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1. 发明申请

US20090060927A1 Pharmaceutical compositions comprising a polynucleotide and optionally an antigen especially for vaccination 审中-公开
标题翻译：包含多核苷酸和任选的抗原的药物组合物，尤其用于疫苗接种
公开(公告)号：US20090060927A1
公开(公告)日：2009-03-05
申请号：US10811226
申请日：2004-03-26
申请人： Hermann Wagner , Grayson Lipford , Klaus Heeg
发明人： Hermann Wagner , Grayson Lipford , Klaus Heeg
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K2039/55561 , Y02A50/41
摘要： The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention was found that the introduction of the pharmaceutical composition into vertebrates will achieve regulation of growth, induction of cellular transcription and translation, protein synthesis, protein expression or protein secretion. The pharmaceutical compositions are useful in vaccination protocols but also in any other therapeutic situation in which immunomodulation is of benefit, such as sub-optimal immune responses, reaction to pathogens, tolerance or autoimmunity.
摘要翻译：本发明涉及包含多核苷酸的至少一个片段，优选至少一种抗原和任选的药学上可接受的载体和/或稀释剂的药物组合物。发现根据本发明，将药物组合物引入脊椎动物将实现生长调节，诱导细胞转录和翻译，蛋白质合成，蛋白质表达或蛋白质分泌。药物组合物可用于疫苗接种方案，但也可用于免疫调节有益的任何其它治疗情况，例如亚最佳免疫应答，对病原体的反应，耐受性或自身免疫性。

2. 发明授权

US07001890B1 Pharmaceutical compositions comprising a polynucleotide and optionally an antigen especially for vaccination 失效
公开(公告)号：US07001890B1
公开(公告)日：2006-02-21
申请号：US09355254
申请日：1998-01-23
申请人： Hermann Wagner , Grayson Lipford , Klaus Heeg
发明人： Hermann Wagner , Grayson Lipford , Klaus Heeg
IPC分类号： A01N43/04 , A01N61/00 , C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： A61K39/39 , A61K2039/55561 , Y02A50/41
摘要： The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention was found that the introduction of the pharmaceutical composition into vertebrates will achieve regulation of growth, induction of cellular transcription and translation, protein synthesis, protein expression or protein secretion. The pharmaceutical compositions are useful in vaccination protocols but also in any other therapeutic situation in which immunomodulation is of benefit, such as sub-optimal immune responses, reaction to pathogens, tolerance or autoimmunity.

3. 发明申请

US20050054601A1 Pharmaceutical composition comprising a polynucleotide and optionally an antigen especially for vaccination 审中-公开
标题翻译：包含多核苷酸和任选的抗原的药物组合物，特别是用于疫苗接种
公开(公告)号：US20050054601A1
公开(公告)日：2005-03-10
申请号：US10894655
申请日：2004-07-16
申请人： Hermann Wagner , Grayson Lipford , Klaus Heeg
发明人： Hermann Wagner , Grayson Lipford , Klaus Heeg
IPC分类号： C12N15/09 , A61K31/7088 , A61K39/00 , A61K39/39 , A61K48/00 , A61P37/04 , C07K14/195 , C07K14/435
CPC分类号： A61K39/39 , A61K2039/55561 , Y02A50/41
摘要： The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention was found that the introduction of the pharmaceutical composition into vertebrates will achieve regulation of growth, induction of cellular transcription and translation, protein synthesis, protein expression or protein secretion. The pharmaceutical compositions are useful in vaccination protocols but also in any other therapeutic situation in which immunomodulation is of benefit, such as sub-optimal immune responses, reaction to pathogens, tolerance or autoimmunity.
摘要翻译：本发明涉及包含多核苷酸的至少一个片段，优选至少一种抗原和任选的药学上可接受的载体和/或稀释剂的药物组合物。发现根据本发明，将药物组合物引入脊椎动物将实现生长的调节，细胞转录和翻译的诱导，蛋白质合成，蛋白质表达或蛋白质分泌。药物组合物可用于疫苗接种方案，但也可用于免疫调节有益的任何其它治疗情况，例如亚最佳免疫应答，对病原体的反应，耐受性或自身免疫性。

4. 发明授权

US08153141B2 Immunostimulatory G, U-containing oligoribonucleotides 有权
标题翻译：免疫刺激G，含U的寡核糖核苷酸
公开(公告)号：US08153141B2
公开(公告)日：2012-04-10
申请号：US10407952
申请日：2003-04-04
申请人： Grayson Lipford , Stefan Bauer , Hermann Wagner
发明人： Grayson Lipford , Stefan Bauer , Hermann Wagner
IPC分类号： A61K45/00 , A61K39/00 , A61K9/127 , A61K47/00 , A61K31/70 , C12N5/00 , C12N5/02
CPC分类号： C07H21/02 , A61K31/205 , A61K31/7105 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K39/39 , A61K39/395 , A61K45/06 , A61K2039/55555 , C12N15/117 , C12N2310/17 , G01N33/566 , A61K2300/00
摘要： Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8). The compositions and methods are useful for stimulating immune activation. Methods useful for screening candidate immunostimulatory compounds are also provided.
摘要翻译：提供了与免疫刺激RNA寡聚体有关的组合物和方法。认为免疫刺激RNA分子代表一种或多种Toll样受体的天然配体，包括Toll样受体7（TLR7）和Toll样受体8（TLR8）。组合物和方法可用于刺激免疫激活。还提供了可用于筛选候选免疫刺激化合物的方法。

5. 发明申请

US20070184465A1 Methods for regulating hematopoiesis using CpG-oligonucleotides 审中-公开
标题翻译：使用CpG寡核苷酸调节造血的方法
公开(公告)号：US20070184465A1
公开(公告)日：2007-08-09
申请号：US11595823
申请日：2006-11-10
申请人： Hermann Wagner , Grayson Lipford
发明人： Hermann Wagner , Grayson Lipford
IPC分类号： C12Q1/68 , C12P21/06
CPC分类号： C12N15/117 , A61K31/70 , A61K39/00 , A61K39/39 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N2310/315 , C12N2310/345 , Y02A50/464
摘要： The invention relates to methods for regulating hematopoiesis using CpG containing oligonucleotides. In particular, the invention relates to methods of treating thrombopoiesis and anemia by regulating hematopoiesis. The invention also relates to methods of regulating immune system remodeling by administering CpG oligonucleotides to control hematopoiesis.
摘要翻译：本发明涉及使用含CpG的寡核苷酸调节造血的方法。特别地，本发明涉及通过调节造血作用治疗血小板生成和贫血的方法。本发明还涉及通过施用CpG寡核苷酸来控制造血功能来调节免疫系统重塑的方法。

6. 发明授权

US06943240B2 Nucleic acids for high throughput screening of CpG-based immuno-agonist/antagonist 失效
标题翻译：用于高通量筛选基于CpG的免疫激动剂/拮抗剂的核酸
公开(公告)号：US06943240B2
公开(公告)日：2005-09-13
申请号：US09954987
申请日：2001-09-17
申请人： Stefan Bauer , Grayson Lipford , Hermann Wagner
发明人： Stefan Bauer , Grayson Lipford , Hermann Wagner
IPC分类号： G01N33/50 , A61K45/00 , A61K48/00 , A61P37/00 , C07K14/705 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N27/447 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/00
CPC分类号： C07K14/705
摘要： The invention pertains to murine TLR9 and related TLR9s which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The invention further relates to methods of using such murine and non-murine TLR9 nucleic acids and polypeptides, especially in methods for screening for agonists and antagonists of immunostimulatory CpG nucleic acids. Also included are murine TLR9 inhibitors which inhibit murine TLR9 activity by inhibiting the expression or function of murine TLR9. In a further aspect the present invention pertains to murine TLR7 and murine TLR8, as well as related TLR7 and TLR8 molecules which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR7 and TLR8. Methods are included for screening for ligands of TLR7 and TLR8, as well as for inhibitors and agonists and antagonists of signaling mediated by TLR7 and TLR8.
摘要翻译：本发明涉及鼠TLR9和相关TLR9，其包括鼠特异性氨基酸，以及编码这些多肽的核酸。本发明还包括鼠TLR9的片段和生物学功能变体。本发明还涉及使用这种鼠和非鼠TLR9核酸和多肽的方法，特别是用于筛选免疫刺激性CpG核酸的激动剂和拮抗剂的方法。还包括通过抑制鼠TLR9的表达或功能来抑制鼠TLR9活性的鼠TLR9抑制剂。在另一方面，本发明涉及鼠TLR7和鼠TLR8，以及包括鼠特异性氨基酸的相关TLR7和TLR8分子，以及编码那些多肽的核酸。本发明还包括鼠TLR7和TLR8的片段和生物功能变体。包括用于筛选TLR7和TLR8配体的方法，以及由TLR7和TLR8介导的抑制剂和激动剂和信号通路拮抗剂。

7. 发明申请

US20050181422A1 Process for high throughput screening of CpG-based immuno-agonist/antagonist 失效
标题翻译：基于CpG的免疫激动剂/拮抗剂的高通量筛选方法
公开(公告)号：US20050181422A1
公开(公告)日：2005-08-18
申请号：US11084777
申请日：2005-03-18
申请人： Stefan Bauer , Grayson Lipford , Hermann Wagner
发明人： Stefan Bauer , Grayson Lipford , Hermann Wagner
IPC分类号： G01N33/50 , A61K45/00 , A61K48/00 , A61P37/00 , C07K14/705 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N27/447 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07K14/705
摘要： The invention pertains to murine TLR9 and related TLR9s which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The invention further relates to methods of using such murine and non-murine TLR9 nucleic acids and polypeptides, especially in methods for screening for agonists and antagonists of immunostimulatory CpG nucleic acids. Also included are murine TLR9 inhibitors which inhibit murine TLR9 activity by inhibiting the expression or function of murine TLR9. In a further aspect the present invention pertains to murine TLR7 and murine TLR8, as well as related TLR7 and TLR8 molecules which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR7 and TLR8. Methods are included for screening for ligands of TLR7 and TLR8, as well as for inhibitors and agonists and antagonists of signaling mediated by TLR7 and TLR8.
摘要翻译：本发明涉及鼠TLR9和相关TLR9，其包括鼠特异性氨基酸，以及编码这些多肽的核酸。本发明还包括鼠TLR9的片段和生物学功能变体。本发明还涉及使用这种鼠和非鼠TLR9核酸和多肽的方法，特别是用于筛选免疫刺激性CpG核酸的激动剂和拮抗剂的方法。还包括通过抑制鼠TLR9的表达或功能来抑制鼠TLR9活性的鼠TLR9抑制剂。在另一方面，本发明涉及鼠TLR7和鼠TLR8，以及包括鼠特异性氨基酸的相关TLR7和TLR8分子，以及编码那些多肽的核酸。本发明还包括鼠TLR7和TLR8的片段和生物功能变体。包括用于筛选TLR7和TLR8配体的方法，以及由TLR7和TLR8介导的抑制剂和激动剂和信号通路拮抗剂。

8. 发明申请

US20060172966A1 Immunostimulatory G, U-containing oligoribonucleotides 有权
公开(公告)号：US20060172966A1
公开(公告)日：2006-08-03
申请号：US11368333
申请日：2006-03-03
申请人： Grayson Lipford , Stefan Bauer , Hermann Wagner
发明人： Grayson Lipford , Stefan Bauer , Hermann Wagner
IPC分类号： A61K48/00 , A61K31/255
CPC分类号： C07H21/02 , A61K31/205 , A61K31/7105 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K39/39 , A61K39/395 , A61K45/06 , A61K2039/55555 , C12N15/117 , C12N2310/17 , G01N33/566 , A61K2300/00
摘要： Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8). The compositions and methods are useful for stimulating immune activation. Methods useful for screening candidate immunostimulatory compounds are also provided.

9. 发明申请

US20050100983A1 Cell-free methods for identifying compounds that affect toll-like receptor 9 (TLR9) signaling 审中-公开
标题翻译：用于鉴定影响toll样受体9（TLR9）信号传导的化合物的无细胞方法
公开(公告)号：US20050100983A1
公开(公告)日：2005-05-12
申请号：US10982193
申请日：2004-11-05
申请人： Stefan Bauer , Grayson Lipford , Hermann Wagner , Mark Rutz
发明人： Stefan Bauer , Grayson Lipford , Hermann Wagner , Mark Rutz
IPC分类号： C07K14/705 , G01N33/566 , C12P21/06
CPC分类号： C07K14/705 , C07K2319/30 , G01N33/566 , G01N2500/02
摘要： The invention is directed to methods for screening for a compound that affects interaction between a Toll-like receptor (TLR) and a ligand for the TLR. The methods involve direct measurement of interaction using, for example, surface plasmon resonance (SPR), particularly under conditions of pH that mimic those of the TLR in vivo. Compounds identified using the methods of the invention may be useful in the development of agents useful in the treatment of conditions characterized by undesirable immune activation, e.g., autoimmunity, inflammation, allergy, asthma, and transplantation.
摘要翻译：本发明涉及筛选影响Toll样受体（TLR）与TLR配体之间相互作用的化合物的方法。所述方法包括使用例如表面等离子体共振（SPR）直接测量相互作用，特别是在体内与模拟TLR的pH的条件下。使用本发明的方法鉴定的化合物可用于开发可用于治疗特征在于不期望的免疫激活（例如自身免疫，炎症，过敏，哮喘和移植）的病症的药剂。

10. 发明授权

US07820379B2 Process for high throughput screening of CpG-based immuno-agonist/antagonist 失效
标题翻译：基于CpG的免疫激动剂/拮抗剂的高通量筛选方法
公开(公告)号：US07820379B2
公开(公告)日：2010-10-26
申请号：US11084777
申请日：2005-03-18
申请人： Stefan Bauer , Grayson B. Lipford , Hermann Wagner
发明人： Stefan Bauer , Grayson B. Lipford , Hermann Wagner
IPC分类号： C12Q1/68 , G01N33/53 , C07K14/00
CPC分类号： C07K14/705
摘要： The invention pertains to murine TLR9 and related TLR9s which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The invention further relates to methods of using such murine and non-murine TLR9 nucleic acids and polypeptides, especially in methods for screening for agonists and antagonists of immunostimulatory CpG nucleic acids. Also included are murine TLR9 inhibitors which inhibit murine TLR9 activity by inhibiting the expression or function of murine TLR9. In a further aspect the present invention pertains to murine TLR7 and murine TLR8, as well as related TLR7 and TLR8 molecules which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR7 and TLR8. Methods are included for screening for ligands of TLR7 and TLR8, as well as for inhibitors and agonists and antagonists of signaling mediated by TLR7 and TLR8.
摘要翻译：本发明涉及鼠TLR9和相关TLR9，其包括鼠特异性氨基酸，以及编码这些多肽的核酸。本发明还包括鼠TLR9的片段和生物学功能变体。本发明还涉及使用这种鼠和非鼠TLR9核酸和多肽的方法，特别是用于筛选免疫刺激性CpG核酸的激动剂和拮抗剂的方法。还包括通过抑制鼠TLR9的表达或功能来抑制鼠TLR9活性的鼠TLR9抑制剂。在另一方面，本发明涉及鼠TLR7和鼠TLR8，以及包括鼠特异性氨基酸的相关TLR7和TLR8分子，以及编码那些多肽的核酸。本发明还包括鼠TLR7和TLR8的片段和生物功能变体。包括用于筛选TLR7和TLR8配体的方法，以及由TLR7和TLR8介导的抑制剂和激动剂和信号通路拮抗剂。

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