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1. 发明授权

US4730068A Tumor retarding (1,2-diphenyl-ethylenediamine)-platinum(II)-complexes 失效
标题翻译：抗肿瘤剂（1,2-二苯基 - 乙二胺） - 铂（II） - 复合物
公开(公告)号：US4730068A
公开(公告)日：1988-03-08
申请号：US831913
申请日：1986-02-21
申请人： Helmut Schonenberger , Erwin von Angerer , Johann Karl , Margaretha Jennerwein , Jurgen Engel
发明人： Helmut Schonenberger , Erwin von Angerer , Johann Karl , Margaretha Jennerwein , Jurgen Engel
IPC分类号： A61K31/28 , A61P35/00 , C07C45/29 , C07C45/51 , C07C45/56 , C07C47/575 , C07F15/00
CPC分类号： C07F15/0093 , C07C45/298 , C07C45/515 , C07C45/562 , C07C47/575
摘要： There are disclosed antitumor active 1,2-diphenyl-ethylenediamine)-platinum(II)-complex of the general formula ##STR1## wherein R.sub.7 is hydrogen or C.sub.1 -C.sub.6 -alkyl and R.sub.2 is either (1) a halogen atom and the groups R.sub.1, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are the same or different and are hydrogen, halogen, trihalomethyl, C.sub.1 -C.sub.6 -alkyl, hydrogen C.sub.1 -C.sub.6 -alkoxy, a C.sub.2 -C.sub.6 -alkanoyloxy or a halo or C.sub.1 -C.sub.4 -alkanesulfonyloxy substituted C.sub.2 -C.sub.6 -alkanoyloxy group, or R.sub.2 is (2) a hydroxy group, a C.sub.1 -C.sub.6 -alkoxy group, a C.sub.2 -C.sub.6 -alkanoyloxy group in the 4-position or a halo or C.sub.1 -C.sub.4 -alkanesulfonyloxy substituted C.sub.2 -C.sub.6 -alkanoyloxy group and if R.sub.2 is (2) then the groups R.sub.1 and R.sub.3 which are the same or differnt are in the 2 and 6 positions of the phenyl group and are halogen, trihalomethyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, a C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.6 -alklanoyloxy group or a halo or C.sub.1 -C.sub.5 -alkanesulfonyloxy substituted C.sub.2 -C.sub.6 -alkanoyloxy group, with the proviso that R.sub.1 can also be hydrogen and the groups R.sub.4, R.sub.5, and R.sub.6 are the same or different and are hydrogen, halogen, trihalomethyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, a C.sub.2 -C.sub.6 -alkanoyloxy group or a halo or C.sub.1 -C.sub.4 -alkanesulfonyloxy substituted C.sub.2 -C.sub.6 -alkanoyloxy group and X is the equivalent of a physiologically compatible anion and process of their production.
摘要翻译：公开了具有通式“IMAGE”I的抗肿瘤活性的1,2-二苯基 - 乙二胺） - 铂（II） - 复合物，其中R 7是氢或C 1 -C 6 - 烷基，R 2是（1）卤素原子，基团R 1，R 3，R 4，R 5和R 6相同或不同，为氢，卤素，三卤甲基，C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，C 2 -C 6 - 烷酰氧基或卤素或C 1 -C 4 - 烷磺酰氧基取代的C 2 -C 6 - 烷酰氧基，或R 2为（2）羟基，C 1 -C 6 - 烷氧基，C 4 -C 6 - 烷酰氧基或卤素或C 1 -C 4 - 烷磺酰氧取代 C 2 -C 6 - 烷酰氧基，如果R 2为（2），则相同或不同的基团R 1和R 3为苯基的2和6位，为卤素，三卤代甲基，C 1 -C 6烷基，羟基， C 1 -C 6 - 烷氧基，C 2 -C 6 - 烷酰氧基或卤素或C 1 -C 5 - 烷磺酰氧基取代的C 2 -C 6 - 烷酰氧基，条件是R 1也可以是氢，基团R 4，R 5和R 6是相同或不同的氢，卤素，三卤代甲基，C 1 -C 6 - 烷基，羟基，C 1 -C 6 - 烷氧基，C 2 -C 6 - 烷酰氧基或卤素或C 1 -C 4 - 烷磺酰氧基取代的C 2 -C 6 - 烷酰氧基，X等同于生理上相容的阴离子及其生产方法。

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