IPC分类号： B27B11/00 , B23D49/16 , B27B11/02
CPC分类号： B23D49/165 , Y10T83/8876
摘要： A reciprocating saw includes a body and a slider supported by the body such that the slider is slidably movable in a longitudinal direction of the body and is pivotally movable in a vertical direction. A first motion conversion mechanism is operable to convert the rotational movement of the rotary member into a reciprocal movement of the slider in the longitudinal direction. A second motion conversion mechanism is operable to convert the rotational movement of the rotary member into a reciprocal pivotal movement of the slider in the vertical direction. The second motion conversion mechanism includes an arm having one end vertically pivotally connected to the slider. An actuating member is rotatable with the rotary member and has an abutting surface on which the other end of the arm slidably abuts. The abutting position of the other end of the arm on the abutting surface is varied as the actuating member is rotated, so that the vertical position of one end of the arm is varied.
摘要翻译：往复锯包括主体和由本体支撑的滑块，使得滑块能够在主体的纵向方向上可滑动地移动，并且能够在垂直方向上枢转运动。第一运动转换机构可操作以将旋转构件的旋转运动转换成滑块在纵向上的往复运动。第二运动转换机构可操作以将旋转构件的旋转运动转换成滑块在垂直方向上的往复运动。第二运动转换机构包括具有一端垂直地枢转地连接到滑块的臂。致动构件可与旋转构件一起旋转并且具有抵靠表面，臂的另一端可滑动地邻接在该邻接表面上。臂的另一端在邻接表面上的邻接位置随着致动构件的旋转而变化，使臂的一端的垂直位置变化。

5. 发明授权

US5018314A Sander 失效
标题翻译：桑德尔
公开(公告)号：US5018314A
公开(公告)日：1991-05-28
申请号：US533812
申请日：1990-06-06
申请人： Fusao Fushiya , Shinobu Yamaguchi
发明人： Fusao Fushiya , Shinobu Yamaguchi
IPC分类号： B24B23/03
CPC分类号： B24B23/03
摘要： A sander has a body, a motor mounted on the body, and a pad driven by the motor. A mechanism is interposed between the motor and the pad for transmitting the rotational motion of the motor to the paid in such a manner that the pad can perform a dual action including an orbital motion and a rotational motion. A resilient member is mounted on the body. The resilient member serves to contact the pad so as to produce frictional resistance against the rotation of the pad.
摘要翻译：砂光机具有主体，安装在主体上的马达以及由马达驱动的垫。电动机和垫之间插入一个机构，用于将电动机的旋转运动传递到支付方式，使得垫可以执行包括轨道运动和旋转运动的双重动作。弹性构件安装在主体上。弹性构件用于接触垫，以产生抵抗垫的旋转的摩擦阻力。

6. 外观设计

USD449899S1 Flashlight 失效
公开(公告)号：USD449899S1
公开(公告)日：2001-10-30
申请号：US29136180
申请日：2001-01-25
申请人： Naohiro Hayakawa , Shinobu Yamaguchi , Shinya Shimizu
设计人： Naohiro Hayakawa , Shinobu Yamaguchi , Shinya Shimizu

7. 外观设计

USD326398S Orbital sander 失效
公开(公告)号：USD326398S
公开(公告)日：1992-05-26
申请号：US437492
申请日：1989-11-15
申请人： Fusao Fushiya , Shinobu Yamaguchi
设计人： Fusao Fushiya , Shinobu Yamaguchi

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