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1. 发明申请

US20060183247A1 Detection method for specific biomolecular interactions using fret between metal nanoparticle and quantum dot 审中-公开
标题翻译：金属纳米粒子与量子点之间特异性生物分子相互作用的检测方法
公开(公告)号：US20060183247A1
公开(公告)日：2006-08-17
申请号：US11355069
申请日：2006-02-16
申请人： Hak-Sung Kim , Eunkeu Oh , Mi-Young Hong , Dohoon Lee , Sunghun Nam
发明人： Hak-Sung Kim , Eunkeu Oh , Mi-Young Hong , Dohoon Lee , Sunghun Nam
IPC分类号： G01N33/551
CPC分类号： G01N33/542 , A61K49/0065 , A61K49/0067 , B82Y5/00 , B82Y10/00 , B82Y30/00
摘要： The present invention relates to (1) a method for detecting a specific binding for bio-molecules; (2) a method for detecting a presence of target molecules within a specimen; and (3) a method for measuring a quantity of target molecules existing in a specimen, in which a pair of energy donor and energy acceptor displaying a FRET phenomenon is used to guide a specific binding between a pair of bio-molecules. According to the present invention, the process is conducted rapidly and easily without a label so as to screen a biochemical substance inhibiting a specific binding between a pair of bio-molecules in an ultra-high speed and measure a quantity of the substance and thereby, it can be applied to develop a novel drug. Further, this method can be used to analyze a characteristic such as change of the amount of carbohydrates in a glycoprotein derived from various cells as a drug candidate and thereby, is applicable for a quality control of proteins etc.
摘要翻译：本发明涉及（1）用于检测生物分子的特异性结合的方法; （2）检测试样中靶分子的存在的方法; 和（3）用于测量存在于样品中的目标分子的量的方法，其中使用一对显示FRET现象的能量供体和能量受体来引导一对生物分子之间的特异性结合。根据本发明，该方法快速且容易地进行而没有标签，以便以超高速筛选抑制一对生物分子之间的特异性结合的生物化学物质并测量该物质的量，它可以应用于开发新型药物。此外，该方法可以用于分析作为候选药物的来自各种细胞的糖蛋白中的碳水化合物的量的变化，从而适用于蛋白质等的质量控制。

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