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1. 发明授权

US5245058A Preparation of 1-nitroanthraquinone-2-carboxylic acids 失效
标题翻译： 1-硝基喹啉-2-羧酸的制备
公开(公告)号：US5245058A
公开(公告)日：1993-09-14
申请号：US936211
申请日：1992-08-27
申请人： Helmut Hagen , Jacques Dupuis , Michael Acker , Udo Bergmann
发明人： Helmut Hagen , Jacques Dupuis , Michael Acker , Udo Bergmann
IPC分类号： C07C201/12 , C07C205/61
CPC分类号： C07C201/12
摘要： 1-Nitroanthraquinone-2-carboxylic acids of the general formula I ##STR1## where X is hydrogen, chlorine or bromine, are prepared by oxidizing a 1-nitro-2-methylanthraquinone of the general formula II ##STR2## with nitric acid in an organic reaction medium.
摘要翻译：通过用硝酸氧化通式II II的1-硝基-2-甲基蒽醌制备通式I的1-硝基蒽醌-2-羧酸，其中X是氢，氯或溴，在有机反应介质中。

2. 发明授权

US5196573A Process for the preparation of sulfonated anthranilic acids 失效
标题翻译：磺化邻氨基苯甲酸的制备方法
公开(公告)号：US5196573A
公开(公告)日：1993-03-23
申请号：US888444
申请日：1992-05-28
申请人： Manfred Patsch , Klaus Pandl , Jacques Dupuis , Helmut Hagen
发明人： Manfred Patsch , Klaus Pandl , Jacques Dupuis , Helmut Hagen
IPC分类号： C07C309/46 , C07C309/48
CPC分类号： C07C309/48 , C07C309/46
摘要： A process for the preparation of 4-sulfonated anthranilic acids by sulfonation of ortho-nitrotoluenes with chlorosulfonic acid or oleum followed by oxidation of the methyl group and, finally, reduction of the nitro group.
摘要翻译：通过用氯磺酸或发烟硫酸磺化邻 - 硝基甲苯，然后氧化甲基，最后还原硝基来制备4-磺化邻氨基苯甲酸的方法。

3. 发明授权

US5130434A Preparation of 3-methylquinoline-8-carboxylic acid 失效
标题翻译： 3-甲基喹啉-8-羧酸的制备
公开(公告)号：US5130434A
公开(公告)日：1992-07-14
申请号：US571232
申请日：1990-08-23
申请人： Helmut Hagen , Jacques Dupuis , Karlheinz Arbogast
发明人： Helmut Hagen , Jacques Dupuis , Karlheinz Arbogast
IPC分类号： C07D215/48
CPC分类号： C07D215/48
摘要： 3-Methylquinoline-8-carboxylic acid I ##STR1## and derivatives thereof are prepared by reacting o-toluidine II or a derivative thereof ##STR2## with methacrolein II ##STR3## in 70-90% strength by weight sulfuric acid in the presence of iodine or of an iodine compound, and oxidizing the resulting 3,8-dimethylquinoline IV or a derivative thereof ##STR4## with nitric acid in a solution containing sulfuric acid, in the presence of vanadium ions, by a process in which, in the sulfuric acid-containing reaction solution of the 3,8-dimethylquinoline IV, the byproducts of the reaction are first decomposed by oxidation, the resulting 3,8-dimethylquinoline solution is concentrated by distillation and the 3,8-dimethylquinoline is then oxidized in situ with nitric acid to give the 3-methylquinoline-carboxylic acid.
摘要翻译： 3-甲基喹啉-8-羧酸I I及其衍生物通过邻甲苯胺II或其衍生物II与甲基丙烯醛II III在70-90％重量比的硫酸中反应制备碘或碘化合物的存在，并且在钒离子存在下，通过硝酸在含硫酸溶液中氧化得到的3,8-二甲基喹啉IV或其衍生物IV，其中在3,8-二甲基喹啉IV的含硫酸的反应溶液中，首先通过氧化分解反应的副产物，然后通过蒸馏浓缩所得的3,8-二甲基喹啉溶液，然后将3,8-二甲基喹啉用硝酸原位氧化得到3-甲基喹啉羧酸。

4. 发明授权

US5006659A Preparation of 7-chloroquinoline-8-carboxylic acids 失效
标题翻译： 7-氯喹啉-8-羧酸的制备
公开(公告)号：US5006659A
公开(公告)日：1991-04-09
申请号：US464568
申请日：1990-01-16
申请人： Helmut Hagen , Jacques Dupuis , Heinz Eilingsfeld
发明人： Helmut Hagen , Jacques Dupuis , Heinz Eilingsfeld
IPC分类号： C07D215/48
CPC分类号： C07D215/48
摘要： 7-Chloroquinoline-8-carboxylic acids of the formula (I) ##STR1## where R is hydrogen, chlorine or methyl, are prepared by direct oxidation of the corresponding 8-methylqunoline compound with nitric acid or nitrogen oxide in the presence of sulfuric acid and a heavy metal catalyst.
摘要翻译：存在式（I）的7-氯喹啉-8-羧酸，其中R是氢，氯或甲基，是通过在硝基或氮氧化物存在下直接氧化相应的8-甲基均聚物化合物的硫酸和重金属催化剂。

5. 发明授权

US5198575A Preparation of nitrobenzoic and anthranilic acids 失效
标题翻译：硝基苯甲酸和壬二酸的制备
公开(公告)号：US5198575A
公开(公告)日：1993-03-30
申请号：US912196
申请日：1992-07-13
申请人： Helmut Hagen , Jacques Dupuis
发明人： Helmut Hagen , Jacques Dupuis
IPC分类号： B01J23/22 , B01J27/053 , C07B61/00 , C07C201/12 , C07C205/57 , C07C205/58 , C07C227/04 , C07C227/06 , C07C227/12 , C07C229/56 , C07C229/60
CPC分类号： C07C201/12 , C07C227/04
摘要： Nitrobenzoic acids I ##STR1## (X.sup.1, X.sup.2 =fluorine, chlorine, bromine, hydrogen or nitro) are prepared by oxidizing the corresponding nitrotoluene II ##STR2## with nitric acid in the presence of sulfuric acid and vanadium(V) compounds, and anthranilic acids III ##STR3## (Y.sup.1, Y.sup.2 =fluorine, chlorine, bromine, hydrogen or amino) are prepared from the nitrobenzoic acids I by reduction.
摘要翻译：通过在硫酸和钒（V）化合物的存在下用硝酸氧化相应的硝基甲苯II II，制备硝基苯甲酸I（X 1，X 2 =氟，氯，溴，氢或硝基）并且通过还原由硝基苯甲酸I制备邻氨基苯甲酸III（Y1，Y2 =氟，氯，溴，氢或氨基）。

6. 发明授权

US4957608A Preparation of 8-bromomethyl-3-methylquinoline compounds 失效
标题翻译： 8-溴甲基-3-甲基喹啉化合物的制备
公开(公告)号：US4957608A
公开(公告)日：1990-09-18
申请号：US361504
申请日：1989-06-05
申请人： Helmut Hagen , Rolf-Dieter Kohler , Jacques Dupuis
发明人： Helmut Hagen , Rolf-Dieter Kohler , Jacques Dupuis
IPC分类号： B01J23/34 , C07B61/00 , C07D215/18 , C07D215/48
CPC分类号： C07D215/48 , C07D215/18
摘要： A process for the preparation of 8-bromomethyl-3-methylquinoline compounds of the formula I ##STR1## where one or both substituents X are chlorine and, where relevant, the other substituent X is hydrogen, by bromination of the corresponding 8-methylquinoline compound in the presence of a 2-phase mixture of a solvent stable to bromination and of, preferably, buffered water.

7. 发明授权

US4845226A Preparation of 8-bromomethyl-3-methylquinoline compounds 失效
标题翻译： 8-溴甲基-3-甲基喹啉化合物的制备
公开(公告)号：US4845226A
公开(公告)日：1989-07-04
申请号：US146691
申请日：1988-01-21
申请人： Helmut Hagen , Rolf-Dieter Kohler , Jacques Dupuis
发明人： Helmut Hagen , Rolf-Dieter Kohler , Jacques Dupuis
IPC分类号： B01J23/34 , C07B61/00 , C07D215/18 , C07D215/48
CPC分类号： C07D215/48 , C07D215/18
摘要： A process for the preparation of 8-bromomethyl-3-methylquinoline compounds of the formula I ##STR1## where one of both substituents X are chlorine and, where relevant, the other substituent X is hydrogen, by bromination of the corresponding 8-methylquinoline compound in the presence of a 2-phase mixture of a solvent stable to bromination and of, preferably, buffered water.
摘要翻译：制备式I的8-溴甲基-3-甲基喹啉化合物的方法，其中两个取代基X中的一个是氯，并且相关的另一取代基X是氢，通过溴化相应的8-甲基喹啉在稳定于溴化的溶剂和优选缓冲水的2相混合物存在下进行化合物。

8. 发明授权

US06670482B2 Process and novel intermediates for preparing isoxazolin-3-ylacyl benzenes 有权
标题翻译：制备异恶唑啉-3-基酰基苯的方法和新型中间体
公开(公告)号：US06670482B2
公开(公告)日：2003-12-30
申请号：US10223019
申请日：2002-08-19
申请人： Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Misslitz , Ernst Baumann
发明人： Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Misslitz , Ernst Baumann
IPC分类号： C07D26104
CPC分类号： C07D413/10 , C07C251/48 , C07C319/14 , C07D261/04 , C07D261/08 , C07C323/09
摘要： The present invention describes a process for preparing isoxazoles of the formula I where: R1 is hydrogen, C1-C6-alkyl, R2 is hydrogen, C1-C6-alkyl, R3, R4, R5 are each hydrogen, C1-C6-alkyl or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are each as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Furthermore, the invention describes novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates.
摘要翻译：本发明描述了制备式I的异恶唑的方法，其中R 1是氢，C 1 -C 6烷基，R 2是氢，C 1 -C 6烷基，R 3，R 4， R 5各自为氢，C 1 -C 6 - 烷基或R 4和R 5一起形成键，R 6为杂环，n为0,1或2;其包括制备中间体其中R 1，R 3，R 4和R 5各自如上所定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。此外，本发明描述了制备式I化合物的新型中间体和制备中间体的新方法。

9. 发明授权

US06548677B1 Method of producing 2-alkyl-3-(4,5-dihydroisoxazole-3-yl)-halobenzenes 有权
标题翻译： 2-烷基-3-（4,5-二氢异恶唑-3-基） - 卤代苯的制备方法
公开(公告)号：US06548677B1
公开(公告)日：2003-04-15
申请号：US09856037
申请日：2001-05-17
申请人： Michael Rack , Norbert Götz , Helmut Hagen , Wolfgang von Deyn , Ernst Baumann , Rene Lochtman , Joachim Gebhardt
发明人： Michael Rack , Norbert Götz , Helmut Hagen , Wolfgang von Deyn , Ernst Baumann , Rene Lochtman , Joachim Gebhardt
IPC分类号： C07D26118
CPC分类号： C07D261/04
摘要： A novel process for preparing the compounds of the formula I where: n is 0, 1 or 2; R1, R2 are C1-C6-alkyl; R3, R4, R5 are hydrogen or C1-C6-alkyl, or R4 and R5 together form a bond; R6 is Cl, Br, which comprises a synthesis sequence starting from 1,2-dialkylbenzenes of the formula II with subsequent halogenation to give 3,6-dihalo-1,2-dialkylbenzenes, haloalkylation to give benzyl bromides, oxidation to give benzaldehydes, oximation, reaction with alkenes to give isoxazoles, conversion into thioethers and, if appropriate, oxidation to give sulfenyl or sulfonyl derivatives of the formula I.
摘要翻译：一种制备式I化合物的新方法，其中n为0,1或2; R 1，R 2为C 1 -C 6 - 烷基; R 3，R 4，R 5为氢或C 1 -C 6烷基，或者R 4和R 5一起形成 R 6是Cl，Br，其包含从式II的1,2-二烷基苯开始的合成序列，随后卤化以得到3,6-二卤代-1,2-二烷基苯，卤代烷基化得到苄基溴，氧化得到苯甲醛，肟化，与烯烃的反应得到异恶唑，转化成硫醚，如果合适，氧化得到式I的磺酰基或磺酰基衍生物。

10. 发明授权

US5422335A Herbicides containing substituted 2-aminothiophenes 失效
公开(公告)号：US5422335A
公开(公告)日：1995-06-06
申请号：US70389
申请日：1993-06-07
申请人： Helmut Hagen , Gerhard Nilz , Helmut Walter , Andreas Landes
发明人： Helmut Hagen , Gerhard Nilz , Helmut Walter , Andreas Landes
IPC分类号： A01N25/32 , A01N35/06 , A01N39/02 , A01N43/10 , C07D333/38 , C07D333/68 , C07D333/70 , C07D409/04 , C07D409/12 , C07D417/12 , A01N43/12 , A01N47/24 , C07D333/54
CPC分类号： C07D409/04 , A01N25/32 , C07D333/38 , C07D333/68 , C07D409/12 , C07D417/12
摘要： A herbicidal composition containing one or more substituted 2-aminothiophenes of the formula I ##STR1## where R.sup.1 and R.sup.2 together from a C.sub.4 -alkylene chain to which a benzene ring may be fused,R.sup.3 is --CN or CX--R.sup.6, where R.sup.6 is hydroxyl, C.sub.1 -C.sub.4 -alkoxy or amino,R.sup.4 is hydrogen or a phenyl group which may carry one or two nitro radicals,--PO(OR.sup.8).sub.2, --CX--R.sup.9, --SO.sub.2 R.sup.10, --CX--N(H) --CO--R.sup.8 or --CX--N(R.sup.7)--SO.sub.2 --R.sup.11,whereR.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or phenyl groupR.sup.9 is C.sub.1 -C.sub.20 -alkyl, partially or completely halogenated C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.6 -cycloalkyl, or amino, C.sub.1 -C.sub.4 -alkylamino, C.sub.3 -C.sub.8 -cycloalkylamino, phenyl or phenylamino, where the aromatic moiety may carry at least one of nitro and halogen;R.sup.10 is C.sub.1 -C.sub.4 -alkyl or phenyl, which may carry one C.sub.1 -C.sub.4 -alkyl radical;R.sup.11 is pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or piperazin-1-yl, where the heterocyclic structures may carry one C.sub.1 -C.sub.4 -group;R.sup.5 is hydrogen;orR.sup.4 and R.sup.5 together form a group .dbd.CR.sup.12 R.sup.13 or --CO--W--CO--, where R.sup.12 is hydrogen, amino, C.sub.1 -C.sub.4 -alkylamino or C.sub.3 -C.sub.8 -cycloalkylamino;R.sup.13 is amino, C.sub.3 -C.sub.8 -cycloalkylamino, phenyl or pyridyl, where the two last mentioned substituents may carry at least one halogen or nitro radicals;W is an ethylene or ethenylene bridge, or a 6-membered 1,2-C-bonded aromatic bridge where these bridge members may carry, on each substitutable carbon atom, at least one halogena 5-membered or 6-membered 1,2-C-bonded cycloalkylene or cycloalkenylene bridge,and the basic salts of the compounds I in which R.sup.3 is hydroxycarbonyl or hydroxythiocarbonyl, and the acidic salts of the compounds I which contain a basic nitrogen atom, as antagonistic compoundsand one or more herbicidal active ingredients from the group consisting ofthe cyclohexenone derivatives of the formula III ##STR2##

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