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1. 发明公开

EP2818108A1 METHOD FOR DETERMINING GLUCOSE CONCENTRATION IN HUMAN BLOOD 有权
标题翻译：曼彻斯丁BLUT VERFAHREN ZUR BESTIMMUNG DER GLUCOSEKONTRATION
公开(公告)号：EP2818108A1
公开(公告)日：2014-12-31
申请号：EP13751962.5
申请日：2013-02-22
申请人： Healbe Corporation
发明人： SOKOLOV, Evgeniy L'vovich , CHECHIK, Andrey Anatol'evich , ELOKHOVSKIY, Vladimir Yur'evich
IPC分类号： A61B5/145 , A61B5/053 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/053 , G01N27/02
摘要： The method involves measurement of impedance for human body region at high frequency (Z HF ) and low frequency (Z LF ) by means of electrodes fastened to a human body. An estimate for the volume of fluid contained in the tissues of a human body region is derived based on Z HF value. An estimate for the volume of extracellular fluid contained in the tissues of a human body region is derived based on Z LF value. The increment of metabolic component of the volume of extracellular fluid (with the said metabolic component being connected with synthesis and utilization of energy carriers in the human body) is determined by calculating the increment of the volume of all fluid as compared to the value obtained from the previous measurement, calculating the increment of the volume of extracellular fluid as compared to the value obtained from the previous measurement, and subsequent calculation of difference between the said increment of the volume of all fluid and increment of the volume of extracellular fluid. A value of increment of glucose concentration is derived via normalization of the said increment of metabolic component of extracellular fluid volume. Glucose concentration in human blood G(t k ) is determined by summing up the said value of glucose concentration increment and value of glucose concentration in blood derived at the previous stage of measurements. The method allows determining glucose concentration in human blood non-invasively and with high accuracy.
摘要翻译：该方法包括通过固定在人体上的电极测量高频（Z HF）和低频（Z LF）的人体区域的阻抗。基于Z HF值推导人体区域组织中含有的流体体积的估计值。基于Z LF值推导人体区域组织中所含的细胞外液体积的估计值。通过计算所有流体体积的增加量与从...获得的值相比，确定细胞外液体积（代谢组分与人体能量载体的合成和利用相关联）的代谢成分的增加先前的测量，计算细胞外液体积的增量与从先前测量获得的值相比较，随后计算所有流体的所述体积的增加和细胞外液体积的增加之间的差异。葡萄糖浓度增量的值通过细胞外液体体积的代谢组分的增加的归一化而得到。通过将上述测量血液中葡萄糖浓度增加值和葡萄糖浓度值汇总在血液中得到，确定人血液G（t k）中的葡萄糖浓度。该方法允许以非侵入性和高准确度测定人血液中的葡萄糖浓度。

2. 发明公开

EP3270165A1 METHOD FOR DETERMINING THE GLYCAEMIC INDEX OF FOOD TO BE CONSUMED BY A PERSON 有权
标题翻译：确定人食用的食物的糖基指数的方法
公开(公告)号：EP3270165A1
公开(公告)日：2018-01-17
申请号：EP16765333.6
申请日：2016-02-24
申请人： Healbe Corporation
发明人： SOKOLOV, Evgeny Lvovich , CHECHIK, Andrey Anatol'evich , ELOKHOVSKIY, Vladimir Yur'evich , KOLONITSKY, Dmitry Ivanovich
IPC分类号： G01N33/66
CPC分类号： G01N33/66 , A61B5/14532 , G01N2400/00
摘要： The invention relates to the field of measurements for diagnostic purposes, in particular to measurements made to assess the effect of nutrition load upon human body. The glycemic index is determined based on the results of blood glucose concentration measurements by evaluating time Δ t from the beginning of food-related increase of blood glucose concentration until the peak of glucose concentration is reached, after which maximum increase Δ G max of said glucose concentration is determined over the given period of time. Thereat, the glycemic index of food is defined as a ratio of maximum increase of blood glucose concentration Δ G max versus maximum increase of said glucose concentration in case of pure glucose intake in the amount equal to carbohydrate content of the consumed food, which is proportional to the product of Δ G max by Δ t. The invention substantially simplifies the procedure for measuring the glycemic index of real food and facilitates the development of simple personal devices for monitoring carbohydrate metabolism.
摘要翻译：本发明涉及用于诊断目的的测量领域，特别涉及为评估营养负载对人体的影响而进行的测量。基于血糖浓度测量的结果，通过从血糖浓度的与食物相关的增加开始评估时间Δt直到达到葡萄糖浓度的峰值，然后确定所述葡萄糖浓度的最大增加量ΔGmax，来确定血糖指数在给定的时间段内。所述食物的血糖指数被定义为：在纯葡萄糖摄入的情况下，所述血糖浓度的最大增加量ΔGmax与所述葡萄糖浓度的最大增加量的比率等于所消耗的食物的碳水化合物含量，其与 ΔGmax乘以Δt的乘积。本发明显着地简化了用于测量真实食物的血糖指数的程序并促进了用于监测碳水化合物代谢的简单个人装置的开发。

3. 发明授权

EP2818108B1 METHOD FOR DETERMINING GLUCOSE CONCENTRATION IN HUMAN BLOOD 有权
标题翻译：测定人血中葡萄糖浓度的方法
公开(公告)号：EP2818108B1
公开(公告)日：2017-05-17
申请号：EP13751962.5
申请日：2013-02-22
申请人： Healbe Corporation
发明人： SOKOLOV, Evgeniy L'vovich , CHECHIK, Andrey Anatol'evich , ELOKHOVSKIY, Vladimir Yur'evich
IPC分类号： A61B5/145 , A61B5/053 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/053 , G01N27/02
摘要： The method involves measurement of impedance for human body region at high frequency (Z HF ) and low frequency (Z LF ) by means of electrodes fastened to a human body. An estimate for the volume of fluid contained in the tissues of a human body region is derived based on Z HF value. An estimate for the volume of extracellular fluid contained in the tissues of a human body region is derived based on Z LF value. The increment of metabolic component of the volume of extracellular fluid (with the said metabolic component being connected with synthesis and utilization of energy carriers in the human body) is determined by calculating the increment of the volume of all fluid as compared to the value obtained from the previous measurement, calculating the increment of the volume of extracellular fluid as compared to the value obtained from the previous measurement, and subsequent calculation of difference between the said increment of the volume of all fluid and increment of the volume of extracellular fluid. A value of increment of glucose concentration is derived via normalization of the said increment of metabolic component of extracellular fluid volume. Glucose concentration in human blood G(t k ) is determined by summing up the said value of glucose concentration increment and value of glucose concentration in blood derived at the previous stage of measurements. The method allows determining glucose concentration in human blood non-invasively and with high accuracy.
摘要翻译：该方法包括通过固定在人体上的电极测量高频（Z HF）和低频（Z LF）下人体区域的阻抗。根据Z HF值推导出人体区域组织中所含流体体积的估计值。根据Z LF值推导出人体区域组织中所含细胞外液量的估计值。通过计算所有流体体积的增量与通过计算所有流体的体积的增量来确定细胞外液的体积的代谢组分的增量（其中所述代谢组分与人体内的能量载体的合成和利用相关）先前的测量，计算细胞外液的体积相对于从先前测量获得的值的增量，并且随后计算所有流体体积的所述增量与细胞外液体积的增量之间的差值。通过标准化细胞外液体积的代谢组分的所述增量来推导葡萄糖浓度的增加值。通过将所述葡萄糖浓度增量值与前一阶段测量得到的血液葡萄糖浓度值相加，确定人体血液葡萄糖浓度G（t k）。该方法允许非侵入性且高准确度地测定人血液中的葡萄糖浓度。

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