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    • 5. 发明申请
    • Continuous glucose monitoring device
    • 连续葡萄糖监测装置
    • US20050137471A1
    • 2005-06-23
    • US10740056
    • 2003-12-18
    • Hans-Peter HaarHans ListFelix BaaderHerbert HarttigGeorge Meacham
    • Hans-Peter HaarHans ListFelix BaaderHerbert HarttigGeorge Meacham
    • A61B5/00G01N35/00A61K9/22
    • A61B5/14528A61B5/14532A61B5/686A61B2562/0295Y10T436/110833
    • The present invention is generally directed towards devices for sensing a concentration of chemical constituents in body fluid such as interstitial fluid, including but not limited to glucose. The devices also relates to systems for measuring and reporting the concentration of body fluid constituents at time intervals shorter than the physiological response time, thereby providing effectively continuous concentration measurements. The device according to the present invention comprises a probe, a reservoir with perfusion fluid connected to an inlet of the probe, at least one test zones which comprise a reagent, to react with the analyte to produce a detectable change, a reader unit which reads test zones wetted with fluid containing the analyte, where the reader unit produces signals according to the concentration of the analyte in the fluid; and a processing unit for processing the signals and the concentration of the analyte.
    • 本发明通常涉及用于感测体液中诸如间质液体(包括但不限于葡萄糖)的化学成分浓度的装置。 这些装置还涉及用于在比生理反应时间短的时间间隔测量和报告体液组分的浓度的系统,从而提供有效的连续浓度测量。 根据本发明的装置包括探针,具有连接到探针的入口的灌注流体的储存器,包含试剂的至少一个测试区域,以与分析物反应以产生可检测的变化;读取器单元,其读取 用含有分析物的流体润湿的测试区域,其中读取器单元根据流体中分析物的浓度产生信号; 以及用于处理信号和分析物浓度的处理单元。
    • 7. 发明申请
    • LANCING SYSTEM FOR THE EXTRACTION OF A BODY FLUID
    • US20100063417A1
    • 2010-03-11
    • US12396838
    • 2009-03-03
    • Hans ListIrio G. CalassoJoachim HoenesHans-Peter HaarUwe KraemerHerbert HarttigVolker Zimmer
    • Hans ListIrio G. CalassoJoachim HoenesHans-Peter HaarUwe KraemerHerbert HarttigVolker Zimmer
    • A61B5/151
    • A61B5/14532A61B5/150022A61B5/150068A61B5/150175A61B5/150389A61B5/150503A61B5/15109A61B5/15113A61B5/15117A61B5/15132
    • Lancing system for extracting a body fluid from the skin of a human or animal comprising a needle element (3) for lancing the skin, a lancing device (2) which includes a lancet drive (15a), by which a lancing movement of the needle element (3) coupled with the lancet drive by means of a coupling mechanism (28) is driven in lancing direction, wherein the lancing device (2) comprises a housing (4) with a housing opening (5) at its in lancing direction front end and the housing opening (5) is surrounded by a housing skin contact surface (7) which is pressed against the skin when using the lancing device (2), the needle element (3) is moved on a predetermined lancing path in a lancing direction in a forward phase of the lancing movement until its tip (3c) enters the skin in order to create a wound and in a return phase of the lancing movement following the reaching of a reversal point corresponding to the lancing depth (S) in the skin is retracted again, a lancing depth reference element (8) with a reference skin contact surface (11) is provided to improve the reproducibility of the lancing depth (S), which is adapted and arranged in such a manner that the reference skin contact surface (11) at the reversal point of the lancing movement is in contact with the skin and the predetermined value of the lancing depth (S) is determined by the distance in lancing direction which prevails at the reversal point of the lancing movement between the reference skin contact surface (11) and the position of the tip (3c) of the needle element (3), at which at the time at which the tip (3c) of the needle element (3) in the forward phase of the lancing movement passes the reference skin contact surface (11) and enters a skin surface which is in contact with said reference skin contact surface, the lancing depth reference element (8) with the reference skin contact surface (11) is in a stationary defined position relative to the reversal point of the lancing movement and the lancing depth reference element (8) is adapted and arranged in such a manner that the skin when pressed against the reference skin contact surface (11) is stabilized with respect to a skin deformation which occurs upon lancing of the skin.