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1. 发明授权

US06384284B1 Biphenyl compounds substituted by camphor or hydantoin derivatives as sunscreen compositions 有权
标题翻译：由樟脑或乙内酰脲衍生物取代的联苯化合物作为防晒组合物
公开(公告)号：US06384284B1
公开(公告)日：2002-05-07
申请号：US09806358
申请日：2001-03-29
申请人： Rudolf Zink , Dieter Reinehr , Helmut Luther , Bernd Herzog
发明人： Rudolf Zink , Dieter Reinehr , Helmut Luther , Bernd Herzog
IPC分类号： C07C4900
CPC分类号： C07C309/24 , A61K8/35 , A61K8/466 , A61K8/4946 , A61Q17/04 , C07C45/74 , C07C49/683
摘要： A description is given of diphenyl compounds of formula wherein R is a camphor or hydantoin derivative; and R1 is hydrogen; or C1-C5alkyl. These compounds are suitable as light stabilizers in cosmetic, pharmaceutical and veterinary formulations.
摘要翻译：给出了二烷基化合物的描述，R是樟脑或乙内酰脲衍生物; 并且R 1是氢; 或C1-C5烷基。这些化合物在化妆品，药物和兽药制剂中适合作为光稳定剂。

2. 发明授权

US06201000B1 Use of selected benzotriazole derivatives for protecting human and animal skin and hair from the harmful effects of UV radiation 失效
标题翻译：使用选择的苯并三唑衍生物保护人体和动物皮肤和头发免受紫外线辐射的有害影响
公开(公告)号：US06201000B1
公开(公告)日：2001-03-13
申请号：US09308423
申请日：1999-05-18
申请人： Helmut Luther , Dieter Reinehr , Rudolf Zink
发明人： Helmut Luther , Dieter Reinehr , Rudolf Zink
IPC分类号： A61K3141
CPC分类号： C07D249/20 , A61K8/49 , A61K8/496 , A61K8/69 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/08 , A61Q5/10 , A61Q17/04
摘要： The invention is related to a composition containing benzotriazole derivatives of formula (I) and the method of treating skin damages due to harmful UV radiation using this claimed composition.
摘要翻译：本发明涉及包含式（I）的苯并三唑衍生物的组合物和使用所要求保护的组合物治疗由于有害的紫外线辐射引起的皮肤损伤的方法。

3. 发明授权

US06596907B1 Process for the preparation of 4,4′-dihalogen-o-hydroxydiphenyl compounds 失效
标题翻译：制备4,4'-二卤代-O-羟基二苯基化合物的方法
公开(公告)号：US06596907B1
公开(公告)日：2003-07-22
申请号：US09806668
申请日：2001-04-03
申请人： Armando Di Teodoro , Werner Hölzl , Dieter Reinehr , Rudolf Zink
发明人： Armando Di Teodoro , Werner Hölzl , Dieter Reinehr , Rudolf Zink
IPC分类号： C07C4100
CPC分类号： C07C41/16 , C07C41/22 , C07C41/26 , C07C43/23 , C07C43/29 , C07C43/295
摘要： A description is given of a three-step process for the preparation of 4,4′-dihalogen-o-hydroxydiphenyl compounds of formula (1) which comprises: a) hologenating an alkoxyphenol of formula (6) (=a1), reacting the resulting halogenated phenol compound of formula (5) with p-dihalobenzene of formula (4a) in the presence of copper and/or copper salts to the diphenyl ether compound of formula (2) (=a2) and subsequent ether fission to the diphenyl ether compound of formula (1) (=a3); or b) reacting an alkoxyphenol of formula (6) with the halophenol of formula (4b) to the compound of formula (3) (=b1), then halogenating this compound (=b2) and subsequent ether fission of the resulting compound of formula (2) to the diphenyl ether compound of formula (1) (=b3). The compounds of formula (1) are used for protecting organic materials and objects against microorganisms.
摘要翻译：给出了制备式（1）的4,4'-二卤代邻羟基二苯基化合物的三步法，其包括：a）使式（6）的烷氧基酚（= a1）氢化，使得到式（5）的卤代酚化合物与式（4a）的对二卤苯在铜和/或铜盐存在下与式（2）（= a2）的二苯基醚化合物反应，随后醚裂解成二苯基醚式（1）化合物（= a3）; 或b）使式（6）的烷氧基酚与式（4b）的卤代酚反应到式（3）的化合物（= b1），然后将该化合物（= b2）卤化，随后将所得的式（2）到式（1）的二苯醚化合物（= b3）。式（1）化合物用于保护有机材料和物体免受微生物侵害。

4. 发明授权

US06215029B1 Process for the preparation of halogenated hydroxydiphenyl compounds 有权
标题翻译：卤代羟基二苯基化合物的制备方法
公开(公告)号：US06215029B1
公开(公告)日：2001-04-10
申请号：US09328744
申请日：1999-06-09
申请人： Urs Burckhardt , Armando Di Teodoro , Werner Hölzl , Dieter Reinehr , Rudolf Zink , Hanspeter Sauter , Uwe Gronde
发明人： Urs Burckhardt , Armando Di Teodoro , Werner Hölzl , Dieter Reinehr , Rudolf Zink , Hanspeter Sauter , Uwe Gronde
IPC分类号： C07C4101
CPC分类号： C07C43/295 , C07C49/84 , C07C67/42 , C07C69/017 , C07C69/65 , C07C69/63
摘要： A process for the preparation of halohydroxydiphenyl compounds useful for protecting organic materials and articles from microorganisms, of the formula by acylation of a halogenated benzene compound (first stage), etherification of the acylated compound with a halogenated phenol compound (second stage), oxidation of the etherified compound (third stage) and hydrolysis of the oxidized compound in a fourth stage, according to the following reaction scheme: in which R1 and R2 independently of one another are F, Cl or Br; R3 and R4 independently of one another are hydrogen; or C1-C4alkyl; m is 1 to 3; and n is 1 or 2.
摘要翻译：用于制备用于保护有机材料和制品免受微生物的卤代羟基联苯化合物的制备方法，卤化苯化合物的制备酰化（第一阶段），酰化化合物与卤化酚化合物的醚化（第二阶段）根据以下反应方案，第四阶段的醚化化合物（第三阶段）和氧化化合物的水解：其中R1和R2彼此独立地为F，Cl或Br; R 3和R 4彼此独立地是氢; 或C 1 -C 4烷基; m为1〜3; n为1或2。

5. 发明授权

US06835329B2 Heteroaryl substituted hydroxyphenyltriazine uv-absorbers 失效
标题翻译：杂芳基取代的羟基苯基三嗪紫外线吸收剂
公开(公告)号：US06835329B2
公开(公告)日：2004-12-28
申请号：US10398040
申请日：2003-03-31
申请人： Dieter Reinehr , Hanspeter Sauter , Rudolf Zink
发明人： Dieter Reinehr , Hanspeter Sauter , Rudolf Zink
IPC分类号： C07D25124
CPC分类号： C07D403/10 , A61K8/4966 , A61Q17/04 , C07D413/10 , C08K5/3492
摘要： The present invention provides compounds having the formula (1) in which each of the radicals R1, R2, R3 and R4, independently, represent hydrogen, hydroxy, halogen, C1-C20-alkyl, C1-C20-alkoxy, CN or COOR5, in which R5 is C1-C20-alkyl and Z represents a heterocyclic residue selected from the 2H-benzo[1,2-d]triazol-2-yl, 2H-naphtho[1,2-d]triazol-2-yl, benzimidazol-2-yl, benzoxazol-2-yl and benzofuran-2-yl moieties, optionally substituted by C1-C4-alkyl, C1-C4-alkoxy, halogen or NHCOC1-C4-alkyl, a process for their preparation, new intermediate benzoxazinones useful for their preparation and use of the compounds of formula (1) as UV-absorbers which have improved absorption spectrum characteristics, superior resistance to exposure to UV light and excellent thermal stability, relative to known triphenyltriazine compounds.
摘要翻译：本发明提供具有式（1）的化合物，其中每个基团R 1，R 2，R 3和R 4独立地代表氢，羟基，卤素，C 1 -C 20 - 烷基，C 1 -C 20 - 烷氧基，CN或COOR 5，其中R 5是C 1 -C 20 - 烷基，Z代表选自2H-苯并[1,2-d]三唑-2-基，2H-萘并[1,2-d]三唑-2-基的杂环残基，苯并恶唑-2-基和苯并呋喃-2-基部分，任选被C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，卤素或NHCOC 1 -C 4 - 烷基取代，其制备方法，新中间体苯并恶嗪酮可用于制备和使用式（1）化合物作为UV吸收剂，其相对于已知的三苯基三嗪化合物具有改进的吸收光谱特征，优异的耐紫外线性和耐热稳定性。

6. 发明授权

US06706930B2 Process for the preparation of halogenated hydroxydiphenyl compounds 失效
标题翻译：卤代羟基二苯基化合物的制备方法
公开(公告)号：US06706930B2
公开(公告)日：2004-03-16
申请号：US10275022
申请日：2002-10-31
申请人： Armando Di Teodoro , Werner Hölzl , Dieter Reinehr , Rudolf Zink
发明人： Armando Di Teodoro , Werner Hölzl , Dieter Reinehr , Rudolf Zink
IPC分类号： C07C4100
CPC分类号： C07C45/46 , C07C41/26 , C07C45/71 , C07C49/807 , C07C49/84 , C07C43/295
摘要： There is described a process for the preparation of halogenated hydroxydiphenyl compounds of formula (1) by acylation of a halogenated benzene compound (first stage), etherification of the acylated compound with a halogenated phenol compound, which is not further substituted in the ortho-position (second stage), oxidation of the etherified compound (third stage) and hydrolysis of the oxidized compound in a fourth stage, wherein the reaction of the second stage is carried out in the presence of K2CO3 and any desired copper catalyst, where K2CO3 is used in a concentration of from 0.5 to 30 mol, based on the phenol compound employed of formula (6), according to the reaction scheme (I) in which R1 and R2 independently of one another are F, Cl or Br; R3 and R4 independently of one another are hydrogen; or C1-C4alkyl; m is 1 to 3; and n is 1 or 2. The compounds of formula (1) are used for protecting organic materials and articles from microorganisms.
摘要翻译：描述了通过酰化卤化苯化合物（第一阶段）制备式（1）的卤代羟基二苯基化合物的方法，酰化化合物与卤代酚化合物的醚化，其在邻位未被进一步取代（第二阶段），醚化化合物的氧化（第三阶段）和氧化化合物在第四阶段的水解，其中第二阶段的反应在K 2 CO 3和任何所需的铜催化剂存在下进行，其中使用K 2 CO 3 根据反应式（I），其中R 1和R 2彼此独立地为F，Cl或Br，其浓度为0.5至30mol，基于式（6）所用的酚化合物; R 3和R 4彼此独立地是氢; 或C 1 -C 4烷基; m为1〜3; 并且n为1或2.式（1）化合物用于保护有机材料和制品免受微生物侵害。

7. 发明授权

US06800762B2 Indolin derivaties as sun protection agents 失效
标题翻译：吲哚衍生物作为防晒剂
公开(公告)号：US06800762B2
公开(公告)日：2004-10-05
申请号：US10055664
申请日：2002-01-23
申请人： Rudolf Zink , Helmut Luther
发明人： Rudolf Zink , Helmut Luther
IPC分类号： C07D20900
CPC分类号： C07D403/04 , A61K8/492 , A61K8/4966 , A61Q17/04 , C07D209/12 , C07D209/14 , C07D209/24
摘要： There is described the use of indoline derivatives of formula wherein R1 is hydrogen; C1-C5alkyl; C1-C18alkoxy; or halogen; R2 is C1-C8alkyl; C5-C7cycloalkyl; C6-C10aryl; R3 is C1-C18alkyl or a radical of formula (1a) R4 is hydrogen; or a radical of formula R5 is C1-C18alkoxy; or a radical of formula R6 and R7 are each independently of the other hydrogen; or C1-C5alkyl; R8 is hydrogen; C1-C5alkyl; C5-C7cycloalkyl; phenyl; phenyl-C1-C3alkyl; R9 is C1-C18alkyl; X is halogen; a radical of formula (1c) and n is 0; or 1, as light-protective agents.
摘要翻译：描述了使用二氢吲哚衍生物的方法，其中R1是氢; C1-C5烷基; C1-C18烷氧基; 或卤素; R 2为C 1 -C 8烷基; C5-C7环烷基; C 6 -C 10芳基; R 3是C 1 -C 18烷基或式（1a）的基团R 4是氢; 或式R 5的基团是C 1 -C 18烷氧基; 或式R6和R7的基团各自独立地为氢; 或C 1 -C 5烷基; R 8是氢; C1-C5烷基; C5-C7环烷基; 苯基; 苯基-C 1 -C 3烷基; R 9为C 1 -C 18烷基; X为卤素; 式（1c）和n的基团为0; 或1，作为防光剂。

8. 发明授权

US06358496B1 Indolin derivatives as sun protection agents 失效
标题翻译：吲哚衍生物作为防晒剂
公开(公告)号：US06358496B1
公开(公告)日：2002-03-19
申请号：US09806349
申请日：2001-03-29
申请人： Rudolf Zink , Helmut Luther
发明人： Rudolf Zink , Helmut Luther
IPC分类号： A61K742
CPC分类号： C07D403/04 , A61K8/492 , A61K8/4966 , A61Q17/04 , C07D209/12 , C07D209/14 , C07D209/24
摘要： There is described the use of indoline derivatives of formula wherein R1 is hydrogen; C1-C5alkyl; C1-C18alkoxy; or halogen; R2 is C1-C8alkyl; C5-C7cycloalkyl; C6-C10aryl; R3 is C1-C18alkyl or a radical of formula R4 is hydrogen; or a radical of formula R5 is C1-C18alkoxy; or a radical of formula R6 and R7 are each independently of the other hydrogen; or C1-C5alkyl; R8 is hydrogen; C1-C5alkyl; C5-C7cycloalkyl; phenyl; phenyl-C1-C3alkyl; R9 is C1-C18alkyl; X is halogen; a radical of formula n is 0; or 1, as light-protective agents.
摘要翻译：描述了使用二氢吲哚衍生物的方法，其中R1是氢; C1-C5烷基; C1-C18烷氧基; 或卤素; R 2为C 1 -C 8烷基; C5-C7环烷基; C 6 -C 10芳基; R 3是C 1 -C 18烷基或式R4的基团是氢; 或式R 5的基团是C 1 -C 18烷氧基; 或式R6和R7的基团各自独立地为氢; 或C 1 -C 5烷基; R 8是氢; C1-C5烷基; C5-C7环烷基; 苯基; 苯基-C 1 -C 3烷基; R 9为C 1 -C 18烷基; X为卤素; 一个民族主义者是0; 或1，作为防光剂。

9. 发明授权

US5468855A Bislactones 失效
标题翻译：双内酯
公开(公告)号：US5468855A
公开(公告)日：1995-11-21
申请号：US298899
申请日：1994-08-31
申请人： Rudolf Zink
发明人： Rudolf Zink
IPC分类号： B41M5/145 , B41M5/327 , C07D493/10 , C07D519/00 , C07D417/00 , C07D307/83 , C07D405/00
CPC分类号： B41M5/1455 , B41M5/3275 , C07D493/10
摘要： The invention relates to bislactone color formers having improved fastness to sublimation and migration stability, to their preparation, to pressure-sensitive and heat-sensitive recording materials containing said compounds and to their preparation. The novel bislactones have the formula (1) as defined in claim 1.
摘要翻译：本发明涉及具有改善的升华牢度和迁移稳定性的双内酯成色剂，其制备方法涉及含有所述化合物的压敏和热敏记录材料及其制备。新颖的双内酯具有如权利要求1所定义的式（1）。

10. 发明授权

US5162550A Bisphthalide lactones, their preparation and the use thereof in recording materials 失效
标题翻译：二硫化IDE ES，S S S S S S S S S S S S S S S S S S S S S
公开(公告)号：US5162550A
公开(公告)日：1992-11-10
申请号：US572929
申请日：1990-08-24
申请人： Rudolf Zink , Ian J. Fletcher
发明人： Rudolf Zink , Ian J. Fletcher
IPC分类号： B41M5/145 , B41M5/327 , C07D493/20 , C09B11/00 , C09B11/26
CPC分类号： C07D493/20 , B41M5/145 , B41M5/327
摘要： Bisphthalide lactones of formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently of one another hydrogen, alkyl of at most 12 carbon atoms which is unsubstituted or substituted by halogen, hydroxy, cyano, tetrahydrofuryl or lower alkoxy; or are acyl of 1 to 12 carbon atoms, cycloalkyl of 5 to 10 carbon atoms or unsubstituted aralkyl or aryl, or aralkyl or aryl each substituted by halogen, cyano, nitro, trifluormethyl, lower alkyl, lower alkoxy, lower alkoxycarbonyl, --NX'X"-- or 4--NX'X--"phenylamino, wherein X' and X" are each independently of the other hydrogen, lower alkyl, cyclohexyl, benzyl or phenyl, or the pairs of substituents --NR.sub.1 R.sub.2 and --NR.sub.3 R.sub.4 are each a 5- or 6-membered, preferably saturated, heterocyclic radical, V.sub.1 and V.sub.2 are hydrogen, halogen, lower alkyl, C.sub.1 -C.sub.12 alkoxy, C.sub.1 -C.sub.12 -acyloxy, benzyl, phenyl, benzyloxy, phenyloxy, or benzyl or benzyloxy, each substituted by halogen, cyano, lower alkyl or lower alkoxy, or are the group --NT.sub.1 T.sub.2, in which T.sub.1 and T.sub.2 are each independently of the other hydrogen, lower alkyl, C.sub.5 -C.sub.10 cycloalkyl, unsubstituted benzyl or benzyl which is substituted by halogen, cyano, lower alkyl or lower alkoxy, or are acyl of 1 to 8 carbon atoms, and T.sub.1 is also unsubstituted phenyl or phenyl which is substituted by halogen, cyano, lower alkyl or lower alkoxy, and the rings A.sub.1 and A.sub.2 are each independently of the other an aromatic or heterocyclic radical of 6 ring atoms which may contain an aromatic fused ring, which rings A.sub.1 and A.sub.2 as well as the fused rings may be substituted.These bisphthalide lactones can be used as color forming components in pressure-sensitive or heat-sensitive recording materials and, when used in conjunction with a condensation component and an acid developer, form intense colored images.
摘要翻译：式（1）的双苯二酮内酯，其中R 1，R 2，R 3和R 4各自独立地为氢，至多12个碳原子的烷基，其未被取代或被卤素，羟基，氰基，四氢呋喃基或低级烷氧基取代; 或者是具有1至12个碳原子的酰基，5至10个碳原子的环烷基或未取代的芳烷基或芳基，或各自被卤素，氰基，硝基，三氟甲基，低级烷基，低级烷氧基，低级烷氧基羰基，-NX' X“ - 或4-NX'X - ”苯基氨基，其中X'和X“各自独立于另一个氢，低级烷基，环己基，苄基或苯基，或取代基-NR1R2和-NR3R4的对是每个5-或6-元，优选饱和的杂环基，V1和V2是氢，卤素，低级烷基，C1-C12烷氧基，C1-C12-酰氧基，苄基，苯基，苄氧基，苯氧基或苄基或苄氧基，被卤素，氰基，低级烷基或低级烷氧基取代，或是-NT1T2基团，其中T1和T2各自独立地为氢，低级烷基，C5-C10环烷基，未取代的苄基或被卤素取代的苄基，氰基，低级烷基或低级烷氧基，或为1至8个碳原子的酰基，且T1也为未取代的苯基或苯基其被卤素，氰基，低级烷基或低级烷氧基取代，并且环A1和A2各自独立地为可以含有芳环的芳环或芳环稠合环的芳环或杂环基，其也环A1和A2 因为稠环可以被取代。这些双苯酞内酯可用作压敏或热敏记录材料中的成色组分，并且当与缩合组分和酸显影剂结合使用时，形成强烈的彩色图像。

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