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1. 发明授权

US06202687B1 Matrix multiple valve system 有权
标题翻译：矩阵多阀系统
公开(公告)号：US06202687B1
公开(公告)日：2001-03-20
申请号：US09508533
申请日：2000-04-03
申请人： Han-Oh Park
发明人： Han-Oh Park
IPC分类号： F16K1102
CPC分类号： B01J4/02 , B01J19/0046 , B01J2219/00394 , C40B60/14 , Y10T137/87096 , Y10T137/87249
摘要： The system opens and closes an n×m array of liquid pathways using n+m valves. The pathways (2) run from top to bottom of a body (1). Control bars (4), also with liquid pathways (2), are inserted in channels (3). These are movable by a power source. The liquid pathways are opened to pass liquid when the pathways in the body and the control bars are aligned with each other.
摘要翻译：该系统使用n + m个阀门打开和关闭nxm阵列的液体通道。路径（2）从身体（1）的顶部到底部延伸。控制杆（4）也带有液体通道（2），插入通道（3）中。这些可以通过电源移动。当身体和控制杆中的路径彼此对准时，液体通路被打开以通过液体。

2. 发明授权

US6153412A Lyophilized reagent for polymerase chain reaction 有权
标题翻译：用于聚合酶链反应的冻干试剂
公开(公告)号：US6153412A
公开(公告)日：2000-11-28
申请号：US206656
申请日：1998-12-07
申请人： Han-Oh Park , Jae-Jong Kim
发明人： Han-Oh Park , Jae-Jong Kim
IPC分类号： C12N9/12 , C12N9/96 , C12P19/34 , C07H21/04 , C12Q1/68
CPC分类号： C12N9/1252 , C12N9/96
摘要： The present invention provides a lyophilized reagent for PCR which is prepared by adding a stabilizing and sedimenting agent to an aqueous reaction mixture and lyophilizing thereof. The lyophilized PCR reagent of the present invention leads to a simplification of multi-step PCR manipulation, an increase of heat stability of the reaction mixture, prevention of carry-over contamination, and improved credibility of experiments. The lyophilized PCR reagent can be applied as a kit for analysis of DNA sequence or for diagnosis of diseases, which guarantee the results of high credibility in a short period of time.
摘要翻译：本发明提供了一种用于PCR的冻干试剂，其通过将稳定和沉降剂加入到水性反应混合物中并将其冻干而制备。本发明的冻干PCR试剂简化了多步PCR操作，提高了反应混合物的热稳定性，防止了携带污染，提高了实验的可信度。冻干PCR试剂可用作DNA序列分析或疾病诊断的试剂盒，可以在短时间内保证高可信度的结果。

3. 发明授权

US09187725B2 Automatic biological sample purification apparatus equipped with magnetic filed applying part, method of extracting target substance from biological sample, and protein expression and purification method 有权
标题翻译：配备磁场应用部件的自动生物样品净化装置，生物样品中提取目标物质的方法，蛋白质表达和纯化方法
公开(公告)号：US09187725B2
公开(公告)日：2015-11-17
申请号：US13643395
申请日：2011-04-29
申请人： Han-Oh Park , Jong-Kab Kim , Yang-Won Lee , Jong-Hoon Kim
发明人： Han-Oh Park , Jong-Kab Kim , Yang-Won Lee , Jong-Hoon Kim
IPC分类号： B03C1/02 , C12M1/32 , C12N15/10
CPC分类号： C12M33/06 , C12N15/1003
摘要： An automatic biological sample purification apparatus is disclosed. The apparatus is equipped with a magnetic field applying part, in which the magnetic field applying part for purifying biological samples and a heating part are integrally formed with each other so as to be movable up and down. A method of extracting a target substance from the biological sample using the automatic biological sample purification apparatus equipped with the magnetic field applying part is also disclosed.
摘要翻译：公开了一种自动生物样品净化装置。该装置配备有磁场施加部，其中用于净化生物样品的磁场施加部和加热部彼此一体地形成为能够上下移动。还公开了使用配备有磁场施加部的自动生物样品净化装置从生物样品中提取目标物质的方法。

4. 发明授权

US06551556B1 Automatic DNA purification apparatus 失效
标题翻译：自动DNA纯化装置
公开(公告)号：US06551556B1
公开(公告)日：2003-04-22
申请号：US09676505
申请日：2000-10-02
申请人： Han-Oh Park , Han-Ee Park , Nam-Sun Kwon , In-Suk Joung
发明人： Han-Oh Park , Han-Ee Park , Nam-Sun Kwon , In-Suk Joung
IPC分类号： B01L300
CPC分类号： G01N35/028 , B01L3/50255 , G01N1/34
摘要： The present invention relates to an automatic DNA isolation apparatus which comprises liquid containers; numerous liquid flow passages; control valves; numerous syringes; numerous injection needles; transportation means; vacuum block; plate rack (31); numerous multi-well plate blocks; and process control unit which regulates the operation of said control valves for selection and transfer of said various liquids, the operation of said syringe for quantitative intake and discharge of said liquids, the transfer of said injection needle connected with said syringes, the sequential transportation of said multi-well plates arranged in said multi-well plate rack, the sequential operation of shaking block and said vacuum block.
摘要翻译：本发明涉及一种包括液体容器的自动DNA分离装置; 许多液体流通道; 控制阀; 许多注射器许多注射针; 交通工具; 真空块板架（31）; 众多多孔板块; 以及过程控制单元，其调节用于所述各种液体的选择和转移的所述控制阀的操作，所述注射器的操作用于定量地吸入和排出所述液体，所述注射针与所述注射器连接的传送，所述多孔板布置在所述多孔板架中，摇动块和所述真空块的顺序操作。

5. 发明授权

US5861251A Lyophilized reagent for polymerase chain reaction 失效
标题翻译：用于聚合酶链反应的冻干试剂
公开(公告)号：US5861251A
公开(公告)日：1999-01-19
申请号：US732662
申请日：1996-10-15
申请人： Han-Oh Park , Jae-Jong Kim
发明人： Han-Oh Park , Jae-Jong Kim
IPC分类号： C07H3/02 , C12Q1/68 , C12P19/34 , C07H5/04 , C12N9/96
CPC分类号： C07H3/02 , C12Q1/686
摘要： The present invention provides a process for preparing a ready-to-use reagent for PCR, which comprises the steps of adding the stabilizer, glucitol or glucose, to an aqueous polymerase chain reaction(PCR) mixture containing a reaction buffer, MgCl.sub.2, dNTPs, a DNA polymerase, the water soluble dye, bromophenol blue, xylene cyanole, bromocresol red or cresol red, a primer, and optionally, ddATP, ddCTP, ddGTP, or ddTTP, and then lyophilizing thereof. The ready-to-use PCR reagent of the present invention leads to a simplification of multi-step PCR manipulation, an increase of heat stability of the reaction mixture, prevention of carry-over contamination, and improved credibility of experiments. The ready-to-use PCR reagent can be applied as a kit for analysis of DNA sequence or for diagnosis of diseases.
摘要翻译：本发明提供了一种制备用于PCR的即用试剂的方法，其包括将稳定剂，葡萄糖醇或葡萄糖添加到含有反应缓冲液，MgCl 2，dNTPs的水性聚合酶链式反应（PCR）混合物的步骤中， DNA聚合酶，水溶性染料，溴酚蓝，二甲苯氰，溴甲酚红或甲酚红，引物，以及任选的ddATP，ddCTP，ddGTP或ddTTP，然后冻干。本发明的即用型PCR试剂简化了多步PCR操作，提高了反应混合物的热稳定性，防止了携带污染，提高了实验的可信度。即用型PCR试剂可用作DNA序列分析或疾病诊断的试剂盒。

6. 发明授权

US08139210B2 Real-time monitoring apparatus for biochemical reaction 有权
标题翻译：生化反应实时监测仪
公开(公告)号：US08139210B2
公开(公告)日：2012-03-20
申请号：US10551784
申请日：2004-04-03
申请人： Jong-Soo Baek , Dong-Yeon Cho , Hanee Park , Han-Oh Park
发明人： Jong-Soo Baek , Dong-Yeon Cho , Hanee Park , Han-Oh Park
IPC分类号： G01J3/00
CPC分类号： G01N21/0332 , B01L7/52 , G01N21/6452 , G01N2021/6484
摘要： The present invention relates to an apparatus for real-time monitoring chemical reaction between various biomaterials. More particularly, the present invention directed to a real-time monitoring apparatus for biochemical reaction, which comprises parabolic mirror and/or an optical waveguide tube for effective irradiation of light over the whole plate with uniform intensity.
摘要翻译：本发明涉及一种用于实时监测各种生物材料之间的化学反应的装置。更具体地说，本发明涉及一种用于生物化学反应的实时监测装置，其包括抛物面反射镜和/或光波导管，用于以均匀的强度在整个板上有效地照射光。

7. 发明申请

US20100255055A1 GOLD-COATED STENT COATED/PLATED THE CHEMICALS AND OLIGONUCLEOTIDE BINDING GOLD-COATED STENT AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：镀金属涂层/涂覆化学品和低聚物结合金涂层的固定体及其制造方法
公开(公告)号：US20100255055A1
公开(公告)日：2010-10-07
申请号：US12665404
申请日：2008-06-16
申请人： Han-Oh Park , Jae-Don Lee , Sam-Yong Lee , Eun-Jung Jung
发明人： Han-Oh Park , Jae-Don Lee , Sam-Yong Lee , Eun-Jung Jung
IPC分类号： A61K31/713 , A61F2/82 , A61L27/28 , A61F2/24 , A61K31/28 , A61P9/10
CPC分类号： A61L31/088 , A61L31/10 , A61L2400/18
摘要： The present invention relates to a gold-plated stent and its preparation method. More specifically, it relates to a gold-plated stent that is coated with various chemical materials such as 2-aminoalkanethiol, epihalogenhydrin, and diamine compounds in a sequence and also oligonucleotide gold-plated stent, which is prepared by binding oligonucleotide, a biomaterial, to the gold-plated stent coated with said chemicals. The oligonucleotide gold-plated stent of the present invention has an advantages of raising the local concentration in injured parts and minimizing the toxicity overall the body, so it can be used for prevention of restenosis after angioplasty.
摘要翻译：本发明涉及镀金支架及其制备方法。更具体地说，涉及一种镀覆支架，其以序列方式涂覆有各种化学物质如2-氨基烷硫醇，表卤代醇和二胺化合物，还涉及寡核苷酸金镀支架，其通过结合寡核苷酸，生物材料，到涂有所述化学品的镀金支架上。本发明的寡核苷酸镀金支架具有提高受伤部位局部浓度，使体内毒性最小化的优点，因此可用于预防血管成形术后的再狭窄。

8. 发明授权

US06746842B2 Bio-molecular chip and manufacturing process thereof 有权
标题翻译：生物分子芯片及其制造方法
公开(公告)号：US06746842B2
公开(公告)日：2004-06-08
申请号：US09799092
申请日：2001-03-06
申请人： Han-Oh Park , Han-Il Ko
发明人： Han-Oh Park , Han-Il Ko
IPC分类号： C12Q168
CPC分类号： G01N33/559 , B01J2219/00529 , B01J2219/00533 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , G01N33/54353
摘要： The present invention relates to a bio-molecular microchip and manufacturing process thereof. More particularly, the present invention is directed to a bio-molecular microchip comprising a substrate; and an amine group-containing bio-molecule immobilized onto a glycidyl moiety-containing polyacrylamide gel via covalent bonds formed between the glycidyl moiety of the polyacryl amide gel and the amine group of the bio-molecule by epoxy ring-opening reaction.
摘要翻译：本发明涉及生物分子微芯片及其制造方法。更具体地，本发明涉及包含基底的生物分子微芯片; 和通过环氧基开环反应在聚丙烯酰胺凝胶的缩水甘油基部分与生物分子的胺基之间形成的共价键固定在含有缩水甘油基部分的聚丙烯酰胺凝胶上的含胺基的生物分子。

9. 发明授权

US6127122A Method for high-sensitive silver staining 失效
标题翻译：高敏感银染的方法
公开(公告)号：US6127122A
公开(公告)日：2000-10-03
申请号：US101305
申请日：1998-07-21
申请人： Han-Oh Park , Jae-Jong Kim , Jae-Hyung You
发明人： Han-Oh Park , Jae-Jong Kim , Jae-Hyung You
IPC分类号： G01N33/68 , C12Q1/68
CPC分类号： C12Q1/6816
摘要： The present invention provides an improved method for silver staining of DNA which comprises the steps of linking DNA to a polymer which has a high affinity for the DNA and binding of a plenty of silver ions to the DNA-polymer complex. The silver staining method of the present invention can be applied for the detection and sequencing of trace amount of DNA.
摘要翻译： PCT No.PCT / KR97 / 00283 Sec。 371日期：1998年7月2日 102（e）1998年7月2日PCT 1997年12月30日PCT PCT。公开号WO98 / 29567 日期：1998年7月9日本发明提供了一种改进的DNA染色方法，其包括以下步骤：将DNA与对DNA具有高亲和力并将大量银离子与DNA-聚合物复合物结合的聚合物进行连接。本发明的银染法可用于痕量DNA的检测和测序。

10. 发明授权

US08263106B2 Gold-coated stent, oligonucleotide bound gold-coated stent, and process for producing the same 有权
标题翻译：金涂层支架，寡核苷酸结合金涂层支架及其制造方法
公开(公告)号：US08263106B2
公开(公告)日：2012-09-11
申请号：US12665404
申请日：2008-06-16
申请人： Han-Oh Park , Jae-Don Lee , Sam-Yong Lee , Eun-Jung Jung
发明人： Han-Oh Park , Jae-Don Lee , Sam-Yong Lee , Eun-Jung Jung
IPC分类号： A61F2/00 , A61F2/02 , A61F2/04 , A61F2/06
CPC分类号： A61L31/088 , A61L31/10 , A61L2400/18
摘要： The present invention relates to a gold-plated stent and its preparation method. More specifically, it relates to a gold-plated stent that is coated with various chemical materials such as 2-aminoalkanethiol, epihalogenhydrin, and diamine compounds in a sequence and also oligonucleotide gold-plated stent, which is prepared by binding oligonucleotide, a biomaterial, to the gold-plated stent coated with said chemicals. The oligonucleotide gold-plated stent of the present invention has an advantages of raising the local concentration in injured parts and minimizing the toxicity overall the body, so it can be used for prevention of restenosis after angioplasty.
摘要翻译：本发明涉及镀金支架及其制备方法。更具体地说，涉及一种镀覆支架，其以序列方式涂覆有各种化学物质如2-氨基烷硫醇，表卤代醇和二胺化合物，还涉及寡核苷酸金镀支架，其通过结合寡核苷酸，生物材料，到涂有所述化学品的镀金支架上。本发明的寡核苷酸镀金支架具有提高受伤部位局部浓度，使体内毒性最小化的优点，因此可用于预防血管成形术后的再狭窄。

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