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1. 发明专利

JP2009298806A Pharmaceutical composition comprising polynucleotide and optionally antigen especially for vaccination 审中-公开
标题翻译：包含多核苷酸和选择性抗原的药物组合物特别用于疫苗接种
公开(公告)号：JP2009298806A
公开(公告)日：2009-12-24
申请号：JP2009212546
申请日：2009-09-14
申请人： Klaus Heeg , Grayson B Lipford , Hermann Wagner , ヒーグ,クラウス , ビー. リップフォード,グレイソン , ワグナー,ハーマン
发明人： WAGNER HERMANN , LIPFORD GRAYSON B , HEEG KLAUS
IPC分类号： A61K39/00 , C12N15/09 , A61K31/7088 , A61K39/39 , A61K48/00 , A61P37/00 , A61P37/04 , C07K14/195 , C07K14/435
CPC分类号： A61K39/39 , A61K2039/55561
摘要： PROBLEM TO BE SOLVED: To provide a means which can be effectively and beneficially applied in a wide range of various situations requiring stimulation, regulation or induction of immunological reaction.
SOLUTION: The present invention relates to a pharmaceutical composition comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention, the above problem was solved by the fact that introduction of the pharmaceutical composition into vertebrates achieved regulation of growth, induction of cellular transcription and translation, protein synthesis, protein expression or protein secretion. The pharmaceutical composition is useful in vaccination protocols but also in any other therapeutic situation in which immunomodulation is of benefit (e.g. sub-optimal immune responses, reaction to pathogens, tolerance or autoimmunity).
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供可以在需要刺激，调节或诱导免疫反应的各种情况的广泛范围内有效和有益地应用的手段。解决方案：本发明涉及包含多核苷酸，优选至少一种抗原和任选的药学上可接受的载体和/或稀释剂的至少一个片段的药物组合物。根据本发明，通过将药物组合物引入脊椎动物实现生长调节，细胞转录和翻译的诱导，蛋白质合成，蛋白质表达或蛋白质分泌的事实，解决了上述问题。药物组合物可用于疫苗接种方案，但也可用于其中免疫调节有益的任何其它治疗情况（例如亚最佳免疫应答，对病原体的反应，耐受性或自身免疫性）。版权所有（C）2010，JPO＆INPIT

2. 发明申请

US20100304526A1 Method of making a photovoltaic module 审中-公开
标题翻译：制造光伏组件的方法
公开(公告)号：US20100304526A1
公开(公告)日：2010-12-02
申请号：US12800716
申请日：2010-05-20
申请人： Walter Psyk , Joerg Reuner , Hermann Wagner
发明人： Walter Psyk , Joerg Reuner , Hermann Wagner
IPC分类号： H01L31/02 , H01L31/0352
CPC分类号： H01L31/03685 , B23K26/364 , B23K26/40 , B23K2103/172 , H01L31/046 , H01L31/048 , Y02E10/545 , Y02E10/548
摘要： Photovoltaic module comprising a transparent substrate (1), a transparent front electrode layer (2), a semiconducting layer (3) of microcrystalline or micromorphous silicon and a rear electrode layer (4), said layers structured to form cells (C1, C2, C3) electrically separated by separating lines (5, 6, 7) and electrically connected in series. A laser beam (14) is used to generate at least in rear electrode layer (4) separating line sections (18, 18′) interconnected to form continuous separating lines (7) by connecting sections (19, 20) extending at an angle (α) to separating line sections (18, 18′).
摘要翻译：包括透明基板（1），透明前电极层（2），微晶或微无定形硅的半导体层（3）和后电极层（4）的光伏模块，所述层被构造成形成电池（C1，C2， C3）通过分离线（5,6,7）电隔离并串联电连接。使用激光束（14）来产生至少在后电极层（4）中，分离通过连接部分（19,20）以一定角度延伸的连接部分（19,20）来互连的线路部分（18,18'），以形成连续的分离线（7） α）分离线段（18,18'）。

3. 发明授权

US07776562B2 Reversible MHC multimer staining for functional purification of antigen-specific T cells 有权
标题翻译：用于功能纯化抗原特异性T细胞的可逆MHC多聚体染色
公开(公告)号：US07776562B2
公开(公告)日：2010-08-17
申请号：US10451865
申请日：2001-12-28
申请人： Dirk H. Busch , Hermann Wagner
发明人： Dirk H. Busch , Hermann Wagner
IPC分类号： G01N33/53 , G01N33/52 , C12N11/06
CPC分类号： G01N33/56972 , A61K2035/124 , A61K2039/5158 , C12N5/0636 , G01N33/505 , G01N33/5094
摘要： The present invention relates to a new method for reversible staining and functional isolation or characterization of cells, e.g. antigen-specific T cells. With this technique, the original functional status of cells can be substantially maintained after their identification and purification. Thus, this new method is of broad benefit for basic research and clinical applications.
摘要翻译：本发明涉及可逆染色和功能分离或表征细胞的新方法，例如，抗原特异性T细胞。通过这种技术，细胞的原始功能状态在其鉴定和纯化后可以被基本保持。因此，这种新方法对于基础研究和临床应用具有广泛的益处。

4. 发明申请

US20090060927A1 Pharmaceutical compositions comprising a polynucleotide and optionally an antigen especially for vaccination 审中-公开
标题翻译：包含多核苷酸和任选的抗原的药物组合物，尤其用于疫苗接种
公开(公告)号：US20090060927A1
公开(公告)日：2009-03-05
申请号：US10811226
申请日：2004-03-26
申请人： Hermann Wagner , Grayson Lipford , Klaus Heeg
发明人： Hermann Wagner , Grayson Lipford , Klaus Heeg
IPC分类号： A61K39/00
CPC分类号： A61K39/39 , A61K2039/55561 , Y02A50/41
摘要： The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention was found that the introduction of the pharmaceutical composition into vertebrates will achieve regulation of growth, induction of cellular transcription and translation, protein synthesis, protein expression or protein secretion. The pharmaceutical compositions are useful in vaccination protocols but also in any other therapeutic situation in which immunomodulation is of benefit, such as sub-optimal immune responses, reaction to pathogens, tolerance or autoimmunity.
摘要翻译：本发明涉及包含多核苷酸的至少一个片段，优选至少一种抗原和任选的药学上可接受的载体和/或稀释剂的药物组合物。发现根据本发明，将药物组合物引入脊椎动物将实现生长调节，诱导细胞转录和翻译，蛋白质合成，蛋白质表达或蛋白质分泌。药物组合物可用于疫苗接种方案，但也可用于免疫调节有益的任何其它治疗情况，例如亚最佳免疫应答，对病原体的反应，耐受性或自身免疫性。

5. 发明授权

US5922016A Apparatus for electric stimulation of auditory nerves of a human being 失效
标题翻译：用于电刺激人类听觉神经的装置
公开(公告)号：US5922016A
公开(公告)日：1999-07-13
申请号：US590567
申请日：1996-01-26
申请人： Hermann Wagner
发明人： Hermann Wagner
IPC分类号： A61F11/04 , A61N1/36 , H04R25/00 , A61F2/18
CPC分类号： A61N1/36032 , A61F11/04
摘要： Apparatus for electric stimulation and diagnostics of auditory nerves of a human being, e.g. for determination of sensation level (SL), most conformable level (MCL) and uncomfortable level (UCL) audibility curves, includes a stimulator detachably secured to a human being for sending a signal into a human ear, and an electrode placed within the human ear and electrically connected to the stimulator by an electric conductor for conducting the signals from the stimulator into the ear. A control unit is operatively connected to the stimulator for instructing the stimulator as to characteristics of the generated signals being transmitted to the ear.
摘要翻译：用于电刺激和诊断人的听觉神经的装置，例如用于确定感觉水平（SL），最适应水平（MCL）和不舒服水平（UCL）可听度曲线，包括可拆卸地固定到人的用于将信号发送到人耳的刺激器和放置在人耳内的电极并且通过用于将刺激器的信号传导到耳中的电导体与刺激器电连接。控制单元可操作地连接到刺激器，用于指示刺激器关于发送到耳朵的所产生的信号的特性。

6. 发明授权

US2302359A Securing means 失效
公开(公告)号：US2302359A
公开(公告)日：1942-11-17
申请号：US37294141
申请日：1941-01-02
申请人： HERMANN WAGNER
发明人： HERMANN WAGNER
IPC分类号： F16B39/286
CPC分类号： F16B39/286 , Y10S411/938 , Y10T29/49609

7. 发明授权

US08623353B1 TLR2 antagonistic antibody and use thereof 有权
标题翻译： TLR2拮抗性抗体及其用途
公开(公告)号：US08623353B1
公开(公告)日：2014-01-07
申请号：US10595204
申请日：2004-09-23
申请人： Carsten Juergen Kirschning , Guangxun Meng , Hermann Wagner
发明人： Carsten Juergen Kirschning , Guangxun Meng , Hermann Wagner
IPC分类号： A61K39/395 , C07H21/04 , C07K16/00 , C07K16/28 , C12N1/00 , C12N5/00 , C12N5/10
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , C07K16/2896 , C07K2316/96 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/76
摘要： The present invention is directed to a cross-reactive antibody that specifically inhibits or blocks mammalian Toll-like receptor 2 (TLR2)-mediated immune cell activation. The invention is further directed to an isolated nucleic acid or vector coding for the variable regions of the heavy and/or light chain of such an antibody. Also provided is a pharmaceutical composition comprising such an antibody, or a nucleic acid or vector encoding it. Further provided are methods of use of such compositions in the prevention and/or treatment of inflammatory processes or any other process induced by bacterial infection, trauma, or chronic inflammation, or for the prevention and/or treatment of bacteriaemia or sepsis.
摘要翻译：本发明涉及特异性抑制或阻断哺乳动物Toll样受体2（TLR2）介导的免疫细胞活化的交叉反应性抗体。本发明还涉及编码这种抗体的重链和/或轻链的可变区的分离的核酸或载体。还提供了包含这种抗体或编码其的核酸或载体的药物组合物。还提供了这样的组合物在预防和/或治疗炎症过程或由细菌感染，创伤或慢性炎症诱导的任何其它过程中或用于预防和/或治疗细菌血症或败血症的方法。

8. 发明申请

US20120199178A1 RAW MODULE FOR PRODUCING A THIN-FILM SOLAR MODULE, AND THIN-FILM SOLAR MODULE 审中-公开
标题翻译：用于生产薄膜太阳能模块的原始模块和薄膜太阳能模块
公开(公告)号：US20120199178A1
公开(公告)日：2012-08-09
申请号：US13365322
申请日：2012-02-03
申请人： Hermann Wagner , Walter Psyk , Peter Lechner
发明人： Hermann Wagner , Walter Psyk , Peter Lechner
IPC分类号： H01L31/042
CPC分类号： H01L31/0468 , H01L31/046 , H01L31/0465 , Y02E10/50
摘要： A raw module is provided that includes a substrate, a front electrode layer, a semiconductor layer, and a rear electrode layer. The layers are separated by structuring trenches into sub cells, which are electrically connected in series in an interconnection direction. The module has a first separating region separating the module into two sub modules along a first separating line running in the interconnection direction. The separating region includes: a first and a second isolation trench running parallel to one another and on both sides of the first separating line in the interconnection direction; a third isolation trench extending from the first isolation trench at least as far as the first separating line but not as far as the second isolation trench; and a fourth isolation trench extending from the second isolation trench at least as far as the separating line but not as far as the first isolation trench.
摘要翻译：提供了一种包括基板，前电极层，半导体层和后电极层的原始模块。通过将沟槽构造成子电池来分离层，其沿互连方向串联电连接。该模块具有第一分离区域，该第一分离区域沿着在互连方向上运行的第一分隔线将模块分成两个子模块。分离区域包括：在互连方向上彼此平行并且在第一分离线的两侧上延伸的第一和第二隔离沟槽; 从所述第一隔离沟槽延伸的第三隔离沟槽至少与所述第一分隔线相同但不等于所述第二隔离沟槽; 以及从所述第二隔离沟槽延伸的第四隔离沟槽至少与所述分离线相同但不等于所述第一隔离沟槽的距离。

9. 发明申请

US20080113929A1 Abasic Oligonucleotide as Carrier Platform for Antigen and Immunostimulatory Agonist and Antagonist 审中-公开
标题翻译：碱性寡核苷酸作为抗原和免疫刺激激动剂和拮抗剂的载体平台
公开(公告)号：US20080113929A1
公开(公告)日：2008-05-15
申请号：US11629106
申请日：2005-06-08
申请人： Grayson B. Lipford , Alexandra Forsbach , Eugen Uhlmann , Hermann Wagner
发明人： Grayson B. Lipford , Alexandra Forsbach , Eugen Uhlmann , Hermann Wagner
IPC分类号： A61K48/00
CPC分类号： C07H21/00 , A61K39/0005 , A61K39/385 , A61K2039/6025 , A61K2039/6087 , A61K2039/6093 , A61K2300/00
摘要： Compositions and methods are provided for enhancing delivery of therapeutic agents. More specifically, compositions and methods are provided for improving antigen delivery to antigen-presenting cells. Conjugates between abasic oligonucleotides and antigen are provided, along with methods for their use in vaccination and in the treatment of cancer, infection, and allergy and asthma. Also provided are conjugates between abasic oligonucleotides and various immunostimulatory nucleic acids, including CpG oligonucleotides, as well as methods of use thereof. Also provided are conjugates between abasic oligonucleotides and various other agonists and antagonists of immunostimulation, as well as methods of use thereof.
摘要翻译：提供了用于增强治疗剂递送的组合物和方法。更具体地，提供了用于改善抗原递送细胞的抗原递送的组合物和方法。提供了无碱基寡核苷酸和抗原之间的结合物，以及它们用于疫苗接种和治疗癌症，感染和过敏和哮喘的方法。还提供了脱碱基寡核苷酸与各种免疫刺激核酸（包括CpG寡核苷酸）之间的缀合物，以及其使用方法。还提供了无碱基寡核苷酸与各种其它激动剂和免疫刺激拮抗剂之间的缀合物，以及其使用方法。

10. 发明授权

US06943240B2 Nucleic acids for high throughput screening of CpG-based immuno-agonist/antagonist 失效
标题翻译：用于高通量筛选基于CpG的免疫激动剂/拮抗剂的核酸
公开(公告)号：US06943240B2
公开(公告)日：2005-09-13
申请号：US09954987
申请日：2001-09-17
申请人： Stefan Bauer , Grayson Lipford , Hermann Wagner
发明人： Stefan Bauer , Grayson Lipford , Hermann Wagner
IPC分类号： G01N33/50 , A61K45/00 , A61K48/00 , A61P37/00 , C07K14/705 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N27/447 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/00
CPC分类号： C07K14/705
摘要： The invention pertains to murine TLR9 and related TLR9s which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The invention further relates to methods of using such murine and non-murine TLR9 nucleic acids and polypeptides, especially in methods for screening for agonists and antagonists of immunostimulatory CpG nucleic acids. Also included are murine TLR9 inhibitors which inhibit murine TLR9 activity by inhibiting the expression or function of murine TLR9. In a further aspect the present invention pertains to murine TLR7 and murine TLR8, as well as related TLR7 and TLR8 molecules which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR7 and TLR8. Methods are included for screening for ligands of TLR7 and TLR8, as well as for inhibitors and agonists and antagonists of signaling mediated by TLR7 and TLR8.
摘要翻译：本发明涉及鼠TLR9和相关TLR9，其包括鼠特异性氨基酸，以及编码这些多肽的核酸。本发明还包括鼠TLR9的片段和生物学功能变体。本发明还涉及使用这种鼠和非鼠TLR9核酸和多肽的方法，特别是用于筛选免疫刺激性CpG核酸的激动剂和拮抗剂的方法。还包括通过抑制鼠TLR9的表达或功能来抑制鼠TLR9活性的鼠TLR9抑制剂。在另一方面，本发明涉及鼠TLR7和鼠TLR8，以及包括鼠特异性氨基酸的相关TLR7和TLR8分子，以及编码那些多肽的核酸。本发明还包括鼠TLR7和TLR8的片段和生物功能变体。包括用于筛选TLR7和TLR8配体的方法，以及由TLR7和TLR8介导的抑制剂和激动剂和信号通路拮抗剂。

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