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1. 发明授权

US11045093B2 Sensor unit 有权
公开(公告)号：US11045093B2
公开(公告)日：2021-06-29
申请号：US15796364
申请日：2017-10-27
申请人： Healbe Corporation
发明人： Mikhail S. Rubin , Igor L. Misjuchenko , Oleg M. Gerasimov , Aleksandr S. Strelnikov
IPC分类号： A61B5/0205 , A61B5/024 , A61B5/0531 , A61B5/00 , A61B5/021
摘要： A sensor unit for use in devices for simultaneous measurement of signals associated with human tissue impedance and pressure to identify human hemodynamic parameters. The sensor unit of the device attached to a skin surface segment of a human body includes a base with a recess, in which a piezoelectric element of pressure sensor is installed. The unit also has a flexible membrane mounted on the base and overlapping said recess. First and second electrodes are attached to the outer surface of the membrane. The first electrode is mounted opposite the recess and is capable of moving together with the membrane. The second immovable electrode surrounds the first electrode. A central support is mounted between the first electrode and the piezoelectric element. Connected to the electrical outputs of said sensor for measuring signals associated with human tissue impedance, the first and second electrodes are configured to enable contact with the skin surface of the human body. At the same time, the operational stability and sensitivity of sensors are increased.

2. 发明申请

US20180263526A1 Method for Detecting Water Deficiency in a Human Body 审中-公开
公开(公告)号：US20180263526A1
公开(公告)日：2018-09-20
申请号：US15988774
申请日：2018-05-24
申请人： Healbe Corporation
发明人： Anatoly A. SOLUNIN , Evgeny L. SOKOLOV , Aleksandr V. KOLCHIN , Mikhail S. RUBIN , Dmitry I. KOLONITSKY , Andrey A. CHECHIK , Igor L. MISJUCHENKO
IPC分类号： A61B5/053 , A61B5/00 , A61B5/145 , A61B5/01
CPC分类号： A61B5/0537 , A61B5/01 , A61B5/14535 , A61B5/4875 , A61B5/6801
摘要： Determining a state of water deficiency in a human body during daily life activities is done by measuring an impedance of a portion of the human body at a low frequency and at a high frequency. An amount of fluid in the body tissues in the volume under study is assessed based on the impedance at the high frequency. A current amount of extracellular fluid in the tissues in the volume is assessed based on the impedance at the low frequency. A reference value of the assessed amount of extracellular fluid in the tissues is preselected at the start of measurements. A correction value is determined based on the changes in blood amount in the volume at the current measurement time. A corrected assessment value is the determined. Using the corrected assessment value, the onset of water deficiency is determined.

3. 发明申请

US20180074069A1 Method for Measuring Glycemic Index of Human-Consumed Food 审中-公开
公开(公告)号：US20180074069A1
公开(公告)日：2018-03-15
申请号：US15703290
申请日：2017-09-13
申请人： Healbe Corporation
发明人： Evgeny L. SOKOLOV , Andrey A. CHECHIK , Vladimir Yu. ELOKHOVSKIY , Dmitry I. KOLONITSKY
IPC分类号： G01N33/66
CPC分类号： G01N33/66 , A61B5/14532 , G01N2400/00
摘要： The glycemic index is determined based on the results of blood glucose concentration measurements by evaluating time Δt from the beginning of food-related increase of blood glucose concentration until the peak of glucose concentration is reached, after which maximum increase ΔGmax of said glucose concentration is determined over the given period of time. Thereat, the glycemic index of food is defined as a ratio of maximum increase of blood glucose concentration ΔGmax versus maximum increase of said glucose concentration in case of pure glucose intake in the amount equal to carbohydrate content of the consumed food, which is proportional to the product of ΔGmax by Δt. The invention substantially simplifies the procedure for measuring the glycemic index of real food and facilitates the development of simple personal devices for monitoring carbohydrate metabolism.

4. 发明申请

US20150351484A1 METHOD FOR MONITORING AN INDIVIDUAL'S MOTOR LOAD AND INSOLE FOR THE IMPLEMENTATION THEREOF 审中-公开
标题翻译：用于监控个人电机负载的方法及其实施方法
公开(公告)号：US20150351484A1
公开(公告)日：2015-12-10
申请号：US14832002
申请日：2015-08-21
申请人： Healbe Corporation
发明人： Mikhail S. RUBIN , Igor L. MISJUCHENKO , Oleg M. GERASIMOV , Evgeniy L. SOKOLOV
IPC分类号： A43B3/00 , A43B5/00
CPC分类号： A43B3/0005 , A43B5/00 , A61B5/1036 , A61B5/1118 , A61B5/6807 , G01G3/14 , G01G19/44 , G01G19/52
摘要： A method for measurements of parameters characterizing human motor activity provides registration of signals generated by load sensors mounted in shoe insoles, with each insole having at least two load sensors, one mounted near the heel, and the other near the toe of the foot. The specific type of motor activity is determined based on temporal correlation of load sensor signals from both insoles and values thereof. Person's weight, including additionally carried weight, is determined by summing up signal values from said load sensors, with the specific type of motor activity considered; thereafter, person's motor stress is determined based on specified type of motor activity and person's weight, including additionally carried weight. The method enables a real-time monitoring of motor stress of a person at different types of motor activity, e.g. running, walking at different pace, standing, with person's weight, including additionally carried weight, taken into consideration.
摘要翻译：用于测量表征人类运动活动的参数的方法提供了安装在鞋垫中的负载传感器产生的信号的登记，每个鞋内底具有至少两个负载传感器，一个安装在脚跟附近，另一个靠近脚的脚趾。基于来自两个鞋垫的载荷传感器信号和其值的时间相关性来确定运动活动的具体类型。通过对所述负载传感器的信号值进行求和，考虑特定类型的运动活动来确定人的体重，包括额外承载的重量; 此后，根据运动活动的特定类型和人的体重（包括附加的重量）来确定人的运动压力。该方法能够实时监测不同类型运动活动的人的运动应激，例如，跑步，以不同的速度行走，站立，与人的体重，包括额外的重量，考虑。

5. 发明授权

US11224385B2 Method for determining a person's sleeping phase which is favourable for waking up 有权
公开(公告)号：US11224385B2
公开(公告)日：2022-01-18
申请号：US14865879
申请日：2015-09-25
申请人： Healbe Corporation
发明人： Mikhail S. Rubin , Yury V. Sviryaev
IPC分类号： A61B5/00 , A61B5/024 , A61B5/08 , G04G13/02 , A61B5/352 , A61B5/0205 , A61B5/11 , G04C3/00 , A61B5/349
摘要： A pulse wave signal is registered and an occurrence of human limb movements detected during sleep using a pulse wave sensor and an accelerometer. The values of RR intervals and respiratory rate are measured at preset time intervals Δti based on pulse wave signal. Mean P1, minimal P2, and maximal P3 values of RR intervals, the standard deviation of RR intervals P4, average respiratory rate P5 and average number of limb movements P6 are determined based on the above measured values. Function value F(Δti) is determined thereafter as: F(Δti)=−K1P1−K2P2−K3P3+K4P4+K5P5+K6P6, where K1-K6 are weight coefficients characterizing the contribution of the corresponding parameter to function value F(Δti); whereat the onset and termination of sleep phase favorable to awakening is determined by increments of function F(Δti).

6. 发明申请

US20190014855A1 METHOD FOR MONITORING AN INDIVIDUAL'S MOTOR LOAD AND INSOLE FOR THE IMPLEMENTATION THEREOF 审中-公开
公开(公告)号：US20190014855A1
公开(公告)日：2019-01-17
申请号：US16103539
申请日：2018-08-14
申请人： Healbe Corporation
发明人： Mikhail S. RUBIN , Igor L. MISJUCHENKO , Oleg M. GERASIMOV , Evgeny L. SOKOLOV
IPC分类号： A43B3/00 , A61B5/00 , A61B5/11 , A43B5/00 , G01G19/52 , G01G19/44 , G01G3/14 , A61B5/103
摘要： A method for measurements of parameters characterizing human motor activity provides registration of signals generated by load sensors mounted in shoe insoles, with each insole having at least two load sensors, one mounted near the heel, and the other near the toe of the foot. The specific type of motor activity is determined based on temporal correlation of load sensor signals from both insoles and values thereof. Person's weight, including additionally carried weight, is determined by summing up signal values from said load sensors, with the specific type of motor activity considered; thereafter, person's motor stress is determined based on specified type of motor activity and person's weight, including additionally carried weight. The method enables a real-time monitoring of motor stress of a person at different types of motor activity, e.g. running, walking at different pace, standing, with person's weight, including additionally carried weight, taken into consideration.

7. 发明申请

US20180035930A1 METHOD FOR DETERMINING GLUCOSE CONCENTRATION IN HUMAN BLOOD 审中-公开
公开(公告)号：US20180035930A1
公开(公告)日：2018-02-08
申请号：US15787432
申请日：2017-10-18
申请人： Healbe Corporation
发明人： Evgeniy L. SOKOLOV , Andrey A. CHECHIK , Vladimir Y. ELOKHOVSKIY
IPC分类号： A61B5/145 , G01N27/02 , A61B5/053
CPC分类号： A61B5/14532 , A61B5/053 , G01N27/02
摘要： Measuring the impedance of a human body region at a high frequency (ZHF) and a low frequency (ZLF). ZHF is used to obtain the value of the volume of fluid in the tissues of the region. ZLF is used to obtain the value of the volume of extracellular fluid in the tissues. The increase in the metabolic component in the volume of extracellular fluid is determined by the increase of the volume of all of the fluid in comparison with the previous measurement, determining the increase in the volume of extracellular fluid in comparison with the previous measurement and subsequently calculating the difference between the increases in the volume of all of the fluid and the volume of extracellular fluid. The glucose concentration G(tk) is determined by adding the amount of increase in the glucose concentration and the value of the glucose concentration determined at the previous measuring stage.

8. 发明授权

US10509040B2 Method for measuring glycemic index of human-consumed food 有权
公开(公告)号：US10509040B2
公开(公告)日：2019-12-17
申请号：US15703290
申请日：2017-09-13
申请人： Healbe Corporation
发明人： Evgeny L. Sokolov , Andrey A. Chechik , Vladimir Yu. Elokhovskiy , Dmitry I. Kolonitsky
IPC分类号： G01N33/50 , G01N33/66 , A61B5/145
摘要： The glycemic index is determined based on the results of blood glucose concentration measurements by evaluating time Δt from the beginning of food-related increase of blood glucose concentration until the peak of glucose concentration is reached, after which maximum increase ΔGmax of said glucose concentration is determined over the given period of time. Thereat, the glycemic index of food is defined as a ratio of maximum increase of blood glucose concentration ΔGmax versus maximum increase of said glucose concentration in case of pure glucose intake in the amount equal to carbohydrate content of the consumed food, which is proportional to the product of ΔGmax by Δt. The invention substantially simplifies the procedure for measuring the glycemic index of real food and facilitates the development of simple personal devices for monitoring carbohydrate metabolism.

9. 发明申请

US20180014756A1 Method for Determining Types of Human Motor Activity and Device for Implementing Thereof 审中-公开
公开(公告)号：US20180014756A1
公开(公告)日：2018-01-18
申请号：US15702860
申请日：2017-09-13
申请人： Healbe Corporation
发明人： Mikhail S. RUBIN , Sergei S. SYSOEV
IPC分类号： A61B5/11 , A61B5/00
CPC分类号： A61B5/1123 , A61B5/0004 , A61B5/11 , A61B5/1121 , A61B5/1124 , A61B5/6824 , A61B2562/0219
摘要： The method pertains to monitoring movements of a human to determine types of human motor activity. Signals generated by a three-component accelerometer attached to human body are recorded and used for calculating acceleration vector magnitudes, forming a time array of acceleration vector magnitudes, and identifying its extrema. Duration of separate motor acts and the differences between adjacent extrema of acceleration vector magnitude for each motor act are determined by counting, consecutively from one extremum to another, the number of extrema equal to a reference number of extrema in at least one pattern, which is pre-formed for a certain type of motor activity and characterized by a specific reference number of acceleration vector magnitude extrema, a specific reference value of motor act duration, and specific reference values of difference between adjacent extrema of acceleration vector magnitude. A determination is made of a type of motor activity.

10. 发明申请

US20150073242A1 METHOD FOR DETERMINING GLUCOSE CONCENTRATION IN HUMAN BLOOD 审中-公开
标题翻译：用于确定人血糖浓度的方法
公开(公告)号：US20150073242A1
公开(公告)日：2015-03-12
申请号：US14466570
申请日：2014-08-22
申请人： Healbe Corporation
发明人： Evgeniy L. SOKOLOV , Andrey A. CHECHIK , Vladimir Y. ELOKHOVSKIY
IPC分类号： A61B5/145 , G01N27/02
CPC分类号： A61B5/14532 , A61B5/053 , G01N27/02
摘要： Measuring the impedance of a human body region at a high frequency (ZHF) and a low frequency (ZLF). ZHF is used to obtain the value of the volume of fluid in the tissues of the region. ZLF is used to obtain the value of the volume of extracellular fluid in the tissues. The increase in the metabolic component in the volume of extracellular fluid is determined by the increase of the volume of all of the fluid in comparison with the previous measurement, determining the increase in the volume of extracellular fluid in comparison with the previous measurement and subsequently calculating the difference between the increases in the volume of all of the fluid and the volume of extracellular fluid. The glucose concentration G(tk) is determined by adding the amount of increase in the glucose concentration and the value of the glucose concentration determined at the previous measuring stage.
摘要翻译：以高频（ZHF）和低频（ZLF）测量人体区域的阻抗。 ZHF用于获得该区域组织中流体体积的值。 ZLF用于获得组织中细胞外液体积的值。细胞外液体积中代谢成分的增加是由与以往测量相比所有流体体积的增加而确定的，与以前的测量相比，确定了细胞外液体积的增加，随后计算所有流体体积增加与细胞外液体积之间的差异。通过加入葡萄糖浓度的增加量和在前一测量阶段确定的葡萄糖浓度的值来确定葡萄糖浓度G（tk）。

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