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1. 发明公开

EP1569556A1 FULL FIELD MAMMOGRAPHY WITH TISSUE EXPOSURE CONTROL, TOMOSYNTHESIS, AND DYNAMIC FIELD OF VIEW PROCESSING 有权
标题翻译：利用组织的曝光控制，断层合成和动态视觉场处理满场乳腺癌图像
公开(公告)号：EP1569556A1
公开(公告)日：2005-09-07
申请号：EP03783784.6
申请日：2003-11-26
申请人： HOLOGIC, INC. , Jing, Zhenxue , Hitzke, Georgia , Kennedy, Donald , Smith, Andrew , Stein, Jay A.
发明人： JING, Zhenxue , HITZKE, Georgia , KENNEDY, Donald , SMITH, Andrew , STEIN, Jay, A.
IPC分类号： A61B6/04
CPC分类号： A61B6/502 , A61B6/025 , A61B6/06 , A61B6/4035 , A61B6/4291 , A61B6/482
摘要： A mammography system using a tissue exposure control relying on estimates of the thickness of the compressed and immobilized breast (20 and 22) and of breast density (26, 28, 30 and 32) to automatically derive one or more technic factors (24). The system further uses a tomosynthesis arrangement that maintains the focus of an anti-scatter grid (12d) on the x-ray source (12a) and also maintains the field of view of the x-ray receptor (12c). Finally, the system finds an outline that forms a reduced field of view (48) that still encompasses the breast in the image (46), and uses for further processing, transmission or archival storage the data within said reduced field of view (48).

2. 发明授权

EP1569556B1 FULL FIELD MAMMOGRAPHY WITH TISSUE EXPOSURE CONTROL, TOMOSYNTHESIS, AND DYNAMIC FIELD OF VIEW PROCESSING 有权
标题翻译：利用组织的曝光控制，X射线照相组合和动态视觉场处理满场乳腺癌图像
公开(公告)号：EP1569556B1
公开(公告)日：2012-04-25
申请号：EP03783784.6
申请日：2003-11-26
申请人： HOLOGIC, INC. , Jing, Zhenxue , Hitzke, Georgia , Kennedy, Donald , Smith, Andrew , Stein, Jay A.
发明人： JING, Zhenxue , HITZKE, Georgia , KENNEDY, Donald , SMITH, Andrew , STEIN, Jay, A.
IPC分类号： A61B6/04 , A61B6/00 , A61B3/00
CPC分类号： A61B6/502 , A61B6/025 , A61B6/06 , A61B6/4035 , A61B6/4291 , A61B6/482
摘要： A mammography system using a tissue exposure control relying on estimates of the thickness of the compressed and immobilized breast (20 and 22) and of breast density (26, 28, 30 and 32) to automatically derive one or more technic factors (24). The system further uses a tomosynthesis arrangement that maintains the focus of an anti-scatter grid (12d) on the x-ray source (12a) and also maintains the field of view of the x-ray receptor (12c). Finally, the system finds an outline that forms a reduced field of view (48) that still encompasses the breast in the image (46), and uses for further processing, transmission or archival storage the data within said reduced field of view (48).

3. 发明申请

WO2008019125A3 ORTHOVOLTAGE BREAST RADIATION THERAPY 审中-公开
公开(公告)号：WO2008019125A3
公开(公告)日：2008-02-14
申请号：PCT/US2007/017470
申请日：2007-08-03
申请人： HOLOGIC, INC. , SMITH, Andrew , STEIN, Jay, A.
发明人： SMITH, Andrew , STEIN, Jay, A.
IPC分类号： A61N5/10
摘要： X-ray breast imaging and therapy can be carried out in a single compression of the breast using the same x-ray source, can be repeated at different orientation of the x-ray beam relative to the breast, and can be based on the geometry of a known mammography system, or a known breast tomosynthesis system, or a known prone table breast biopsy system.

4. 发明申请

WO2004049949A1 FULL FIELD MAMMOGRAPHY WITH TISSUE EXPOSURE CONTROL, TOMOSYNTHESIS, AND DYNAMIC FIELD OF VIEW PROCESSING 审中-公开
标题翻译：具有组织接触控制，动力学和动态视野处理领域的全场动画
公开(公告)号：WO2004049949A1
公开(公告)日：2004-06-17
申请号：PCT/US2003/037763
申请日：2003-11-26
申请人： HOLOGIC, INC. , JING, Zhenxue , HITZKE, Georgia , KENNEDY, Donald , SMITH, Andrew , STEIN, Jay, A.
发明人： JING, Zhenxue , HITZKE, Georgia , KENNEDY, Donald , SMITH, Andrew , STEIN, Jay, A.
IPC分类号： A61B6/04
CPC分类号： A61B6/502 , A61B6/025 , A61B6/06 , A61B6/4035 , A61B6/4291 , A61B6/482
摘要： A mammography system using a tissue exposure control relying on estimates of the thickness of the compressed and immobilized breast (20 and 22) and of breast density (26, 28, 30 and 32) to automatically derive one or more technic factors (24). The system further uses a tomosynthesis arrangement that maintains the focus of an anti-scatter grid (12d) on the x-ray source (12a) and also maintains the field of view of the x-ray receptor (12c). Finally, the system finds an outline that forms a reduced field of view (48) that still encompasses the breast in the image (46), and uses for further processing, transmission or archival storage the data within said reduced field of view (48).
摘要翻译：依赖于压缩和固定的乳房（20和22）的厚度估计和乳房密度（26,28,30和32）的自动导出一个或多个技术因素（24）的组织暴露控制的乳房摄影系统。该系统进一步使用将防散射栅格（12d）的焦点保持在x射线源（12a）上并且还保持x射线受体（12c）的视野的断层合成装置。最后，系统找到形成仍然包含图像（46）中的乳房的缩小视场（48）的轮廓，并且用于进一步处理，传输或存档在所述缩小视场（48）内的数据，。

5. 发明申请

WO2006058160A2 INTEGRATED MULTI-MODE MAMMOGRAPHY/TOMOSYNTHESIS X-RAY SYSTEM AND METHOD 审中-公开
标题翻译：综合多模式人机界面/ TOMOSYNTHESIS X射线系统及方法
公开(公告)号：WO2006058160A2
公开(公告)日：2006-06-01
申请号：PCT/US2005/042613
申请日：2005-11-23
申请人： HOLOGIC, INC. , DEFREITAS, Ken , FARBIZIO, Tom , REN, Baori , RUTH, Chris , SHAW, Ian , SMITH, Andrew , STEIN, Jay
发明人： DEFREITAS, Ken , FARBIZIO, Tom , REN, Baori , RUTH, Chris , SHAW, Ian , SMITH, Andrew , STEIN, Jay
IPC分类号： G06K9/00
CPC分类号： A61B6/4417 , A61B6/025 , A61B6/0414 , A61B6/107 , A61B6/4291 , A61B6/482 , A61B6/502
摘要： A system for multi-mode breast x-ray imaging which comprises a compression arm assembly for compressing and immobilizing a breast for x-ray imaging, an x-ray tube assembly, and an x-ray image receptor is provided. The system is configured for a plurality of imaging protocols and modes.
摘要翻译：提供了一种用于多模式乳房x射线成像的系统，其包括用于压缩和固定用于X射线成像的乳房的压缩臂组件，X射线管组件和x射线图像接收器。该系统被配置用于多个成像协议和模式。

6. 发明申请

WO2010102011A1 SYSTEM AND METHOD FOR LOW DOSE TOMOSYNTHESIS 审中-公开
标题翻译：低剂量酪氨酸酶的系统和方法
公开(公告)号：WO2010102011A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/026062
申请日：2010-03-03
申请人： HOLOGIC, INC. , STEIN, Jay , SMITH, Andrew , JING, Zhenzue , NIKLASON, Loren
发明人： STEIN, Jay , SMITH, Andrew , JING, Zhenzue , NIKLASON, Loren
IPC分类号： A61B6/00 , A61B6/02
CPC分类号： A61B6/025 , A61B6/405 , A61B6/4417 , A61B6/502 , A61B6/5235 , A61B6/5247 , A61B6/542 , A61B8/0825 , G01N23/046
摘要： A breast imaging system leverages the combined strengths of two- dimensional and three-dimensional imaging to provide a breast cancer screening with improved sensitivity, specificity and patient dosing. A tomosynthesis system supports the acquisition of three-dimensional images at a dosage lower than that used to acquire a two-dimensional image. The low-dose three-dimensional image may be used for mass detection, while the two-dimensional image may be used for calcification detection. Obtaining tomosynthesis data at low dose provides a number of advantages in addition to mass detection including the reduction in scan time and wear and tear on the x-ray tube. Such an arrangement provides a breast cancer screening system with high sensitivity and specificity and reduced patient dosing.
摘要翻译：乳房成像系统利用二维和三维成像的综合优势，提供具有改善的敏感性，特异性和患者剂量的乳腺癌筛查。断层合成系统支持以比用于获取二维图像的剂量低的剂量获取三维图像。低剂量三维图像可以用于质量检测，而二维图像可以用于钙化检测。以低剂量获得断层合成数据除了质量检测之外还提供了许多优点，包括扫描时间的减少以及X射线管上的磨损和撕裂。这种布置提供了具有高灵敏度和特异性并减少患者给药的乳腺癌筛查系统。

7. 发明申请

WO2010059920A3 SYSTEM AND METHOD FOR GENERATING A 2D IMAGE FROM A TOMOSYNTHESIS DATA SET 审中-公开
公开(公告)号：WO2010059920A3
公开(公告)日：2010-05-27
申请号：PCT/US2009/065288
申请日：2009-11-20
申请人： HOLOGIC, INC. , RUTH, Chris , SMITH, Andrew , STEIN, Jay
发明人： RUTH, Chris , SMITH, Andrew , STEIN, Jay
IPC分类号： G06T15/00 , G06T11/00 , A61B6/00
摘要： A 2D mammogram image is synthesized from at least one of tomosynthesis projection images and/or the tomosynthesis reconstructed image data. In a simplest form, the mammogram may be synthesized by selecting one of the tomosynthesis projection images for display as a synthesized mammogram. Other methods of synthesizing a mammogram include re-projecting and filtering projection data and/or reconstructed data. The synthesized mammogram is advantageously displayed together with at least a portion of the reconstructed data to aid in review of the reconstructed data. The present invention thus provides a familiar image which may be used to facilitate review of a tomosynthesis data set.

8. 发明申请

WO2009038948A3 BREAST TOMOSYNTHESIS WITH DISPLAY OF HIGHLIGHTED SUSPECTED CALCIFICATIONS 审中-公开
公开(公告)号：WO2009038948A3
公开(公告)日：2009-03-26
申请号：PCT/US2008/074762
申请日：2008-08-29
申请人： HOLOGIC, INC. , RUTH, Chris , STEIN, Jay , NIKLASON, Loren , SMITH, Andrew
发明人： RUTH, Chris , STEIN, Jay , NIKLASON, Loren , SMITH, Andrew
IPC分类号： G06K9/00 , G06K9/36
摘要： Systems and methods that facilitate the presentation and assessment of selected features in projection and/or reconstructed breast images, such as calcifications that meet selected criteria of size, shape, presence in selected slice images, distribution of pixels that could be indicative of calcification relative to other pixels or of other image features of clinical interest.

9. 发明申请

WO2010060007A1 METHOD AND SYSTEM FOR CONTROLLING X-RAY FOCAL SPOT CHARACTERISTICS FOR TOMOSYNTHESIS AND MAMMOGRAPHY IMAGING 审中-公开
标题翻译：用于控制X射线焦点特征的方法和系统，用于骨骼形成和乳腺成像
公开(公告)号：WO2010060007A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/065451
申请日：2009-11-23
申请人： HOLOGIC INC. , REN, Baorui , STEIN, Jay , JING, Zhenxue , SMITH, Andrew
发明人： REN, Baorui , STEIN, Jay , JING, Zhenxue , SMITH, Andrew
IPC分类号： A61B6/03 , H05G1/52 , H01J35/24
CPC分类号： A61B6/4021 , A61B6/025 , A61B6/032 , A61B6/502 , H01J35/14 , H05G1/52
摘要： An x-ray tube is described that includes components for increasing x-ray image clarity in the presence of a moving x-ray source by modifying focal spot characteristics, including focal spot size and focal spot position, tn a first arrangement a static focal spot is moved in a direction contrary to the movement of the x-ray source so that an effective focal spot position is essentially fixed in space relative to one of the imaged object and/or detector during a tomosynthesis exposure. In a second arrangement, the size of the static focal spot is increased, and the resulting increase in tube current reduces the exposure time and concomitant blur effect. The methods may be used alone or in combination; for example an x-ray tube with a larger, moveable static focal spot will result in a system that fully utilizes the x-ray tube generator, provides a high quality image with reduced blur and, due to the decrease in exposure time, may scan the patient more quickly.
摘要翻译：描述了一种X射线管，其包括用于通过改变焦点特性（包括焦斑尺寸和焦点位置）来改变在存在移动的X射线源的X射线图像清晰度的组件，在第一布置静态焦点在与x射线源的运动相反的方向上移动，使得在断层融合曝光期间，有效焦点位置相对于成像对象和/或检测器之一基本上固定在空间中。在第二种布置中，静态焦点的尺寸增加，并且由此导致的管电流的增加降低了曝光时间并伴随着模糊效果。这些方法可以单独使用或组合使用; 例如具有较大可移动静电焦点的X射线管将导致完全利用x射线管发生器的系统，提供具有减少的模糊的高质量图像，并且由于曝光时间的减少可能扫描病人更快

10. 发明申请

WO2010028208A1 INTEGRATED MULTI-MODE MAMMOGRAPHY/TOMOSYNTHESIS X-RAY SYSTEM AND METHOD 审中-公开
标题翻译：综合多模式人机界面/ TOMOSYNTHESIS X射线系统与方法
公开(公告)号：WO2010028208A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/055981
申请日：2009-09-04
申请人： HOLOGIC, INC. , REN, Baorui , SMITH, Andrew , JING, Zhenxue , STEIN, Jay
发明人： REN, Baorui , SMITH, Andrew , JING, Zhenxue , STEIN, Jay
IPC分类号： A61B6/00 , A61B6/10 , A61B6/02
CPC分类号： A61B6/502 , A61B6/025 , A61B6/0414 , A61B6/107 , A61B6/4291 , A61B6/4417 , A61B6/4441 , A61B6/482 , A61B6/488 , A61B6/5235 , A61B6/545
摘要： A system for multi-mode breast x-ray imaging which comprises a compression arm assembly for compressing and immobilizing a breast for x-ray imaging, an x-ray tube assembly, and an x-ray image receptor is provided. The system is configured for a plurality of imaging protocols and modes, and in a combination mode, at least one imaging procedure is executed differently in at least two imaging modes.
摘要翻译：提供了一种用于多模式乳房x射线成像的系统，其包括用于压缩和固定用于X射线成像的乳房的压缩臂组件，X射线管组件和x射线图像接收器。该系统被配置用于多个成像协议和模式，并且在组合模式中，在至少两个成像模式中不同地执行至少一个成像过程。

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