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1. 发明授权

US06225131B1 Device for performing an assay, a method for manufacturing said device, and use of a membrane in the manufacture of said device 有权
标题翻译：用于进行测定的装置，制造所述装置的方法以及在制造所述装置中使用膜
公开(公告)号：US06225131B1
公开(公告)日：2001-05-01
申请号：US09403559
申请日：1999-10-25
申请人： Hendrik Sibolt van Damme , Hermanus Johannes Maria Kreuwel
发明人： Hendrik Sibolt van Damme , Hermanus Johannes Maria Kreuwel
IPC分类号： G01N33551
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00378 , B01J2219/00497 , B01J2219/00511 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , C12Q1/6834 , C12Q1/6837 , C12Q1/703 , C40B40/06 , C40B60/14 , G01N33/551 , Y10S435/81
摘要： A device for performing an assay comprising a substrate having through-going channels that open out onto a surface for sample application, the channels being provided in at least one cross-sectional area with a first binding substance capable of binding a particular analyte, the substrate being an electrochemically manufactured metal oxide membrane and containing the first binding substance within the through-going channels.
摘要翻译：一种用于执行测定的装置，其包括具有开放到表面上的用于样品施加的贯穿通道的基底，所述通道在至少一个横截面区域中提供有能够结合特定分析物的第一结合物质，所述基底作为电化学制造的金属氧化物膜并且在通过通道内容纳第一结合物质。

2. 发明授权

US06855539B2 Device for performing an assay, a method for manufacturing said device, and use of a membrane in the manufacture of said device 失效
标题翻译：用于进行测定的装置，制造所述装置的方法以及在制造所述装置中使用膜
公开(公告)号：US06855539B2
公开(公告)日：2005-02-15
申请号：US09997213
申请日：2001-11-27
申请人： Hendrik Sibolt van Damme , Hermanus Johannes Maria Kreuwel , Tim Kievits , Marinus Gerardus Johannus van Beuningen , Pieter Jacob Boender
发明人： Hendrik Sibolt van Damme , Hermanus Johannes Maria Kreuwel , Tim Kievits , Marinus Gerardus Johannus van Beuningen , Pieter Jacob Boender
IPC分类号： B01J19/00 , C12Q1/68 , C12Q1/70 , C40B40/06 , C40B60/14 , G01N33/551 , C12M1/34
CPC分类号： C12Q1/703 , B01J19/0046 , B01J2219/00378 , B01J2219/00497 , B01J2219/00511 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , C12Q1/6834 , C12Q1/6837 , C40B40/06 , C40B60/14 , G01N33/551 , Y10S436/81
摘要： Disclosed is a device useful for performing an assay comprising a substrate having interconnecting channels that open out onto a surface for sample application, the channels being provided in at least one cross-sectional area with a first binding substance capable of binding a particular analyte, the substrate being an electrochemically manufactured metal oxide membrane and containing the first binding substance within the through-going channels. Similar devices are also useful for chemical synthesis. Assay and chemical synthesis methods are also disclosed, as are kits for performing the assays or chemical syntheses.
摘要翻译：公开了一种用于执行测定的装置，其包括具有互连通道的基板，所述基板具有向表面施加的样品的开口，所述通道在至少一个横截面区域中具有能够结合特定分析物的第一结合物质，衬底是电化学制造的金属氧化物膜，并且在穿通通道内含有第一结合物质。类似的装置也可用于化学合成。还公开了测定和化学合成方法，以及用于进行测定或化学合成的试剂盒。

3. 发明授权

US06864102B2 Device for performing an assay, a method for manufacturing said device, and use of a membrane in the manufacture of said device 失效
标题翻译：用于进行测定的装置，制造所述装置的方法以及在制造所述装置中使用膜
公开(公告)号：US06864102B2
公开(公告)日：2005-03-08
申请号：US09845198
申请日：2001-05-01
申请人： Hendrik Sibolt van Damme , Hermanus Johannes Maria Kreuwel
发明人： Hendrik Sibolt van Damme , Hermanus Johannes Maria Kreuwel
IPC分类号： G01N33/543 , B01J19/00 , B01L3/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C12Q1/70 , C40B40/06 , C40B60/14 , G01N33/551 , G01N33/553 , G01N37/00
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00378 , B01J2219/00497 , B01J2219/00511 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , C12Q1/6834 , C12Q1/6837 , C12Q1/703 , C40B40/06 , C40B60/14 , G01N33/551 , Y10S435/81
摘要： The present invention relates to a device for performing an assay, which device comprises a substrate having oriented through-going channels, said channels opening out on a surface for sample application, the channels in at least one area of the surface for sample application being provided with a first binding substance capable of binding to an analyte. The object of the present invention is to provide a substrate having both a high channel density and a high porosity, allowing high density arrays comprising different first binding substances to be applied to the surface for sample application. More in particular, the object of the present invention is to provide a device comprising a relatively cheap substrate that does not require the use of any typical microfabrication technology and, that offers an improved control over the liquid distribution over the surface of the substrate. The above objects are achieved with a device as mentioned above wherein the porous substrate is an electrochemically manufactured metal oxide membrane.
摘要翻译：本发明涉及一种用于进行测定的装置，该装置包括具有定向贯穿通道的基板，所述通道在用于样品施加的表面上开口，提供用于样品施加的表面的至少一个区域中的通道具有能够结合分析物的第一结合物质。本发明的目的是提供一种具有高通道密度和高孔隙率的基底，允许将包含不同第一结合物质的高密度阵列施加到表面用于样品施加。更具体地，本发明的目的是提供一种包括相对便宜的基底的装置，其不需要使用任何典型的微细加工技术，并且提供对衬底表面上的液体分布的改进的控制。上述目的通过如上所述的装置实现，其中多孔基底是电化学制造的金属氧化物膜。

4. 发明授权

US06635493B2 Device for performing an assay, a method for manufacturing said device, and use of a membrane in the manufacture of said device 失效
公开(公告)号：US06635493B2
公开(公告)日：2003-10-21
申请号：US09843929
申请日：2001-04-30
申请人： Hendrik Sibolt van Damme , Hermanus Johannes Maria Kreuwel
发明人： Hendrik Sibolt van Damme , Hermanus Johannes Maria Kreuwel
IPC分类号： G01N33551
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00378 , B01J2219/00497 , B01J2219/00511 , B01J2219/00527 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , C12Q1/6834 , C12Q1/6837 , C12Q1/703 , C40B40/06 , C40B60/14 , G01N33/551 , Y10S435/81
摘要： The present invention relates to a device for performing an assay, which device comprises a substrate having oriented through-going channels, said channels opening out on a surface for sample application, the channels in at least one area of the surface for sample application being provided with a first binding substance capable of binding to an analyte. The object of the present invention is to provide a substrate having both a high channel density and a high porosity, allowing high density arrays comprising different first binding substances to be applied to the surface for sample application. More in particular, the object of the present invention is to provide a device comprising a relatively cheap substrate that does not require the use of any typical microfabrication technology and, that offers an improved control over the liquid distribution over the surface of the substrate. The above objects are achieved with a device as mentioned above wherein the porous substrate is an electrochemically manufactured metal oxide membrane.

5. 发明授权

US07105134B2 Device for holding a substrate 有权
公开(公告)号：US07105134B2
公开(公告)日：2006-09-12
申请号：US10095992
申请日：2002-03-11
申请人： Hendrik Sibolt van Damme , Wilhelmus Marinus Carpay
发明人： Hendrik Sibolt van Damme , Wilhelmus Marinus Carpay
IPC分类号： B01L9/00
CPC分类号： B01L3/5023 , B01L3/50255 , B01L9/527 , B01L2200/027 , B01L2300/0681 , B01L2300/0822 , B01L2400/0406
摘要： A device for holding a substrate comprises upper and lower plates adapted to receive the substrate sandwiched in the interface between the plates. Each plate has at least one opening with a projecting rim surrounding the opening and directed away from the interface. The openings in the upper and lower plates are preferably at least partially aligned in the sandwiched position of the plates. Each opening in the lower plate can be provided with a shielding member partially shielding the opening of the lower plate.

6. 发明授权

US08586349B2 Moving droplet diagnostic assay 有权
标题翻译：移动液滴诊断测定
公开(公告)号：US08586349B2
公开(公告)日：2013-11-19
申请号：US10344226
申请日：2001-08-06
申请人： Thomas Augustinus Maria Beumer , Petrus Franciscus Hendrikus M. Verheijden , Hendrik Sibolt van Damme
发明人： Thomas Augustinus Maria Beumer , Petrus Franciscus Hendrikus M. Verheijden , Hendrik Sibolt van Damme
IPC分类号： G01N33/00 , G01N33/53 , C12Q1/00 , C12Q1/68 , D21C3/00
CPC分类号： G01N33/54393 , G01N33/54366 , Y10T436/2525
摘要： The present invention concerns a method for the detection of an analyte in a droplet of fluid comprising the steps of providing a solid phase with a hydrophobic surface comprising at least one capture zone on which at least one binding agent with affinity for the analyte is immobilized, applying said droplet to the surface of said solid phase, applying a force that makes the droplet travel along the surface of said solid phase along a predetermined path thereby allowing the droplet to repeatedly contact said binding agent on the capture zone, applying conditions wherein said analyte is allowed to bind to said binding agent and detecting a complex of analyte and binding reagent at the position of the capture zone. The effect of a moving droplet is that the reactants in the droplet are well mixed which eliminates the risk of diffusion limitation. Such advantageous mixing is not obtained with conventional assays in which the surface is continuously exposed to the liquid. The use of a droplet eliminates the need for external mixing and also circumvents the need to dilute the sample in order to obtain sufficient volume to wet a large surface area.
摘要翻译：本发明涉及一种用于检测流体液滴中的分析物的方法，包括以下步骤：向固相提供包含至少一个捕获区的疏水表面，在该捕获区上固定有至少一种对分析物具有亲和力的结合剂，将所述液滴施加到所述固相的表面，施加使液滴沿着预定路径沿着所述固相的表面行进的力，从而允许液滴在捕获区上反复接触所述粘合剂，施加条件，其中所述分析物被允许结合到所述结合剂并且在捕获区的位置检测分析物和结合试剂的复合物。移动液滴的作用是液滴中的反应物充分混合，消除了扩散限制的风险。用表面连续暴露于液体的常规测定法不能获得这种有利的混合。使用液滴消除了对外部混合的需要，并且还避免了稀释样品的需要，以便获得足够的体积以润湿大的表面积。

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