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1. 发明授权

US08824042B2 Ellipsoidal raman signal amplifier 有权
标题翻译：椭圆形拉曼信号放大器
公开(公告)号：US08824042B2
公开(公告)日：2014-09-02
申请号：US13564461
申请日：2012-08-01
申请人： James M. Tedesco , Joseph B. Slater
发明人： James M. Tedesco , Joseph B. Slater
IPC分类号： H01S3/30 , G02B5/10
CPC分类号： G01N21/65 , G01J3/021 , G01J3/44 , H01S3/08 , H01S3/08095 , H01S3/305 , H01S3/307
摘要： Raman signal amplification apparatus comprises an ellipsoidal reflector providing a first real focus f1, and second real or virtual focus f2, both foci being situated within a sample volume. When an input laser excitation beam having an initial numerical aperture (NA) is focused onto one of the foci, the beam is reflected by the reflector and refocused onto alternating foci, such that the NA of the reflected optical path progressively increases for higher efficiency collection of Raman emissions from the multiple foci. The ellipsoidal reflector may be a half section providing a single real focus f1, with a flat reflector producing a mirror image of the ellipsoidal reflector, such that f2 is a virtual focus occupying the same point as f1. Alternatively, the ellipsoidal reflector may have a first half section with a first real focus f1 and a second half section with a second real focus f2.
摘要翻译：拉曼信号放大装置包括提供第一实际焦点f1的椭球反射器和第二实际或虚拟焦点f2，两个焦点位于样本体积内。当具有初始数值孔径（NA）的输入激光激发光束聚焦到焦点之一时，光束被反射器反射并重新聚焦到交替的焦点上，使得反射光路的NA逐渐增加以获得更高的效率的多焦点的拉曼散射。椭圆反射器可以是提供单个实际焦点f1的半部分，平面反射器产生椭圆反射体的镜像，使得f2是与f1相同的点。或者，椭球反射器可以具有带有第一实际焦点f1的第一半部分和具有第二实心f2的第二半部分。

2. 发明申请

US20140036347A1 ELLIPSOIDAL RAMAN SIGNAL AMPLIFIER 有权
标题翻译： ELLIPSOIDAL拉曼信号放大器
公开(公告)号：US20140036347A1
公开(公告)日：2014-02-06
申请号：US13564461
申请日：2012-08-01
申请人： James M. Tedesco , Joseph B. Slater
发明人： James M. Tedesco , Joseph B. Slater
IPC分类号： H01S3/30
CPC分类号： G01N21/65 , G01J3/021 , G01J3/44 , H01S3/08 , H01S3/08095 , H01S3/305 , H01S3/307
摘要： Raman signal amplification apparatus comprises an ellipsoidal reflector providing a first real focus f1, and second real or virtual focus f2, both foci being situated within a sample volume. When an input laser excitation beam having an initial numerical aperture (NA) is focused onto one of the foci, the beam is reflected by the reflector and refocused onto alternating foci, such that the NA of the reflected optical path progressively increases for higher efficiency collection of Raman emissions from the multiple foci. The ellipsoidal reflector may be a half section providing a single real focus f1, with a flat reflector producing a mirror image of the ellipsoidal reflector, such that f2 is a virtual focus occupying the same point as f1. Alternatively, the ellipsoidal reflector may have a first half section with a first real focus f1 and a second half section with a second real focus f2.
摘要翻译：拉曼信号放大装置包括提供第一实际焦点f1的椭球反射器和第二实际或虚拟焦点f2，两个焦点位于样本体积内。当具有初始数值孔径（NA）的输入激光激发光束聚焦到焦点之一时，光束被反射器反射并重新聚焦到交替的焦点上，使得反射光路的NA逐渐增加以获得更高的效率的多焦点的拉曼散射。椭圆反射器可以是提供单个实际焦点f1的半部分，平面反射器产生椭圆反射体的镜像，使得f2是与f1相同的点。或者，椭球反射器可以具有带有第一实际焦点f1的第一半部分和具有第二实心f2的第二半部分。

3. 发明授权

US07148963B2 Large-collection-area optical probe 有权
标题翻译：大型采集区光探头
公开(公告)号：US07148963B2
公开(公告)日：2006-12-12
申请号：US11007969
申请日：2004-12-09
申请人： Harry Owen , David J. Strachan , Joseph B. Slater , James M. Tedesco
发明人： Harry Owen , David J. Strachan , Joseph B. Slater , James M. Tedesco
IPC分类号： G01N21/64
CPC分类号： G01N21/65 , G01J3/0291 , G01J3/44 , G01N21/645 , G01N2021/6484
摘要： A compact Raman/fluorescence probe is capable of collecting spectra from a relatively large spot size as compared to traditional confocal Raman probes. The inventive probe collects spectra from an area or 1 mm or greater, preferably 3–12 mm or more, compared to current instruments which utilize spot sizes on the order of 2–60 microns. The larger spot size facilitates the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding, and reactor cleanliness validation.
摘要翻译：与传统的共焦拉曼探针相比，紧凑的拉曼/荧光探针能够从相对较大的光斑尺寸收集光谱。与使用大约2-60微米的光斑尺寸的现有仪器相比，本发明的探针从区域收集光谱或1mm或更大，优选3-12mm或更大。较大的斑点尺寸有助于收集来自不均匀和激光敏感样品的统计学上有用的数据，以及其他应用。潜在的药物应用包括片剂剂量水平测量，以及在线和在线质量控制（QC）监测机会。其他应用包括将片剂鉴定作为识别假冒药品的法医工具; 制粒和混合均匀性，通过更好的工艺理解和反应堆清洁度验证改进配方。

4. 发明授权

US06873409B1 Optical probe with sampling window cleaning configuration 有权
公开(公告)号：US06873409B1
公开(公告)日：2005-03-29
申请号：US09441683
申请日：1999-11-16
申请人： Joseph B. Slater
发明人： Joseph B. Slater
IPC分类号： B08B17/06 , G01J3/02 , G01N21/15 , G01J3/44
CPC分类号： B08B17/06 , G01J3/02 , G01J3/0256 , G01N21/15 , G01N2021/151
摘要： A self-cleaning optical probe includes a probe body having a window with a surface oriented toward a sample under investigation. A sampling beam carrying wavelengths representative of the sample passes into the probe body through the window for analysis. A conduit, preferably forming part of the probe body, is used to carry a fluid to the surface of the window oriented toward the sample, and a partition proximate to the window is used to direct the fluid across the window as a laminar flow. The partition further includes an aperture through which the sampling wavelengths pass. This partition also permits a portion of the fluid to pass though the aperture to ensure that the sample under investigation does not reach the window. The fluid may be a liquid or gas, and is preferably a solvent to maximize window cleaning. Although the fluid may be discharged without entering into the environment being sampled, the fluid may also be discharged into the sample, depending upon the application, volume of the respective fluid/sample flows, and other such factors.

5. 发明授权

US06831739B2 Compression-bonded probe window 有权
标题翻译：压接探头窗口
公开(公告)号：US06831739B2
公开(公告)日：2004-12-14
申请号：US10350525
申请日：2003-01-24
申请人： Joseph B. Slater
发明人： Joseph B. Slater
IPC分类号： G01J302
CPC分类号： G01N21/8507 , G01N2021/656
摘要： In an optical measurement probe of the type which incorporates a window configuration suited to on-line process control and other applications this invention provides an improved technique for bonding such a window to probe body or process vessel. In general terms, the improvement arises through the use of a compression ring around the bonding area to maintain a consistent seal. In terms of apparatus, a hollow probe body terminates in a distal end having a flanged portion with an inner and outer wall that extends back into the body. The outer wall of the window is sealed against the inner wall of the flanged portion, with compression material urged against the outer wall of the flanged portion to pressurize the seal between the window and the inner wall of the flanged portion. In the preferred embodiment, the compression material is ring-shaped and exhibits substantially the same thermal expansion coefficient as the window. In the case where a sapphire window is used, titanium or Invar may be used for the compression material. The window may be generally cylindrical though, in the preferred embodiments, cork-shaped or spherical window are used.
摘要翻译：在包括适合于在线过程控制和其它应用的窗口配置的类型的光学测量探针中，本发明提供了一种用于将这样的窗口结合到探针体或处理容器的改进技术。一般来说，通过在粘合区域周围使用压缩环来保持一致的密封，产生了改进。在设备方面，空心探针体终止于远端，其具有凸缘部分，其内壁和外壁延伸回身体。窗口的外壁被密封在法兰部分的内壁上，压缩材料被压靠在凸缘部分的外壁上，以加压窗口与法兰部分的内壁之间的密封。在优选实施例中，压缩材料是环形的并且表现出与窗口基本上相同的热膨胀系数。在使用蓝宝石窗的情况下，可以使用钛或殷钢作为压缩材料。在优选实施例中，窗口可以是大致圆柱形的，但是使用软木形或球形窗。

6. 发明授权

US06650412B1 Thermal compensation for optical apparatus 有权
标题翻译：光学仪器热补偿
公开(公告)号：US06650412B1
公开(公告)日：2003-11-18
申请号：US09588968
申请日：2000-06-07
申请人： Joseph B. Slater
发明人： Joseph B. Slater
IPC分类号： G01J328
CPC分类号： G01J3/02 , G01J3/0202 , G01J3/0286 , G02B7/028
摘要： Reliable and economical passive thermal compensation in both focus (parallel to the optical axis) and lateral position (perpendicular to the optical axis) is disclosed for optical apparatus, including spectrographs. In the preferred embodiment, to maintain the position of the lens along the optical axis, two or more polymer spacers are used between the lens mount and a floating flange to which the lens is attached. The polymer spacers have a thermal coefficient of expansion such that when the temperature increases the lens is moved toward the detector array by the spacers to compensate for the normal increase of the lens-detector spacing with temperature. Flexure mounts, which bend by a predetermined amount in a known direction when the temperature changes, are preferably used to connect the lens mount to the floating plate, thereby moving the lens in a direction lateral to the optical axis. In the case of a spectrograph, this lateral motion maintains the positional stability of given spectral lines on their respective detector pixel elements.
摘要翻译：公开了光学设备（包括光谱仪）在焦点（平行于光轴）和横向位置（垂直于光轴）的可靠和经济的无源热补偿。在优选实施例中，为了保持透镜沿着光轴的位置，在透镜支架和透镜附着的浮动凸缘之间使用两个或更多个聚合物间隔物。聚合物间隔物具有热膨胀系数，使得当温度升高时，透镜通过间隔物向检测器阵列移动，以补偿透镜检测器间隔随温度的正常增加。优选地，当温度变化时，以已知方向弯曲预定量的挠曲安装件将透镜安装件连接到浮动板，从而沿着光轴的横向方向移动透镜。在光谱仪的情况下，该横向运动保持给定光谱线在其各自的检测器像素元件上的位置稳定性。

7. 发明授权

US6038363A Fiber-optic spectroscopic probe with reduced background luminescence 失效
标题翻译：具有降低背景发光的光纤光谱探针
公开(公告)号：US6038363A
公开(公告)日：2000-03-14
申请号：US918459
申请日：1997-08-26
申请人： Joseph B. Slater , Michael J. Pelletier
发明人： Joseph B. Slater , Michael J. Pelletier
IPC分类号： G01J3/44 , G02B6/00
CPC分类号： G01J3/44
摘要： A fiber-optic spectroscopic probe minimizes unwanted sources of luminescence through the use of one or more non-luminescing beam-redirecting elements operative to aperture share the optical collection path. Preferably, the beam-redirecting element is reflective, and may take the form of a spot mirror on an otherwise optically transparent window to fold at least a portion of the excitation radiation into the optical collection path or a mirror having a centralized aperture may be used to introduce the excitation radiation into the optical collection path. In either case, the excitation radiation may first pass through a dispersive element in a bandpass filter configuration. Several complete fiber-optic-based probe head designs are disclosed along with results indicating reduced luminescence, spurious fluorescence, in particular.
摘要翻译：光纤光谱探测器通过使用一个或多个非发光光束重定向元件来使不需要的发光源最小化，该光束重定向元件可操作以共享光学收集路径。优选地，光束重定向元件是反射性的，并且可以在另外的光学透明窗口上采取点样镜的形式，以将激发辐射的至少一部分折叠到光学收集路径中，或者可以使用具有集中孔的反射镜以将激发辐射引入光学收集路径。在任一情况下，激发辐射可以首先通过带通滤波器配置中的色散元件。公开了几种完整的基于光纤的探针头设计以及尤其是减少的发光，杂散荧光的结果。

8. 发明授权

US5943128A Grating-based optical probe 失效
标题翻译：基于光栅的光学探针
公开(公告)号：US5943128A
公开(公告)日：1999-08-24
申请号：US105723
申请日：1998-06-26
申请人： Joseph B. Slater
发明人： Joseph B. Slater
IPC分类号： G01J3/44 , G01N21/64 , G01N21/65
CPC分类号： G01J3/4406 , G01J3/44
摘要： A dispersive grating, preferably in the form of a volume-phase holographic optical element, or HOE, is used as a beam combiner in an optical measurement probe of the type used to analyze induced radiative effects such as Raman or fluorescence detection. Although a reflective grating may be used, a transmission grating of holographic derivation is used in the preferred embodiment. Although the grating may define an area substantially equivalent to the cross-section or aperture of the collection path, a grating which consumes a fraction of the collection aperture may instead be utilized, thereby allowing collected light to pass around the grating to further enhance the efficiency of detection. As a further advantageous option, the grating may be fabricated with `power,` that is, with the capability of collimating excitation energy that has been focused onto the grating surface. In this manner, a "spot" grating may be positioned centrally along the axis of the collection path, thereby realizing the multiple advantages of relaxed alignment demand, reduced spurious scattering, and high efficiency and throughput.
摘要翻译：优选以体积相位全息光学元件或HOE的形式的色散光栅用作用于分析诱发的辐射效应（例如拉曼或荧光检测）的类型的光学测量探针中的光束组合器。尽管可以使用反射光栅，但是在优选实施例中使用全息衍射的透射光栅。虽然光栅可以限定基本上等于收集路径的横截面或孔径的区域，但是可以替代地使用消耗收集孔径的一部分的光栅，从而允许收集的光通过光栅周围以进一步提高效率的检测。作为另一个有利的选择，光栅可以用“功率”制造，即具有准直已经聚焦到光栅表面上的激发能的能力。以这种方式，“点”光栅可以沿着收集路径的轴线定位在中心，从而实现放宽的对准需求，减少的散射散射以及高效率和吞吐量的多个优点。

9. 发明授权

US5929986A Synchronous spectral line imaging methods and apparatus 失效
标题翻译：同步谱线成像方法和装置
公开(公告)号：US5929986A
公开(公告)日：1999-07-27
申请号：US918313
申请日：1997-08-26
申请人： Joseph B. Slater , Michael J. Pelletier
发明人： Joseph B. Slater , Michael J. Pelletier
IPC分类号： G01J3/28
CPC分类号： G01J3/28
摘要： Methods and apparatus for synchronous spectral line imaging are disclosed for use in conjunction with any of a number of radiative analysis techniques such as Raman or fluorescence detection. Light emitted points on a sample are separated into wavelength components and directed onto a two-dimensional image sensor such that the wavelength components impinge along one dimension of the sensor. The other dimension of the sensor is used in conjunction with spatial position relative to the sample, with at least certain of the steps being repeated for the different sample points so as to form the spectral line image. In terms of apparatus, the invention preferably utilizes at least one optical fiber having an input end to receive the light emitted by the sample and an output end to deliver the emitted light to the two-dimensional image sensor. The use of a flexible optical fiber facilitates the movement of the light received from the sample, movement of the received light relative to the sensor, or both. A wavelength-separating optical element such as a diffraction grating is disposed between the output end of the optical fiber and the sensor. The image may represent a straight line on the sample, or it may be curved, intermittent or discontinuous.
摘要翻译：公开了用于同时光谱线成像的方法和装置，以与许多辐射分析技术中的任何一种结合使用，例如拉曼或荧光检测。样品上的光发射点被分离成波长分量并被引导到二维图像传感器上，使得波长分量沿传感器的一个维度撞击。传感器的另一个尺寸与相对于样品的空间位置结合使用，对于不同的采样点，至少某些步骤是重复的，以形成谱线图像。在装置方面，本发明优选地利用至少一个具有输入端的光纤来接收由样本发射的光和输出端，以将发射的光传送到二维图像传感器。使用柔性光纤有助于从样品接收的光的移动，接收的光相对于传感器的移动，或两者的移动。诸如衍射光栅的波长分离光学元件设置在光纤的输出端与传感器之间。图像可以表示样品上的直线，或者它可以是弯曲的，间歇的或不连续的。

10. 发明授权

US07755818B2 High-integrity seal for optical elements, dichromated gelatin holographic optical elements in particular 有权
标题翻译：特别是光学元件的高完整性密封，重铬酸盐明胶全息光学元件
公开(公告)号：US07755818B2
公开(公告)日：2010-07-13
申请号：US10352309
申请日：2003-01-27
申请人： Joseph B. Slater , Timothy J. Britton , Eric M. Ferree
发明人： Joseph B. Slater , Timothy J. Britton , Eric M. Ferree
IPC分类号： G03H1/02
CPC分类号： G03H1/0252 , C03C27/046 , G03H1/02 , G03H2250/37 , G03H2260/10 , Y10T29/49885 , Y10T403/35
摘要： A method and apparatus for encapsulating optical elements, particularly dichromated gelatin (DGC) holographic optical elements (HOEs), exhibits a very high degree of environmental integrity. In broad terms, the optical element is disposed between opposing plates, and a metal seal soldered to the edge(s) of the plates to seal the optical element therewithin. In the preferred embodiment, the metalization includes chrome and nickel, or alloys thereof, followed by gold or platinum. The metallization is preferably applied using a low-temperature process such as vacuum deposition or sputtering. The metal seal may be in the form of a foil or wire. One or both of the plates are compatible with wavelengths of interest, and the technique may be used in transmissive and reflective configurations.
摘要翻译：用于封装光学元件，特别是重铬酸盐明胶（DGC）全息光学元件（HOE））的方法和装置表现出非常高的环境完整性。广义上，光学元件设置在相对的板之间，并且金属密封件焊接到板的边缘以将光学元件密封在其中。在优选实施例中，金属化包括铬和镍或其合金，其次是金或铂。金属化优选使用诸如真空沉积或溅射的低温工艺来进行。金属密封件可以是箔或线的形式。一个或两个板与感兴趣的波长兼容，并且该技术可以用于透射和反射配置。

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