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1. 发明授权

US4423227A Process for the preparation of reactive, couplable derivatives of the thyroid hormones 失效
标题翻译：制备甲状腺激素的反应性，偶联性衍生物的方法
公开(公告)号：US4423227A
公开(公告)日：1983-12-27
申请号：US307141
申请日：1981-09-30
申请人： Hans-Georg Batz , Winfried Albert , Helmut Lenz , Hans-Ralf Linke , Fritz Stahler
发明人： Hans-Georg Batz , Winfried Albert , Helmut Lenz , Hans-Ralf Linke , Fritz Stahler
IPC分类号： C07C67/00 , C07C231/00 , C07C231/02 , C07C233/47 , C07C233/49 , C07D207/44 , C07D207/452 , C07F7/18 , G01N33/53 , G01N33/60 , G01N33/78 , C07F7/10
CPC分类号： C07D207/452 , G01N33/78
摘要： Process for the preparation of reactive, couplable derivatives of the thyroid hormones 3,3',5-triiodothyronine (T.sub.3) and 3,3',5,5'-tetraiodothyronine (T.sub.4) by reaction with reactive carboxylic acid derivatives, which process comprises sylylating all the functional groups of the thyroid hormone by reaction with a reactive triorganosylyl derivative and then reacting the persylylated derivative of the thyroid hormone thus obtained with an activated carboxylic acid derivative.
摘要翻译：通过与活性羧酸衍生物反应制备3,3'，5-三碘甲状腺原氨酸（T3）和3,3'，5,5'-四碘甲状腺原氨酸（T4）的活性，偶联衍生物的方法，该方法包括通过与反应性三有机基团衍生物反应来甲酰化甲状腺激素的所有官能团，然后使由此获得的甲状腺激素的透性衍生物与活化的羧酸衍生物反应。

2. 发明授权

US4578361A Creatinine antibody 失效
标题翻译：肌酸酐抗体
公开(公告)号：US4578361A
公开(公告)日：1986-03-25
申请号：US656957
申请日：1984-10-02
申请人： Joachim Siedel , Ulrich Neumann , Joachim Ziegenhorn , Hans-Georg Batz , Helmut Lenz , Brigitte Pautz , Winfried Albert
发明人： Joachim Siedel , Ulrich Neumann , Joachim Ziegenhorn , Hans-Georg Batz , Helmut Lenz , Brigitte Pautz , Winfried Albert
IPC分类号： G01N33/53 , A61K38/00 , C07K16/18 , G01N33/531 , G01N33/543 , G01N33/577 , G01N33/70 , A61K39/00
CPC分类号： C07K16/18 , G01N33/531 , G01N33/54306 , G01N33/577 , G01N33/70 , A61K38/00
摘要： The present invention provides a creatinine antibody and a process for the preparation thereof, wherein a conjugate of creatinine and a material suitable for antiserum formation, which are connected via an aliphatic or araliphatic carboxylic acid as bridge member, is used as immunogen for antiserum formation.The present invention is also concerned with the use of the above antibody for the immunological determination of creatinine, wherein the antibody is incubated with a creatinine-containing sample solution, reacted with a conjugate of creatinine with a hapten carrier substance, whereby one of the components, antibody and conjugate, is present in the solid phase or in dissolved form and the other component is present in dissolved form and the inhibition of the binding reaction between the antibody and the creatinine conjugate is measured.Furthermore, the present invention provides a reagent for the immunological determination of creatinine, wherein it contains the above antibody, a conjugate of creatinine with a hapten carrier substance and buffer substance.
摘要翻译：本发明提供一种肌酸酐抗体及其制备方法，其中通过脂肪族或脂环族羧酸作为桥接剂连接肌酸酐和适于抗血清形成的物质的缀合物，用作抗血清形成的免疫原。本发明还涉及上述抗体用于肌酸酐免疫学测定的用途，其中将抗体与含肌酸酐的样品溶液一起温育，与肌酸酐的缀合物与半抗原载体物质反应，由此其中一种成分，抗体和缀合物以固相或溶解形式存在，另一组分以溶解形式存在，并测量抗体与肌酐结合物之间结合反应的抑制。此外，本发明提供了用于肌酸酐免疫测定的试剂，其中含有上述抗体，肌酸酐与半抗原载体物质和缓冲物质的结合物。

3. 发明授权

US4543325A Process and reagent for the determination of creatinine 失效
标题翻译：用于测定肌酐的方法和试剂
公开(公告)号：US4543325A
公开(公告)日：1985-09-24
申请号：US449925
申请日：1982-12-15
申请人： Winfried Albert , Joachim Ziegenhorn , Joachim Siedel , Hans-Georg Batz , Helmut Lenz , Brigitte Pautz
发明人： Winfried Albert , Joachim Ziegenhorn , Joachim Siedel , Hans-Georg Batz , Helmut Lenz , Brigitte Pautz
IPC分类号： G01N33/53 , G01N33/70 , C12N9/96 , C12Q1/34
CPC分类号： G01N33/70 , Y10S435/81 , Y10S435/961 , Y10S436/822
摘要： The present invention provides a process for the immunological determination of creatinine, wherein creatinine is converted into 1-methylhydantoin, the 1-methylhydantoin formed is incubated in an aqueous medium with antibodies which are directed against a conjugate of a first hydantoin derivative of the general formula: ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which can be the same or different, are hydrogen atoms, alkyl radicals containing up to 3 carbon atoms or phenyl radicals, with a first hapten carrier substance suitable for antibody formation, reacted with a conjugate of a second hydantoin derivative of general formula (I) with a second hapten carrier substance, one of the components antibody and conjugate being present in the solid phase or in dissolved form and the other component being present in dissolved form, and the inhibition of the binding reaction between the antibodies and the hydantoin conjugate with the second hapten carrier substance is measured.The present invention also provides a reagent for the immunological determination of creatinine, wherein it contains creatinine iminohydrolase, antibodies against a conjugate of a hydantoin of the general formula: ##STR2## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which can be the same or different, are hydrogen atoms, alkyl radicals containing up to 3 carbon atoms or phenyl radicals, with a first hapten carrier substance, a conjugate of a hydantoin of general formula (I) with a second hapten carrier substance which does not cross-react substantially with the first hapten carrier substance and a buffer substance.
摘要翻译：本发明提供了一种免疫学测定肌酐的方法，其中将肌酐转化为1-甲基乙内酰脲，所形成的1-甲基乙内酰脲在水性介质中与针对通式：其中可以相同或不同的R 1，R 2，R 3和R 4为氢原子，含有至多3个碳原子的烷基或苯基，其中第一半抗原载体物质适用于抗体与通式（I）的第二乙内酰脲衍生物与第二半抗原载体物质的缀合物反应，抗体和缀合物之一是固相或溶解形式存在，另一种成分以溶解形式存在并且测量了与第二半抗原载体物质的抗体和乙内酰脲缀合物之间的结合反应的抑制。本发明还提供了一种用于免疫测定肌酐的试剂，其中含有肌酐亚氨基水解酶，针对通式如下的乙内酰脲的缀合物的抗体：其中R1，R2，R3和R4可以相同或不同的是氢原子，含有至多3个碳原子的烷基或苯基，具有第一半抗原载体物质，通式（I）的乙内酰脲与不会基本上交叉反应的第二半抗原载体物质的缀合物具有第一半抗原载体物质和缓冲物质。

4. 发明授权

US4436828A Reactive asymmetrical dicarboxylic acid esters and reagents for the investigation of cardiac glycosides 失效
标题翻译：活性不对称二羧酸酯和试剂用于研究强心苷
公开(公告)号：US4436828A
公开(公告)日：1984-03-13
申请号：US200838
申请日：1980-10-27
申请人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Weimann
发明人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Weimann
IPC分类号： C07D249/20 , A61K31/22 , A61K31/265 , A61K31/275 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/70 , A61P43/00 , C07C43/32 , C07C67/00 , C07C69/34 , C07C69/42 , C07C69/67 , C07C205/43 , C07C253/00 , C07C255/16 , C07C327/22 , C07D207/40 , C07D207/46 , C07D209/48 , C07D213/63 , C07D227/12 , C07D249/18 , C07J19/00 , C07J41/00 , C07J43/00 , C07K19/00 , G01N33/53 , G01N33/531 , A61K43/00 , C07G7/00 , G01N33/56
CPC分类号： C07C255/00 , C07J41/0055 , C07J41/0094 , C07J43/003 , G01N33/531 , Y10S436/822 , Y10S436/823
摘要： New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R.sub.1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R.sub.2 and R.sub.3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, p-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5, are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).
摘要翻译：式（I）的新的反应性不对称二羧酸酯化合物，其中R 1是含有至多3个碳原子的烷基或是地高辛或二氧杂辛基残基，R2和R3可以相同或不同，是烷氧基含有3个碳原子或一起代表氧原子的基团，X是氰基甲氧基，琥珀酰亚胺-N-氧基，N-甲基 - 吡啶氧基，2,4-二硝基苯氧基，2,4,5-三氯苯氧基，五氯苯氧基，苯硫基，p - 硝基苯氧基，对硝基苯硫基，哌啶基-N-氧基，苯二甲酰亚氨基-N-氧基或苯并三唑-N-氧基，n为2,3,4或5可用于制备用于研究强心苷的试剂（洋地黄糖苷）。

5. 发明授权

US4202873A Alkylolamides of iodizable amino acids and immune test reagents containing them 失效
标题翻译：可碘化氨基酸的烷基酰胺和含有它们的免疫试剂
公开(公告)号：US4202873A
公开(公告)日：1980-05-13
申请号：US782868
申请日：1977-03-30
申请人： Hans-Georg Batz , Klaus Stellner , Hans-Ralf Linke , Gunter Weimann
发明人： Hans-Georg Batz , Klaus Stellner , Hans-Ralf Linke , Gunter Weimann
IPC分类号： A61K31/165 , A61K31/415 , A61K51/00 , A61P43/00 , C07C20060101 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C237/20 , C07D233/54 , C07D233/64 , C07D233/90 , C07J19/00 , C07J41/00 , G01N33/60 , C07C103/78 , A61K43/00 , C07D233/02
CPC分类号： C07D233/64 , A61K31/165 , A61K31/415 , C07D233/54 , C07D233/90 , C07J41/0055 , G01N33/60
摘要： Novel alkylolamides of iodizable amino acids of the formula ##STR1## wherein, R.sup.1 is hydroxybenzyl, dihydroxybenzyl or imidazol-4-yl-methyl andR.sup.2 is monohydroxy-alkyl of 1 or 2 carbon atoms or dihydroxy-alkyl of up to 4 carbon atoms,and the water-soluble salts thereof are provided; these materials are useful as components of radioiodizable immune test reagents.
摘要翻译：新颖的式可光化氨基酸的烷基酰胺，其中R1是羟基苄基，二羟基苄基或咪唑-4-基 - 甲基，R2是1或2个碳原子的单羟基烷基或至多4个碳原子的二羟基烷基，并提供其水溶性盐; 这些材料可用作可放射性免疫测试试剂的组分。

6. 发明授权

US4282151A Reactive asymmetrical dicarboxylic acid esters and reagents for the investigation of cardiac glycosides 失效
标题翻译：活性不对称二羧酸酯和试剂用于研究强心苷
公开(公告)号：US4282151A
公开(公告)日：1981-08-04
申请号：US883981
申请日：1978-03-06
申请人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Wiemann
发明人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Wiemann
IPC分类号： C07D249/20 , A61K31/22 , A61K31/265 , A61K31/275 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/70 , A61P43/00 , C07C43/32 , C07C67/00 , C07C69/34 , C07C69/42 , C07C69/67 , C07C205/43 , C07C253/00 , C07C255/16 , C07C327/22 , C07D207/40 , C07D207/46 , C07D209/48 , C07D213/63 , C07D227/12 , C07D249/18 , C07J19/00 , C07J41/00 , C07J43/00 , C07K19/00 , G01N33/53 , G01N33/531
CPC分类号： C07C255/00 , C07J41/0055 , C07J41/0094 , C07J43/003 , G01N33/531 , Y10S436/822 , Y10S436/823
摘要： New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R.sub.1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R.sub.2 and R.sub.3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, n-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5, are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).
摘要翻译：式（I）的新的反应性不对称二羧酸酯化合物，其中R 1是含有至多3个碳原子的烷基或是地高辛或二氧杂辛基残基，R2和R3可以相同或不同，是烷氧基含有3个碳原子或一起代表氧原子的基团，X是氰基甲氧基，琥珀酰亚胺-N-氧基，N-甲基 - 吡啶氧基，2,4-二硝基苯氧基，2,4,5-三氯苯氧基，五氯苯氧基，苯硫基，p 硝基苯氧基，正硝基苯硫基，哌啶基-N-氧基，苯二甲酰亚氨基-N-氧基或苯并三唑-N-氧基，n为2,3,4或5可用于制备用于研究强心苷的试剂（洋地黄糖苷）。

7. 发明授权

US4133949A Dicarboxylic acid esters of cardiac glycosides 失效
标题翻译：强心苷的二羧酸酯
公开(公告)号：US4133949A
公开(公告)日：1979-01-09
申请号：US715020
申请日：1976-08-16
申请人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Weimann
发明人： Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Weimann
IPC分类号： C07D249/20 , A61K31/22 , A61K31/265 , A61K31/275 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/70 , A61P43/00 , C07C43/32 , C07C67/00 , C07C69/34 , C07C69/42 , C07C69/67 , C07C205/43 , C07C253/00 , C07C255/16 , C07C327/22 , C07D207/40 , C07D207/46 , C07D209/48 , C07D213/63 , C07D227/12 , C07D249/18 , C07J19/00 , C07J41/00 , C07J43/00 , C07K19/00 , G01N33/53 , G01N33/531
CPC分类号： C07C255/00 , C07J41/0055 , C07J41/0094 , C07J43/003 , G01N33/531 , Y10S436/822 , Y10S436/823
摘要： New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R.sub.1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R.sub.2 and R.sub.3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, p-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5. are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).
摘要翻译：式（I）的新的反应性不对称二羧酸酯化合物，其中R 1是含有至多3个碳原子的烷基或是地高辛或二氧杂辛基残基，R2和R3可以相同或不同，是烷氧基含有最多3个碳原子或一起代表氧原子的基团，X是氰基甲氧基，琥珀酰亚胺-N-氧基，N-甲基 - 吡啶氧基，2,4-二硝基苯氧基，2,4,5-三氯苯氧基，五氯苯氧基，苯硫基，p - 硝基苯氧基，对硝基苯硫基，哌啶基-N-氧基，苯二甲酰亚氨基-N-氧基或苯并三唑-N-氧基，n为2,3,4或5.可用于制备用于研究强心苷的试剂（洋地黄糖苷）。

8. 发明授权

US4742159A Digitalis antibodies, process for the preparation thereof and the use thereof for the therapy of digitalis intoxications 失效
标题翻译：洋地黄抗体，其制备方法及其用于治疗洋地黄中毒的用途
公开(公告)号：US4742159A
公开(公告)日：1988-05-03
申请号：US563217
申请日：1983-12-19
申请人： Hans-Georg Batz , Herbert Jungfer , Helmut Lenz , Albert Roder
发明人： Hans-Georg Batz , Herbert Jungfer , Helmut Lenz , Albert Roder
IPC分类号： C07K14/415 , A61K38/00 , A61K39/395 , A61K39/44 , A61P39/02 , C07K1/22 , C07K14/00 , C07K14/435 , C07K16/00 , C07K16/16 , G01N33/53 , G01N33/94 , C07K13/00 , C12P21/00 , C12Q1/00
CPC分类号： C07K16/16 , G01N33/9453 , A61K38/00 , Y10S424/809 , Y10S530/866
摘要： The present invention provides a process for the preparation of digitalis antibodies in which appropriate mammals are immunized with a digoxin bound to protein, the animal serum is obtained, the immune globulin-containing protein fraction is separated in known manner, the immunologically-active globulins are adsorbed on an immunologically-active column and separated from the other proteins, the antibodies are again eluted from the column and the Fab fractions are split with papain and purified, wherein, as immunologically-active adsorbent, there is used an inorganic matrix of large surface area to which digitoxin aldehyde is bound via a spacer which cannot be split with papain and the splitting off of the Fab fraction from the antibodies is carried out on the matrix.The present invention also provides digitalis antibodies obtained by this process, which antibodies can be used for the therapy of digitalis intoxications and for preparing immunological reagents for the determination of digitalis glycosides.
摘要翻译：本发明提供了一种制备洋地黄抗体的方法，其中用与蛋白质结合的地高辛免疫合适的哺乳动物，获得动物血清，以已知方式分离含免疫球蛋白的蛋白质级分，免疫活性球蛋白吸附在免疫活性柱上并与其他蛋白质分离，抗体再次从柱中洗脱出来，Fab级分用木瓜蛋白酶分离纯化，其中作为免疫活性吸附剂，使用大面积的无机基质通过不能与木瓜蛋白酶分离的间隔基结合数毒素醛的区域，并且在基质上进行Fab级分与抗体的分离。本发明还提供通过该方法获得的洋地黄抗体，其抗体可用于治疗洋地黄中毒，并用于制备用于测定洋地黄糖苷的免疫试剂。

9. 发明授权

US4182695A Polyamide-fixed biologically active protein 失效
标题翻译：聚酰胺固定生物活性蛋白
公开(公告)号：US4182695A
公开(公告)日：1980-01-08
申请号：US878545
申请日：1978-02-16
申请人： Jurgen Horn , Winfried Albert , Hans-Georg Batz , Michael Nelbock-Hochstetter
发明人： Jurgen Horn , Winfried Albert , Hans-Georg Batz , Michael Nelbock-Hochstetter
IPC分类号： C08G69/00 , C08G69/48 , C08G69/50 , C08H1/00 , C12N11/08 , A61K31/765 , A61K31/775
CPC分类号： C08G69/50 , C12N11/08 , Y10S530/816
摘要： Biologically active protein compositions comprising protein or a protein substrate bound onto a polyamide of the general formula: ##STR1## in which R and R.sub.1, which may be the same or different, are polyamide residues bound onto the amido group,R.sub.2 is the residue of a compound which can be condensed with formaldehyde and which contains at least one further reactive group,R.sub.3 is the residue of a bi- or poly-functional protein reagent,n is 0 or 1, andP is a biologically active protein;these compositions are obtainable by the reaction of a polyamides with amounts, equimolar to one another, of formaldehyde and of a compound condensable with formaldehyde, in a solvent for polyamides, reacting the product thereby obtained with a bi- or poly-functional protein reagent and coupling the resulting reaction product with the biologically active protein or protein substrate.
摘要翻译：生物活性蛋白质组合物，其包含结合到以下通式的聚酰胺上的蛋白质或蛋白质底物：其中R和R 1可以相同或不同，是结合到酰胺基上的聚酰胺残基，R2是残基可与甲醛缩合并含有至少一个其它反应性基团的化合物，R3是双功能或多功能蛋白质试剂的残基，n为0或1，P为生物活性蛋白; 这些组合物可以通过聚酰胺与等量的甲醛和与甲醛缩合的化合物的量与聚酰胺的溶剂反应，使由此获得的产物与双功能或多功能蛋白质试剂和将所得反应产物与生物活性蛋白质或蛋白质底物偶联。

10. 发明授权

US6117973A PNA monomers with electron donor or acceptor 失效
标题翻译： PNA单体与电子给体或受体
公开(公告)号：US6117973A
公开(公告)日：2000-09-12
申请号：US805411
申请日：1997-02-24
申请人： Hans-Georg Batz , Henrik Frydenlund Hansen , Henrik Orum , Troels Koch , Gary B. Shuster , Bruce A. Armitage
发明人： Hans-Georg Batz , Henrik Frydenlund Hansen , Henrik Orum , Troels Koch , Gary B. Shuster , Bruce A. Armitage
IPC分类号： C07H21/00 , C07K14/00 , C12Q1/68 , C07K5/00
CPC分类号： C07H21/00 , C07K14/003 , C12Q1/6818 , Y10S435/81
摘要： New electron transfer moiety labeled nucleic acid analogue probes are provided that can be used in methods for determining nucleic acids in a sample. The new probes can be prepared using novel monomer subunits in a chemical synthesis route. The nucleic acids can be determined by binding the probe molecules to the nucleic acid and inducing electron transfer within the complex formed. The occurrence of the electron transfer is determined as a measure of the nucleic acid.
摘要翻译：提供了新的电子转移部分标记的核酸类似物探针，其可用于测定样品中核酸的方法。可以在化学合成途径中使用新型单体亚单位制备新的探针。核酸可以通过将探针分子与核酸结合并在形成的复合物内诱导电子转移来确定。电子转移的发生被确定为核酸的量度。

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