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1. 发明授权

US09073821B2 Hydroxamic acid derivative 有权
标题翻译：羟肟酸衍生物
公开(公告)号：US09073821B2
公开(公告)日：2015-07-07
申请号：US13642320
申请日：2011-04-20
申请人： Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
发明人： Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
IPC分类号： C07C259/06 , C07C323/62 , C07D305/06 , C07D307/14 , C07D317/30 , C07D319/18 , C07D295/08 , C07D285/12 , C07D271/12 , C07D265/30 , C07D263/14 , C07D261/08 , C07D241/04 , C07C271/22 , C07C271/28 , C07C311/08 , C07C317/28 , C07C317/44 , C07C323/41 , C07D205/12 , C07D207/12 , C07D207/27 , C07D207/327 , C07D209/12 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/70 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/14 , C07D217/12 , C07D231/56 , C07D257/04 , C07D263/32 , C07D263/56 , C07D265/38 , C07D267/10 , C07D277/20 , C07D277/30 , C07D277/62 , C07D277/66 , C07D295/12 , C07D295/14 , C07D295/16 , C07D305/08 , C07D307/18 , C07D307/52 , C07D307/54 , C07D307/78 , C07D307/82 , C07D307/87 , C07D309/04 , C07D309/14 , C07D317/60 , C07D319/20 , C07D333/24 , C07D405/06 , C07D413/06 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/20 , C07D498/08 , C07F9/09 , C07D239/26 , C07D235/04 , C07D233/61 , C07D231/12 , C07D217/04 , C07D211/14 , C07D209/08 , C07D207/10 , C07D205/04
CPC分类号： C07C233/83 , C07C235/84 , C07C237/36 , C07C259/06 , C07C271/22 , C07C271/28 , C07C309/30 , C07C311/08 , C07C317/28 , C07C317/44 , C07C323/41 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07D205/04 , C07D205/12 , C07D207/10 , C07D207/12 , C07D207/27 , C07D207/327 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/70 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/14 , C07D217/04 , C07D217/12 , C07D231/12 , C07D231/56 , C07D233/61 , C07D235/04 , C07D257/04 , C07D261/08 , C07D263/14 , C07D263/32 , C07D263/56 , C07D265/30 , C07D265/36 , C07D265/38 , C07D267/10 , C07D271/12 , C07D277/20 , C07D277/30 , C07D277/62 , C07D277/66 , C07D285/12 , C07D295/08 , C07D295/12 , C07D295/14 , C07D295/16 , C07D305/06 , C07D305/08 , C07D307/14 , C07D307/18 , C07D307/52 , C07D307/54 , C07D307/78 , C07D307/81 , C07D307/82 , C07D307/87 , C07D309/04 , C07D309/14 , C07D317/30 , C07D317/60 , C07D319/18 , C07D319/20 , C07D333/24 , C07D405/06 , C07D413/06 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/20 , C07D498/04 , C07D498/08 , C07F9/091
摘要： Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:
摘要翻译：提供了通过抑制LpxC活性可用作药物组合物的新型化合物，从而对包括绿脓假单胞菌及其耐药细菌在内的革兰氏阴性细菌表现出有效的抗微生物活性。提供由以下通式[1]表示的异羟肟酸衍生物或其药学上可接受的盐：

2. 发明申请

US20130072677A1 NOVEL HYDROXAMIC ACID DERIVATIVE 有权
公开(公告)号：US20130072677A1
公开(公告)日：2013-03-21
申请号：US13642320
申请日：2011-04-20
申请人： Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
发明人： Hajime Takashima , Risa Tsuruta , Tetsuya Yabuuchi , Yusuke Oka , Hiroki Urabe , Yoichiro Suga , Masato Takahashi , Fumito Uneuchi , Hironori Kotsubo , Muneo Shoji , Yasuko Kawaguchi
IPC分类号： C07C259/06 , C07D267/10 , C07D261/08 , C07D205/04 , C07D211/46 , C07D498/04 , C07D305/08 , C07D491/107 , C07D307/52 , C07D295/155 , C07D413/06 , C07D265/36 , C07D295/088 , C07D305/06
CPC分类号： C07C233/83 , C07C235/84 , C07C237/36 , C07C259/06 , C07C271/22 , C07C271/28 , C07C309/30 , C07C311/08 , C07C317/28 , C07C317/44 , C07C323/41 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07D205/04 , C07D205/12 , C07D207/10 , C07D207/12 , C07D207/27 , C07D207/327 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/44 , C07D209/52 , C07D211/14 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/56 , C07D211/70 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/14 , C07D217/04 , C07D217/12 , C07D231/12 , C07D231/56 , C07D233/61 , C07D235/04 , C07D257/04 , C07D261/08 , C07D263/14 , C07D263/32 , C07D263/56 , C07D265/30 , C07D265/36 , C07D265/38 , C07D267/10 , C07D271/12 , C07D277/20 , C07D277/30 , C07D277/62 , C07D277/66 , C07D285/12 , C07D295/08 , C07D295/12 , C07D295/14 , C07D295/16 , C07D305/06 , C07D305/08 , C07D307/14 , C07D307/18 , C07D307/52 , C07D307/54 , C07D307/78 , C07D307/81 , C07D307/82 , C07D307/87 , C07D309/04 , C07D309/14 , C07D317/30 , C07D317/60 , C07D319/18 , C07D319/20 , C07D333/24 , C07D405/06 , C07D413/06 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/20 , C07D498/04 , C07D498/08 , C07F9/091
摘要： Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:

3. 发明申请

US20070262238A1 PHOTO DETECTING APPARATUS 失效
标题翻译：照片检测装置
公开(公告)号：US20070262238A1
公开(公告)日：2007-11-15
申请号：US11692709
申请日：2007-03-28
申请人： Hajime Takashima , Kuniyuki Tani
发明人： Hajime Takashima , Kuniyuki Tani
IPC分类号： H01L27/00
CPC分类号： H04N5/378 , H04N5/3745
摘要： A pixel circuit includes a first detector which amplifies a voltage obtained by charging and discharging a capacitance with a photocurrent flowing through a photo detecting element and then outputs it to a first data line, and a second detector which outputs an electric charge stored in the capacitance by the photocurrent, to a second data line. The pixel circuit operates in a first operation mode where the first detector is activated, a second operation mode where the second detector is activated and an initialization mode where the photo detecting element is initialized. With a first transistor turned on, the second detector outputs an electric charge stored in the capacitance in the second operation mode, and in the initialization mode a reset voltage set in the second data line is applied to the other end of the photo detecting element to initialize the photo detecting element.
摘要翻译：像素电路包括第一检测器，其放大通过流过光检测元件的光电流对电容进行充电和放电而获得的电压，然后将其输出到第一数据线;以及第二检测器，其输出存储在电容中的电荷通过光电流传输到第二数据线。像素电路在其中第一检测器被激活的第一操作模式中工作，第二检测器被激活的第二操作模式和初始化光检测元件的初始化模式。在第一晶体管导通的情况下，第二检测器在第二操作模式下输出存储在电容中的电荷，并且在初始化模式中，将设置在第二数据线中的复位电压施加到光检测元件的另一端初始化光电检测元件。

4. 发明授权

US07916199B2 Photo detection device 有权
标题翻译：照片检测装置
公开(公告)号：US07916199B2
公开(公告)日：2011-03-29
申请号：US12278141
申请日：2007-01-31
申请人： Keiichiro Kagawa , Jun Ohta , Yugo Nose , Atsushi Wada , Hajime Takashima
发明人： Keiichiro Kagawa , Jun Ohta , Yugo Nose , Atsushi Wada , Hajime Takashima
IPC分类号： H04N3/14 , H04N5/335
CPC分类号： G01J1/46 , H04N5/353 , H04N5/355 , H04N5/3559 , H04N5/374 , H04N5/3745 , H04N5/37452
摘要： A pixel includes a photodiode, an overflow circuit, a first sensing circuit, and a second sensing circuit. The first sensing circuit charges and discharges a cathode capacitance by a photocurrent flowing through a photodiode, and amplifies an obtained voltage by a source follower amplifier so as to be outputted to a data line. The second sensing circuit charges and discharged the cathode capacitance by the photocurrent flowing through the photodiode, and outputs electric charge stored in the cathode capacitance via the data line. A pixel circuit is configured so that a first mode in which the first sensing circuit becomes active and a second mode in which the second sensing circuit becomes active can be switched. The first mode and the second mode are switched according to an amount of light received by the photodiode included in each pixel circuit. Gain is controlled according to the amount of light received, in the first mode, and the storage time is controlled in the second mode.
摘要翻译：像素包括光电二极管，溢出电路，第一感测电路和第二感测电路。第一感测电路通过流过光电二极管的光电流对阴极电容进行充电和放电，并且通过源极跟随器放大器放大所获得的电压，以将其输出到数据线。第二感测电路通过流过光电二极管的光电流对阴极电容进行充电和放电，并通过数据线输出存储在阴极电容中的电荷。像素电路被配置为使得第一感测电路变为活动的第一模式和第二感测电路变为活动的第二模式被切换。第一模式和第二模式根据由每个像素电路中包括的光电二极管接收的光量进行切换。在第一模式下，根据所接收的光量来控制增益，并且在第二模式中控制存储时间。

5. 发明申请

US20090153708A1 SOLID-STATE IMAGING DEVICE AND CAMERA 有权
标题翻译：固态成像装置和摄像机
公开(公告)号：US20090153708A1
公开(公告)日：2009-06-18
申请号：US12331116
申请日：2008-12-09
申请人： Isao Hirota , Kouichi Harada , Nobuhiro Karasawa , Yasushi Maruyama , Yoshikazu Nitta , Hiroyuki Terakago , Hajime Takashima , Hideo Nomura
发明人： Isao Hirota , Kouichi Harada , Nobuhiro Karasawa , Yasushi Maruyama , Yoshikazu Nitta , Hiroyuki Terakago , Hajime Takashima , Hideo Nomura
IPC分类号： H04N5/335 , H04N5/225
CPC分类号： H01L27/1464 , H01L27/14621 , H01L27/14623 , H01L27/14627 , H01L27/14629 , H01L27/1463
摘要： A solid-state imaging device includes pixel cells that are formed on a substrate having a first substrate surface side, on which light is irradiated, and a second substrate surface side, on which elements are formed, and separated by an adjacent cell group and an element separation layer for each of the pixel cells or with plural pixel cells as a unit. Each of the pixel cells has a first conductive well formed on the first substrate surface side and a second conductive well formed on the second substrate surface side. The first conductive well receives light from the first substrate surface side and has a photoelectric conversion function and a charge accumulation function for the received light. A transistor that detects accumulated charges in the first conductive well and has a threshold modulation function is formed in the second conductive well.
摘要翻译：固态成像装置包括形成在具有照射光的第一基板表面侧的基板上的像素单元和形成元件的第二基板表面侧，并且被相邻单元组分隔开，元素分离层用于每个像素单元或多个像素单元作为单元。每个像素单元具有形成在第一基板表面侧上的第一导电阱和形成在第二基板表面侧上的第二导电阱。第一导电孔从第一基板表面侧接收光，并且具有用于所接收的光的光电转换功能和电荷累积功能。在第二导电孔中形成检测第一导电阱中的累积电荷并具有阈值调制功能的晶体管。

6. 发明申请

US20090086071A1 PHOTO DETECTION DEVICE 有权
标题翻译：照片检测装置
公开(公告)号：US20090086071A1
公开(公告)日：2009-04-02
申请号：US12278141
申请日：2007-01-31
申请人： Keiichiro Kagawa , Jun Ohta , Yugo Nose , Atsushi Wada , Hajime Takashima
发明人： Keiichiro Kagawa , Jun Ohta , Yugo Nose , Atsushi Wada , Hajime Takashima
IPC分类号： H04N5/335
CPC分类号： G01J1/46 , H04N5/353 , H04N5/355 , H04N5/3559 , H04N5/374 , H04N5/3745 , H04N5/37452
摘要： A pixel includes a photodiode, an overflow circuit, a first sensing circuit, and a second sensing circuit. The first sensing circuit charges and discharges a cathode capacitance by a photocurrent flowing through a photodiode, and amplifies an obtained voltage by a source follower amplifier so as to be outputted to a data line. The second sensing circuit charges and discharged the cathode capacitance by the photocurrent flowing through the photodiode, and outputs electric charge stored in the cathode capacitance via the data line. A pixel circuit is configured so that a first mode in which the first sensing circuit becomes active and a second mode in which the second sensing circuit becomes active can be switched. The first mode and the second mode are switched according to an amount of light received by the photodiode included in each pixel circuit. Gain is controlled according to the amount of light received, in the first mode, and the storage time is controlled in the second mode.
摘要翻译：像素包括光电二极管，溢出电路，第一感测电路和第二感测电路。第一感测电路通过流过光电二极管的光电流对阴极电容进行充电和放电，并且通过源极跟随器放大器放大所获得的电压，以将其输出到数据线。第二感测电路通过流过光电二极管的光电流对阴极电容进行充电和放电，并通过数据线输出存储在阴极电容中的电荷。像素电路被配置为使得第一感测电路变为活动的第一模式和第二感测电路变为活动的第二模式被切换。第一模式和第二模式根据由每个像素电路中包括的光电二极管接收的光量进行切换。在第一模式下，根据所接收的光量来控制增益，并且在第二模式中控制存储时间。

7. 发明申请

US20120113292A1 SOLID-STATE IMAGING DEVICE AND CAMERA 有权
标题翻译：固态成像装置和摄像机
公开(公告)号：US20120113292A1
公开(公告)日：2012-05-10
申请号：US13348760
申请日：2012-01-12
申请人： Isao Hirota , Kouichi Harada , Nobuhiro Karasawa , Yasushi Maruyama , Yoshikazu Nitta , Hiroyuki Terakago , Hajime Takashima , Hideo Nomura
发明人： Isao Hirota , Kouichi Harada , Nobuhiro Karasawa , Yasushi Maruyama , Yoshikazu Nitta , Hiroyuki Terakago , Hajime Takashima , Hideo Nomura
IPC分类号： H04N5/335
CPC分类号： H01L27/1464 , H01L27/14621 , H01L27/14623 , H01L27/14627 , H01L27/14629 , H01L27/1463
摘要： A solid-state imaging device includes pixel cells that are formed on a substrate having a first substrate surface side, on which light is irradiated, and a second substrate surface side, on which elements are formed, and separated by an adjacent cell group and an element separation layer for each of the pixel cells or with plural pixel cells as a unit. Each of the pixel cells has a first conductive well formed on the first substrate surface side and a second conductive well formed on the second substrate surface side. The first conductive well receives light from the first substrate surface side and has a photoelectric conversion function and a charge accumulation function for the received light. A transistor that detects accumulated charges in the first conductive well and has a threshold modulation function is formed in the second conductive well.
摘要翻译：固态成像装置包括形成在具有照射光的第一基板表面侧的基板上的像素单元和形成元件的第二基板表面侧，并且被相邻单元组分隔开，元素分离层用于每个像素单元或多个像素单元作为单元。每个像素单元具有形成在第一基板表面侧上的第一导电阱和形成在第二基板表面侧上的第二导电阱。第一导电孔从第一基板表面侧接收光，并且具有用于所接收的光的光电转换功能和电荷累积功能。在第二导电孔中形成检测第一导电阱中的累积电荷并具有阈值调制功能的晶体管。

8. 发明授权

US07391004B2 Photo detecting apparatus 失效
标题翻译：照相检测装置
公开(公告)号：US07391004B2
公开(公告)日：2008-06-24
申请号：US11692709
申请日：2007-03-28
申请人： Hajime Takashima , Kuniyuki Tani
发明人： Hajime Takashima , Kuniyuki Tani
IPC分类号： H01L27/00 , H04N5/335
CPC分类号： H04N5/378 , H04N5/3745
摘要： A pixel circuit includes a first detector which amplifies a voltage obtained by charging and discharging a capacitance with a photocurrent flowing through a photo detecting element and then outputs it to a first data line, and a second detector which outputs an electric charge stored in the capacitance by the photocurrent, to a second data line. The pixel circuit operates in a first operation mode where the first detector is activated, a second operation mode where the second detector is activated and an initialization mode where the photo detecting element is initialized. With a first transistor turned on, the second detector outputs an electric charge stored in the capacitance in the second operation mode, and in the initialization mode a reset voltage set in the second data line is applied to the other end of the photo detecting element to initialize the photo detecting element.
摘要翻译：像素电路包括第一检测器，其放大通过流过光检测元件的光电流对电容进行充电和放电而获得的电压，然后将其输出到第一数据线;以及第二检测器，其输出存储在电容中的电荷通过光电流传输到第二数据线。像素电路在其中第一检测器被激活的第一操作模式中工作，第二检测器被激活的第二操作模式和初始化光检测元件的初始化模式。在第一晶体管导通的情况下，第二检测器在第二操作模式下输出存储在电容中的电荷，并且在初始化模式中，将设置在第二数据线中的复位电压施加到光检测元件的另一端初始化光电检测元件。

9. 发明申请

US20070096773A1 Sample and hold circuit with multiple channel inputs, and analog-digital converter incorporating the same 审中-公开
标题翻译：具有多通道输入的采样和保持电路以及并入其中的模拟数字转换器
公开(公告)号：US20070096773A1
公开(公告)日：2007-05-03
申请号：US11590003
申请日：2006-10-31
申请人： Hajime Takashima , Shigeto Kobayashi , Atsushi Wada
发明人： Hajime Takashima , Shigeto Kobayashi , Atsushi Wada
IPC分类号： G11C27/02
CPC分类号： G11C27/026 , H03F3/45188 , H03F3/45192 , H03F3/45475 , H03F2203/45136 , H03F2203/45166 , H03F2203/45512 , H03F2203/45536 , H03F2203/45551 , H03F2203/45616 , H03F2203/45722 , H03M1/1225
摘要： It is required to provide a further reduction in circuit scale to perform time division sampling and holding using a plurality of sampling capacitors and a common operational amplifier. The plurality of sampling capacitors sample input analog signals of multiple channels on each channel. Switches are provided corresponding in number to the sampling capacitors to selectively output a voltage sampled at one terminal of each of the sampling capacitors from the other terminal to the operational amplifier. A feedback capacitor is provided in a feedback path that connects between the input terminal and the output terminal of the operational amplifier. An S&H circuit performs time division sampling and holding by the switches being selectively turned ON.
摘要翻译：需要进一步降低电路规模以使用多个采样电容器和公共运算放大器进行时分采样和保持。多个采样电容器对每个通道上的多个通道的输入模拟信号进行采样。按照与采样电容器相对应的开关，选择性地将从每个采样电容器的一个端子采样的电压从另一个端子输出到运算放大器。在连接在运算放大器的输入端和输出端之间的反馈路径中提供反馈电容器。 S＆H电路通过选择性地导通的开关进行时分采样和保持。

10. 发明授权

US06631391B1 Parallel computer system and parallel computing method 失效
标题翻译：并行计算机系统和并行计算方法
公开(公告)号：US06631391B1
公开(公告)日：2003-10-07
申请号：US09544359
申请日：2000-04-06
申请人： Shinjiro Inabata , So Yamada , Nobuaki Miyakawa , Takashi Amisaki , Hajime Takashima , Kunihiro Kitamura
发明人： Shinjiro Inabata , So Yamada , Nobuaki Miyakawa , Takashi Amisaki , Hajime Takashima , Kunihiro Kitamura
IPC分类号： G06F738
CPC分类号： G06F7/483 , G06F7/5443 , G06F9/30014 , G06F9/30025 , G06F9/3885
摘要： There is provided a parallel computer and a parallel computing method which allows high precision parallel calculation to be executed without requiring a hardware scale while maintaining high calculation speed. A system is constructed by connecting a host processor with a plurality of special purpose processors via buses. The host processor carries out the operation in a format of double-precision floating-point and the special purpose processor carries out the operation in an internal format of floating-point. The special purpose processor comprises an input data converting section for converting from the double-precision to the internal format and an output data converting section for converting from the internal format to the double-precision. Because the sign part and the exponent part can use data in common in the data before and after the conversion, only the mantissa part is converted by a specific procedure.
摘要翻译：提供了并行计算机和并行计算方法，其允许执行高精度并行计算，而不需要硬件规模，同时保持高的计算速度。通过总线将主机处理器与多个专用处理器连接构成系统。主机处理器以双精度浮点格式进行操作，专用处理器以浮点的内部格式进行操作。专用处理器包括用于从双精度转换为内部格式的输入数据转换部分和用于从内部格式转换为双精度的输出数据转换部分。因为符号部分和指数部分可以在转换之前和之后的数据中使用共同的数据，所以仅通过特定过程转换尾数部分。

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