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1. 发明授权

US07652006B2 Substituted 1(2H)-phthalazinones and pharmaceutical compositions thereof 失效
标题翻译：取代的1（2H） - 酞嗪酮及其药物组合物
公开(公告)号：US07652006B2
公开(公告)日：2010-01-26
申请号：US10772445
申请日：2004-02-06
申请人： Ravi Upasani , Sui X Cai , Nancy C Lan , Yan Wang , George Field , David B Fick
发明人： Ravi Upasani , Sui X Cai , Nancy C Lan , Yan Wang , George Field , David B Fick
IPC分类号： C07D487/04 , A61K31/5025 , A61K31/496 , C07D491/14 , C07D319/16 , C07D307/83 , C07D317/50 , C07D323/02 , A61K31/517 , A61K31/5355 , A61K31/497 , A61P25/18 , A61P25/28 , A61P25/08 , A61P25/00
CPC分类号： C07D231/12 , C07D233/56 , C07D239/82 , C07D249/08 , C07D491/04
摘要： The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus, Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.
摘要翻译：本发明涉及作为AMPA受体的拮抗剂或阳性调节剂的新型喹唑啉和杂环，以及其用于治疗，预防或改善与中风，全身和局灶性缺血，CNS创伤，低血糖和手术相关的神经元损失以及治疗或改善神经变性疾病，包括阿尔茨海默病，肌萎缩性侧索硬化，亨廷顿病，帕金森病和唐氏综合征，治疗，预防或改善兴奋性氨基酸过度刺激的不良后果，治疗，预防或改善焦虑，精神病，惊厥，慢性疼痛，青光眼，视网膜炎，尿失禁，肌肉痉挛和诱导麻醉，以及治疗或改善兴奋性氨基酸缺乏症如精神分裂症，肌阵挛，阿尔茨海默病和营养不良及神经发育不良后果，以及认知和学习增强剂。

2. 发明授权

US06465472B1 Substituted quinazolines and analogs and use thereof 有权
标题翻译：取代的喹唑啉和类似物及其用途
公开(公告)号：US06465472B1
公开(公告)日：2002-10-15
申请号：US09654839
申请日：2000-09-01
申请人： Ravi Upasani , Sui X. Cai , Nancy C. Lan , Yan Wang , George Field , David B. Fick
发明人： Ravi Upasani , Sui X. Cai , Nancy C. Lan , Yan Wang , George Field , David B. Fick
IPC分类号： C07D23726
CPC分类号： C07D231/12 , C07D233/56 , C07D239/82 , C07D249/08 , C07D491/04
摘要： The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus. Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.
摘要翻译：本发明涉及作为AMPA受体的拮抗剂或阳性调节剂的新型喹唑啉和杂环，以及其用于治疗，预防或改善与中风，全身和局灶性缺血，CNS创伤，低血糖和手术相关的神经元损失以及治疗或改善神经变性疾病，包括阿尔茨海默病，肌萎缩性侧索硬化，亨廷顿病，帕金森病和唐氏综合征，治疗，预防或改善兴奋性氨基酸过度刺激的不良后果，治疗，预防或改善焦虑，精神病，惊厥，慢性疼痛，青光眼，视网膜炎，尿失禁，肌肉痉挛和诱导麻醉，以及治疗或改善兴奋性氨基酸缺乏症如精神分裂症，肌阵挛的不良后果。阿尔茨海默病和营养不良和神经发育不良，以及认知和学习增强剂。

3. 发明授权

US06765006B2 Substituted quinazolines and analogs and the use thereof 失效
标题翻译：取代的喹唑啉和类似物及其用途
公开(公告)号：US06765006B2
公开(公告)日：2004-07-20
申请号：US10219755
申请日：2002-08-16
申请人： Ravi Upasani , Sui X. Cai
发明人： Ravi Upasani , Sui X. Cai
IPC分类号： C07D23726
CPC分类号： C07D231/12 , C07D233/56 , C07D239/82 , C07D249/08 , C07D491/04
摘要： The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus, Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.
摘要翻译：本发明涉及作为AMPA受体的拮抗剂或阳性调节剂的新型喹唑啉和杂环，以及其用于治疗，预防或改善与中风，全身和局灶性缺血，CNS创伤，低血糖和手术相关的神经元损失以及治疗或改善神经变性疾病，包括阿尔茨海默病，肌萎缩性侧索硬化，亨廷顿病，帕金森病和唐氏综合征，治疗，预防或改善兴奋性氨基酸过度刺激的不良后果，治疗，预防或改善焦虑，精神病，惊厥，慢性疼痛，青光眼，视网膜炎，尿失禁，肌肉痉挛和诱导麻醉，以及治疗或改善兴奋性氨基酸缺乏症如精神分裂症，肌阵挛，阿尔茨海默病和营养不良及神经发育不良后果，以及认知和学习增强剂。

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