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1. 发明授权

US06316673B2 Process for producing aminodiphenylamines 失效
标题翻译：氨基二苯胺的制备方法
公开(公告)号：US06316673B2
公开(公告)日：2001-11-13
申请号：US09776104
申请日：2001-02-02
申请人： Henry Giera , Torsten Pohl , Uwe Hugger , Adolf Sicheneder , Fred Schuhmacher , Adolf Brill
发明人： Henry Giera , Torsten Pohl , Uwe Hugger , Adolf Sicheneder , Fred Schuhmacher , Adolf Brill
IPC分类号： C07C20900
CPC分类号： C07C209/36 , C07C209/10 , C07C211/55 , C07C211/56
摘要： The present invention relates to the production of aminodiphenyl-amines resulting in good yields and high purity levels when aromatic amines are reacted with nitrohalobenzenes in the presence of a palladium catalyst and a base and the product thus obtained is subsequently hydrogenated with hydrogen.
摘要翻译：本发明涉及氨基二苯基胺的制备，当芳族胺在钯催化剂和碱的存在下与硝基卤代苯反应时，得到良好的产率和高纯度水平，随后用氢氢化所得产物。

2. 发明授权

US06235937B1 Process for the preparation of nitrodiphenylamines 失效
标题翻译：硝基二苯胺的制备方法
公开(公告)号：US06235937B1
公开(公告)日：2001-05-22
申请号：US09652072
申请日：2000-08-31
申请人： Henry Giera , Walter Lange , Torsten Pohl , Adolf Sicheneder , Christoph Schild
发明人： Henry Giera , Walter Lange , Torsten Pohl , Adolf Sicheneder , Christoph Schild
IPC分类号： C07C20910
CPC分类号： B01J31/2452 , B01J31/0212 , B01J31/24 , B01J31/2404 , B01J31/2409 , B01J31/26 , B01J2231/4205 , B01J2531/0266 , B01J2531/824 , C07C209/10 , C07C211/56
摘要： The invention relates to a process for the preparation of nitrodiphenylamines by reaction of nitrohalogenobenzenes with aromatic amines in the presence of a palladium catalyst and a base, the base being ground and/or dried before its use.
摘要翻译：本发明涉及通过在钯催化剂和碱的存在下将硝基卤代苯与芳族胺反应来制备硝基二苯胺的方法，碱在使用前进行研磨和/或干燥。

3. 发明授权

US06274775B1 Process for the preparation of nitrosobenzenes 失效
标题翻译：制备亚硝基苯的方法
公开(公告)号：US06274775B1
公开(公告)日：2001-08-14
申请号：US09707261
申请日：2000-11-06
申请人： Henry Giera , Michaela Meiers , Uwe Hugger
发明人： Henry Giera , Michaela Meiers , Uwe Hugger
IPC分类号： C07C20506
CPC分类号： C07C201/00 , C07C207/04 , C07C207/02
摘要： The invention relates to a process for the preparation of nitrosobenzene from aromatic amines by oxidation with hydrogen peroxide in the presence of a catalyst based on compounds of tungsten and/or molybdenum without the addition of the organic solvents conventionally used.
摘要翻译：本发明涉及一种通过在基于钨和/或钼的化合物的催化剂的存在下用过氧化氢氧化从芳族胺制备亚硝基苯的方法，而不添加常规使用的有机溶剂。

4. 发明授权

US6069148A Cycloalkano-pyridines 失效
标题翻译：环烷基 - 吡啶
公开(公告)号：US6069148A
公开(公告)日：2000-05-30
申请号：US889530
申请日：1997-07-08
申请人： Gunter Schmidt , Arndt Brandes , Rolf Angerbauer , Michael Logers , Matthias Muller-Gliemann , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt , Joachim Schuhmacher , Henry Giera , Holger Paulsen , Paul Naab , Michael Conrad , Jurgen Stoltefuss
发明人： Gunter Schmidt , Arndt Brandes , Rolf Angerbauer , Michael Logers , Matthias Muller-Gliemann , Carsten Schmeck , Klaus-Dieter Bremm , Hilmar Bischoff , Delf Schmidt , Joachim Schuhmacher , Henry Giera , Holger Paulsen , Paul Naab , Michael Conrad , Jurgen Stoltefuss
IPC分类号： C07D215/20 , A61K31/435 , A61K31/47 , A61K31/4709 , A61K31/473 , A61P3/06 , A61P9/00 , A61P9/10 , C07C225/18 , C07D215/22 , C07D215/36 , C07D215/40 , C07D215/54 , C07D221/04 , C07D221/16 , C07D221/20 , C07D405/06 , C07D491/056 , C07D491/08 , C07D491/10 , C07D491/107 , C07F7/18 , A61K31/438 , C07D215/00 , C07D217/00
CPC分类号： C07D221/04 , C07C225/18 , C07D215/22 , C07D215/36 , C07D215/40 , C07D221/16 , C07D221/20 , C07D405/06 , C07D491/08 , C07D491/10 , C07F7/1856 , C07C2101/08
摘要： The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varying the functional groups accordingly. The, cycloalkanopyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of hyperlipoproteinaemia and arteriosclerosis.
摘要翻译：通过使相应的环烷基 - 吡啶 - 醛与合适的有机金属化合物或Wittig或格氏试剂反应或使环烷基 - 吡啶醇类型的化合物与合适的溴化合物反应，并且任选地相应地改变官能团，制备环烷基 - 吡啶。环烷基吡啶类药物适合作为药物中的活性化合物，特别是用于治疗高脂蛋白血症和动脉硬化的药物。

5. 发明授权

US6166256A Process for preparing (4-nitro-sophenyl)phenylhydroxylamine 失效
标题翻译：制备（4-硝基 - 苯基）苯基羟胺的方法
公开(公告)号：US6166256A
公开(公告)日：2000-12-26
申请号：US566073
申请日：2000-05-08
申请人： Henry Giera , Carl Casser , Pieter Ooms , Michael Schelhaas , Christian Laue , Michaela Meiers , Gerhard Braun
发明人： Henry Giera , Carl Casser , Pieter Ooms , Michael Schelhaas , Christian Laue , Michaela Meiers , Gerhard Braun
IPC分类号： B01J31/02 , C07B61/00 , C07C239/10 , C07C239/00
CPC分类号： C07C239/10
摘要： The present invention provides a process for preparing (4-nitroso-phenyl)phenyl-hydroxylamine which is characterized in that nitrobenzene is reacted in the presence of hydroxide and/or oxide-containing bases, optionally in the presence of solvents, at temperatures of 20 to 180.degree. C. and pressures of 0.1 to 10 bar.The process according to the invention has the particular advantage that it uses inexpensive and cost-effective nitrobenzene as starting material instead of the nitrosobenzene conventionally used hitherto.
摘要翻译：本发明提供一种制备（4-亚硝基苯基）苯基羟胺的方法，其特征在于硝酸苯在含氢氧化物和/或氧化物的碱存在下，任选地在溶剂存在下，在20℃的温度下反应至180℃，压力为0.1至10巴。根据本发明的方法具有特别的优点，它使用廉价且具有成本效益的硝基苯作为起始原料，而不是迄今为止常规使用的亚硝基苯。

6. 发明授权

US5866353A Electro chemical biosensor containing diazacyanine mediator for co-enzyme regeneration 失效
标题翻译：含有二氮芥酸介质的电化学生物传感器用于辅酶再生
公开(公告)号：US5866353A
公开(公告)日：1999-02-02
申请号：US762098
申请日：1996-12-09
申请人： Horst Berneth , Thomas Bocker , Henry Giera , Alison J. Murray , Hans-Ulrich Siegmund
发明人： Horst Berneth , Thomas Bocker , Henry Giera , Alison J. Murray , Hans-Ulrich Siegmund
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/32 , C09B44/10 , C12M1/00 , G01N27/26
CPC分类号： C12Q1/004 , Y10S435/817
摘要： A variety of diazacyanine mediators that are soluble in aqueous media and which do not inhibit enzymatic activity are provided for use on the surface of a working electrode of a electrochemical biosensor for electrochemical co-enzyme regeneration. The co-enzyme, dihydronicotinamide adenine dinucleotide (NADH) or dihydronicotinamide adenine dinucleotide phosphate (NADPH), is oxidized to NAD.sup.+ OR NADP.sup.+ which is reduced by an oxidoreductase such as a dehydrogenase acting on a substrate. By applying the mediator together with NADH or NADPH to the surface of the working electrode, the voltage necessary to achieve oxidation is substantially reduced. Biosensor electrodes such as graphite electrodes may be produced-by screen printing techniques.
摘要翻译：提供了可溶于水性介质并且不抑制酶活性的各种二氮芥酸介质用于电化学生物传感器用于电化学辅酶再生的工作电极的表面。辅酶，二氢烟酰胺腺嘌呤二核苷酸（NADH）或二氢烟酰胺腺嘌呤二核苷酸磷酸（NADPH）被氧化成NAD + OR NADP +，其由氧化还原酶例如作用于底物的脱氢酶而还原。通过将介体与NADH或NADPH一起施加到工作电极的表面，实现氧化所需的电压显着降低。生物传感器电极如石墨电极可以通过丝网印刷技术制造。

7. 发明授权

US06414192B1 Process for preparing 4-aminodiphenylamine 失效
标题翻译：制备4-氨基二苯胺的方法
公开(公告)号：US06414192B1
公开(公告)日：2002-07-02
申请号：US10007014
申请日：2001-11-06
申请人： Michael Schelhaas , Carl Casser , Dietmar Bielefeldt , Pieter Ooms , Joachim Haider , Manfred Jautelat , Christian Laue , Henry Giera
发明人： Michael Schelhaas , Carl Casser , Dietmar Bielefeldt , Pieter Ooms , Joachim Haider , Manfred Jautelat , Christian Laue , Henry Giera
IPC分类号： C07C20900
CPC分类号： C07C209/38 , C07C211/55
摘要： The invention provides a process for preparing 4-aminodiphenylamine, an important starting product for synthesizing antioxidants and stabilizers in the rubber and polymer industry, by hydrogenating nitrosobenzene with hydrogen in the presence of a proton acid as catalyst and in the presence of a hydrogenating catalyst, optionally in the presence of an inert organic solvent and thermally decomposing the 4-ADPA ammonium salt produced in this way, wherein 4-ADPA is obtained. 4-aminodiphenylamine is produced in good yields and high purity by the process according to the present invention. Furthermore, no effluent is produced, which makes the process particularly economic and ecological.
摘要翻译：本发明提供一种制备4-氨基二苯胺的方法，该方法是在质子酸作为催化剂存在下，在氢化催化剂存在下，通过在氢气存在下，用氢气将亚硝基苯氢化，在橡胶和聚合物工业中合成抗氧化剂和稳定剂的重要起始产物，任选地在惰性有机溶剂的存在下，并以这种方式产生的4-ADPA铵盐热分解，得到4-ADPA。4-氨基二苯胺通过本发明的方法以良好的产率和高纯度生产。此外，没有产生流出物，这使得该过程特别经济和生态。

8. 发明授权

US5725607A Method for reducing the toxicity of spent liquors and novel cationic dyes 失效
公开(公告)号：US5725607A
公开(公告)日：1998-03-10
申请号：US670045
申请日：1996-06-25
申请人： Henry Giera , Felix Reichel , Horst Berneth , Thomas Bocker , Karin Hassenruck , Karl Lange , Karlheinrich Meisel
发明人： Henry Giera , Felix Reichel , Horst Berneth , Thomas Bocker , Karin Hassenruck , Karl Lange , Karlheinrich Meisel
IPC分类号： C07D249/06 , C07D213/38 , C07D231/56 , C07D249/14 , C07D277/20 , C07D277/50 , C07D409/04 , C09B23/14 , C09B23/16 , C09B26/04 , C09B44/10 , C09B44/20 , C09B55/00 , C09B57/00 , D06P1/00 , D06P1/41
CPC分类号： C09B23/143 , C09B23/145 , C09B23/164 , C09B26/04 , C09B44/10 , D06P1/41 , Y10S8/917 , Y10S8/919 , Y10S8/922 , Y10S8/924 , Y10S8/927
摘要： There has been found 1) a method for reducing the toxicity of spent liquors from dyeing with cationic dyes or mixtures thereof, characterized by the step of dyeing with cationic dyes having a computed electrostatic shielding energy (idealized hydration energy) of .gtoreq.50 kcal/mol, 2) cationic, generally low toxicity dyes, their preparation and use for dyeing.

9. 发明授权

US06303820B1 Process for the preparation of nitrosobenzenes 失效
标题翻译：制备亚硝基苯的方法
公开(公告)号：US06303820B1
公开(公告)日：2001-10-16
申请号：US09707188
申请日：2000-11-06
申请人： Henry Giera , Walter Lange , Michaela Meiers , Raul Pires
发明人： Henry Giera , Walter Lange , Michaela Meiers , Raul Pires
IPC分类号： C07C20506
CPC分类号： C07C201/00 , C07C207/02 , C07C207/04
摘要： The invention relates to a process for the preparation of nitrosobenzenes from aromatic amines by oxidation with hydrogen peroxide in the presence of sodium molybdate dihydrate and an inert organic solvent.
摘要翻译：本发明涉及一种通过在钼酸钠二水合物和惰性有机溶剂的存在下用过氧化氢氧化由芳族胺制备亚硝基苯的方法。

10. 发明授权

US5749925A Dyeing or printing process with new and known cationic 4,5-dihydro-iH-1,2,3-triazolium compounds as dyestuffs and new cationic 4,5-dihydro-1H-1,2,3-triazolium compounds 失效
标题翻译：新的和已知的阳离子4,5-二氢-h-1,2,3-三唑鎓化合物作为染料和新的阳离子4,5-二氢-1H-1,2,3-三唑鎓化合物的染色或印刷方法
公开(公告)号：US5749925A
公开(公告)日：1998-05-12
申请号：US670913
申请日：1996-06-26
申请人： Thomas Bocker , Horst Berneth , Henry Giera
发明人： Thomas Bocker , Horst Berneth , Henry Giera
IPC分类号： C07D249/06 , C07D417/04 , C09B26/06 , C09B57/00 , D06P3/24 , D06P3/32 , D06P3/52 , D06P3/70 , D06P1/42 , D06P3/76
CPC分类号： C07D417/04 , C07D249/06 , C09B26/06 , C09B57/00 , Y10S8/917 , Y10S8/918 , Y10S8/919 , Y10S8/927
摘要： 4,5-Dihydro-1H-1,2,3-triazolium compounds of the formula (I) ##STR1## in which R.sup.1 and R.sup.2 independently of one another denote C.sub.6 -C.sub.14 -aryl or a heterocyclic radical having up to 3 rings and up to 4 heteroatoms from the series consisting of O, S and N, R.sup.3 and R.sup.4 independently of one another denote hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.12 -alkenyl, C.sub.4 -C.sub.8 -cycloalkyl, C.sub.7 -C.sub.17 -aralkyl, C.sub.6 -C.sub.14 -aryl or nitrile or R.sup.3 and R.sup.4 together denote a 2- to 5-membered C bridge, which can optionally be interrupted by up to two oxygen and/or nitrogen atoms, and X.sup.- denotes an anion, wherein all the alkyl, alkenyl, cycloalkyl, aralkyl and aryl radicals and fused and heterocyclic radicals present can optionally be substituted by nonionic substituents, carboxyl groups, ammonium groups and/or pyridinium groups, are used as dyestuffs. New 4,5-dihydro-1H-1,2,3-triazolium compounds correspond to the formula (I), with the provisos that if R.sup.3 and R.sup.4 in each case denote hydrogen then in the case where R.sup.1 =4-methylphenyl R.sup.2 does not represent 4-nitrophenyl, 4-methoxyphenyl or phenyl and R.sup.1 and R.sup.2 do not both simultaneously represent 4-methylphenyl, 4-nitrophenyl, 4-methoxyphenyl or phenyl.
摘要翻译： R 1和R 2彼此独立地表示的式（I）的化合物（I）的4,5-二氢-1H-1,2,3-三唑鎓表示C 6 -C 14 - 芳基或具有至多 3个环和至多4个由O，S和N组成的系列的杂原子，R 3和R 4彼此独立地表示氢，C 1 -C 12 - 烷基，C 2 -C 12 - 链烯基，C 4 -C 8环烷基，C 7 -C 17 - 芳烷基，C 6 -C 14 - 芳基或腈，或者R 3和R 4一起表示2-至5-元C桥，其可以任选地被多达两个氧和/或氮原子间隔，X-表示阴离子，其中所有存在的烷基，烯基，环烷基，芳烷基和芳基以及稠合和杂环基团可任选被非离子取代基，羧基，铵基和/或吡啶鎓基取代，用作染料。新的4,5-二氢-1H-1,2,3-三唑鎓化合物对应于式（I），条件是如果R 3和R 4在每种情况下表示氢，则在R1 = 4-甲基苯基R2的情况下不代表4-硝基苯基，4-甲氧基苯基或苯基，R1和R2不同时表示4-甲基苯基，4-硝基苯基，4-甲氧基苯基或苯基。

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