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1. 发明专利

PT820483E 未知
公开(公告)号：PT820483E
公开(公告)日：2001-03-30
申请号：PT96909990
申请日：1996-04-03
申请人： MOGENS HAVSTEEN JAKOBSEN , TROELS KOCH
发明人： JAKOBSEN MOGENS HAVSTEEN , KOCH TROELS
IPC分类号： G01N33/547 , B01J20/281 , B01J20/283 , C07K1/04 , C08J7/12 , C08J7/18 , G01N30/88 , G01N33/543
摘要： PCT No. PCT/DK96/00167 Sec. 371 Date Oct. 7, 1997 Sec. 102(e) Date Oct. 7, 1997 PCT Filed Apr. 3, 1996 PCT Pub. No. WO96/31557 PCT Pub. Date Oct. 10, 1996A method of immobilizing a ligand (L) to the surface (P) of a carbon-containing substrate material; said method comprising: a photochemical step of linking of one or more photochemically reactive compounds (Q) to a carbon-containing material surface (P); wherein the photochemically reactive compound (Q) is a quinone compound containing a cyclic hydrocarbon, or from 2 to 10 fused cyclic hydrocarbons, with at least two conjugated carbonyl groups; and wherein the photochemical step comprises irradiation of the photochemically reactive compound (Q) with non-ionizing electromagnetic radiation having a wavelength in the range from UV to visible light.

2. 发明授权

US06225052B1 Method for determining a nucleic acid 失效
标题翻译：确定核酸的方法
公开(公告)号：US06225052B1
公开(公告)日：2001-05-01
申请号：US08975894
申请日：1997-11-21
申请人： Hans-Georg Batz , Henrik Frydenlund Hansen , Henrik Orum , Troels Koch , Gary B. Schuster , Bruce A. Armitage , Danith Ly
发明人： Hans-Georg Batz , Henrik Frydenlund Hansen , Henrik Orum , Troels Koch , Gary B. Schuster , Bruce A. Armitage , Danith Ly
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07K14/003 , C12Q1/6818 , Y10S435/81
摘要： New electron transfer moiety labeled nucleic acid analogue probes are provided that can be used in methods for determining nucleic acids in a sample. The new probes can be prepared using novel monomer subunits in a chemical synthesis route. The nucleic acids can be determined by binding the probe molecules to the nucleic acid and inducing electron transfer within the complex formed. The occurrence of the electron transfer is determined as a measure of the nucleic acid.
摘要翻译：提供了新的电子转移部分标记的核酸类似物探针，其可用于测定样品中核酸的方法。可以在化学合成途径中使用新型单体亚单位制备新的探针。核酸可以通过将探针分子与核酸结合并在形成的复合物内诱导电子转移来确定。电子转移的发生被确定为核酸的量度。

3. 发明授权

US08653252B2 Short interfering RNA (siRNA) analogues 有权
标题翻译：短干扰RNA（siRNA）类似物
公开(公告)号：US08653252B2
公开(公告)日：2014-02-18
申请号：US10550152
申请日：2004-03-22
申请人： Joachim Elmén , Claes Wahlestedt , Zicai Liang , Anders Malling Sørensen , Henrik Ørum , Troels Koch
发明人： Joachim Elmén , Claes Wahlestedt , Zicai Liang , Anders Malling Sørensen , Henrik Ørum , Troels Koch
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1131 , A61K38/00 , A61K38/09 , A61K38/2013 , A61K38/212 , A61K38/31 , C12N15/111 , C12N15/1135 , C12N2310/14 , C12N2310/315 , C12N2310/3231 , C12N2310/3233 , C12N2310/3341 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/465 , A61K2300/00
摘要： The present invention is directed to novel double-stranded short interfering (siRNA) analogues comprising locked nucleic acid (LNA) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). The compounds disclosed herein has improved properties compared to non-modified siRNAs and may, accordingly, be useful as therapeutic agents, e.g., in the treatment of various cancer forms. More particularly, the present invention is directed to siRNA analogues comprising a sense strand and an antisense strand, wherein each strand comprises 12-35 nucleotides and wherein the siRNA analogues comprise at least one locked nucleic acid (LNA) monomer.
摘要翻译：本发明涉及包含锁定核酸（LNA）单体的新型双链短干扰（siRNA）类似物。这种化合物通过称为RNA干扰（RNAi）的方法在许多生物体中诱导序列特异性的转录后基因沉默。本文公开的化合物与未修饰的siRNA相比具有改善的性质，因此可用作治疗剂，例如用于治疗各种癌症形式。更具体地，本发明涉及包含有义链和反义链的siRNA类似物，其中每条链包含12-35个核苷酸，并且其中siRNA类似物包含至少一个锁定核酸（LNA）单体。

4. 发明授权

US07687617B2 Oligonucleotides with alternating segments of locked and non-locked nucleotides 有权
标题翻译：具有锁定和非锁定核苷酸交替区段的寡核苷酸
公开(公告)号：US07687617B2
公开(公告)日：2010-03-30
申请号：US10717434
申请日：2003-11-18
申请人： Charlotte Albaek Thrue , Christoph Rosenbohm , Henrik Frydenlund Hansen , Majken Westergaard , Nikolaj Dam Mikkelsen , Signe M. Christensen , Troels Koch , Daniel Sejer Pedersen , Miriam Frieden
发明人： Charlotte Albaek Thrue , Christoph Rosenbohm , Henrik Frydenlund Hansen , Majken Westergaard , Nikolaj Dam Mikkelsen , Signe M. Christensen , Troels Koch , Daniel Sejer Pedersen , Miriam Frieden
IPC分类号： C07H21/04 , A61K31/70
CPC分类号： C12N15/113 , A61K31/7088 , C07H19/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/341 , C12N2310/344 , C12N2320/30 , C12N2320/51
摘要： The present invention is directed to novel oligonucleotides with improved antisense properties. The novel oligonucleotides comprise at least one Locked Nucleic Acid (LNA) selected from beta-D-thio/amino-LNA or alpha-L-oxy/thio/amino-LNA. The oligonucleotides comprising LNA may also include DNA and/or RNA nucleotides. The present invention also provides a new class of pharmaceuticals which comprise antisense oligonucleotides and are useful in antisense therapy.
摘要翻译：本发明涉及具有改进的反义性质的新型寡核苷酸。所述新型寡核苷酸包含至少一种选自β-D-thio / amino-LNA或α-L-氧基/硫代/氨基-LNA的锁定核酸（LNA）。包含LNA的寡核苷酸还可以包括DNA和/或RNA核苷酸。本发明还提供了一类新的药物，其包含反义寡核苷酸并且可用于反义治疗。

5. 发明授权

US07569575B2 Synthesis of locked nucleic acid derivatives 有权
标题翻译：锁定核酸衍生物的合成
公开(公告)号：US07569575B2
公开(公告)日：2009-08-04
申请号：US10435607
申请日：2003-05-08
申请人： Mads Detlef Sørensen , Jesper Wengel , Troels Koch , Signe M. Christensen , Christoph Rosenbohm , Daniel Sejer Pedersen
发明人： Mads Detlef Sørensen , Jesper Wengel , Troels Koch , Signe M. Christensen , Christoph Rosenbohm , Daniel Sejer Pedersen
IPC分类号： C07D473/06 , C07D473/16 , C07D473/18 , C07D473/34 , C07D473/32 , C07D473/40 , C07D239/10 , C07D239/22 , A61K31/52 , A61K31/522 , A61K31/506 , A61P31/22
CPC分类号： C07H19/20 , C07H19/00 , C07H19/04 , C07H19/048
摘要： The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilizing intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues.
摘要翻译：本发明涉及一种用于合成锁定核酸衍生物的新策略，例如α-小鼠，L

6. 发明授权

US07153954B2 Method for preparation of LNA phosphoramidites 有权
公开(公告)号：US07153954B2
公开(公告)日：2006-12-26
申请号：US10194950
申请日：2002-07-12
申请人： Troels Koch , Christoph Rosenbohn , Daniel Sejer Pedersen
发明人： Troels Koch , Christoph Rosenbohn , Daniel Sejer Pedersen
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07H19/10 , C07H19/20 , C07H21/00
摘要： The present invention relates to large scale preparation of LNA phosphoramidites using a 2-cyanoethyl-N,N,N′,N′-tetra-substituted phosphoramidite and a nucleophilic activator, e.g. 2-cyanoethyl-N,N,N′,N′-tetraisopropylphosphoramidite and 4,5-dicyanoimidazole. The method is faster and more cost efficient that previously known methods.

7. 发明授权

US6033784A Method of photochemical immobilization of ligands using quinones 失效
标题翻译：使用醌对配体进行光化学固定的方法
公开(公告)号：US6033784A
公开(公告)日：2000-03-07
申请号：US930623
申请日：1997-10-07
申请人： Mogens Havsteen Jacobsen , Troels Koch
发明人： Mogens Havsteen Jacobsen , Troels Koch
IPC分类号： G01N33/547 , B01J20/281 , B01J20/283 , C07K1/04 , C08J7/12 , C08J7/18 , G01N30/88 , G01N33/543 , B05D3/06 , B05D1/36
CPC分类号： G01N33/54353 , C07K1/042 , C08J7/12 , Y10T428/31504 , Y10T428/31515 , Y10T428/31518
摘要： A method of immobilizing a ligand (L) to the surface (P) of a carbon-containing substrate material; said method comprising: a photochemical step of linking of one or more photochemically reactive compounds (Q) to a carbon-containing material surface (P); wherein the photochemically reactive compound (Q) is a quinone compound containing a cyclic hydrocarbon, or from 2 to 10 fused cyclic hydrocarbons, with at least two conjugated carbonyl groups; and wherein the photochemical step comprises irradiation of the photochemically reactive compound (Q) with non-ionizing electromagnetic radiation having a wavelength in the range from UV to visible light.
摘要翻译： PCT No.PCT / DK96 / 00167 Sec。 371日期1997年10月7日第 102（e）日期1997年10月7日PCT 1996年4月3日PCT PCT。公开号WO96 / 31557 日期：1996年10月10日将配体（L）固定在含碳基板材料的表面（P）上的方法; 所述方法包括：将一种或多种光化学反应性化合物（Q）与含碳材料表面（P）连接的光化学步骤; 其中所述光化学反应性化合物（Q）是含有环状烃或2-10个稠合环状烃与至少两个共轭羰基的醌化合物; 并且其中所述光化学步骤包括用具有在从UV到可见光的范围内的波长的非电离电磁辐射照射所述光化学反应性化合物（Q）。

8. 发明申请

US20120165514A1 SYNTHESIS OF LOCKED NUCLEIC ACID DERIVATIVES 有权
标题翻译：锁定核酸衍生物的合成
公开(公告)号：US20120165514A1
公开(公告)日：2012-06-28
申请号：US13336303
申请日：2011-12-23
申请人： Mads Detlef Sørensen , Jesper Wengel , Troels Koch , Signe M. Christensen , Christoph Rosenbohm , Daniel Sejer Pedersen
发明人： Mads Detlef Sørensen , Jesper Wengel , Troels Koch , Signe M. Christensen , Christoph Rosenbohm , Daniel Sejer Pedersen
IPC分类号： C07H19/02
CPC分类号： C07H19/20 , C07H19/00 , C07H19/04 , C07H19/048
摘要： The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues.
摘要翻译：本发明涉及一种合成锁定核酸衍生物的新策略，如α-L-氧-LNA，氨基-LNA，α-L-氨基-LNA，硫代-LNA，α-L-硫代-LNA，硒代-LNA和亚甲基LNA，其利用也可以产生其他LNA类似物如oxy-LNA的中间体提供可伸缩的高产反应。此外，式X的化合物是可能与各种亲核试剂反应的重要中间体，导致各种各样的LNA类似物。

9. 发明授权

US08084458B2 Synthesis of locked nucleic acid derivatives 有权
标题翻译：锁定核酸衍生物的合成
公开(公告)号：US08084458B2
公开(公告)日：2011-12-27
申请号：US12534711
申请日：2009-08-03
申请人： Mads Detlef Sørensen , Jesper Wengel , Troels Koch , Signe M. Christensen , Christoph Rosenbohm , Daniel Sejer Pedersen
发明人： Mads Detlef Sørensen , Jesper Wengel , Troels Koch , Signe M. Christensen , Christoph Rosenbohm , Daniel Sejer Pedersen
IPC分类号： C07D473/06 , C07D473/16 , C07D473/18 , C07D473/34 , C07D473/40 , C07D239/10 , C07D239/52 , A61P31/22
CPC分类号： C07H19/20 , C07H19/00 , C07H19/04 , C07H19/048
摘要： Methods are described for the synthesis of Locked Nucleic Acid (LNA) derivatives using certain nitrogen-containing nucleophiles.
摘要翻译：描述了使用某些含氮亲核试剂合成锁定核酸（LNA）衍生物的方法。

10. 发明申请

US20080034969A1 Air Purification by Electromagnetic Rediation of a Dispersed System 审中-公开
标题翻译：通过分散系统的电磁清除进行空气净化
公开(公告)号：US20080034969A1
公开(公告)日：2008-02-14
申请号：US11632169
申请日：2005-07-13
申请人： Troels Koch , Henrik Bohr
发明人： Troels Koch , Henrik Bohr
IPC分类号： B01D49/00 , B01D53/92 , B01J19/12 , F24F3/16
CPC分类号： F01N3/04 , B01D53/92 , B01D2259/806 , F01N3/01 , F01N2240/04 , H05B6/806 , Y02A50/2357 , Y02T10/20
摘要： The present invention relates to a method of purifying a flow of a gas, in particular an exhaust gas from a Diesel engine, which is contaminated with a particulate material (e.g. nanoparticles) using an apparatus comprising (i) a conduit for passage of the gas flow, (ii) means for applying electromagnetic radiation, e.g. microwaves, and (iii) means for supplying a dipolar liquid, e.g. water, said method comprising the steps of allowing the contaminated gas to flow through the conduit; and applying the electromagnetic radiation to said gas and said liquid. The invention also relates to an apparatus, e.g. a diesel engine exhaust system for purifying a continuous exhaust gas flow contaminated with particulate material(s), e.g. nanoparticles, in order to reduce the content of nanoparticles.
摘要翻译：本发明涉及一种净化气体流，特别是来自柴油发动机的废气的方法，其使用以下装置被颗粒材料（例如纳米颗粒）污染，该装置包括：（i）用于气体通过的导管流动，（ii）施加电磁辐射的装置，例如微波，和（iii）供应偶极液体的装置，例如。水，所述方法包括以下步骤：允许污染的气体流过导管; 以及将电磁辐射施加到所述气体和所述液体。本发明还涉及一种装置，例如，用于净化由颗粒物质污染的连续排气流的柴油发动机排气系统，例如，纳米粒子，以减少纳米粒子的含量。

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