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1. 发明授权

US07148963B2 Large-collection-area optical probe 有权
标题翻译：大型采集区光探头
公开(公告)号：US07148963B2
公开(公告)日：2006-12-12
申请号：US11007969
申请日：2004-12-09
申请人： Harry Owen , David J. Strachan , Joseph B. Slater , James M. Tedesco
发明人： Harry Owen , David J. Strachan , Joseph B. Slater , James M. Tedesco
IPC分类号： G01N21/64
CPC分类号： G01N21/65 , G01J3/0291 , G01J3/44 , G01N21/645 , G01N2021/6484
摘要： A compact Raman/fluorescence probe is capable of collecting spectra from a relatively large spot size as compared to traditional confocal Raman probes. The inventive probe collects spectra from an area or 1 mm or greater, preferably 3–12 mm or more, compared to current instruments which utilize spot sizes on the order of 2–60 microns. The larger spot size facilitates the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding, and reactor cleanliness validation.
摘要翻译：与传统的共焦拉曼探针相比，紧凑的拉曼/荧光探针能够从相对较大的光斑尺寸收集光谱。与使用大约2-60微米的光斑尺寸的现有仪器相比，本发明的探针从区域收集光谱或1mm或更大，优选3-12mm或更大。较大的斑点尺寸有助于收集来自不均匀和激光敏感样品的统计学上有用的数据，以及其他应用。潜在的药物应用包括片剂剂量水平测量，以及在线和在线质量控制（QC）监测机会。其他应用包括将片剂鉴定作为识别假冒药品的法医工具; 制粒和混合均匀性，通过更好的工艺理解和反应堆清洁度验证改进配方。

2. 发明申请

US20090294673A1 High-volume on-line spectroscopic composition testing of manufactured pharmaceutical dosage units 审中-公开
标题翻译：制造药物剂量单位的大容量在线光谱组成测试
公开(公告)号：US20090294673A1
公开(公告)日：2009-12-03
申请号：US12218504
申请日：2008-07-15
申请人： E. Neil Lewis , David J. Strachan , Linda H. Kidder
发明人： E. Neil Lewis , David J. Strachan , Linda H. Kidder
IPC分类号： G01J5/02
CPC分类号： G01N21/31 , G01N21/253
摘要： Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.
摘要翻译：公开了药物剂量单位制造过程控制装置和方法。这些可以包括沿着垂直于药物剂量单位的流动方向的轴线获取不同波长的药物剂量单位流的多个多像素图像，处理在获取步骤中获取的图像并提供关于基于加工步骤的药物剂量单位的流动的指示。

3. 发明授权

US07399968B2 Spectroscopic instruments and methods employing array detector and variable filtering 失效
标题翻译：使用阵列检测器和可变滤波器的光谱仪器和方法
公开(公告)号：US07399968B2
公开(公告)日：2008-07-15
申请号：US10776029
申请日：2004-02-10
申请人： E. Neil Lewis , David J. Strachan , Linda H. Kidder
发明人： E. Neil Lewis , David J. Strachan , Linda H. Kidder
IPC分类号： G01J3/28
CPC分类号： G01N21/31 , G01N21/253
摘要： Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.
摘要翻译：公开了药物剂量单位制造过程控制装置和方法。这些可以包括沿着垂直于药物剂量单位的流动方向的轴线获取不同波长的药物剂量单位流的多个多像素图像，处理在获取步骤中获取的图像并提供关于基于加工步骤的药物剂量单位的流动的指示。

4. 发明授权

US06690464B1 High-volume on-line spectroscopic composition testing of manufactured pharmaceutical dosage units 失效
标题翻译：制造药物剂量单位的大容量在线光谱组成测试
公开(公告)号：US06690464B1
公开(公告)日：2004-02-10
申请号：US09507293
申请日：2000-02-18
申请人： E. Neil Lewis , David J. Strachan , Linda H. Kidder
发明人： E. Neil Lewis , David J. Strachan , Linda H. Kidder
IPC分类号： G01J328
CPC分类号： G01N21/31 , G01N21/253
摘要： Disclosed are pharmaceutical dosage unit manufacturing process control apparatus and methods. These can include acquiring a plurality of multi-pixel images of a flow of pharmaceutical dosage units at different wavelengths along an axis that is perpendicular to a direction of the flow of pharmaceutical dosage units, processing the images acquired in the step of acquiring, and providing an indication about the flow of pharmaceutical dosage units based on the step of processing.
摘要翻译：公开了药物剂量单位制造过程控制装置和方法。这些可以包括沿着垂直于药物剂量单位的流动方向的轴线获取不同波长的药物剂量单位流的多个多像素图像，处理在获取步骤中获取的图像并提供关于基于加工步骤的药物剂量单位的流动的指示。

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