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1. 发明授权

US06416471B1 Portable remote patient telemonitoring system 失效
标题翻译：便携式远程病人远程监控系统
公开(公告)号：US06416471B1
公开(公告)日：2002-07-09
申请号：US09292405
申请日：1999-04-15
申请人： Harpal S. Kumar , Paul Johnson , Michael D. Llewellyn , William J. Mullarkey , William New, Jr. , Laurence J. Nicolson , William G. O'Brien , John D. Place , Peter M. Relph
发明人： Harpal S. Kumar , Paul Johnson , Michael D. Llewellyn , William J. Mullarkey , William New, Jr. , Laurence J. Nicolson , William G. O'Brien , John D. Place , Peter M. Relph
IPC分类号： A61B500
CPC分类号： G06F19/3418 , A61B5/0006 , A61B5/0022 , A61B5/7232 , A61B2560/0209 , G06F19/00 , G16H10/65 , Y02A90/22 , Y02A90/26 , Y10S128/903 , Y10S128/904
摘要： A system and method for monitoring vital signs and capturing data from a patient remotely using radiotelemetry techniques. The system is characterized by a cordless, disposable sensor band with sensors form measuring full waveform ECG, full waveform respiration, skin temperature, and motion, and transmission circuitry for the detection and transmission of vital signs data of the patient. A small signal transfer unit that can either be worn by the patient, e.g., on his or her belt, or positioned nearby receives data from the sensor band, which it then forwards by e.g., radio transmission to a base station that can be located up to 60 meters away. The base station receives data transmissions from the signal transfer unit and is designed to connect to conventional phone lines for transferring the collected data to a remote monitoring station. The base station may also capture additional clinical data, such as blood pressure data, and to perform data checks. Patient safety is enhanced by the ability of the base station to compare clinical data, e.g., ECG, against given profiles and to mark events when appropriate or when the base station is programmed to do so. Such events are indicated to the physician and could be indicated to the patient by reverse transmission to the signal transfer unit. A remote monitoring station allows the presentation and review of data (including events) forwarded by the sensor band. ECG analysis software and a user-friendly graphical user interface are provided to remotely analyze the transmitted data and to permit system maintenance and upkeep. The system of the invention has useful application to the collection of patient clinical data during drug trials and medical testing for regulatory approvals as well as management of patients with chronic diseases.
摘要翻译：一种用于使用无线电测量技术远程监测生命体征并从患者捕获数据的系统和方法。该系统的特点是无绳，一次性传感器带，传感器形成测量全波形ECG，全波形呼吸，皮肤温度和运动，以及用于检测和传输患者生命体征数据的传输电路。可以由患者穿戴的小信号传递单元，例如在他或她的皮带上，或者位于附近，从传感器带接收数据，然后传感器带通过例如无线电传输转发到可以位于上的基站到60米远。基站从信号传送单元接收数据传输，并被设计成连接到传统的电话线路，用于将收集的数据传送到远程监控站。基站还可以捕获额外的临床数据，例如血压数据，并执行数据检查。通过基站比较临床数据（例如ECG）与给定配置文件的能力以及在适当时或当基站进行编程时标记事件的能力来增强患者安全性。向医生指示这种事件，并且可以通过向信号传送单元的反向传输向患者指示。远程监控站允许呈现和检查由传感器带转发的数据（包括事件）。提供ECG分析软件和用户友好的图形用户界面，以远程分析传输的数据并允许系统维护和维护。本发明的系统可用于在药物试验期间收集患者临床数据，并进行监管批准的医疗检测以及慢性病患者的管理。

2. 发明授权

US06450953B1 Portable signal transfer unit 失效
标题翻译：便携式信号传输单元
公开(公告)号：US06450953B1
公开(公告)日：2002-09-17
申请号：US09292158
申请日：1999-04-15
申请人： John D. Place , Paul Johnson , Steven Jones , Harpal S. Kumar , William J. Mullarkey , William New, Jr. , Laurence J. Nicolson , Peter M. Relph
发明人： John D. Place , Paul Johnson , Steven Jones , Harpal S. Kumar , William J. Mullarkey , William New, Jr. , Laurence J. Nicolson , Peter M. Relph
IPC分类号： A61B500
CPC分类号： A61B5/0002 , Y10S128/903
摘要： A portable signal transfer unit for relaying a signal representative of physiological data of a mammalian subject from a remote physiological sensor to a remote receiver unit. The portable transfer unit includes an input device which operably receives the signal, a memory for buffering the signal, and an output device which wirelessly transmits the signal to the remote unit. The signal transfer unit also includes a signal processor for relaying the signal from the signal input to the output device, wherein the signal processor has two or more receivers each receiver adapted to handle a specified signal carrier frequency. An indicator is also provided which indicates to the subject whether the signal transfer unit is within range of the remote unit to enable effective transmission of the signal from the signal transfer unit to the remote unit.
摘要翻译：一种便携式信号传送单元，用于将表示哺乳动物受试者的生理数据的信号从远程生理传感器传送到远程接收器单元。便携式传送单元包括可操作地接收信号的输入设备，用于缓冲信号的存储器以及将信号无线地发送到远程单元的输出设备。信号传送单元还包括用于将信号从信号输入中继到输出设备的信号处理器，其中信号处理器具有两个或多个接收器，每个接收器适于处理指定的信号载波频率。还提供了一个指示器，其向主体指示信号传送单元是否在远程单元的范围内，以使信号能够从信号传送单元有效传输到远程单元。

3. 发明授权

US06494829B1 Physiological sensor array 失效
标题翻译：生理传感器阵列
公开(公告)号：US06494829B1
公开(公告)日：2002-12-17
申请号：US09292159
申请日：1999-04-15
申请人： William New, Jr. , Andrea J. Harry , Paul Johnson , Harpal S. Kumar , William J. Mullarkey , Laurence J. Nicolson , John D. Place
发明人： William New, Jr. , Andrea J. Harry , Paul Johnson , Harpal S. Kumar , William J. Mullarkey , Laurence J. Nicolson , John D. Place
IPC分类号： A61B500
CPC分类号： H04M11/002 , A61B5/0002 , A61B5/0205 , A61B5/04085 , A61B5/1135 , G06F19/00 , Y10S128/903
摘要： A physiological sensor device for attachment to a mammalian subject comprising an output transmitter, at least two physiological sensors each for sensing one of the subject's physiological parameters, and a controller operably in communication with the physiological sensors which controller communicates a signal comprising data representative of both the sensed physiological parameters to the output transmitter which operably transmits the signal to a remote location, wherein the controller comprises a multiplexer which operably switches the data from both the physiological sensors into a serial output signal. Respiration may be detected by a bend sensor including an elongate member and an electrical component mounted thereon which electrical component has an electrical property which varies in dependence on the extent of bending of the elongate member. Other parameters such as temperature and full waveform ECG may also be measured.
摘要翻译：一种用于附接到哺乳动物受试者的生理传感器装置，包括输出发射器，每个用于感测受试者生理参数之一的至少两个生理传感器，以及可操作地与生理传感器通信的控制器，所述控制器传达包括代表两者的数据的信号感测到的输出发射器的生理参数，其可操作地将信号传输到远程位置，其中控制器包括将数据从生理传感器可操作地切换成串行输出信号的多路复用器。呼吸可以由包括细长构件和安装在其上的电气部件的弯曲传感器检测到，该电气部件具有根据细长构件的弯曲程度而变化的电性质。也可以测量其他参数，例如温度和全波形ECG。

4. 发明授权

US10301167B2 Apparatus and method for automatically updating the relationship between measured storage tank depth and storage tank volume, and monitoring the accuracy of a dispenser flow meter 有权
公开(公告)号：US10301167B2
公开(公告)日：2019-05-28
申请号：US15226968
申请日：2016-08-03
申请人： Paul Johnson , Thomas D'Alesandro , Mark Butsch
发明人： Paul Johnson , Thomas D'Alesandro , Mark Butsch
IPC分类号： B67D7/08 , B67D7/78 , G01F1/86 , G01F22/00 , G01F25/00 , G01N9/00 , G01F1/00
摘要： An automated liquid inventory monitoring and inventory reconciliation system. The system uses a liquid densitometer to precisely measure the density of liquid being dispensed. This allows the system to account for the significant temperature-induced volume variations existing in common liquids such as gasoline. In the preferred embodiments, a fuel inventory processor tracks the quantity of fuel loaded into the tank and the quantity of fuel dispensed to maintain an ongoing computation of the quantity of fuel that should be present in the tank. An accurate tank depth measurement device is also employed. The processor compares the tank depth measurement to the computed quantity of fuel in the tank and uses the values to create an updated tank strapping chart.

5. 发明申请

US20160228107A1 SELF-CONTAINED PORT CLOSURE TROCAR AND METHOD OF USE 审中-公开
标题翻译：自包式端口封闭和使用方法
公开(公告)号：US20160228107A1
公开(公告)日：2016-08-11
申请号：US14878777
申请日：2015-10-08
申请人： Spencer Madsen , Mike Fogarty , Paul Johnson , John Langell
发明人： Spencer Madsen , Mike Fogarty , Paul Johnson , John Langell
IPC分类号： A61B17/00 , A61B17/04
CPC分类号： A61B17/0057 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/3417 , A61B2017/0046 , A61B2017/00637 , A61B2017/00663 , A61B2017/0409 , A61B2017/0414 , A61B2017/0472 , A61B2017/346
摘要： A self-contained, port-closing trocar and method of use which may include an elongated body having a first end, a second end opposite the first end, and a side wall between the first end and the second end, the body further including at least two channels therein, each of the channels originating near the second end, running parallel to the elongated body, and curving towards and forming an opening in the side wall near the first end. The self-closing trocar may also include at least two needles, each disposed within one of the at least two channels, and a handle insertable into the second end of the elongated body, the handle having at least two needle drivers coupled thereto, each needle driver being insertable into one of the at least two channels and engagable with an end of a needle.
摘要翻译：一种独立的封口套管针和使用方法，其可以包括具有第一端，与第一端相对的第二端和在第一端和第二端之间的侧壁的细长主体，所述主体还包括在在其中的至少两个通道中，每个通道始终靠近第二端，平行于细长主体延伸，并且朝向并在第一端附近的侧壁中形成开口弯曲。自封闭套管针还可以包括至少两个针，每个针布置在至少两个通道中的一个中，并且可插入到细长主体的第二端的手柄，手柄具有与之相连的至少两个针驱动器，每个针驾驶员可以插入到所述至少两个通道中的一个中并且可与针的一端接合。

6. 发明授权

US08470577B2 Viral vectors and their use in therapeutic methods 有权
公开(公告)号：US08470577B2
公开(公告)日：2013-06-25
申请号：US12721599
申请日：2010-03-11
申请人： Paul Johnson , Robert L. Martuza , Samuel D. Rabkin , Tomoki Todo
发明人： Paul Johnson , Robert L. Martuza , Samuel D. Rabkin , Tomoki Todo
IPC分类号： C12N7/00 , C12N7/01 , A61K39/245
CPC分类号： A61K39/245 , A61K35/763 , A61K35/768 , A61K38/162 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/585 , C12N7/00 , C12N15/86 , C12N2710/16632 , C12N2710/16634 , C12N2710/16643 , C12N2710/16662 , C12N2710/16671
摘要： The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.

7. 发明申请

US20120226945A1 PROVIDING AUTOMATIC RETRY OF TRANSACTIONS WITH DIAGNOSTICS 审中-公开
标题翻译：提供自动检测交易与诊断
公开(公告)号：US20120226945A1
公开(公告)日：2012-09-06
申请号：US13470856
申请日：2012-05-14
申请人： Paul Johnson , Colin R. Penfold
发明人： Paul Johnson , Colin R. Penfold
IPC分类号： G06F11/07
CPC分类号： G06F9/466 , G06F11/0778 , G06F11/0793 , G06F11/1474
摘要： A method, system and computer program product for handling a unit of work in a transaction processing system, in which the system comprises one or more production regions operating minimal or no diagnostic functions and one or more diagnostic regions operating maximal or full diagnostic functions. A unit of work is received, which is routed to a production region. After receiving a notification that the work has failed, the work is routed to a diagnostic region.
摘要翻译：一种用于处理事务处理系统中的工作单元的方法，系统和计算机程序产品，其中所述系统包括操作最小或不具有诊断功能的一个或多个生产区域以及操作最大或全部诊断功能的一个或多个诊断区域。接收到一个工作单元，该单元被转送到生产区域。在收到工作失败的通知后，工作将路由到诊断区域。

8. 发明授权

US08186506B2 Packaging system for transdermal drug delivery systems 有权
标题翻译：透皮给药系统包装系统
公开(公告)号：US08186506B2
公开(公告)日：2012-05-29
申请号：US11130325
申请日：2005-05-16
申请人： David P. Kanios , Juan A. Mantelle , Paul Johnson , Chensheng Li
发明人： David P. Kanios , Juan A. Mantelle , Paul Johnson , Chensheng Li
IPC分类号： B65D81/26
CPC分类号： A61K9/7061 , A61F15/001 , A61J1/00 , A61K9/7069 , B65D81/268
摘要： A device and method for stabilizing a drug, particularly a chiral drug or the active enantiomer(s) thereof, in a carrier composition of a transdermal delivery system prior to the systems use by providing a product packaging system to prevent or control degradation reactions that can result from certain packaging materials and moisture contamination, while at the same time providing a child-resistant wrapping for the transdermal system.
摘要翻译：一种用于在系统使用之前将药物，特别是手性药物或其活性对映异构体稳定在透皮递送系统的载体组合物中的装置和方法，其通过提供产品包装系统来预防或控制降解反应来自某些包装材料和水分污染，同时为透皮系统提供抗儿童包装。

9. 发明申请

US20110070262A1 Viral Vectors and Their Use in Therapeutic Methods 有权
标题翻译：病毒载体及其在治疗方法中的应用
公开(公告)号：US20110070262A1
公开(公告)日：2011-03-24
申请号：US12721599
申请日：2010-03-11
申请人： Paul Johnson , Robert L. Martuza , Samuel D. Rabkin , Tomoki Todo
发明人： Paul Johnson , Robert L. Martuza , Samuel D. Rabkin , Tomoki Todo
IPC分类号： A61K39/245 , C12N7/04 , A61K35/76 , A61P35/00 , A61P37/04 , A61P31/00
CPC分类号： A61K39/245 , A61K35/763 , A61K35/768 , A61K38/162 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/585 , C12N7/00 , C12N15/86 , C12N2710/16632 , C12N2710/16634 , C12N2710/16643 , C12N2710/16662 , C12N2710/16671
摘要： The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
摘要翻译：本发明提供病毒载体（例如，疱疹病毒载体）以及使用这些载体治疗疾病的方法。

10. 发明授权

US07906826B2 Many million pixel image sensor 有权
标题翻译：许多百万像素图像传感器
公开(公告)号：US07906826B2
公开(公告)日：2011-03-15
申请号：US11904782
申请日：2007-09-28
申请人： Peter Martin , Paul Johnson , Chris Sexton
发明人： Peter Martin , Paul Johnson , Chris Sexton
IPC分类号： H01L31/062
CPC分类号： H01L27/14634 , G03F7/70433 , G03F7/70475 , H01L27/14643 , H01L27/14647 , H01L27/14652 , H01L27/14683
摘要： A CMOS image sensor with a many million pixel count. Applicants have developed techniques for combining its continuous layer photodiode CMOS sensor technology with CMOS integrated circuit lithography stitching techniques to provide digital cameras with an almost unlimited number of pixels. A preferred CMOS stitching technique exploits the precise alignment accuracy of CMOS stepper processes by using specialized mask sets to repeatedly produce a single pixel array pattern many times on a single silicon wafer with no pixel array discontinuities. The single array patterns are stitched together lithographically to form a pixel array of many million pixels. A continuous multilayer photodiode layer is deposited over the top of the many million pixel array to provide a many million pixel sensor with a fill factor of 100 percent or substantially 100 percent.
摘要翻译：具有数百万像素数的CMOS图像传感器。申请人已经开发出将连续层光电二极管CMOS传感器技术与CMOS集成电路光刻拼接技术相结合的技术，为数码相机提供几乎无限数量的像素。优选的CMOS拼接技术利用CMOS步进工艺的精确对准精度通过使用专门的掩模组在单个硅晶片上多次重复产生单个像素阵列图案，而不存在像素阵列不连续性。将单阵列图案光刻地缝合在一起以形成数百万像素的像素阵列。连续的多层光电二极管层沉积在数百万像素阵列的顶部，以提供百万像素传感器，其填充因子为100％或基本为100％。

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