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1. 发明申请

US20050032875A1 Process for the preparation of indole derivatives 审中-公开
标题翻译：吲哚衍生物的制备方法
公开(公告)号：US20050032875A1
公开(公告)日：2005-02-10
申请号：US10487269
申请日：2002-08-13
申请人： Heinz Wolleb , Annemarie Wolleb , Paul Van Der Schaaf , Roman Kolly , Nicole End
发明人： Heinz Wolleb , Annemarie Wolleb , Paul Van Der Schaaf , Roman Kolly , Nicole End
IPC分类号： C07D209/12 , B01J31/18 , B01J31/24 , C07D209/24 , C07D319/06 , C07D405/06 , C07F5/02 , A61K31/405
CPC分类号： C07D405/06 , C07D209/24 , C07D319/06 , C07F5/025 , Y02P20/55
摘要： A process for the preparation of compounds of formula (I) wherein R1 is unsubstituted or substituted C1-C8alkyl, R2, R3, R4 and R5 are each independently of the others hydrogen, unsubstituted or substituted C1-C8alkyl, C1-C8 alkoxy, phenoxy or benzyloxy, or halogen, Y1 and Y2 are each independently of the other hydrogen or a protecting group, or Y1 and Y2 together form a protecting bridge, and X1 is hydrogen, an organic radical or a cation, in which process a compound of formula (II) wherein R1 R2, R3, R4 and R5 are as defined above and Z1 is a leaving group, is reacted, in the presence of a catalytically effective amount of a palladium catalyst, with a compound of formula (III) wherein R6 is hydrogen, bromine, chlorine, iodine, —OSO2CF3, —COCI, —B(OH)2 or a mono- or di-ester derived from —B(OH)2, Y3 and Y4 are each a protecting group, or Y3 and Y4 together form a protecting bridge, and X1 is as defined above, to form a compound of formula (IV) and if desired the radicals Y3 and Y4 are converted into the radicals Y1 and Y2 where Y1 and Y2 are hydrogen.
摘要翻译：制备其中R 1为未取代或取代的C 1 -C 8烷基，R 2，R 3，R 4和R 5的式（I）化合物的方法各自独立地为氢，未取代或取代的C 1 -C 8烷基，C 1 -C 8烷氧基，苯氧基或苄氧基或卤素，Y1和Y2各自独立地为另一个氢或保护基，或Y1和Y2一起形成保护桥，并且X 1是氢，有机基团或阳离子，其中式（II）其中R1 R2，R3，R4和R5如上定义，Z1是离去基团，在催化有效量的钯催化剂存在下，与式（III）化合物反应，其中R 6是氢，溴，氯，碘，-OSO 2 CF 3，-COCI，-B（OH）2或衍生自-B（OH）2，Y 3和Y 4的单酯或二酯各自为保护基，或Y 3和Y 4 一起形成保护桥，X1如上所定义，形成式（IV）的化合物，如果需要，基团Y 3和Y 4是转化为Y1和Y2基团，其中Y1和Y2是氢。

2. 发明授权

US5912376A Process for the preparation of catalysts 失效
标题翻译：制备催化剂的方法
公开(公告)号：US5912376A
公开(公告)日：1999-06-15
申请号：US958680
申请日：1997-10-27
申请人： Paul Adriaan Van Der Schaaf , Roman Kolly , Andreas Hafner , Andreas Muhlebach
发明人： Paul Adriaan Van Der Schaaf , Roman Kolly , Andreas Hafner , Andreas Muhlebach
IPC分类号： B01J31/24 , C07F15/00 , C07F9/02
CPC分类号： C07F15/0046 , C07F15/002
摘要： A process for the preparation of a metal carbene, in which a metal salt is first reacted in the presence of a base and a secondary or tertiary alcohol with a tertiary phosphine or phosphite or a ditertiary diphosphine or diphosphite and then reacted in the presence of an acid with an alkyne and, if desired, an alkene.
摘要翻译：一种制备金属卡宾的方法，其中金属盐首先在碱和仲或叔醇的存在下与叔膦或亚磷酸酯或二次二膦或二亚磷酸酯反应，然后在酸，如果需要，可以使用烯烃。

3. 发明申请

US20090062560A1 Electroluminescent Metal Complexes With Triazoles 有权
标题翻译：电子发光金属配合物与三唑
公开(公告)号：US20090062560A1
公开(公告)日：2009-03-05
申请号：US12086646
申请日：2006-12-18
申请人： Roger Pretot , Roman Kolly , Thomas Schafer , Paul Adriaan Van Der Schaaf
发明人： Roger Pretot , Roman Kolly , Thomas Schafer , Paul Adriaan Van Der Schaaf
IPC分类号： C07F17/02
CPC分类号： C09K11/06 , C07F15/0033 , C09K2211/1059 , C09K2211/185 , H01L51/0085 , H01L51/5016 , H05B33/14
摘要： Disclosed are electroluminescent metal complexes with triazoles of the formula (I), where n1 is an integer of 1 to 3, m1 and m2 each are an integer 0, 1 or 2, M1 is a metal with an atomic weight of greater than 40, L1 is a monodentate ligand or a bidentate ligand, L2 is a monodentate ligand, Q2 stands for an organic bridging group completing, together with the bonding carbon atoms of the triazole ring, an annellated, carbocyclic or heterocyclic, non-aromatic ring, which optionally may be substituted, Q3 represents a group of forming a condensed aromatic, or heteroaromatic ring, which can optionally be substituted, as well as new intermediates for the preparation of these complexes, electronic devices comprising the metal complexes and their use in electronic devices, especially organic light emitting diodes (OLEDs), as oxygen sensitive indicators, as phosphorescent indicators in bioassays, and as catalysts.
摘要翻译：公开了具有式（I）的三唑的电致发光金属络合物，其中n1为1〜3的整数，m1和m2各自为整数0,1或2，M1为原子量大于40的金属， L1是单齿配体或二齿配体，L2是单齿配体，Q2表示完全有机桥基，连同三唑环的键合碳原子，环状的，碳环或杂环的非芳香环，其任选地可以被取代，Q3表示形成稠合芳族或可以任意被取代的杂芳环的基团，以及用于制备这些络合物的新中间体，包含金属络合物的电子器件及其在电子器件中的用途，特别是有机发光二极管（OLED）作为氧敏感指标，作为生物测定中的磷光指示剂，以及作为催化剂。

4. 发明授权

US06806386B1 Process for the preparation of ketimines 失效
标题翻译：酮亚胺的制备方法
公开(公告)号：US06806386B1
公开(公告)日：2004-10-19
申请号：US10130198
申请日：2002-05-14
申请人： Marc Thommen , Andreas Hafner , Frédëric Brunner , Hans-Jörg Kirner , Roman Kolly
发明人： Marc Thommen , Andreas Hafner , Frédëric Brunner , Hans-Jörg Kirner , Roman Kolly
IPC分类号： C07C20900
CPC分类号： C07C249/02 , C07C251/20
摘要： The present invention relates to a process for the preparation of compounds of formula (1), in which R1, R2 and R3 independently of one another are hydrogen, halogen , trifluoromethyl of or C1-C4alkoxy, wherein a compound of formula (2), in which R1, R2 and R3 are as defined in formula (1), is reacted with methlyamine in the presence of a non-alcoholic solvent and, if desired, in the presence of a sulfonic acid catalyst to give the compound of formula (2) and, if desired, is subject to purification by recrystallization.
摘要翻译：本发明涉及制备式（1）化合物的方法，其中R 1，R 2和R 3彼此独立地是氢，卤素，或C 1 -C 4烷氧基的三氟甲基，其中式（2）的化合物，其中R 1，R 2和R 3如式（1）中所定义）与甲胺在非醇溶剂存在下反应，如果需要，在磺酸催化剂的存在下反应得到式（2）的化合物），如果需要，通过重结晶进行纯化。

5. 发明授权

US06693218B1 Process for the preparation of ketimines 失效
标题翻译：酮亚胺的制备方法
公开(公告)号：US06693218B1
公开(公告)日：2004-02-17
申请号：US10130199
申请日：2002-09-20
申请人： Marc Thommen , Andreas Hafner , Roman Kolly , Hans-Jörg Kirner , Frédéric Brunner
发明人： Marc Thommen , Andreas Hafner , Roman Kolly , Hans-Jörg Kirner , Frédéric Brunner
IPC分类号： C07C24902
CPC分类号： C07C249/02 , C07C251/20
摘要： Described is a process for the preparation of compounds of formula (1a) which comprises reacting an isomeric mixture consisting of from 75 to 95% of compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, to form a sertraline-imine isomeric mixture consisting of from 75 to 95% of formula (1a) and from 5 to 25% of formula (1b)(A1), or reacting an isomeric mixture consisting of from 75 to 95% of a compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, using suitable methods of isolation to form an enriched sertraline-imine isomeric mixture, consisting of >99% of a compound of formula (1a) and
摘要翻译：描述了制备式（1a）化合物的方法，其包括将由75至95％的式（2a）化合物和5至25％的式（2b）化合物组成的异构体混合物与甲胺在合适的溶剂中形成由75至95％的式（1a）和5至25％的式（1b）（A1）组成的舍曲林 - 亚胺异构体混合物，或将由75 至95％的式（2a）化合物和5至25％的式（2b）化合物与甲胺在合适的溶剂中，使用合适的分离方法形成富集的舍曲林 - 亚胺异构体混合物，其由 > 99％的式（1a）化合物和<1％式（1b）化合物（A2）的化合物; 然后根据反应路线（A1）或（A2）得到的舍曲林 - 亚胺异构体混合物在合适的溶剂中，按照式（Ⅰ）中式（Ⅰa）中R1，R2 和R 3各自独立地为氢，卤素，三氟甲基或C 1 -C 4烷氧基，式（1b），（2a）和（2b）如说明书中所定义。

6. 发明授权

US07928242B2 Electroluminescent metal complexes with triazoles 有权
标题翻译：电致发光金属络合物与三唑
公开(公告)号：US07928242B2
公开(公告)日：2011-04-19
申请号：US12086646
申请日：2006-12-18
申请人： Roger Prétôt , Roman Kolly , Thomas Schäfer , Paul Adriaan Van Der Schaaf
发明人： Roger Prétôt , Roman Kolly , Thomas Schäfer , Paul Adriaan Van Der Schaaf
IPC分类号： C07F15/00 , C07F3/00 , B32B9/00 , H01J1/62
CPC分类号： C09K11/06 , C07F15/0033 , C09K2211/1059 , C09K2211/185 , H01L51/0085 , H01L51/5016 , H05B33/14
摘要： Disclosed are electroluminescent metal complexes with triazoles of the formula (I), where n1 is an integer of 1 to 3, m1 and m2 each are an integer 0, 1 or 2, M1 is a metal with an atomic weight of greater than 40, L1 is a monodentate ligand or a bidentate ligand, L2 is a monodentate ligand, Q2 stands for an organic bridging group completing, together with the bonding carbon atoms of the triazole ring, an annellated, carbocyclic or heterocyclic, non-aromatic ring, which optionally may be substituted, Q3 represents a group of forming a condensed aromatic, or heteroaromatic ring, which can optionally be substituted, as well as new intermediates for the preparation of these complexes, electronic devices comprising the metal complexes and their use in electronic devices, especially organic light emitting diodes (OLEDs), as oxygen sensitive indicators, as phosphorescent indicators in bioassays, and as catalysts.
摘要翻译：公开了具有式（I）的三唑的电致发光金属络合物，其中n1为1〜3的整数，m1和m2各自为整数0,1或2，M1为原子量大于40的金属， L1是单齿配体或二齿配体，L2是单齿配体，Q2表示完全有机桥基，连同三唑环的键合碳原子，环状的，碳环或杂环的非芳香环，其任选地可以被取代，Q3表示形成稠合芳族或可以任意被取代的杂芳环的基团，以及用于制备这些络合物的新中间体，包含金属络合物的电子器件及其在电子器件中的用途，特别是有机发光二极管（OLED）作为氧敏感指标，作为生物测定中的磷光指示剂，以及作为催化剂。

7. 发明授权

US06465554B1 Ruthenium and osmium carbene carbonyl catalysts 有权
标题翻译：钌和咔咔羰基催化剂
公开(公告)号：US06465554B1
公开(公告)日：2002-10-15
申请号：US09647031
申请日：2000-09-25
申请人： Paul Adriaan Van Der Schaaf , Roman Kolly , Andreas Mühlebach , Andreas Hafner
发明人： Paul Adriaan Van Der Schaaf , Roman Kolly , Andreas Mühlebach , Andreas Hafner
IPC分类号： C08K318
CPC分类号： C07F15/002 , C07F15/0046 , C08G61/06 , C08G61/08
摘要： The invention relates to compositions of hexacoordinated ruthenium and osmium carbenes with a carbonyl group as ligand and a vinyl group as substituent on the carbene group as catalysts for the photoinduced ring-opening metathesis of strained cycloolefins. It also relates to novel hexacoordinated ruthenium and osmium carbenes having a carbonyl group as ligand and a vinyl group as substituent on the carbene group, to compositions of the catalyst with cycloolefins, and to the polymerization process.
摘要翻译：本发明涉及六配位的钌和咔唑碳组合物，其中羰基作为配体，乙烯基作为卡宾的取代基，作为应变环烯烃的光诱导开环复分解的催化剂。它还涉及具有羰基作为配体和乙烯基作为卡宾基团上的取代基的新型六配位钌和咔啉，催化剂与环烯烃的组成以及聚合方法。

8. 发明授权

US06417363B1 Heterocyclyl ligand containing ruthenium and osmium catalysts 有权
标题翻译：含钌和锇催化剂的杂环配体
公开(公告)号：US06417363B1
公开(公告)日：2002-07-09
申请号：US09555308
申请日：2000-05-26
申请人： Paul Adriaan Van Der Schaaf , Andreas Mühlebach , Andreas Hafner , Roman Kolly
发明人： Paul Adriaan Van Der Schaaf , Andreas Mühlebach , Andreas Hafner , Roman Kolly
IPC分类号： B01J3124
CPC分类号： C08G61/06 , C07F15/002 , C07F15/0046
摘要： Penta- and hexa-coordinated, bridged ruthenium and osmium catalysts of the formula wherein Me is ruthenium or osmium; L1 and L2 are neutral ligands having electron donor properties; X is an anionic ligand; Y is oxygen or sulphur; A is a direct bond, C1-C4alkylene or C2-C4alkylidene; Z is a direct bond, oxygen, sulphur or the groups wherein R1 and R2 are hydrogen or hydrocarbon radicals; their preparation and their us in the synthesis of polymers, in the ring-closure metathesis of diolefins, in the cross metathesis of olefins and in the isomerisation of olefins are disclosed.
摘要翻译：锑化合物Me的五和六配位的桥联钌和锇催化剂是钌或锇; L1和L2是具有电子给体性质的中性配体; X是阴离子配体; Y是氧或硫; A是直接键，C1-C4亚烷基或C2-C4亚烷基; Z是直接键，氧，硫或其中R1和R2是氢或烃基的基团; 公开了它们在聚合物的合成，二烯烃的闭环复分解，烯烃的交叉复分解和烯烃异构化中的制备及其制备。

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