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1. 发明授权

US09051410B2 Polyurea-based fabric glue 有权
标题翻译：聚脲基织物胶
公开(公告)号：US09051410B2
公开(公告)日：2015-06-09
申请号：US13384295
申请日：2010-07-06
申请人： Heike Heckroth , Hartmut Nefzger , Christoph Eggert
发明人： Heike Heckroth , Hartmut Nefzger , Christoph Eggert
IPC分类号： C08L75/02 , C08L75/04 , C09D175/02 , C08G18/10 , A61L24/04 , C08G18/18 , C09J175/12
CPC分类号： A61L24/046 , C08G18/10 , C08G18/18 , C09J175/02 , C09J175/12 , C08G18/3821 , C08L75/04
摘要： The present invention relates to a polyurea system, the use of such a polyurea system for sealing, linking, gluing, or covering of cellular tissue, and a dosing system having two chambers for a polyurea system such as this. The polyurea system comprises as components: A) an isocyanate-functioning prepolymer, which can be derived by reacting aliphatic isocyanates with polyoles, and B) an amino-functioning ester of aspartic acid. According to the invention, water and/or tertiary amine is added to the system, in order to increase the reacting speed of the prepolymer with the amino-functioning ester of aspartic acid while decreasing the setting time at the same time.
摘要翻译：本发明涉及聚脲系统，这种聚脲体系用于密封，连接，胶合或覆盖细胞组织，以及具有用于这种聚脲系统的两个室的计量系统。聚脲体系包含如下组分：A）异氰酸酯官能的预聚物，其可以通过使脂族异氰酸酯与多元醇反应得到，和B）天冬氨酸的氨基官能化酯。根据本发明，向系统中加入水和/或叔胺，以便增加预聚物与天冬氨酸的氨基官能酯的反应速度，同时同时降低凝固时间。

2. 发明申请

US20120244107A1 BIODEGRADABLE HYDROGEL 审中-公开
标题翻译：生物可降解水凝胶
公开(公告)号：US20120244107A1
公开(公告)日：2012-09-27
申请号：US13502397
申请日：2010-10-07
申请人： Heike Heckroth , Christoph Eggert , Hartmut Nefzger , Jörg Hofmann , Edward Browne , Klaus Lorenz
发明人： Heike Heckroth , Christoph Eggert , Hartmut Nefzger , Jörg Hofmann , Edward Browne , Klaus Lorenz
IPC分类号： A61K31/785
CPC分类号： A61L31/14 , A61L31/06 , C08G18/10 , C08G18/4866 , C08G2210/00 , C08G18/3281 , C08L75/04
摘要： The present invention relates to a hydrogel on the basis of polyurethane or polyurethane urea, said hydrogel comprising hydrolysable functional groups in the polymer chain, to a method for producing the hydrogel and to the use of the hydrogel as adhesion barriers.
摘要翻译：本发明涉及基于聚氨酯或聚氨酯脲的水凝胶，所述水凝胶包括聚合物链中的可水解官能团，制备水凝胶的方法以及使用水凝胶作为粘合屏障。

3. 发明申请

US20120178847A1 POLYUREA-BASED FABRIC GLUE 有权
标题翻译：基于POLYUREA的织物玻璃
公开(公告)号：US20120178847A1
公开(公告)日：2012-07-12
申请号：US13384295
申请日：2010-07-06
申请人： Heike Heckroth , Hartmut Nefzger , Christoph Eggert
发明人： Heike Heckroth , Hartmut Nefzger , Christoph Eggert
IPC分类号： C09J175/02 , C09D175/02
CPC分类号： A61L24/046 , C08G18/10 , C08G18/18 , C09J175/02 , C09J175/12 , C08G18/3821 , C08L75/04
摘要： The present invention relates to a polyurea system, the use of such a polyurea system for sealing, linking, gluing, or covering of cellular tissue, and a dosing system having two chambers for a polyurea system such as this. The polyurea system comprises as components: A) an isocyanate-functioning prepolymer, which can be derived by reacting aliphatic isocyanates with polyoles, and B) an amino-functioning ester of aspartic acid. According to the invention, water and/or tertiary amine is added to the system, in order to increase the reacting speed of the prepolymer with the amino-functioning ester of aspartic acid while decreasing the setting time at the same time.
摘要翻译：本发明涉及聚脲系统，这种聚脲体系用于密封，连接，胶合或覆盖细胞组织，以及具有用于这种聚脲系统的两个室的计量系统。聚脲体系包含如下组分：A）异氰酸酯官能的预聚物，其可以通过使脂族异氰酸酯与多元醇反应得到，和B）天冬氨酸的氨基官能化酯。根据本发明，向系统中加入水和/或叔胺，以便增加预聚物与天冬氨酸的氨基官能酯的反应速度，同时同时降低凝固时间。

4. 发明授权

US09000089B2 Polyurea systems, processes for preparing the same and use thereof for postoperative adhesion barriers 有权
标题翻译：聚脲体系，其制备方法以及其用于术后粘连屏障的方法
公开(公告)号：US09000089B2
公开(公告)日：2015-04-07
申请号：US12370639
申请日：2009-02-13
申请人： Heike Heckroth , Hartmut Nefzger , Christian Wamprecht
发明人： Heike Heckroth , Hartmut Nefzger , Christian Wamprecht
IPC分类号： C08G18/08 , C08G69/44 , C08L75/00 , C08L77/00 , C08L83/00 , D06M15/643 , C08L79/00 , C08L73/00 , C08L67/00 , C08G63/60 , C09K3/00 , C08G18/00 , C09D4/00 , C09D201/00 , B32B27/00 , B32B27/40 , A61L15/26 , A61L31/06 , C08G18/10 , C08G18/42 , C08G18/48 , C08G18/73 , C08G18/76
CPC分类号： C08G18/3821 , A61L15/26 , A61L31/06 , A61L31/148 , A61L2430/00 , C08G18/10 , C08G18/4252 , C08G18/4841 , C08G18/485 , C08G18/73 , C08G18/7621 , Y10T428/31551 , Y10T428/31594 , C08L75/02
摘要： Polyurea systems comprising: (a) an amino-functional aspartic ester of the general formula (I) wherein X represents an n-valent organic radical derived from a corresponding n-functional primary amine X(NH2)n, R1 and R2 each independently represent an organic radical having no Zerevitinov active hydrogens and n represents an integer of at least 2; and (b) an isocyanate functional prepolymer having a residual monomer content of less than 1% by weight, the prepolymer prepared by reacting: (b1) an aliphatic isocyante; and (b2) a polyol component having a number average molecular weight of ≧400 g/mol and an average OH functionality of 2 to 6, wherein the polyol component comprises one or more constituents selected from the group consisting of polyester polyols, polyester-polyether polyols and mixtures thereof; processes for making the same; postoperative adhesions barriers prepared therewith and dispensing systems for such polyurea systems.
摘要翻译：聚脲体系包括：（a）通式（I）的氨基官能天冬氨酸酯，其中X表示衍生自相应的正官能伯胺X（NH 2）n的n价有机基团，R 1和R 2各自独立地表示没有泽列维诺夫活性氢的有机基团，n表示至少2的整数; 和（b）具有小于1重量％的残余单体含量的异氰酸酯官能预聚物，所述预聚物通过使（b1）脂族异氰酸酯反应制备; 和（b2）数均分子量≥400g/ mol，平均OH官能度为2-6的多元醇组分，其中多元醇组分包括一种或多种选自聚酯多元醇，聚酯 - 聚醚多元醇及其混合物; 制作相同的过程; 用其制备的术后粘连屏障和用于这种聚脲系统的分配系统。

5. 发明申请

US20090221071A1 Polyurea Systems, Processes for Preparing the Same and Use Thereof for Postoperative Adhesion Barriers 有权
标题翻译：聚脲系统，其制备方法及其应用于术后粘合屏障
公开(公告)号：US20090221071A1
公开(公告)日：2009-09-03
申请号：US12370639
申请日：2009-02-13
申请人： Heike Heckroth , Hartmut Nefzger , Christian Wamprecht
发明人： Heike Heckroth , Hartmut Nefzger , Christian Wamprecht
IPC分类号： C12N5/06 , C08G18/00 , C08L75/04 , C08K5/053
CPC分类号： C08G18/3821 , A61L15/26 , A61L31/06 , A61L31/148 , A61L2430/00 , C08G18/10 , C08G18/4252 , C08G18/4841 , C08G18/485 , C08G18/73 , C08G18/7621 , Y10T428/31551 , Y10T428/31594 , C08L75/02
摘要： Polyurea systems comprising: (a) an amino-functional aspartic ester of the general formula (I) wherein X represents an n-valent organic radical derived from a corresponding n-functional primary amine X(NH2)n, R1 and R2 each independently represent an organic radical having no Zerevitinov active hydrogens and n represents an integer of at least 2; and (b) an isocyanate functional prepolymer having a residual monomer content of less than 1% by weight, the prepolymer prepared by reacting: (b1) an aliphatic isocyante; and (b2) a polyol component having a number average molecular weight of ≧400 g/mol and an average OH functionality of 2 to 6, wherein the polyol component comprises one or more constituents selected from the group consisting of polyester polyols, polyester-polyether polyols and mixtures thereof; processes for making the same; postoperative adhesions barriers prepared therewith and dispensing systems for such polyurea systems.
摘要翻译：聚脲体系包括：（a）通式（I）的氨基官能天冬氨酸酯，其中X表示衍生自相应的正官能伯胺X（NH 2）n的n价有机基团，R 1和R 2各自独立地表示没有泽列维诺夫活性氢的有机基团，n表示至少2的整数; 和（b）具有小于1重量％的残余单体含量的异氰酸酯官能预聚物，所述预聚物通过使（b1）脂族异氰酸酯反应制备; 和（b2）数均分子量> = 400g / mol，平均OH官能度为2-6的多元醇组分，其中多元醇组分包括一种或多种选自聚酯多元醇，聚酯 - 聚醚多元醇及其混合物; 制作相同的过程; 用其制备的术后粘连屏障和用于这种聚脲系统的分配系统。

6. 发明授权

US09393345B2 Medical adhesive for stemming bleeding 有权
标题翻译：用于止血的医用胶粘剂
公开(公告)号：US09393345B2
公开(公告)日：2016-07-19
申请号：US14112368
申请日：2012-04-17
申请人： Heike Heckroth , Christoph Eggert
发明人： Heike Heckroth , Christoph Eggert
IPC分类号： C08G18/10 , C08G18/12 , C08G18/73 , A61L24/04 , A61L24/00
CPC分类号： A61L24/046 , A61L24/0015 , C08G18/10 , C08G18/12 , C08G18/73 , C08G18/3821 , C08L75/02
摘要： The present invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which in particular can have a number-average molecular weight of ≧400 g/mol and a mean OH functionality of from 2 to 6, as component B) an amino-functional compound of the general formula (I) in which X is an organic radical containing a secondary amino function, Y is an organic radical that contains a tertiary amino group and does not contain Zerewitinoff-active hydrogen, R1 is a CH2—COOR3 radical in which R3 is an organic radical that does not contain Zerewitinoff-active hydrogen, a linear or branched C1- to C4-alkyl radical, a cyclopentyl radical, a cyclohexyl radical or H, R2 is an organic radical that does not contain Zerewitinoff-active hydrogen, a is 1 or 2, b is 1 or 2, and a+b=2 or 3, for stemming the escape of blood, and to a metering system for the polyurea system according to the invention.
摘要翻译：本发明涉及一种聚脲系统，其包含作为组分A）的异氰酸酯官能的预聚物，其可通过脂族异氰酸酯A1）与多元醇A2）的反应获得，该多异氰酸酯官能的预聚物特别可以具有≥400g/ mol的数均分子量， 2〜6的OH官能团，作为组分B）通式（I）的氨基官能化合物，其中X是含有仲氨基官能团的有机基团，Y是含有叔氨基的有机基团，并且不含有Zerewitinoff活性氢，R1是CH2-COOR3基团，其中R3是不含Zerewitinoff活性氢的有机基团，直链或支链C 1 -C 4烷基，环戊基，环己基或 H，R2是不含Zerewitinoff活性氢的有机基团，a是1或2，b为1或2，a + b = 2或3，用于阻止血液逸出，并且用于计量系统根据本发明的聚脲系统。

7. 发明申请

US20130317134A1 TISSUE ADHESIVE BASED ON TRIFUNCTIONAL ASPARTATES 审中-公开
标题翻译：基于功能性ASPARTATES的组织粘合剂
公开(公告)号：US20130317134A1
公开(公告)日：2013-11-28
申请号：US13984170
申请日：2012-02-06
申请人： Heike Heckroth , Christoph Eggert
发明人： Heike Heckroth , Christoph Eggert
IPC分类号： A61L24/04
CPC分类号： A61L24/046 , C08G18/10 , C08G18/3821 , Y10T137/87571 , C08L75/02
摘要： The present invention relates to a compound of formula (I) wherein R1, R2 each independently of the other are identical or different organic radicals which do not contain Zerewitinoff-active hydrogen, and R4, R5, R6 each independently of the others are saturated, linear or branched organic radicals which do not contain Zerewitinoff-active hydrogen and which are also optionally substituted in the chain by heteroatoms, for use in a polyurea system which is provided in particular for sealing, bonding, gluing or covering cell tissue. The invention further provides a polyurea system comprising the compound according to the invention, and a metering system for the polyurea system according to the invention.
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2各自独立地为相同或不同的不含Zerewitinoff活性氢的有机基团，R 4，R 5，R 6各自独立地为饱和的，不含Zerewitinoff-活性氢的线性或支化有机基团，并且其也可任选地被杂原子取代在链中，用于特别用于密封，粘合，胶合或覆盖细胞组织的聚脲体系。本发明还提供一种包含根据本发明的化合物的聚脲体系，以及根据本发明的聚脲体系的计量系统。

8. 发明授权

US09421298B2 Tissue adhesive based on nitrogen-modified aspartates 有权
标题翻译：基于氮改性天冬氨酸的组织粘合剂
公开(公告)号：US09421298B2
公开(公告)日：2016-08-23
申请号：US13984186
申请日：2012-02-06
申请人： Heike Heckroth , Christoph Eggert
发明人： Heike Heckroth , Christoph Eggert
IPC分类号： C08L75/02 , C08L75/04 , C09D175/02 , C08G18/10 , A61L24/04 , C08G18/38 , C08G18/42 , C08G18/73 , A61L24/00
CPC分类号： A61L24/046 , A61L24/0015 , C08G18/10 , C08G18/3821 , C08G18/4252 , C08G18/73 , C08L75/04
摘要： The invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers which can be obtained by reacting aliphatic isocyanates A1) with polyols A2) that can have a number-average molecular weight of =400 g/mol and an average OH functionality of 2 to 6 in particular; and as component B) amino-functional aspartic acid esters of the general formula (I) in which X is an organic group containing a secondary amino function, R1, R2 are the same or different organic groups that do not have Zerewitinoff-active hydrogen, and n is a whole number of at least 2, in particular for sealing, bonding, gluing, or covering cell tissue. The invention also relates to a metering system for the polyurea system according to the invention.
摘要翻译：本发明涉及一种包含作为组分A）异氰酸酯官能的预聚物的聚脲体系，该异氰酸酯官能的预聚物可通过使脂族异氰酸酯A1）与数均分子量为400g / mol和平均OH官能度的多元醇A2）特别是2到6; 和作为组分B）通式（I）的氨基官能天冬氨酸酯，其中X是含有仲氨基官能团的有机基团，R 1，R 2是相同或不同的不具有齐维诺芬活性氢的有机基团，并且n是至少为2的整数，特别是用于密封，粘合，胶合或覆盖细胞组织。本发明还涉及根据本发明的聚脲系统的计量系统。

9. 发明申请

US20140065091A1 MEDICAL ADHESIVE FOR STEMMING BLEEDING 有权
标题翻译：医用胶粘剂
公开(公告)号：US20140065091A1
公开(公告)日：2014-03-06
申请号：US14112368
申请日：2012-04-17
申请人： Heike Heckroth , Christoph Eggert
发明人： Heike Heckroth , Christoph Eggert
IPC分类号： A61L24/04
CPC分类号： A61L24/046 , A61L24/0015 , C08G18/10 , C08G18/12 , C08G18/73 , C08G18/3821 , C08L75/02
摘要： The present invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which in particular can have a number-average molecular weight of ≧400 g/mol and a mean OH functionality of from 2 to 6, as component B) an amino-functional compound of the general formula (I) in which X is an organic radical containing a secondary amino function, Y is an organic radical that contains a tertiary amino group and does not contain Zerewitinoff-active hydrogen, R1 is a CH2—COOR3 radical in which R3 is an organic radical that does not contain Zerewitinoff-active hydrogen, a linear or branched C1- to C4-alkyl radical, a cyclopentyl radical, a cyclohexyl radical or H, R2 is an organic radical that does not contain Zerewitinoff-active hydrogen, a is 1 or 2, b is 1 or 2, and a+b=2 or 3, for stemming the escape of blood, and to a metering system for the polyurea system according to the invention.
摘要翻译：本发明涉及包含作为组分A）的异氰酸酯官能的预聚物本发明涉及通过脂族异氰酸酯A1）与多元醇A2）的反应得到的异氰酸酯官能的预聚物，其特别是其数均分子量> 400g / mol，平均OH官能度为2至6，作为组分B）通式（I）的氨基官能化合物，其中X为含有仲氨基官能团的有机基团，Y为含有叔氨基的有机基团，不含Zerewitinoff活性氢，R1是CH2-COOR3基团，其中R3是不含有Zerewitinoff活性氢的有机基团，直链或支链C 1 -C 4烷基，环戊基，环己基或H，R2是不含Zerewitinoff活性氢的有机基团，a是1或2，b为1或2，a + b = 2或3，用于阻止血液的逸出，并且计量系统对于根据本发明的聚脲系统。

10. 发明申请

US20140066981A1 TISSUE ADHESIVE WITH ACCELERATED CURING 有权
标题翻译：组织粘合加速固化
公开(公告)号：US20140066981A1
公开(公告)日：2014-03-06
申请号：US14112132
申请日：2012-04-17
申请人： Heike Heckroth , Christoph Eggert
发明人： Heike Heckroth , Christoph Eggert
IPC分类号： A61L24/04 , A61B17/00 , A61L24/00
CPC分类号： A61L24/046 , A61B17/00491 , A61B2017/00495 , A61L24/0015 , A61M5/19 , C08G18/10 , C08G18/12 , C08G18/325 , C08G18/3821 , C08G18/73 , C09J175/02 , C08L75/02
摘要： The present invention relates to a polyurea system encompassing as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which can in particular have a number average molecular weight of ≧400 g/mol and an average OH functionality of 2 to 6, as component B) amino-functional compounds of general formula (I) in which X is an organic residue comprising a tertiary amino function, having no Zerewitinoff active hydrogen, R1 is a CH2—COOR3 residue, in which R3 is an organic residue having no Zerewitinoff active hydrogen, a linear or branched C1 to C4 alkyl residue, a cyclopentyl or cyclohexyl residue or H, R2 is an organic residue having no Zerewitinoff active hydrogen, n is an integer ≧2 or ≦3, in particular for closing, binding, bonding or covering cell tissue, and to a metering system for the polyurea system according to the invention.
摘要翻译：本发明涉及包含作为组分A）异氰酸酯官能的预聚物的聚脲体系，该异氰酸酯官能的预聚物可通过脂族异氰酸酯A1）与多元醇A2）的反应获得，其特别是其数均分子量> OH官能度为2至6，作为组分B）通式（I）的氨基官能化合物，其中X是包含叔氨基官能团的有机残基，没有齐来维诺活性氢，R1是CH2-COOR3残基，其中 R3是不具有齐维诺夫活性氢，直链或支链C1至C4烷基残基，环戊基或环己基残基或H的有机残基，R2是不含齐维诺芬活性氢的有机残基，n为整数> = 2或@ 3 ，特别是用于封闭，结合，粘合或覆盖细胞组织，以及用于根据本发明的聚脲系统的计量系统。

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