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1. 发明专利

CA2064108A1 Thiazolidinone and Oxazolidinone Derivatives, Their Preparation and Their Use as Vasodilators 未知
公开(公告)号：CA2064108A1
公开(公告)日：1992-09-28
申请号：CA2064108
申请日：1992-03-26
申请人： ISHIHARA SADAO , SAITO FUJIO , YOSHIOKA TAKAO , KOIKE HIROYUKI , MIYAKE SHIGEKI , MIZUNO HIROSHI
发明人： ISHIHARA SADAO , SAITO FUJIO , YOSHIOKA TAKAO , KOIKE HIROYUKI , MIYAKE SIGEKI , MIZUNO HIROSHI
IPC分类号： A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/44 , A61P9/00 , A61P9/08 , A61P9/10 , C07D263/20 , C07D263/24 , C07D277/14 , C07D413/04 , C07D417/04
摘要： Compounds of formula (I): in which: W represents a sulphur or oxygen atom and X represents a group of formula -N(R )-, or W represents a group of formula -N(R )- and X represents a sulphur or oxygen atom; R is hydrogen, alkyl or aralkyl; R and R are each hydrogen, alkyl, aralkyl, aryl or aromatic heterocyclic; R is hydrogen, alkyl or aralkyl; and A is alkylene which is optionally substituted by carboxy; and pharmaceutically acceptable salts and esters thereof, have a valuable vasodilatory activity.

2. 发明申请

WO1997031896A1 THIAZOLIDINE DERIVATIVES 审中-公开
标题翻译：噻唑烷衍生物
公开(公告)号：WO1997031896A1
公开(公告)日：1997-09-04
申请号：PCT/JP1997000581
申请日：1997-02-27
申请人： SANKYO COMPANY, LIMITED , ISHIHARA, Sadao , SAITO, Fujio , MASUKO, Hidekazu , OHHATA, Yasuo , MIYAKE, Shigeki , YORIKANE, Ryosuke , FUKUDA, Norio
发明人： SANKYO COMPANY, LIMITED
IPC分类号： C07D207/16
CPC分类号： C07D277/06
摘要： Thiazolidine derivatives represented by general formula (I), or pharmacologically acceptable salts thereof. In said formula, X represents methylene, oxygen, or sulfur; R represents an alkanoyl group having one or more substituents [wherein essential substituents comprise groups represented by the formula: -S-R (where R represents hydrogen, aliphatic acyl, alkoxycarbonyl, arylcarbonyl optionally substituted by alkyl, alkoxy, or halogeno, or aromatic heterocyclic carbonyl which contains a heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur and which may be optionally substituted by alkyl, alkoxy, or halogeno), while desirable substituents represent amino, mono- or dialkylamino, protected amino, or protected monoalkylamino]; and "A" represents alkylene or a group represented by the formula: -B-D-E- (where B and E may be the same or different and each represents a single bond or alkylene, and D represents cycloalkylene optionally substituted by alkyl). The compounds have excellent collateral vasodilating and antianginal actions, and are useful for the treatment or prevention of angina pectoris.
摘要翻译：由通式（I）表示的噻唑烷衍生物或其药理学上可接受的盐。在所述式中，X表示亚甲基，氧或硫; R 1表示具有一个或多个取代基的烷酰基[其中基本取代基包括由下式表示的基团-SR 2（其中R 2表示氢，脂族酰基，烷氧基羰基，任选被烷基，烷氧基取代的芳基羰基，或卤素，或芳族杂环羰基，其含有选自氮，氧和硫的杂原子，并且其可任选被烷基，烷氧基或卤素取代），而所需的取代基表示氨基，单或二烷基氨基，保护的氨基或受保护的单烷基氨基]; 和“A”表示亚烷基或由下式表示的基团：-B-D-E-（其中B和E可以相同或不同，各自表示单键或亚烷基，D表示任选被烷基取代的亚环烷基）。该化合物具有优异的侧支血管扩张和抗心绞痛作用，可用于治疗或预防心绞痛。

3. 发明申请

WO1997000239A1 ANTIANGINAL DRUG COMPRISING NITROXY DERIVATIVE AS ACTIVE INGREDIENT 审中-公开
标题翻译：包含硝基衍生物作为活性成分的抗生素药物
公开(公告)号：WO1997000239A1
公开(公告)日：1997-01-03
申请号：PCT/JP1996001625
申请日：1996-06-14
申请人： SANKYO COMPANY, LIMITED , ISHIHARA, Sadao , SAITO, Fujio , OHHATA, Yasuo , MIYAKE, Shigeki
发明人： SANKYO COMPANY, LIMITED
IPC分类号： C07C219/16
CPC分类号： C07C219/16 , A61K31/21 , C07C233/18
摘要： Constitution: a composition for treating or preventing angina pectoris which comprises as the active ingredient a nitroxy derivative having the following general formula (I) or a pharmacologically acceptable salt of the same: R NH - A - ONO2, wherein R represents hydrogen or C1-6 alkanoyl; and A represents C2-8 alkylene or C2-4 alkylene substituted by C2-5 alkylene, provided that the alkylene substituents bind to the same carbon atom of the C2-4 alkylene group. Effect: because of having an excellent antianginal effect, the nitroxy derivative or a pharmacologically acceptable salt thereof is useful as a preventive or remedy for angina pectoris.
摘要翻译：构成：用于治疗或预防心绞痛的组合物，其包含作为活性成分的具有以下通式（I）的硝基氧衍生物或其药理学上可接受的盐：R 1 NH-A-ONO 2，其中R 1 >表示氢或C 1-6烷酰基; 并且A表示C2-8亚烷基或被C2-5亚烷基取代的C2-4亚烷基，条件是亚烷基取代基与C2-4亚烷基的相同碳原子结合。效果：由于具有优异的抗心绞痛作用，所以硝基氧衍生物或其药理学上可接受的盐可用作心绞痛的预防或治疗。

4. 发明申请

WO1996026931A1 OPTICALLY ACTIVE THIAZOLIDINONE DERIVATIVES 审中-公开
标题翻译：光学有效的噻唑烷酮衍生物
公开(公告)号：WO1996026931A1
公开(公告)日：1996-09-06
申请号：PCT/JP1996000487
申请日：1996-03-01
申请人： SANKYO COMPANY, LIMITED , ISHIHARA, Sadao , SAITO, Fujio , OHHATA, Yasuo , MIYAKE, Shigeki , YORIKANE, Ryosuke , FUKUDA, Norio , TABATA, Keiichi , MAKINO, Mitsuko
发明人： SANKYO COMPANY, LIMITED
IPC分类号： C07D277/14
CPC分类号： C07D277/14
摘要： Constitution: optically active thiazolidinone derivatives represented by general formula (I), wherein R represents hydrogen, C1-C4 alkyl, phenyl (which may be substituded by C1-C4 alkyl, C1-C4 alkoxy or halogeno), or phenyl-C1-C2-alkyl (which may be substituted by C1-C4 alkyl, C1-C4 alkoxy or halogeno), R represents C1-C6 alkyl, and n represents 1 or 2. Effect: the compounds have an excellent antianginal effect, thus being useful for preventing or treating angina pectoris, and also have an antiulcer effect, thus being useful for preventing or treating ulcerous diseases.
摘要翻译：结构式：由通式（I）表示的光学活性噻唑烷酮衍生物，其中R 1表示氢，C 1 -C 4烷基，苯基（其可以被C 1 -C 4烷基，C 1 -C 4烷氧基或卤素取代）或苯基 - C 1 -C 2 - 烷基（其可以被C 1 -C 4烷基，C 1 -C 4烷氧基或卤素取代），R 2表示C 1 -C 6烷基，n表示1或2.效果：该化合物具有优异的抗心绞痛效应因此可用于预防或治疗心绞痛，并且还具有抗溃疡作用，因此可用于预防或治疗溃疡性疾病。

5. 发明申请

WO1993009085A1 NITROXYALKYLAMIDE DERIVATIVE 审中-公开
标题翻译：硝基甲酰胺衍生物
公开(公告)号：WO1993009085A1
公开(公告)日：1993-05-13
申请号：PCT/JP1992001419
申请日：1992-11-02
申请人： SANKYO COMPANY, LIMITED , ISHIHARA, Sadao , SAITO, Fujio , KATAOKA, Mitsuru , KOIKE, Hiroyuki , MIYAKE, Shigeki , MIZUNO, Hiroshi
发明人： SANKYO COMPANY, LIMITED
IPC分类号： C07C235/22
CPC分类号： C07D261/10 , C07C235/20 , C07C271/48 , C07C323/60 , C07D261/08 , C07D261/12 , C07D307/68 , C07D307/71 , C07D319/20 , C07D333/38
摘要： Constitution: a nitroxyalkylamide derivative represented by the general formula (I): R -(A)n-COHN-B-ONO2, wherein R represents optionally substituted heterocyclic, heterocyclic oxy, aryloxy or arylthio; A represents C1-C4 alkylene; B represents C1-C4 alkylene; and n represents 0 or 1. Effect: this compound is excellent in collateral vasodilatory and antianginal activities and hence is useful as a remedy for angina pectoris.
摘要翻译：结构：由通式（I）表示的硝基烷基酰胺衍生物：R 1 - （A）n -COOHN-B-ONO 2，其中R 1表示任选取代的杂环，杂环氧基，芳氧基或芳硫基; A表示C1-C4亚烷基; B表示C1-C4亚烷基; n表示0或1.效果：该化合物在附着血管扩张和抗血管活性方面优异，因此可用于治疗心绞痛。

6. 发明申请

WO1993001163A1 AMINO ACID DERIVATIVE 审中-公开
标题翻译：氨基酸衍生物
公开(公告)号：WO1993001163A1
公开(公告)日：1993-01-21
申请号：PCT/JP1992000823
申请日：1992-06-30
申请人： SANKYO COMPANY, LIMITED , ISHIHARA, Sadao , SAITO, Fujio , YOSHIOKA, Takao , KOIKE, Hiroyuki , MIYAKE, Shigeki , MIZUNO, Hiroshi
发明人： SANKYO COMPANY, LIMITED
IPC分类号： C07C237/08
CPC分类号： C07D213/81 , C07C237/08 , C07C237/20 , C07C237/22 , C07C271/22 , C07C323/60 , C07C327/34 , C07C329/06 , C07D209/18 , C07D213/82 , C07D213/83 , C07D233/64 , C07D277/30 , C07D317/38
摘要： Constitution: an amino acid derivative represented by the general formula (I): R NH-CH(R )-CONH-A-ONO2 and a pharmacologically acceptable salt thereof, wherein R represents hydrogen, C1-C7 alkanoyl, C1-C6 alkoxycarbonyl, C6-C10 arylcarbonyl, C7-C13 aralkylcarbonyl, C7-C13 aralkyloxycarbonyl, or 5- or 6-membered heteroarylcarbonyl; R represents substituted C1-C6 alkyl; and A represents C2-C5 alkylene. Effect: this compound is excellent in a collateral vessel dilator activity and an antianginal activity, and hence useful as an antianginal drug.
摘要翻译：结构：由通式（I）表示的氨基酸衍生物：R 1 NH-CH（R 2）-CONH-A-ONO 2及其药理学上可接受的盐，其中R 1表示氢，C1 C 7烷酰基，C 1 -C 6烷氧基羰基，C 6 -C 10芳基羰基，C 7 -C 13芳烷基羰基，C 7 -C 13芳烷氧基羰基或5-或6-元杂芳基羰基; R 2表示取代的C 1 -C 6烷基; A表示C2-C5亚烷基。效果：该化合物在侧支血管扩张器活性和抗心绞痛活性方面优异，因此可用作抗心绞痛药物。

7. 发明申请

WO1996018620A1 THIAZOLIDINONE COMPOUNDS OR ANGINA PECTORIS REMEDY OR PREVENTIVE CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：噻唑烷酮化合物或神经酰胺类药物补充或预防作为活性成分
公开(公告)号：WO1996018620A1
公开(公告)日：1996-06-20
申请号：PCT/JP1995002545
申请日：1995-12-13
申请人： SANKYO COMPANY, LIMITED , ISHIHARA, Sadao , SAITO, Fujio , OHHATA, Yasuo , MIYAKE, Shigeki , YORIKANE, Ryosuke , FUKUDA, Norio
发明人： SANKYO COMPANY, LIMITED
IPC分类号： C07D263/24
CPC分类号： C07D263/20 , C07D277/14 , C07D277/30 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
摘要： Constitution: a thiazolidinone compound represented by general formula (I) or a pharmacoligically acceptable salt thereof, wherein W represents sulfur or oxygen and X represents -N(R )-, or alternatively X represents sulfur or oxygen and W represents -N(R )-, and R represents hydrogen, alkyl or substituted alkyl; R and R are the same or different from each other, and each represents hydrogen, alkyl, substituted alkyl, aryl, or 5- or 6- membered heteroaryl; R represents hydrogen, alkyl or substituted C1-C4 alkyl; R represents substituted cycloalkyl which may contain nitrogen, provided the substituents include -B-ONO2 (wherein B represents a single bond or alkylene) as the indispensable member and alkyl groups as optional members; and A represents a single bond or alkylene. Effect: the compound has an excellent anti-anginal effect and thus is useful as an angina pectoris remedy or preventive.
摘要翻译：结构式：由通式（I）表示的噻唑烷酮化合物或其药物学可接受的盐，其中W表示硫或氧，X表示-N（R 1） - ，或者X表示硫或氧，W表示-N （R 1） - ，且R 1表示氢，烷基或取代的烷基; R 2和R 3彼此相同或不同，各自表示氢，烷基，取代的烷基，芳基或5-或6-元杂芳基; R 4表示氢，烷基或取代的C 1 -C 4烷基; 如果取代基包括-B-ONO2（其中B表示单键或亚烷基）作为不可缺少的成员，并且烷基作为任选成员，则R 5表示可以含有氮的取代的环烷基; A表示单键或亚烷基。效果：该化合物具有优异的抗心绞痛作用，因此可用作心绞痛治疗或预防。

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