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1. 发明授权

US4184848A Eliminating turbidity in serum undergoing photometric assay 失效
标题翻译：消除血液中经过光度测定的浊度
公开(公告)号：US4184848A
公开(公告)日：1980-01-22
申请号：US836111
申请日：1977-09-23
申请人： Hans-Georg Batz , Brigitte Draeger , August W. Wahlefeld , Gunter Weimann , Wolfgang Gruber
发明人： Hans-Georg Batz , Brigitte Draeger , August W. Wahlefeld , Gunter Weimann , Wolfgang Gruber
IPC分类号： C07C69/28 , C12Q1/00 , G01N21/82 , G01N33/48 , G01N33/50 , G01N33/52 , G01N33/16 , G01N31/14
CPC分类号： C12Q1/00 , G01N33/50 , Y10T436/25125
摘要： An agent for the elimination of turbidity in serum, especially in serum samples wherein photometric measurements are to be made, consisting essentially of one or more mono- or di-esters of polyethylene glycol and fatty acids of 9 to 14 carbon atoms with at most 8 ethylene oxide units per fatty acid moiety in the molecule, said esters having an HLB value of from 8 to 12.8.
摘要翻译：用于消除血清中浊度的试剂，特别是在其中进行光度测量的血清样品中，基本上由一种或多种聚乙二醇和9至14个碳原子的脂肪酸的单酯或二酯组成，最多8个分子中每个脂肪酸部分的环氧乙烷单元，所述酯的HLB值为8至12.8。

2. 发明授权

US4247630A Method and reagent for the determination of uric acid 失效
标题翻译：测定尿酸的方法和试剂
公开(公告)号：US4247630A
公开(公告)日：1981-01-27
申请号：US892360
申请日：1978-03-31
申请人： Joachim Ziegenhorn , Eberhard Munz , Brigitte Draeger , Alexander Hagen , Wolfgang Gruber
发明人： Joachim Ziegenhorn , Eberhard Munz , Brigitte Draeger , Alexander Hagen , Wolfgang Gruber
IPC分类号： G01N33/50 , C12Q1/62 , C12Q1/30
CPC分类号： C12Q1/62
摘要： The invention relates to an improvement in a conventional method for the determination of uric acid involving uricase/catalase/aldehyde dehydrogenase, resulting in the formation of produced NAD(P)H as a measure of the initial uric acid present, which improvement comprises adding at least one compound selected from oxalates, malonic acid mono-lower alkyl esters, trihaloethanols, pyrazole, pyridine, substituted pyrazole and pyridine wherein the substituents are selected from lower alkyl and halogen, pyridine carboxylic acids, pyridine carboxylic acids substituted with a lower radical, pyridine carboxylic acid amides and pyridine carboxylic acid lower alkyl esters, thiourea, isobutyramide and chelate-forming complexing agents, in order to suppress disturbance-causing creep reactions in said method. Reagents containing such additive compounds are also provided.
摘要翻译：本发明涉及用于测定尿酸/过氧化氢酶/醛脱氢酶的尿酸的常规方法的改进，导致产生的NAD（P）H的形成作为存在的初始尿酸的量度，其改进包括在选自草酸盐，丙二酸单低级烷基酯，三卤代乙醇，吡唑，吡啶，取代的吡唑和吡啶中的至少一种化合物，其中取代基选自低级烷基和卤素，吡啶羧酸，被低级基团取代的吡啶羧酸，吡啶羧酸酰胺和吡啶羧酸低级烷基酯，硫脲，异丁酰胺和螯合形成络合剂，以抑制所述方法中的扰动引起的蠕变反应。还提供了含有这些添加剂化合物的试剂。

3. 发明授权

US4521519A Reagent for the precipitation of apo-B-containing lipoproteins 失效
标题翻译：含有载脂蛋白B的脂蛋白的沉淀试剂
公开(公告)号：US4521519A
公开(公告)日：1985-06-04
申请号：US369382
申请日：1982-04-19
申请人： Brigitte Draeger , Joachim Ziegenhorn
发明人： Brigitte Draeger , Joachim Ziegenhorn
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/92 , G01N2800/044 , Y10S436/825 , Y10T436/107497 , Y10T436/25
摘要： The present invention provides a reagent for the precipitation of apo-B-containing lipoproteins, wherein it comprises 0.2 to 3 grams per liter of phosphotungstic acid and more than 2 mmols per liter of magnesium ions in aqueous solution.The present invention also provides a process for the preparation of this reagent and a process for the precipitation of apo-B-containing lipoproteins using this reagent.
摘要翻译：本发明提供了用于沉淀含有载脂蛋白B的脂蛋白的试剂，其中它包含0.2-3克/升磷钨酸和大于2毫摩尔/升的镁离子在水溶液中。本发明还提供了制备该试剂的方法和使用该试剂沉淀含有载脂蛋白B的脂蛋白的方法。

4. 发明授权

US4786591A Process for determining the binding capacity of thyroxin-binding globulin 失效
标题翻译：确定甲状腺素结合球蛋白结合能力的方法
公开(公告)号：US4786591A
公开(公告)日：1988-11-22
申请号：US945785
申请日：1986-12-23
申请人： Brigitte Draeger , Winfried Albert , Martina Junius , Jurgen Rasch
发明人： Brigitte Draeger , Winfried Albert , Martina Junius , Jurgen Rasch
IPC分类号： G01N33/78 , G01N33/53 , G01N33/543 , G01N33/549
CPC分类号： G01N33/78 , Y10S436/817
摘要： The present invention provides a process for determining the binding capacity of thyroxin-binding globulin (TBG) according to the principle of heterogeneous enzyme immunoassay, wherein the serum sample to be investigated is incubated with enzyme-labelled T.sub.4 or T.sub.3 and immobilized antibody against TBG or T.sub.4, the phase are separated and the labelling enzyme is measured in one of the phases.
摘要翻译：本发明提供了一种根据异源酶免疫测定原理确定甲状腺素结合球蛋白（TBG）的结合能力的方法，其中待研究的血清样品与酶标记的T4或T3一起孵育，并针对TBG或 T4，分离相并在其中一个相中测量标记酶。

5. 发明授权

US4569917A Method for the direct determination of the lipid content of blood beta-lipoproteins 失效
标题翻译：直接测定血液中β-脂蛋白脂质含量的方法
公开(公告)号：US4569917A
公开(公告)日：1986-02-11
申请号：US240720
申请日：1981-03-05
申请人： Josef Maier , Manfred Gloger , Brigitte Draeger
发明人： Josef Maier , Manfred Gloger , Brigitte Draeger
IPC分类号： G01N33/68 , C12Q1/68 , G01N33/92
CPC分类号： C12Q1/68 , G01N33/92 , G01N2800/044 , Y10T436/255
摘要： Method of direct determination of beta-lipoproteins in a blood sample containing pre-beta-lipoprotein, (VLDL) alpha-lipoprotein (HDL), and beta-lipoprotein (LDL), comprising mixing the blood plasma or serum of the blood sample with a solid, water-insoluble anion exchanger operable to retain the pre-beta-lipoprotein (VLDL) and the alpha-lipoprotein (HDL) to remove them from solution, separating the blood plasma or serum from the anion exchanger and thereafter determining the amount of beta-lipoprotein (LDL) remaining in solution.
摘要翻译：含有前β-脂蛋白（VLDL）α-脂蛋白（HDL）和β-脂蛋白（LDL）的血液样品中直接测定β-脂蛋白的方法，包括将血液样品的血浆或血清与固体，不溶于水的阴离子交换剂，其可操作地保留前β-脂蛋白（VLDL）和α-脂蛋白（HDL）以从溶液中除去它们，将血浆或血清与阴离子交换剂分离，然后测定β - 脂蛋白（LDL）残留在溶液中。

6. 发明授权

US4551427A Process and reagent for the determination of blood glucose in haemolysed whole blood 失效
标题翻译：用于测定溶血全血中血糖的方法和试剂
公开(公告)号：US4551427A
公开(公告)日：1985-11-05
申请号：US575409
申请日：1984-01-30
申请人： Brigitte Draeger , Joachim Ziegenhorn
发明人： Brigitte Draeger , Joachim Ziegenhorn
IPC分类号： G01N33/66 , C12Q1/32 , C12Q1/48 , C12Q1/54
CPC分类号： C12Q1/54
摘要： A reagent and improved process for the determination of D-glucose in body fluids by reaction with ATP in the presence of hexokinase, glucose-6-phosphate dehydrogenase, NADP, Mg.sup.++ ions and buffer and measurement of the NADPH formed. The improved process requires, before reaction with ATP, the mixing of the whole blood with a reagent which is composed of 0.01 to 0.5% weight/volume of an alkyl sulphate or sulphonate or of an alkyl-aryl sulphonate wherein the alkyl moiety is C.sub.8 to C.sub.32 and optionally contains one or more hydroxylalkylamino radicals as substituents and/or is interrupted by one or more ether oxygen atoms and the alkyl-aryl radicals having C.sub.8 to C.sub.18 alkyls and optionally a preserving agent.
摘要翻译：在己糖激酶，葡萄糖-6-磷酸脱氢酶，NADP，Mg ++离子和缓冲液的存在下与ATP反应测定体液中D-葡萄糖的试剂和改进方法，并测量形成的NADPH。改进的方法需要在与ATP反应之前，将全血与由0.01至0.5％重量/体积的烷基硫酸盐或磺酸盐或烷基 - 芳基磺酸盐组成的试剂混合，其中烷基部分为C8至 C32并且任选地含有一个或多个羟烷基氨基作为取代基和/或被一个或多个醚氧原子间隔，并且具有C8-C18烷基的烷基 - 芳基和任选的保存剂。

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