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1. 发明申请

WO2007146038A3 ALBUMIN FUSION PROTEINS 审中-公开
公开(公告)号：WO2007146038A3
公开(公告)日：2008-10-09
申请号：PCT/US2007013383
申请日：2007-06-07
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BELL ADAM , LAFLEUR DAVID W , WOODS DOUGLAS B , FENG PING , SMITH RODGER G
发明人： ROSEN CRAIG A , BELL ADAM , LAFLEUR DAVID W , WOODS DOUGLAS B , FENG PING , SMITH RODGER G
IPC分类号： A61K38/26 , C07K14/605 , C07K14/76
CPC分类号： C12N9/96 , A61K38/00 , C07K14/765 , C07K2319/00 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

2. 发明申请

WO2007146038A9 ALBUMIN FUSION PROTEINS 审中-公开
公开(公告)号：WO2007146038A9
公开(公告)日：2008-02-14
申请号：PCT/US2007013383
申请日：2007-06-07
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BELL ADAM , LAFLEUR DAVID W , WOODS DOUGLAS B , FENG PING , SMITH RODGER G
发明人： ROSEN CRAIG A , BELL ADAM , LAFLEUR DAVID W , WOODS DOUGLAS B , FENG PING , SMITH RODGER G
IPC分类号： A61K38/38
CPC分类号： C12N9/96 , A61K38/00 , C07K14/765 , C07K2319/00 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

3. 发明申请

WO2005077042A3 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2005077042A3
公开(公告)日：2006-11-30
申请号：PCT/US2005004041
申请日：2005-02-09
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , HASELTINE WILLIAM A , MOORE PAUL A , BOCK JASON B , BELL ADAM , SHI YANGGU , LAFLEUR DAVID
发明人： ROSEN CRAIG A , HASELTINE WILLIAM A , MOORE PAUL A , BOCK JASON B , BELL ADAM , SHI YANGGU , LAFLEUR DAVID
IPC分类号： A61K38/38 , C07K14/76 , C07K14/765 , C12N15/62
CPC分类号： C07K14/765 , A61K38/00 , C07K2319/31 , C07K2319/35 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

4. 发明申请

WO2005018536A2 AGONIST ANTIBODIES THAT SPECIFICALLY BIND THE GLUCAGON LIKE PEPTIDE-1 RECEPTOR 审中-公开
标题翻译：特异性抑制GLUCAGON样肽受体的激素抗体
公开(公告)号：WO2005018536A2
公开(公告)日：2005-03-03
申请号：PCT/US2004015866
申请日：2004-05-20
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BELL ADAM
发明人： ROSEN CRAIG A , BELL ADAM
IPC分类号： A61K20060101 , A61K39/395 , C07K16/28 , A61K
CPC分类号： C07K16/2869 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that specifically bind to the glucagon like peptide-1 (GLP-1) receptor. Such antibodies have uses, for example, in the treatment of diabetes, obesity, hyperglycemia, neurodegenerative disorders, and heart disease. The invention also relates to nucleic acid molecules encoding anti-GLP-1 receptor antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder including diabetes, obesity, hyperglycemia, neurodegenerative disorders, and heart disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to the GLP-1 receptor.
摘要翻译：本发明涉及特异性结合胰高血糖素样肽-1（GLP-1）受体的抗体和相关分子。这样的抗体具有例如用于治疗糖尿病，肥胖症，高血糖症，神经变性疾病和心脏病的用途。本发明还涉及编码抗GLP-1受体抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。本发明涉及用于预防，检测，诊断，治疗或改善包括糖尿病，肥胖症，高血糖症，神经变性疾病和心脏病的疾病或病症的方法和组合物，其包括向动物，优选人类施用有效量的一种或多种与GLP-1受体特异性结合的抗体或其片段或变体，或相关分子。

5. 发明申请

WO2005097184A3 ANTIBODIES AGAINST NOGO RECEPTOR 审中-公开
标题翻译：针对NOGO受体的抗体
公开(公告)号：WO2005097184A3
公开(公告)日：2007-07-12
申请号：PCT/US2005010211
申请日：2005-03-25
申请人： HUMAN GENOME SCIENCES INC , BELL ADAM , ROSEN CRAIG A
发明人： BELL ADAM , ROSEN CRAIG A
IPC分类号： C07K16/00 , A61K38/00 , A61K39/00 , A61K39/395 , C07K5/00 , C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.
摘要翻译：本发明涉及特异性结合Nogo受体（NogoR）的抗体和相关分子。这样的抗体具有例如用于治疗脊髓损伤，脑损伤，麻痹，退行性神经系统疾病和中风的用途。本发明还涉及编码抗NogoR抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。

6. 发明申请

WO02097038A2 CHEMOKINE BETA-1 FUSION PROTEINS 审中-公开
标题翻译： CHEMOKINE BETA-1融合蛋白
公开(公告)号：WO02097038A2
公开(公告)日：2002-12-05
申请号：PCT/US0216525
申请日：2002-05-24
申请人： HUMAN GENOME SCIENCES INC , BELL ADAM , RUBEN STEVEN M
发明人： BELL ADAM , RUBEN STEVEN M
IPC分类号： C07K14/52 , C12N
CPC分类号： C07K14/523 , C07K2319/00
摘要： The present invention relates to novel chemokine polypeptides and encoding nucleic acids. More specifically, therapeutic compositions and methods are provided using isolated nucleic acid molecules encoding a human chemokine beta-1 (Ck DOLLAR G(b)-1 or Ckb1) polypeptide (previously termed monocyte-colony inhibitory factor (M-CIF), MIP1-gamma, and Hemofiltrate CC chemokine-1 (HCC-1)), and Ckb1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same. Also provided are methods of treating, preventing, ameliorating diseases using such compounds.
摘要翻译：本发明涉及新型趋化因子多肽和编码核酸。更具体地，使用分离的编码人趋化因子β-1（Ck DOLLAR G（b）-1或Ckb1）多肽（以前称为单核细胞集落抑制因子（M-CIF）），MIP1- γ和Hemofiltrate CC趋化因子-1（HCC-1））和Ckb1多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。还提供了使用这些化合物治疗，预防和改善疾病的方法。

7. 发明申请

WO2007021494A3 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2007021494A3
公开(公告)日：2007-07-26
申请号：PCT/US2006029391
申请日：2006-07-31
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG , BELL ADAM , MOORE PAUL , SHI YANGGU , LAFLEUR DAVID , LAIRD MICHAEL , HASELTINE WILLIAM , WOODS DOUGLAS , BOCK JASON , SUBRAMANIAN MANI
发明人： ROSEN CRAIG , BELL ADAM , MOORE PAUL , SHI YANGGU , LAFLEUR DAVID , LAIRD MICHAEL , HASELTINE WILLIAM , WOODS DOUGLAS , BOCK JASON , SUBRAMANIAN MANI
IPC分类号： C07K14/00
CPC分类号： C07K14/765 , A61K47/643 , C07K2319/00
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括清蛋白融合蛋白。编码本发明的清蛋白融合蛋白的核酸分子也包括在本发明中，含有这些核酸的载体，用这些核酸载体转化的宿主细胞以及制备本发明的清蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。此外，本发明涵盖包含清蛋白融合蛋白的药物组合物以及使用本发明的清蛋白融合蛋白治疗，预防或改善疾病，病症或病症的方法。

8. 发明申请

WO02097038A9 CHEMOKINE BETA-1 FUSION PROTEINS 审中-公开
标题翻译： CHEMOKINE BETA-1融合蛋白
公开(公告)号：WO02097038A9
公开(公告)日：2004-05-13
申请号：PCT/US0216525
申请日：2002-05-24
申请人： HUMAN GENOME SCIENCES INC , BELL ADAM , RUBEN STEVEN M
发明人： BELL ADAM , RUBEN STEVEN M
IPC分类号： C07K14/52 , A61K38/16 , A61K38/19 , C07K14/00 , C07K14/435 , C07K14/475 , C07K19/00
CPC分类号： C07K14/523 , C07K2319/00
摘要： The present invention relates to novel chemokine polypeptides and encoding nucleic acids. More specifically, therapeutic compositions and methods are provided using isolated nucleic acid molecules encoding a human chemokine beta-1 (Ckbeta-1 or Ckb1) polypeptide (previously termed monocyte-colony inhibitory factor (M-CIF), MIP1-gamma, and Hemofiltrate CC chemokine-1 (HCC-1)), and Ckb1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same. Also provided are methods of treating, preventing, ameliorating diseases using such compounds.
摘要翻译：本发明涉及新型趋化因子多肽和编码核酸。更具体地，使用分离的编码人趋化因子β-1（Ckbeta-1或Ckb1）多肽（以前称为单核细胞集落抑制因子（M-CIF），MIP1-γ和Hemofiltrate CC 趋化因子-1（HCC-1））和Ckb1多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。还提供了使用这些化合物治疗，预防和改善疾病的方法。

9. 发明专利

BRPI0614761A2 未知
公开(公告)号：BRPI0614761A2
公开(公告)日：2009-05-19
申请号：BRPI0614761
申请日：2006-07-31
申请人： HUMAN GENOME SCIENCES INC
发明人： ROSEN CRAIG , MOORE PAUL , SHI YANGGU , LAFLEUR DAVID , LAIRD MICHAEL , HASELTINE WILLIAM , WOODS DOUGLAS , BOCK JASON , SUBRAMANIAN MANI , BELL ADAM
IPC分类号： C07K14/00
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

10. 发明专利

MX2008001865A PROTEINAS DE FUSION DE ALBUMINA. 未知
公开(公告)号：MX2008001865A
公开(公告)日：2008-04-15
申请号：MX2008001865
申请日：2006-07-31
申请人： HUMAN GENOME SCIENCES INC
发明人： BELL ADAM , SHI YANGGU , LAFLEUR DAVID , ROSEN CRAIG , MOORE PAUL , LAIRD MICHAEL , HASELTINE WILLIAM , WOODS DOUGLAS , BOCK JASON , SUBRAMANIAN MANI
IPC分类号： C07K14/00
摘要： La presente invencion comprende proteinas de fusion de albumina. Las moleculas del acido nucleico que codifican las proteinas de fusion de albumina de la invencion tambien se comprenden por la invencion, al igual que vectores que contienen estos acidos nucleicos, las celulas hospedadoras transformadas con estos vectores de acidos nucleicos, y metodos para elaborar las proteinas de fusion de albumina de la invencion y utilizar estos acidos nucleicos, vectores y/o celulas hospedadoras. Adicionalmente la presente invencion comprende composiciones farmaceuticas que comprenden proteinas de fusion de albumina y metodos para tratar, prevenir, o mejorar enfermedades, trastornos o condiciones usando proteinas de fusion de albumina de la invencion.

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