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1. 发明申请

US20120059142A1 PREPARING POLYESTER ALCOHOLS 审中-公开
标题翻译：制备聚酯醇
公开(公告)号：US20120059142A1
公开(公告)日：2012-03-08
申请号：US13226213
申请日：2011-09-06
申请人： Hermann Graf , Ulrike Mahn , Stefan Käshammer , Günter Scherr , Christian Nitschke
发明人： Hermann Graf , Ulrike Mahn , Stefan Käshammer , Günter Scherr , Christian Nitschke
IPC分类号： C08G63/85 , C08G63/181
CPC分类号： C08G63/78 , C08G18/10 , C08G18/4252 , C08G63/672
摘要： A process for preparing polyester alcohols by condensation of polytetrahydrofuran with aromatic dicarboxylic acids and/or their anhydrides and/or their esters, preferably isophthalic acid, phthalic acid and terephthalic acid and more preferably isophthalic acid, in the presence of a transesterification catalyst in a multi-stage operation at different pressure levels with at least one reaction stage at atmospheric pressure and at least one reaction stage at reduced pressure, where distillate is removed from the reaction system, comprises deactivating the catalyst after the polycondensation by using phosphoric acid in a molar ratio of 1:1 to 1:3.5 for catalyst to phosphoric acid.
摘要翻译：一种通过聚四氢呋喃与芳族二羧酸和/或其酸酐和/或它们的酯缩合制备聚酯醇的方法，优选间苯二甲酸，邻苯二甲酸和对苯二甲酸，更优选间苯二甲酸，在多酯交换催化剂存在下，在大气压下至少一个反应阶段和至少一个减压反应阶段，其中馏出物从反应体系中除去的不同压力水平的步骤包括在缩聚后通过使用摩尔比的磷酸来使催化剂失活催化剂与磷酸的比例为1：1至1：3.5。

2. 发明申请

US20120059143A1 PREPARING POLYESTER ALCOHOLS 审中-公开
标题翻译：制备聚酯醇
公开(公告)号：US20120059143A1
公开(公告)日：2012-03-08
申请号：US13227068
申请日：2011-09-07
申请人： Gerlinde Tischer , Ulrike Mahn , Stefan Käshammer , Hermann Graf , Christian Seitz , Christian Nitschke , Dieter Rodewald
发明人： Gerlinde Tischer , Ulrike Mahn , Stefan Käshammer , Hermann Graf , Christian Seitz , Christian Nitschke , Dieter Rodewald
IPC分类号： C08G63/80 , C08G63/668
CPC分类号： C08G63/78 , C08G18/4252 , C08G63/672
摘要： The subject of the present invention is a process for preparing polyester alcohols by condensation of polytetrahydrofuran with aromatic dicarboxylic acids and/or their anhydrides in the presence of a transesterification catalyst in a multi-stage operation at different pressure levels with at least one reaction stage at atmospheric pressure and at least one reaction stage at reduced pressure, where distillate is removed from the reaction system, which process comprises heating the reaction mixture in two or more phases in the atmospheric-pressure reaction stage wherein the heating phases are interrupted by at least one phase in which the temperature is kept constant.
摘要翻译：本发明的主题是通过在不同压力水平的多级操作中在酯交换催化剂存在下，将聚四氢呋喃与芳族二羧酸和/或它们的酸酐缩合制备聚酯醇的方法，其中至少一个反应阶段在大气压力和至少一个反应阶段，其中从反应体系中除去馏出物，该方法包括在大气压反应阶段中将反应混合物加热至两相或更多阶段，其中加热阶段被至少一个温度保持恒定的相。

3. 发明申请

US20070129487A1 Mixtures containing polytetrahydrofuran and a stabiliser 有权
标题翻译：含有四氢呋喃和稳定剂的混合物
公开(公告)号：US20070129487A1
公开(公告)日：2007-06-07
申请号：US10584767
申请日：2004-12-30
申请人： Hauke Malz , Dieter Rodewald , Hermann Graf
发明人： Hauke Malz , Dieter Rodewald , Hermann Graf
IPC分类号： C08G18/08
CPC分类号： C08L71/02 , C08G18/4808 , C08G18/4854 , C08G18/4887 , C08G2290/00 , C08K5/1345 , C08L71/14 , C08L2666/18 , C08L2666/14
摘要： The invention relates to mixtures (1) comprising (a) polytetrahydrofuran and (b) stabilizers having a molecular weight of from 600 g/mol to 10000 g/mol and comprising at least two phenolic groups.
摘要翻译：本发明涉及包含（a）聚四氢呋喃和（b）分子量为600g / mol至10000g / mol并包含至少两个酚基的稳定剂的混合物（1）。

4. 发明授权

US06274759B1 Diisocyanates containing hydantoin groups and polyurethanes in which they are present 失效
标题翻译：含有乙内酰脲基团的二异氰酸酯和存在它们的聚氨酯
公开(公告)号：US06274759B1
公开(公告)日：2001-08-14
申请号：US09235019
申请日：1999-01-21
申请人： Hermann Graf , Udo Rotermund , Günter Mohrhardt
发明人： Hermann Graf , Udo Rotermund , Günter Mohrhardt
IPC分类号： C07C26700
CPC分类号： C07D233/78 , C08G18/4018 , C08G18/6216 , C08G18/6674 , C08G18/7887 , C08G2101/0025 , C08G2101/0058
摘要： Diisocyanates of the formula (I) where R1 is a C1-C10-hydrocarbon radical and R3 is a C1-Cl2-hydrocarbon group and n is an integer from 1 to 10, are described.
摘要翻译：其中R 1是C 1 -C 10烃基，R 3是C 1 -C 12 - 烃基，n是1至10的整数的式（I）的二异氰酸酯。

5. 发明授权

US6117895A Pharmaceutical preparations for TNF inhibition 失效
标题翻译： TNF抑制药物制剂
公开(公告)号：US6117895A
公开(公告)日：2000-09-12
申请号：US683467
申请日：1996-07-18
申请人： Helmut Wachtel , Hermann Graf , Herbert Schneider , Daryl Faulds , H. Daniel Perez , Harald Dinter
发明人： Helmut Wachtel , Hermann Graf , Herbert Schneider , Daryl Faulds , H. Daniel Perez , Harald Dinter
IPC分类号： C07D263/22 , A61K31/42 , A61K31/421 , A61P11/00 , A61P17/00 , A61P25/00 , A61P29/00 , A61P37/00
CPC分类号： A61K31/421
摘要： Compounds of formula I ##STR1## are useful for treating TNF-mediated diseases.
摘要翻译：式I化合物可用于治疗TNF介导的疾病。

6. 发明授权

US08461285B2 Process for preparing polyether polyols 有权
标题翻译：制备聚醚多元醇的方法
公开(公告)号：US08461285B2
公开(公告)日：2013-06-11
申请号：US13042780
申请日：2011-03-08
申请人： Fatemeh Ahmadnian , Vinit Chilekar , Andreas Brodhagen , Achim Loeffler , Hermann Graf
发明人： Fatemeh Ahmadnian , Vinit Chilekar , Andreas Brodhagen , Achim Loeffler , Hermann Graf
IPC分类号： C08G18/32 , C07C43/13
CPC分类号： C08G18/4841 , C08G18/4829 , C08G65/2696 , C08G2101/0008 , C08G2101/0083
摘要： The present invention relates to a process for the catalytic preparation of polyetherols, wherein the power input by means of at least one stirrer and/or by means of at least one pump, based on the reactor volume, is in the range from 0.001 to 8.2 kW/m3.
摘要翻译：本发明涉及一种催化制备聚乙烯醇的方法，其中通过至少一个搅拌器和/或通过至少一个泵基于反应器体积输入的功率在0.001至8.2的范围内 kW / m3。

7. 发明授权

US5155164A Products of the condensation of phenolmonosulfonic acids, dihydroxydiphenyl sulfones, urea and formaldehyde 失效
标题翻译：苯二酚酸，二羟基二苯基硫醚，尿素和甲醛的浓缩产物
公开(公告)号：US5155164A
公开(公告)日：1992-10-13
申请号：US696912
申请日：1991-05-08
申请人： Hermann Graf , Adolf Stuebinger , Klaus Lorenz , Ortwin Schaffer , Karl Stork
发明人： Hermann Graf , Adolf Stuebinger , Klaus Lorenz , Ortwin Schaffer , Karl Stork
IPC分类号： C08G14/02
CPC分类号： C08G14/02
摘要： Products of the condensation of phenolmonosulfonic acids, dihydroxydiphenyl sulfones, urea and formaldehyde can be obtained by(A) preparing a homogeneous reaction mixture in sulfuric acid from the phenolmonosulfonic acid and dihydroxydiphenyl sulfone in the molar ratio of from 3:1 to 10:1, with the proviso that the water content of the mixture is not more than 10% of the total weight of the components, and the mixture contains from 0.3 to 1.5 moles of sulfuric acid per mole of dihydroxydiphenyl sulfone, at from 100.degree. to 180.degree. C.,(B) subsequently, at from 40.degree. to 90.degree. C., carrying out a precondensation with 1 to 2 moles of formaldehyde and 0.5 to 1.5 moles of urea per mole of phenol units present in aqueous medium,(C) partially neutralizing the reaction mixture,(D) adding to the partially neutralized reaction mixture 0 to 0.5 mole of phenol per mole of phenol units present and then 0.1 to 0.8 mole of formaldehyde per mole of phenol units then present,(E) further condensing at from 40.degree. to 90.degree. C.,(F) shifting the pH of the reaction mixture into the neutral range and(G) subsequently acidifying with a weak acid.
摘要翻译：苯酚磺酸，二羟基二苯基砜，脲和甲醛缩合的产物可以通过以下方法获得：（A）在苯磺酸和二羟基二苯基砜的硫酸中以3:1至10:1的摩尔比制备均匀的反应混合物，条件是混合物的水含量不超过组分总重量的10％，并且混合物含有0.3至1.5摩尔硫酸/摩尔二羟基二苯基砜，在100至180℃ （B）随后在40℃至90℃下，每1摩尔含水介质中的苯酚单元进行1至2摩尔甲醛和0.5至1.5摩尔脲的预缩合，（C）部分中和反应混合物中，（D）向部分中和的反应混合物中加入每摩尔苯酚单元0至0.5摩尔苯酚，然后存在每摩尔苯酚单元0.1至0.8摩尔甲醛，（E）进一步冷凝在40℃至90℃下，（F）将反应混合物的pH转移到中性范围，（G）随后用弱酸酸化。

8. 发明授权

US4663324A Pyridazinone derivatives, their preparation and their use as fungicides 失效
标题翻译：哒嗪酮衍生物，它们的制备及其作为杀真菌剂的用途
公开(公告)号：US4663324A
公开(公告)日：1987-05-05
申请号：US639324
申请日：1984-08-10
申请人： Hermann Graf , Costin Rentzea , Winfried Richarz , Helmut Froehlich , Eberhard Ammermann , Ernst-Heinrich Pommer
发明人： Hermann Graf , Costin Rentzea , Winfried Richarz , Helmut Froehlich , Eberhard Ammermann , Ernst-Heinrich Pommer
IPC分类号： A01N43/58 , C07D237/18
CPC分类号： C07D237/18 , A01N43/58
摘要： Pyridazinone derivatives of the formula I ##STR1## where R.sup.1 is hydrogen, unsubstituted or substituted alkyl, cycloalkyl, or unsubstituted or substituted phenyl or is carboxyl, hydroxymethyl or --CH.sub.2 O--COR.sup.3, where R.sup.3 is alkyl, or is --CH.sub.2 O[CH.sub.2 CH.sub.2 O].sub.p R.sup.4, where R.sup.4 is alkyl or phenyl and p is 1, 2 or 3,R.sup.2 is phenyl, unsubstituted or substituted vinyl or 2-propenyl,X is halogen,m is 1 or 2 andn is 1, 2, 3 or 4, and fungicides containing these compounds.
摘要翻译：式I的哒嗪酮衍生物其中R1是氢，未取代或取代的烷基，环烷基或未取代或取代的苯基或羧基，羟甲基或-CH2O-COR3，其中R3是烷基，或是-CH2O [ CH2CH2O] pR4，其中R4是烷基或苯基，p是1,2或3，R2是苯基，未取代或取代的乙烯基或2-丙烯基，X是卤素，m是1或2，n是1,2,3或 4，含有这些化合物的杀真菌剂。

9. 发明申请

US20110224397A1 PROCESS FOR PREPARING POLYOLS USING BASE CATALYSIS 审中-公开
标题翻译：使用基础催化制备多元醇的方法
公开(公告)号：US20110224397A1
公开(公告)日：2011-09-15
申请号：US13042781
申请日：2011-03-08
申请人： Thomas OSTROWSKI , Anne-Kathrin Merten , Achim Löffler , Hermann Graf
发明人： Thomas OSTROWSKI , Anne-Kathrin Merten , Achim Löffler , Hermann Graf
IPC分类号： C08G18/48 , C07C41/26 , C07C43/03
CPC分类号： C07C41/03 , C08G18/4829 , C08G65/2609 , C08G65/2648 , C08G65/2696 , C07C43/11
摘要： The present invention relates to a process for preparing polyetherols in the presence of basic catalysts, wherein propylene oxide (PO) and/or ethylene oxide (EO) whose summated contents of aldehydes, expressed by the contents determined by gas chromatography or titrimetrically using the bisulfite method and calculated for propionaldehyde, do not exceed the value of 300 ppm and of allyl alcohol determined by gas chromatography do not exceed the value of 2500 ppm and of water determined by Karl-Fischer titration do not exceed the value of 1700 ppm and of acid, expressed by the contents determined by acid-base titration and calculated for acetic acid, do not exceed the value of 100 ppm and of carbon dioxide determined by KOH titration do not exceed the value of 500 ppm are used.
摘要翻译：本发明涉及一种在碱性催化剂存在下制备聚醚的方法，其中由醛的含量表示的环氧丙烷（PO）和/或环氧乙烷（EO）通过气相色谱法或滴定法使用亚硫酸氢盐方法并计算丙醛，不超过300ppm，由气相色谱法测定的烯丙醇不超过2500ppm，由卡尔费休滴定测定的水不超过1700ppm的酸和酸由酸碱滴定测定的含量表示，乙酸计算值不超过100ppm，通过KOH滴定测定的二氧化碳的值不超过500ppm。

10. 发明授权

US6060501A Combined treatment of multiple sclerosis 失效
标题翻译：联合治疗多发性硬化症
公开(公告)号：US6060501A
公开(公告)日：2000-05-09
申请号：US937081
申请日：1997-09-24
申请人： Helmut Wachtel , Peter-Andreas Loschmann , Hermann Graf , H. Daniel Perez
发明人： Helmut Wachtel , Peter-Andreas Loschmann , Hermann Graf , H. Daniel Perez
IPC分类号： A01N43/36 , A01N43/76
CPC分类号： A01N43/36 , A01N43/76
摘要： A pharmaceutically composition for treating MS comprising an effective amount of a combination of a PDE IV inhibitor and an anti-inflammatory and immunomodulatory drug in a pharmaceutically acceptable carrier.
摘要翻译：一种用于治疗MS的药物组合物，其包含在药学上可接受的载体中有效量的PDE IV抑制剂和抗炎和免疫调节药物的组合。

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