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1. 发明专利

JP2002325590A KERATINOCYTE GROWTH FACTOR-2 审中-公开
公开(公告)号：JP2002325590A
公开(公告)日：2002-11-12
申请号：JP2002026835
申请日：2002-02-04
申请人： HUMAN GENOME SCIENCES INC
发明人： GRUBER JOACHIM R , DILLON PATRICK J
IPC分类号： G01N33/50 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K38/04 , A61K38/27 , A61K48/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To provide a new polypeptide presumably identified as a member of a fibroblast growth factor(FGF) family and further especially presumably identified as a keratinocyte growth factor-2(KGF-2) as a result of amino acid sequence homology to other members of the FGF family and a polynucleotide encoding the polypeptde. SOLUTION: (a) This polypeptide has a specific presumed amino acid sequence or the polynucleotide encodes a fragment, an analog or a derivative of the polypeptide. (b) The polypeptide has an amino acid sequence encoded with a cDNA contained in an ATCC accession number 75977 or the isolated polynucleotide is selected from the group consisting of polynuleotides encoding the fragment, the analog or the derivative of the polypeptide and the polypeptide is encoded with the polynucleotide.

2. 发明专利

MX9709217A FACTOR DE CRECIMIENTO 13 DE FIBROBLASTOS. 未知
公开(公告)号：MX9709217A
公开(公告)日：1998-07-31
申请号：MX9709217
申请日：1997-11-27
申请人： HUMAN GENOME SCIENCES INC
发明人： GREENE JOHN M , GRUBER JOACHIM R , ROSEN CRAIG A
IPC分类号： C07K14/50 , C12N15/12 , C12N15/18
摘要： Se da a conocer un polipéptido del factor de crecimiento 13 humano de fibroblastos, y el ADN (ARN) que codifica este polipéptido. También se suministra un procedimiento para producir este polipéptido por las técnicas recombinantes. Iguallmente se dan a conocer métodos para utilizar tal polipéptido para promover la cicatrizacion de heridas, por ejemplo como resultado de quemaduras y ulceras, para impedir el daño nueronal asociado con ataques de apoplejía y debidos a desordenes neuronales y promover el crecimiento neuronal, y para impedir el envejecimiento de la piel y la pérdida del cabello, para estimular la angiogénesis, la induccion mesodermal en embriones primarios y la regeneracion de mienbros. Los antagonistas contra tales polipéptidos y su uso como un agente terapéutico para impedir la proliferacion celular anormal, las enfermedades hipervasculares y la proliferacion de células epiteliales de tipo lente también se dan conocer. También se revelan métodos de diagnostico para detectar mutaciones en la secuencia codificadora y alteraciones en la concentracion de los polipéptidos en una muestra derivada de un huésped.

3. 发明专利

AU2697995A Fibroblast growth factor 13 未知
公开(公告)号：AU2697995A
公开(公告)日：1996-12-24
申请号：AU2697995
申请日：1995-06-05
申请人： HUMAN GENOME SCIENCES INC
发明人： GREENE JOHN M , GRUBER JOACHIM R , ROSEN CRAIG A
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K48/00 , C07K14/50 , C07K16/22 , C12N5/10 , C12N15/12 , C12P21/08 , G01N33/15 , G01N33/50 , C12N15/18
摘要： Disclosed is a human Fibroblast growth factor-13 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

4. 发明申请

WO02077155A3 KERATINOCYTE GROWTH FACTOR-2 审中-公开
公开(公告)号：WO02077155A3
公开(公告)日：2003-01-03
申请号：PCT/US0200101
申请日：2002-01-04
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , JIMENEZ PABLO , DUAN D ROXANNE , RAMPY MARK A , MENDRICK DONNA , ZHANG JUN , NI JIAN , MOORE PAUL A , COLEMAN TIMOTHY A , GRUBER JOACHIM R , DILLON PATRICK J , GENTZ REINER L
发明人： RUBEN STEVEN M , JIMENEZ PABLO , DUAN D ROXANNE , RAMPY MARK A , MENDRICK DONNA , ZHANG JUN , NI JIAN , MOORE PAUL A , COLEMAN TIMOTHY A , GRUBER JOACHIM R , DILLON PATRICK J , GENTZ REINER L
IPC分类号： A61K38/00 , A61K48/00 , C07K14/50 , C12N5/08 , A01N1/00 , A01N43/04 , C07H21/02 , C07K1/00 , C12P21/04
CPC分类号： C07K14/50 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译：本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

5. 发明申请

WO0071567A3 FIBROBLAST GROWTH FACTOR 13 审中-公开
公开(公告)号：WO0071567A3
公开(公告)日：2001-03-22
申请号：PCT/US0040080
申请日：2000-05-04
申请人： HUMAN GENOME SCIENCES INC , MELDER ROBERT , DUAN ROXANNE D , ALDERSON RALPH , ROSEN CRAIG A , GREENE JOHN M , GRUBER JOACHIM R
发明人： MELDER ROBERT , DUAN ROXANNE D , ALDERSON RALPH , ROSEN CRAIG A , GREENE JOHN M , GRUBER JOACHIM R
IPC分类号： A61K38/00 , A61K48/00 , C07K14/50 , C07H21/04 , A61K38/18 , C07K16/22 , C12N15/00 , C12N15/63 , C12N15/85 , C12Q1/68 , G01N33/58
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00
摘要： The present invention relates to a novel human protein called Fibroblast Growth Factor 13, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译：本发明涉及称为成纤维细胞生长因子13的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

6. 发明专利

AU753987B2 Keratinocyte growth factor-2 未知
公开(公告)号：AU753987B2
公开(公告)日：2002-10-31
申请号：AU5934499
申请日：1999-11-11
申请人： HUMAN GENOME SCIENCES INC
发明人： GRUBER JOACHIM R , DILLON PATRICK J
IPC分类号： A61K38/18 , C07K14/50 , G01N33/68

7. 发明专利

CA2433458A1 KERATINOCYTE GROWTH FACTOR-2 未知
公开(公告)号：CA2433458A1
公开(公告)日：2002-10-03
申请号：CA2433458
申请日：2002-01-04
申请人： HUMAN GENOME SCIENCES INC
发明人： DUAN D ROXANNE , RAMPY MARK A , MENDRICK DONNA , ZHANG JUN , GRUBER JOACHIM R , NI JIAN , COLEMAN TIMOTHY A , MOORE PAUL A , DILLON PATRICK J , JIMENEZ PABLO , GENTZ REINER L , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/50 , C12N5/08 , C07K1/00 , A01N1/00 , C07H21/02 , A01N43/04 , C12P21/04
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" als o formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention furth er relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that sho w enhanced activity, increased stability, higher yield or better solubility.

8. 发明专利

AU4730601A Immune system-related polynucleotides, polypeptides, and antibodies 未知
公开(公告)号：AU4730601A
公开(公告)日：2001-09-17
申请号：AU4730601
申请日：2001-03-07
申请人： HUMAN GENOME SCIENCES INC
发明人： NI JIAN , HILBERT DAVID , KENNY JOSEPH J , MOORE PAUL A , CHOI GIL H , SOPPET DANIEL R , EBNER REINHARD , GRUBER JOACHIM R , ENDRESS GREGORY A , RUBEN STEVEN M
IPC分类号： G01N33/50 , A61K38/00 , A61K48/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P31/18 , A61P31/20 , A61P31/22 , A61P37/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , G01N33/15 , G01N33/68 , C12N15/11 , C12N15/00 , C12N15/63 , C07K16/00 , C12Q1/68
摘要： The present invention relates to novel human immune system-related polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human immune system-related polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human immune system-related polypeptides.

9. 发明专利

AU5934499A Keratinocyte growth factor-2 未知
公开(公告)号：AU5934499A
公开(公告)日：2000-02-03
申请号：AU5934499
申请日：1999-11-11
申请人： HUMAN GENOME SCIENCES INC
发明人： GRUBER JOACHIM R , DILLON PATRICK J
IPC分类号： A61K38/18 , C07K14/50 , G01N33/68

10. 发明专利

MX9706204A FACTOR 2 DE CRECIMIENTO DE QUERATINOCITOS. 未知
公开(公告)号：MX9706204A
公开(公告)日：1997-10-31
申请号：MX9706204
申请日：1997-08-14
申请人： HUMAN GENOME SCIENCES INC
发明人： GRUBER JOACHIM R , DILLON PATRICK J
IPC分类号： C12N15/63
摘要： Se describe un polipéptido humano el ADN (ARN) que codifica para tal polipéptido, y el procedimiento para la produccion de tal polipéptido mediante técnicas recombinantes. También se describen los métodos para la utilizacion de tal polipéptido para estimular el crecimiento de células epiteliales, las cuales pueden ser utilizadas para estimular el sanado de heridas, reducir la cicatrizacion y prevenir la perdida del cabello. Se describen también los antagonistas contra tales polipéptidos y su uso como un agente terapéutico para tratar las enfermedades proliferativas tales como el cáncer, retinopatia y restenosis. Se describen también los métodos de diagnostico para detectar las mutaciones en la secuencia de codificacion de KGF-2 y las alteraciones en la concentracion de la proteína KGF-2 en una muestra derivada de un huésped.

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