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1. 发明授权

US07951572B2 Construction of gold nanoparticle-based peptide chip, and assaying enzyme activity and inhibitor effect using secondary ion mass spectrometric analysis thereof 有权
标题翻译：基于金纳米颗粒的肽芯片的构建，以及使用其二次离子质谱分析测定酶活性和抑制剂作用
公开(公告)号：US07951572B2
公开(公告)日：2011-05-31
申请号：US11711036
申请日：2007-02-27
申请人： Hak-Sung Kim , Young-Pil Kim , Eunkeu Oh , Mi-Young Hong , Dohoon Lee , Tae Geol Lee , Dae Won Moon
发明人： Hak-Sung Kim , Young-Pil Kim , Eunkeu Oh , Mi-Young Hong , Dohoon Lee , Tae Geol Lee , Dae Won Moon
IPC分类号： C12N9/50 , C07K5/00
CPC分类号： G01N33/6848 , B82Y15/00 , C12Q1/00 , C12Q1/37 , C12Q1/42 , C12Q1/485 , G01N33/553 , G01N33/588 , G01N2500/04 , G01N2610/00
摘要： Disclosed herein is a gold nanoparticle (AuNP)-based peptide chip prepared by forming a monolayer of AuNPs onto a self-assembled monolayer constructed on a solid support, and then immobilizing a peptide on the AuNPs. The AuNPs can effectively amplify the mass signal of the peptide, thus making it possible to measure the mass change of the peptide in a simple and accurate manner. Also, when secondary ion mass spectrometric analysis (spectrum or imaging) is performed on the AuNP-based peptide chip, the activities of enzymes and related inhibitors can be effectively quantified. The disclosed invention enables various enzyme activities to be analyzed rapidly and accurately, and thus can provide an important method for disease diagnosis and new drug development through the elucidation of signaling and interaction mechanisms.
摘要翻译：本文公开了通过在固体支持物上构建的自组装单层上形成单层AuNP，然后将肽固定在AuNP上而制备的金纳米颗粒（AuNP）基肽芯片。 AuNPs可以有效地扩增肽的质量信号，从而使得可以以简单和准确的方式测量肽的质量变化。此外，当在基于AuNP的肽芯片上进行二次离子质谱分析（光谱或成像）时，可以有效地量化酶和相关抑制剂的活性。所公开的发明使得能够快速且准确地分析各种酶活性，因此可以通过阐明信号和相互作用机制来提供疾病诊断和新药开发的重要方法。

2. 发明申请

US20080076676A1 Novel construction of gold nanoparticle-based peptide chip, and assaying enzyme activity and inhibitor effect using secondary ion mass spectrometric analysis thereof 有权
标题翻译：基于金纳米颗粒的肽芯片的新型构建，以及使用其二次离子质谱分析来测定酶活性和抑制剂效应
公开(公告)号：US20080076676A1
公开(公告)日：2008-03-27
申请号：US11711036
申请日：2007-02-27
申请人： Hak-Sung Kim , Young-Pil Kim , Eunkeu Oh , Mi-Young Hong , Dohoon Lee , Tae Lee , Dae Moon
发明人： Hak-Sung Kim , Young-Pil Kim , Eunkeu Oh , Mi-Young Hong , Dohoon Lee , Tae Lee , Dae Moon
IPC分类号： C40B30/10 , C12Q1/00 , C12Q1/37 , C40B40/10 , G01N33/68 , C12Q1/42 , C12Q1/48
CPC分类号： G01N33/6848 , B82Y15/00 , C12Q1/00 , C12Q1/37 , C12Q1/42 , C12Q1/485 , G01N33/553 , G01N33/588 , G01N2500/04 , G01N2610/00
摘要： Disclosed herein is a gold nanoparticle (AuNP)-based peptide chip prepared by forming a monolayer of AuNPs onto a self-assembled monolayer constructed on a solid support, and then immobilizing a peptide on the AuNPs. The AuNPs can effectively amplify the mass signal of the peptide, thus making it possible to measure the mass change of the peptide in a simple and accurate manner. Also, when secondary ion mass spectrometric analysis (spectrum or imaging) is performed on the AuNP-based peptide chip, the activities of enzymes and related inhibitors can be effectively quantified. The disclosed invention enables various enzyme activities to be analyzed rapidly and accurately, and thus can provide an important method for disease diagnosis and new drug development through the elucidation of signaling and interaction mechanisms.
摘要翻译：本文公开了通过在固体支持物上构建的自组装单层上形成单层AuNP，然后将肽固定在AuNP上而制备的金纳米颗粒（AuNP）基肽芯片。 AuNPs可以有效地扩增肽的质量信号，从而使得可以以简单和准确的方式测量肽的质量变化。此外，当在基于AuNP的肽芯片上进行二次离子质谱分析（光谱或成像）时，可以有效地量化酶和相关抑制剂的活性。所公开的发明使得能够快速且准确地分析各种酶活性，因此可以通过阐明信号和相互作用机制来提供疾病诊断和新药开发的重要方法。

3. 发明申请

US20060183247A1 Detection method for specific biomolecular interactions using fret between metal nanoparticle and quantum dot 审中-公开
标题翻译：金属纳米粒子与量子点之间特异性生物分子相互作用的检测方法
公开(公告)号：US20060183247A1
公开(公告)日：2006-08-17
申请号：US11355069
申请日：2006-02-16
申请人： Hak-Sung Kim , Eunkeu Oh , Mi-Young Hong , Dohoon Lee , Sunghun Nam
发明人： Hak-Sung Kim , Eunkeu Oh , Mi-Young Hong , Dohoon Lee , Sunghun Nam
IPC分类号： G01N33/551
CPC分类号： G01N33/542 , A61K49/0065 , A61K49/0067 , B82Y5/00 , B82Y10/00 , B82Y30/00
摘要： The present invention relates to (1) a method for detecting a specific binding for bio-molecules; (2) a method for detecting a presence of target molecules within a specimen; and (3) a method for measuring a quantity of target molecules existing in a specimen, in which a pair of energy donor and energy acceptor displaying a FRET phenomenon is used to guide a specific binding between a pair of bio-molecules. According to the present invention, the process is conducted rapidly and easily without a label so as to screen a biochemical substance inhibiting a specific binding between a pair of bio-molecules in an ultra-high speed and measure a quantity of the substance and thereby, it can be applied to develop a novel drug. Further, this method can be used to analyze a characteristic such as change of the amount of carbohydrates in a glycoprotein derived from various cells as a drug candidate and thereby, is applicable for a quality control of proteins etc.
摘要翻译：本发明涉及（1）用于检测生物分子的特异性结合的方法; （2）检测试样中靶分子的存在的方法; 和（3）用于测量存在于样品中的目标分子的量的方法，其中使用一对显示FRET现象的能量供体和能量受体来引导一对生物分子之间的特异性结合。根据本发明，该方法快速且容易地进行而没有标签，以便以超高速筛选抑制一对生物分子之间的特异性结合的生物化学物质并测量该物质的量，它可以应用于开发新型药物。此外，该方法可以用于分析作为候选药物的来自各种细胞的糖蛋白中的碳水化合物的量的变化，从而适用于蛋白质等的质量控制。

4. 发明授权

US6144792A Device for fixing the optical elements of an optical fiber amplifier 失效
标题翻译：用于固定光纤放大器的光学元件的装置
公开(公告)号：US6144792A
公开(公告)日：2000-11-07
申请号：US958211
申请日：1997-10-27
申请人： Tae-Ryong Kim , Mi-Young Hong , Chan-Sik Park
发明人： Tae-Ryong Kim , Mi-Young Hong , Chan-Sik Park
IPC分类号： G02B6/00 , G02B6/24 , G02B6/44 , G02B6/46 , H01S3/06 , H01S3/067 , H01S3/10 , G02B6/36
CPC分类号： H01S3/06704 , G02B6/4454
摘要： A device for fixing the optical elements of an optical fiber amplifier in a packaging box comprises a central opening provided in the packaging box for making a connection with an electronic circuit, an optical fiber holder for holding the erbium doped optical fiber around the central opening, a plurality of guide supports provided in the upper and lower sides of the optical fiber holder for holding the optical isolators, wavelength division multiplexers and optical taps, and protectors provided in the left and right sides of the optical fiber holder for holding the thermocontractile tubes.
摘要翻译：用于将光纤放大器的光学元件固定在包装盒中的装置包括设置在用于与电子电路连接的包装盒中的中央开口，用于将掺铒光纤保持在中心开口周围的光纤保持器，设置在光纤保持器的上侧和下侧的多个引导支撑件，用于保持光隔离器，波分复用器和光学抽头以及设置在用于保持热收缩管的光纤保持器的左侧和右侧的保护器。

5. 发明授权

US6011645A EDFA for amplifying transmitted light by dividing an exciting pump power in two directions 失效
标题翻译： EDFA，用于通过在两个方向上分配激励泵浦功率来放大透射光
公开(公告)号：US6011645A
公开(公告)日：2000-01-04
申请号：US892717
申请日：1997-07-15
申请人： Mi-Young Hong
发明人： Mi-Young Hong
IPC分类号： H01S3/10 , H01S3/06 , H01S3/067 , H01S3/094 , H04B10/25 , H04B10/2525 , H04B10/293 , G02F1/35
CPC分类号： H04B10/2525 , H01S3/094003 , H04B10/291 , H04B10/2912 , H01S3/094011 , H04B2210/003
摘要： An erbium doped fiber amplifier having one pumping source which outputs pump power so as to excite a light signal, the amplifier including: a first erbium doped fiber for receiving an excitation light signal input from the pumping source, and amplifying a transmitted light signal input from an input stage; a first wavelength division multiplexer located at an output of the first erbium doped fiber, for inputting the excitation light signal input from the pumping source to the first erbium doped fiber, the first multiplexer also receiving the transmitted light signal amplified from the first erbium doped fiber and outputting it to a next stage; a dispersion compensation fiber at an output of the first wavelength division multiplexer for compensating for loss caused due to the dispersion characteristics of the transmitted light signal; a second wavelength division multiplexer located at an output of the dispersion compensation fiber, for receiving the input transmitted light signal and the excitation light signal input from the pumping source at two input terminals and inputting the two signals to a second erbium doped fiber; and the second erbium doped fiber located at an output of the first wavelength division multiplexer for amplifying the transmitted light signal with the excitation light signal input.
摘要翻译：一种掺铒光纤放大器，具有一个泵浦源，其输出泵浦功率以激发光信号，所述放大器包括：第一掺铒光纤，用于接收从所述泵浦源输入的激发光信号，以及放大从输入阶段位于第一掺铒光纤的输出处的第一波分复用器，用于将从泵浦源输入的激发光信号输入到第一掺铒光纤，第一多路复用器还接收从第一掺铒光纤放大的透射光信号并将其输出到下一级; 在第一波分复用器的输出处的色散补偿光纤用于补偿由于透射光信号的色散特性引起的损耗; 位于色散补偿光纤的输出处的第二波分复用器，用于接收在两个输入端从泵浦源输入的输入透射光信号和激发光信号，并将这两个信号输入到第二掺铒光纤; 以及位于第一波分多路复用器的输出处的第二掺铒光纤，用于用激发光信号输入放大透射光信号。

6. 发明授权

US5808788A Optical fiber amplifier 失效
标题翻译：光纤放大器
公开(公告)号：US5808788A
公开(公告)日：1998-09-15
申请号：US792679
申请日：1997-01-29
申请人： Chan-Sik Park , Mi-Young Hong
发明人： Chan-Sik Park , Mi-Young Hong
IPC分类号： H01S3/07 , H01S3/06 , H01S3/10 , H04B10/17 , G02B6/36
CPC分类号： H01S3/10023 , H01S2301/02
摘要： An optical fiber amplifier includes an optical filter, an optical isolator for blocking a reverse flow of a reflected light, the optical isolator including a lens coated with an integral filter having a predetermined bandwidth and an output end tab for monitoring the intensity of the output signal, the optical filter being coupled between the optical isolator and output end tab so as to only pass a specified wavelength band.
摘要翻译：光纤放大器包括滤光器，用于阻挡反射光的反向流动的光隔离器，光隔离器包括涂覆有具有预定带宽的积分滤光器的透镜和用于监视输出信号强度的输出端片光滤波器耦合在光隔离器和输出端片之间，以便仅通过指定的波长带。

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