专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

CA2034616A1 THIAZOLIDINE DERIVATIVES HAVING ANTI-HYPERTENSIVE ACTIVITY AND THEIR THERAPEUTIC USE 未知
公开(公告)号：CA2034616A1
公开(公告)日：1991-07-23
申请号：CA2034616
申请日：1991-01-21
申请人： HORIKOSHI HIROYOSHI , FUJIWARA TOSHIHIKO , YOSHIOKA SHINJI , NISHINO HIROSHI , KOIKE HIROYUKI , YOSHIOKA TAKAO , SANKYO CO
发明人： HORIKOSHI HIROYOSHI , FUJIWARA TOSHIHIKO , YOSHIOKA SHINJI , NISHINO HIROSHI , KOIKE HIROYUKI , YOSHIOKA TAKAO
IPC分类号： C07D417/12 , A61K31/425 , A61P3/04 , A61P3/08 , A61P9/12
摘要： Thiazolidine derivatives of formula (I): (I) (in which: R1, R2, R4, R5 are each hydrogen or alkyl; and R3 is hydrogen, aliphatic acyl, alkoxycarbonyl, or arylcarbonyl) and pharmaceutically acceptable salts thereof are anti-hypertensive agents and are useful in the treatment of obesity-related hypertension.

2. 发明专利

CA2064108A1 Thiazolidinone and Oxazolidinone Derivatives, Their Preparation and Their Use as Vasodilators 未知
公开(公告)号：CA2064108A1
公开(公告)日：1992-09-28
申请号：CA2064108
申请日：1992-03-26
申请人： ISHIHARA SADAO , SAITO FUJIO , YOSHIOKA TAKAO , KOIKE HIROYUKI , MIYAKE SHIGEKI , MIZUNO HIROSHI
发明人： ISHIHARA SADAO , SAITO FUJIO , YOSHIOKA TAKAO , KOIKE HIROYUKI , MIYAKE SIGEKI , MIZUNO HIROSHI
IPC分类号： A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/44 , A61P9/00 , A61P9/08 , A61P9/10 , C07D263/20 , C07D263/24 , C07D277/14 , C07D413/04 , C07D417/04
摘要： Compounds of formula (I): in which: W represents a sulphur or oxygen atom and X represents a group of formula -N(R )-, or W represents a group of formula -N(R )- and X represents a sulphur or oxygen atom; R is hydrogen, alkyl or aralkyl; R and R are each hydrogen, alkyl, aralkyl, aryl or aromatic heterocyclic; R is hydrogen, alkyl or aralkyl; and A is alkylene which is optionally substituted by carboxy; and pharmaceutically acceptable salts and esters thereof, have a valuable vasodilatory activity.

3. 发明专利

CA2111662C BIPHENYL DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE TREATMENT OF HYPERTENSION AND CARDIAC DISEASE 未知
公开(公告)号：CA2111662C
公开(公告)日：2004-11-23
申请号：CA2111662
申请日：1993-12-16
申请人： YANAGISAWA HIROAKI , AMEMIYA YOSHIYA , KANAZAKI TAKURO , SHIMOJI YASUO , KOIKE HIROYUKI , SADA TOSHIO
发明人： YANAGISAWA HIROAKI , AMEMIYA YOSHIYA , KANAZAKI TAKURO , SHIMOJI YASUO , KOIKE HIROYUKI , SADA TOSHIO
IPC分类号： A61K31/415 , A61K31/41 , A61K31/4164 , A61K31/4184 , A61K31/4188 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/505 , A61P9/00 , A61P9/12 , A61P43/00 , C07D213/60 , C07D213/80 , C07D233/58 , C07D233/64 , C07D233/68 , C07D233/70 , C07D233/88 , C07D233/90 , C07D233/92 , C07D235/04 , C07D235/08 , C07D235/14 , C07D235/26 , C07D239/42 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/12 , C07D471/04 , C07D403/02
摘要： Compounds of formula (I): (see formula I) [wherein: A represents a group (IIa), (IIb) or (IIc): (see formula IIa, IIb) (see formula IIc) R1 is alkyl, alkenyl, cycloalkyl or a group of formula R4-Y-R5-, where: R4 is hydrogen, alkyl, or cycloalkyl, R5 is a single bond or alkylene, and Y is oxygen, sulfur or imino group; R2 is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, hydroxy, amino, alkylamino, dialkylamino, formyl, alkylcarbonyl, alkoxy, alkylthio, cyano or nitro; R3 is hydrogen, alkyl, carboxy, protected carboxy, carbamoyl or tetrazol-5-yl; X is of formula -CH=, -N= or -C(COOR6)=, where R6 is hydrogen or a carboxy-protecting group; Z is a single bond, alkylene or vinylene; and B is carboxy, protected carboxy or tetrazol-5-yl]; and pharmaceutically acceptable salts and esters thereof have the ability to inhibit the action of angiotensin II and thus can be used for the treatment and prophylaxis of hypertension and cardiac diseases.

4. 发明专利

CA2110251A1 ALPHA, OMEGA-DIARYLALKANE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT AND PREVENTION OF CIRCULATORY DISEASES AND PSYCHOSIS 未知
公开(公告)号：CA2110251A1
公开(公告)日：1994-05-31
申请号：CA2110251
申请日：1993-11-29
申请人： FUJIMOTO KOICHI , TANAKA NAOKI , ASAI FUMITOSHI , ITO TOMIYOSHI , KOIKE HIROYUKI
发明人： FUJIMOTO KOICHI , TANAKA NAOKI , ASAI FUMITOSHI , ITO TOMIYOSHI , KOIKE HIROYUKI
IPC分类号： C07C15/12 , A61K31/085 , A61K31/135 , A61K31/138 , A61K31/166 , A61K31/225 , A61K31/277 , A61K31/40 , A61K31/4164 , A61K31/445 , A61K31/4453 , A61K31/4458 , A61K31/4462 , A61K31/4465 , A61K31/495 , A61K31/5375 , A61K31/54 , A61P7/00 , A61P25/18 , C07C15/24 , C07C217/18 , C07C217/32 , C07C219/06 , C07C235/42 , C07C255/54 , C07D207/08 , C07D207/12 , C07D211/18 , C07D211/22 , C07D211/42 , C07D211/46 , C07D213/24 , C07D265/30 , C07D295/08 , C07D521/00 , C07D207/04 , C07D249/02 , C07D295/088 , A61K31/275 , A61K31/395 , C07C217/54 , C07D233/60
摘要： Compounds of formula (I): (I) ¢wherein: R1 is aryl; R2 is hydrogen, alkyl, alkoxy, halogen or cyano; R3 is a group of formula -B-NR4R5, where R4 and R5 are independently hydrogen, alkyl or substituted alkyl or R4 and R5, together with the nitrogen to which they are attached, form a heterocycle, and B is alkylene or a group of formula -CH2CH(OR6)CH2-, where R6 is hydrogen, alkanoyl, substituted alkanoyl or arylcarbonyl, or a group of formula -D-R7, where D is a single bond or alkylene and R7 is a heterocycle; and A is alkylene; and pharmaceutically acceptable salts and esters thereof! are useful for the treatment and prevention of circulatory diseases and psychosis.

5. 发明申请

WO2014096934A3 VEHICLE SIDE DOOR STRUCTURE 审中-公开
标题翻译：车辆侧门结构
公开(公告)号：WO2014096934A3
公开(公告)日：2014-08-28
申请号：PCT/IB2013002798
申请日：2013-12-18
申请人： TOYOTA MOTOR CO LTD , KOIKE HIROYUKI
发明人： KOIKE HIROYUKI
IPC分类号： B60J10/08 , B60J5/04
CPC分类号： B60J5/0468 , B60J5/0402 , B60J5/0443 , B60J10/78 , B60J10/88
摘要： In a state where a glass run channel (40) that sandwiches an end portion of a door glass (16) sandwiches a flange portion (26) formed at an outer side of a door frame (18) in a vehicle width direction, the glass run channel (40) is attached to the door frame (18). A bracket (50) is connected to a portion (outer wall upper portion (24D2)) of the door frame (18), which is different from the flange portion (26). Therefore, it is possible to ensure continuity in the cross-sectional shape of the glass run channel (40). Thus, even when the glass run channel (40) is attached to the door frame (18) so as to sandwich the flange portion (26), it is possible to inhibit a deformation of a design surface of the glass run channel (40) due to thermal effect, or the like.
摘要翻译：在夹着门玻璃（16）的端部的玻璃导槽（40）夹着形成在车门框架（18）的车宽方向的外侧的凸缘部（26）的状态下，玻璃运行通道（40）连接到门框（18）。支架（50）与门框（18）的与凸缘部（26）不同的部分（外壁上部（24D2））连接。因此，可以确保玻璃导槽（40）的截面形状的连续性。因此，即使当将玻璃导槽40连接到门框18以夹住凸缘部26时，也可以抑制玻璃导槽40的设计面的变形，由于热效应等。

6. 发明专利

CA2077695C HYDROPYRIDINE DERIVATIVES HAVING ANTITHROMBOTIC ACTIVITY 未知
公开(公告)号：CA2077695C
公开(公告)日：2002-08-20
申请号：CA2077695
申请日：1992-09-08
申请人： KOIKE HIROYUKI , ASAI FUMITOSHI , SUGIDACHI ATSUHIRO , KIMURA TOMIO , INOUE TERUHIKO , NISHINO SHIGEYOSHI , TSUZAKI YASUNORI
发明人： KOIKE HIROYUKI , ASAI FUMITOSHI , SUGIDACHI ATSUHIRO , KIMURA TOMIO , INOUE TERUHIKO , NISHINO SHIGEYOSHI , TSUZAKI YASUNORI
IPC分类号： A61K31/435 , A61K31/135 , A61K31/365 , A61K31/4365 , A61P7/02 , C07D221/00 , C07D333/00 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to a series of new tetrahydrothieno[3,2-c]pyridine derivatives and furo and pyrrolo analogs of these derivatives, and provides processes for preparing these derivatives as well as methods and compositions using them for inhibiting blood platelet aggregation. More specifically, disclosed is a compound of formula (I): (See formula I) wherein, preferably: R1 represents a hydrogen atom, a methyl group, an ethyl group, a halogen atom, a methyl group substituted by at least one fluorine atom, a hydroxy group, a methoxy group, an ethoxy group, a methoxy group substituted by at least one fluorine atom, a methylthio group, a methylthio group substituted by at least one fluorine atom, a formyl group, an acetyl group, an acetyl group substituted by at least one fluorine atom, an alkoxycarbonyl group having from 2 to 4 carbon atoms, a carbamoyl group, a cyano group, a nitro group, a methanesulfonyl group, an ethanesulfonyl group, a methanesulfonyl group substituted by at least one fluorine atom, or a sulfamoyl group; R2 represents an alkanoyl group having from 2 to 6 carbon atoms, a substituted alkanoyl group which has from 2 to 6 carbon atoms and which is substituted by at least one fluorine atom, a cycloalkylcarbonyl group having from 4 to 7 carbon atoms, or a substituted cycloalkylcarbonyl group which is substituted by at least one fluorine atom; R3 represents a hydrogen atom, a hydroxy group, a methoxy group, an ethoxy group, a t-butoxy group, a methoxymethoxy group, an alkanoyloxymethoxy group in which the alkanoyl part has from 1 to 5 carbon atoms, a benzyloxy group, an alkanoyloxy group having from 1 to 12 carbon atoms, an alkenoyloxy group having 3 or 4 carbon atoms, a cycloalkylcarbonyloxy group having from 4 to 7 carbon atoms, a benzoyloxy group, an alkoxycarbonyloxy group having from 2 to 5 carbon atoms, a benzyloxycarbonyloxy group, a phthalidyloxy group, a (5-methyl-2-oxo-1,3- dioxolen-4-yl)methoxy group, a (5-phenyl-2-oxo-1,3- dioxolen-9-yl)methoxy group, an amino group or a t- butoxycarbonylamino group; Y represents an oxygen or sulfur atom; and n is 1 to 3.

7. 发明专利

CA2097444A1 ANGIOTENSIN II ANTAGONIST IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE 未知
公开(公告)号：CA2097444A1
公开(公告)日：1993-12-03
申请号：CA2097444
申请日：1993-06-01
申请人： YANAGISAWA HIROAKI , SHIMOJI YASUO , AMEMIYA YOSHIYA , KANAZAKI TAKURO , KOIKE HIROYUKI , SADA TOSHIO
发明人： YANAGISAWA HIROAKI , SHIMOJI YASUO , AMEMIYA YOSHIYA , KANAZAKI TAKURO , KOIKE HIROYUKI , SADA TOSHIO
IPC分类号： A61K31/415 , A61K31/41 , A61K31/4164 , A61K31/4174 , A61P9/00 , A61P9/12 , A61P43/00 , C07D233/00 , C07D233/66 , C07D233/90 , C07D403/10 , C07D405/12 , C07D405/14
摘要： Compounds of formula (I): (I) ¢in which: R1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R2 is a single bond, alkylene or alkylidene; R3 and R4 are each hydrogen or alkyl; R6 is carboxy or tetrazol-5-yl; and X is oxygen or sulfurl; and pharmaceutically acceptable salts and esters thereof are AII antagonists and can be used for the treatment and prophylaxis of hypertension and cardiovascular diseases.

8. 发明专利

CA2097444C ANGIOTENSIN II ANTAGONIST IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE 未知
公开(公告)号：CA2097444C
公开(公告)日：2005-03-29
申请号：CA2097444
申请日：1993-06-01
申请人： YANAGISAWA HIROAKI , SHIMOJI YASUO , AMEMIYA YOSHIYA , KANAZAKI TAKURO , KOIKE HIROYUKI , SADA TOSHIO
发明人： YANAGISAWA HIROAKI , SHIMOJI YASUO , AMEMIYA YOSHIYA , KANAZAKI TAKURO , KOIKE HIROYUKI , SADA TOSHIO
IPC分类号： A61K31/415 , A61K31/41 , A61K31/4164 , A61K31/4174 , A61P9/00 , A61P9/12 , A61P43/00 , C07D233/00 , C07D233/66 , C07D233/90 , C07D403/10 , C07D405/12 , C07D405/14
摘要： Compounds of formula (I): (see formula I) [in which: R1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R2 is a single bond, alkylene or alkylidene; R3 and R4 are each hydrogen or alkyl; R6 is carboxy or tetrazol-5-yl; and X is oxygen or sulfur]; and pharmaceutically acceptable salts and esters thereof are AII antagonists and can be used for the treatment and prophylaxis of hypertension and cardiovascular diseases.

9. 发明专利

CA2111662A1 BIPHENYL DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE TREATMENT OF HYPERTENSION AND CARDIAC DISEASE 未知
公开(公告)号：CA2111662A1
公开(公告)日：1994-06-18
申请号：CA2111662
申请日：1993-12-16
申请人： YANAGISAWA HIROAKI , AMEMIYA YOSHIYA , KANAZAKI TAKURO , SHIMOJI YASUO , KOIKE HIROYUKI , SADA TOSHIO
发明人： YANAGISAWA HIROAKI , AMEMIYA YOSHIYA , KANAZAKI TAKURO , SHIMOJI YASUO , KOIKE HIROYUKI , SADA TOSHIO
IPC分类号： A61K31/415 , A61K31/41 , A61K31/4164 , A61K31/4184 , A61K31/4188 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/505 , A61P9/00 , A61P9/12 , A61P43/00 , C07D213/60 , C07D213/80 , C07D233/58 , C07D233/64 , C07D233/68 , C07D233/70 , C07D233/88 , C07D233/90 , C07D233/92 , C07D235/04 , C07D235/08 , C07D235/14 , C07D235/26 , C07D239/42 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/12 , C07D471/04 , C07D403/02
摘要： Compounds of formula (I): (I) ¢wherein: A represents a group (IIa), (IIb) or (IIc): (IIa) (IIb) (IIc) R1 is alkyl, alkenyl, cycloalkyl or a group of formula R4-Y-R5-, where: R4 is hydrogen, alkyl, or cycloalkyl, R5 is a single bond or alkylene, and Y is oxygen, sulfur or imino group; R2 is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, hydroxy, amino, alkylamino, dialkylamino, formyl, alkylcarbonyl, alkoxy, alkylthio, cyano or nitro; R3 is hydrogen, alkyl, carboxy, protected carboxy, carbamoyl or tetrazol-5-yl; X is of formula -CH=, -N= or -C(COOR6)=, where R6 is hydrogen or a carboxy-protecting group; Z is a single bond, alkylene or vinylene; and B is carboxy, protected carboxy or tetrazol-5-yl!; and pharmaceutically acceptable salts and esters thereof have the ability to inhibit the action of angiotensin II and thus can be used for the treatment and prophylaxis of hypertension and cardiac diseases.

10. 发明专利

CA2061607A1 1-BIPHENYLIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE 未知
公开(公告)号：CA2061607A1
公开(公告)日：1992-08-22
申请号：CA2061607
申请日：1992-02-20
申请人： YANAGISAWA HIROAKI , SHIMOJI YASUO , FUJIMOTO KOICHI , KANAZAKI TAKURO , AMEMIYA YOSHIYA , KOIKE HIROYUKI , SADA TOSHIO
发明人： YANAGISAWA HIROAKI , SHIMOJI YASUO , FUJIMOTO KOICHI , KANAZAKI TAKURO , AMEMIYA YOSHIYA , KOIKE HIROYUKI , SADA TOSHIO
IPC分类号： A61K31/415 , A61K20060101 , A61K31/41 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/435 , A61K31/44 , A61K31/695 , A61P9/12 , A61P43/00 , C07D20060101 , C07D233/60 , C07D233/74 , C07D233/90 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07F7/10 , C07F7/18
摘要： N-Phenylbenzyl imidazole derivs. of formula (I) and their pharmaceutically acceptable salts and esters are new. In (I), R1 = 1-6C alkyl or 3-6C alkenyl; R2 and R3 = H, 1-6C alkyl, 3-6C alkenyl, 3-10C cycloalkyl (opt. polycyclic), aryl(1-6C)alkyl, aryl or aryl fused to 3-10C cycloalkyl; R4 = H, 1-6C alkyl, 1-6C alkanoyl (opt. substd. by one or more halo or 1-6C alkoxy if other than formyl), 3-6C alkenoyl, arylcarbonyl, 1-6C alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl or tetrahydrofuryl (these 4 opt. substd. by one or more halo or 1-6C alkoxy), SiRaRbRc, 1-6C alkoxymethyl, 1-6C alkoxy(1-6C)alkoxymethyl, halo(1-6C)alkoxymethyl, 1-6C alkyl substd. by at least one aryl, or 1-6C alkanoyl-oxymethoxycarbonyl; Ra, Rb and Rc = 1-6C alkyl or aryl, but not all aryl; R5 = COOH or CONR8R9; R8 and R9 = H, 1-6C alkyl (opt. substd. by at least one (a)) or together are 2-6C alkylene opt. substd. by at least one COOH or alkoxycarbonyl; R6 = H, 1-6C alkyl or alkoxy, or halo; R7 = COOH or tetrazol-5-yl; (a) = aryl, 5-6 membered heterocyclic with 1-4 N, O and/or S, halo, OH, 1-6C alkoxy, COOH, 1-6C alkoxycarbonyl, NH2 or acylamino (acyl = 1-6C alkanoyl or arylcarbonyl); aryl = 6-14C aromatic carbocyclic gp. opt. substd. by at least one of NO2, CN, halo, 6-10C carbocyclic aryl (unsubstd.), 1-6C alkyl or alkoxy, COOH, 1-6C alkoxy-carbonyl, or 1-3C alkylenedioxy or alkylidenedioxy. 23 Cpds. e.g. pivaloyloxymethyl (or (5-methyl-2-oxo -1,3-dioxolen-4-yl)methyl) 4-(1-hydroxy-1-methylethyl) -2-(ethyl, propyl or butyl)-1-(4-(2-tetrazol -5-yl)phenyl)phenyl)methylimidazole -5-carboxylate.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式