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1. 发明授权

US5891871A Substituted 2,3-benzodiazepin-4-ones and the use thereof 失效
标题翻译：取代的2,3-苯并二氮杂-4-酮及其用途
公开(公告)号：US5891871A
公开(公告)日：1999-04-06
申请号：US821638
申请日：1997-03-20
申请人： Haiji Xia , Sui Xiong Cai , George Field , Nancy C. Lan , Yan Wang
发明人： Haiji Xia , Sui Xiong Cai , George Field , Nancy C. Lan , Yan Wang
IPC分类号： A61K31/00 , A61K31/55 , A61K31/551 , A61P25/08 , A61P25/16 , A61P25/28 , C07D243/02 , C07D243/04 , C07D243/10 , C07D491/04 , C07D491/056
CPC分类号： C07D491/04 , C07D243/02 , C07D243/10
摘要： The invention relates to substituted 2,3-benzodiazepin-4-ones which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, CMV retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition enhancers. The invention also is directed to the process for the preparation of the substituted 2,3-benzodiazepin-4-ones.
摘要翻译：本发明涉及作为AMPA受体的拮抗剂或阳性调节剂的取代2,3-苯并二氮杂-4-酮及其用于治疗，预防或改善与中风，全身和局灶性缺血，CNS创伤，低血糖和手术，以及治疗或改善神经变性疾病，包括阿尔茨海默病，肌萎缩性侧索硬化，亨廷顿病，帕金森病和唐氏综合症，治疗，预防或改善兴奋性氨基酸过度刺激的不良后果，治疗或改善焦虑，精神病，抽搐，慢性疼痛，青光眼，CMV视网膜炎，尿失禁，肌肉痉挛和诱导麻醉，以及治疗或改善兴奋性氨基酸缺乏症如精神分裂症，阿尔茨海默病和营养不良以及神经发育不良的不良后果以及认知增强剂。本发明还涉及制备取代的2,3-苯并二氮杂-4-酮的方法。

2. 发明授权

US07652006B2 Substituted 1(2H)-phthalazinones and pharmaceutical compositions thereof 失效
标题翻译：取代的1（2H） - 酞嗪酮及其药物组合物
公开(公告)号：US07652006B2
公开(公告)日：2010-01-26
申请号：US10772445
申请日：2004-02-06
申请人： Ravi Upasani , Sui X Cai , Nancy C Lan , Yan Wang , George Field , David B Fick
发明人： Ravi Upasani , Sui X Cai , Nancy C Lan , Yan Wang , George Field , David B Fick
IPC分类号： C07D487/04 , A61K31/5025 , A61K31/496 , C07D491/14 , C07D319/16 , C07D307/83 , C07D317/50 , C07D323/02 , A61K31/517 , A61K31/5355 , A61K31/497 , A61P25/18 , A61P25/28 , A61P25/08 , A61P25/00
CPC分类号： C07D231/12 , C07D233/56 , C07D239/82 , C07D249/08 , C07D491/04
摘要： The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus, Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.
摘要翻译：本发明涉及作为AMPA受体的拮抗剂或阳性调节剂的新型喹唑啉和杂环，以及其用于治疗，预防或改善与中风，全身和局灶性缺血，CNS创伤，低血糖和手术相关的神经元损失以及治疗或改善神经变性疾病，包括阿尔茨海默病，肌萎缩性侧索硬化，亨廷顿病，帕金森病和唐氏综合征，治疗，预防或改善兴奋性氨基酸过度刺激的不良后果，治疗，预防或改善焦虑，精神病，惊厥，慢性疼痛，青光眼，视网膜炎，尿失禁，肌肉痉挛和诱导麻醉，以及治疗或改善兴奋性氨基酸缺乏症如精神分裂症，肌阵挛，阿尔茨海默病和营养不良及神经发育不良后果，以及认知和学习增强剂。

3. 发明授权

US06465472B1 Substituted quinazolines and analogs and use thereof 有权
标题翻译：取代的喹唑啉和类似物及其用途
公开(公告)号：US06465472B1
公开(公告)日：2002-10-15
申请号：US09654839
申请日：2000-09-01
申请人： Ravi Upasani , Sui X. Cai , Nancy C. Lan , Yan Wang , George Field , David B. Fick
发明人： Ravi Upasani , Sui X. Cai , Nancy C. Lan , Yan Wang , George Field , David B. Fick
IPC分类号： C07D23726
CPC分类号： C07D231/12 , C07D233/56 , C07D239/82 , C07D249/08 , C07D491/04
摘要： The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus. Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.
摘要翻译：本发明涉及作为AMPA受体的拮抗剂或阳性调节剂的新型喹唑啉和杂环，以及其用于治疗，预防或改善与中风，全身和局灶性缺血，CNS创伤，低血糖和手术相关的神经元损失以及治疗或改善神经变性疾病，包括阿尔茨海默病，肌萎缩性侧索硬化，亨廷顿病，帕金森病和唐氏综合征，治疗，预防或改善兴奋性氨基酸过度刺激的不良后果，治疗，预防或改善焦虑，精神病，惊厥，慢性疼痛，青光眼，视网膜炎，尿失禁，肌肉痉挛和诱导麻醉，以及治疗或改善兴奋性氨基酸缺乏症如精神分裂症，肌阵挛的不良后果。阿尔茨海默病和营养不良和神经发育不良，以及认知和学习增强剂。

4. 发明授权

US5283336A Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline 失效
标题翻译：由1,2,3,4-四氢喹啉制备7-羟基-1,2,3,4-四氢喹啉的方法
公开(公告)号：US5283336A
公开(公告)日：1994-02-01
申请号：US941813
申请日：1992-09-08
申请人： George Field , Peter R. Hammond
发明人： George Field , Peter R. Hammond
IPC分类号： C07D215/20 , C07D215/22 , C07D215/227 , C07D491/14 , C09B11/26
CPC分类号： C07D215/227 , C07D215/20 , C07D491/14 , C09B11/26
摘要： Methods for the efficient preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline include a first method in which the acylation of m-aminophenol obtains a lactam which is reduced to give the desired quinoline and a second method in which tetrahydroquinoline is nitrated and hydrogenated and then hydrolyzed to obtain the desire quinoline. 7-hydroxy-1,2,3,4-tetrahydroquinoline is used in the efficient synthesis of four lasing dyes of the rhodamine class.
摘要翻译：有效制备7-羟基-1,2,3,4-四氢喹啉的方法包括第一种方法，其中间氨基苯酚的酰化获得内酰胺，其被还原得到所需的喹啉，第二种方法是将四氢喹啉硝化并氢化，然后水解，得到所需的喹啉。 7-羟基-1,2,3,4-四氢喹啉用于有效合成罗丹明类四种激光染料。

5. 发明申请

US20070163939A1 Distributor for water conditioner 审中-公开
标题翻译：水调节器经销商
公开(公告)号：US20070163939A1
公开(公告)日：2007-07-19
申请号：US11331260
申请日：2006-01-13
申请人： George Field
发明人： George Field
IPC分类号： B01D21/24 , B01D24/40
CPC分类号： B01D24/14 , B01D24/4631 , C02F1/001 , C02F2303/16
摘要： A conventional water conditioner includes a tank having a side wall, closed bottom and top ends, an opening in the top end, receiving and discharging material, a control valve assembly over said opening for introducing material into the tank and discharging material therefrom, a bed of particulate material for conditioning water and a dip tube extending downwardly from the assembly into the bed of particulate material. An umbrella-shaped distributor with a plurality of openings therein ensures that material entering the top of the tank around the dip tube is evenly distributed over the top surface of the bed. A bottom distributor defined by radially extending tubes ensures even distribution of liquid during the backwash cycle.
摘要翻译：传统的水调节器包括具有侧壁，封闭的底部和顶端的罐，顶端的开口，接收和排出材料，在所述开口上方的控制阀组件，用于将材料引入罐中并从其中排出材料;床用于调节水的颗粒材料和从组件向下延伸到颗粒材料床中的浸渍管。在其中具有多个开口的伞形分配器确保进入汲取管周围的罐的顶部的材料均匀地分布在床的顶表面上。由径向延伸的管限定的底部分配器确保反冲洗循环期间液体的均匀分布。

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