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1. 发明专利

SK279514B6 METHOD OF OESTROGEN-CONTAINING DRESSING PRODUCTION 未知
公开(公告)号：SK279514B6
公开(公告)日：1998-12-02
申请号：SK485990
申请日：1990-10-05
申请人： HOFFMANN HANS-RAINER , KLEIN ROBERT-PETER , MECONI REINHOLD , CORDES GUNTER , WOLFF HANS M.
发明人： HOFFMANN HANS-RAINER , KLEIN ROBERT-PETER , MECONI REINHOLD , CORDES GUNTER , WOLFF HANS M
IPC分类号： A61K9/70 , A61K31/56 , A61K31/565 , A61L15/16 , A61M37/00 , A61L15/44 , A61L15/58 , C09J7/02
摘要： An adhesive based on homo- and/or copolymers is homogenised with at least one derivative of acrylic or methacrylic acid and is added, before or simultaneously, with an oestrogen or oestrogens and their pharmaceutically acceptable derivatives alone or in combination with gestagens. The adhesive is applied on a re-detachable protective layer or a re-detachable semi-layer and after evaporation of a diluent, it is covered with a backing layer retaining the active substance.

2. 发明专利

SK277941B6 NICOTINE AGENT 未知
公开(公告)号：SK277941B6
公开(公告)日：1995-08-09
申请号：SK587488
申请日：1988-08-31
申请人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
发明人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
IPC分类号： A61K9/22 , A61K9/70 , A61K31/465 , A61L15/16 , A61M35/00 , A61L15/44 , A61L15/58 , A61M37/00 , A61P25/30 , G01N33/52
摘要： Nicotine agent contains reservoir (14) of nicotine for controlled release of nicotine in to skin (18), back layer (10), which is impermeable for nicotine and layer (12) of melting contact adhesive with elaborating temperature 40 to 80 degrees of Celsius.

3. 发明专利

SK279297B6 DEVICE FOR CONTROLLED RELEASE OF NITROGLYCERINE AND METHOD OF ITS PRODUCTION 未知
公开(公告)号：SK279297B6
公开(公告)日：1998-09-09
申请号：SK587288
申请日：1988-08-31
申请人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
发明人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
IPC分类号： A61K9/22 , A61K9/70 , A61L15/16 , A61K31/21 , A61L15/44 , A61L15/58 , A61M37/00 , A61P9/08 , A61P9/10 , B01J4/00 , G01N33/52
摘要： A device is processed by applying a hot-melt adhesive, which contains nitroglycerine to be released, on a back layer, e.g. a polyester film, at temperatures from 40 to 80 degrees Celsius. The film is, on the side where the adhesive is meant to be applied, silicificated and aluminized and then a protective layer, e.g. an aluminized polyester film, is applied.

4. 发明专利

SK279300B6 DEVICE FOR RELEASE SUBSTANCES MADE OF HOT-MELT ADHESIVES, PROCESS FOR ITS MANUFACTURE AND USE THEREOF 未知
公开(公告)号：SK279300B6
公开(公告)日：1998-09-09
申请号：SK587388
申请日：1988-08-31
申请人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
发明人： JAEGER HALVOR , HOFFMANN HANS-RAINER , MECONI REINHOLD , KLEIN ROBERT-PETER
IPC分类号： A61K9/22 , A61K9/70 , A61L15/16 , A61M35/00 , A61L15/44 , A61M37/00 , G01N33/48 , G01N33/52
摘要： The invention concerns a device for the release of substances made of hot-melt adhesives with uniform or non-uniform distribution of the substances wherein the hot-melt adhesive has a processing temperature between 40 and 80 degrees Celsius. Also described is a process for manufacturing the device in which the melted hot-melt adhesive containing the substances to be released is applied continuously or intermittently on a support or on a layer of protective material. The device can be used in both human and veterinary medicine, diagnostic or cosmetics, especially for release of substances which are thermo-sensitive or highly volatile.

5. 发明申请

WO2010091822A8 N-HYDROXYLATED AMIDINE-, GUANIDINE- AND/OR AMINOHYDRAZONE-TYPE PRODRUGS FOR APPLICATION ON THE SKIN 审中-公开
标题翻译：前体药物类型N-羟基脒，胍和/或AMINOHYDRAZONE通过皮肤施用
公开(公告)号：WO2010091822A8
公开(公告)日：2011-08-11
申请号：PCT/EP2010000715
申请日：2010-02-05
申请人： LOHMANN THERAPIE SYST LTS , MATUSCH RUDOLF , HOFFMANN HANS-RAINER , ASMUSSEN BODO , KOCH ANDREAS
发明人： MATUSCH RUDOLF , HOFFMANN HANS-RAINER , ASMUSSEN BODO , KOCH ANDREAS
IPC分类号： A61K9/00 , A61K9/70 , A61K31/155 , A61K31/4245 , A61K47/48
CPC分类号： A61K9/0014
摘要： The invention relates to N-hydroxylated amidines, guanidines and aminohydrazones for application on the skin. In particular, the invention relates to transdermal therapeutic systems, containing N-hydroxylated amidines, guanidines and aminohydrazones as a prodrug, and to methods for producing and using such systems.
摘要翻译：本发明涉及N-羟基化脒，胍，和Aminohydrazone用于皮肤上的应用程序。特别地，本发明涉及一种透皮治疗系统使用N-羟基脒，胍，和Aminohydrazone包含作为前药，以及制造和使用这种系统的方法。

6. 发明申请

WO0048582A3 PHARMACEUTICAL COMPOSITION CONTAINING DESOXYPEGANINE FOR THE TREATMENT OF DRUG DEPENDENCE 审中-公开
标题翻译：药物组合物含desoxypeganine药物成瘾的治疗
公开(公告)号：WO0048582A3
公开(公告)日：2001-04-12
申请号：PCT/EP0000974
申请日：2000-02-08
申请人： LOHMANN THERAPIE SYST LTS , ASMUSSEN BODO , HILLE THOMAS , HOFFMANN HANS RAINER , OPITZ KLAUS
发明人： ASMUSSEN BODO , HILLE THOMAS , HOFFMANN HANS-RAINER , OPITZ KLAUS
IPC分类号： C07D487/04 , A61K9/10 , A61K9/22 , A61K9/52 , A61K31/519 , A61P25/30
CPC分类号： A61K31/519
摘要： Desoxypeganine and its pharmaceutically acceptable acid addition salts can be used in the treatment of drug addiction or drug dependence. Said substances are administered preferably in a continuos and controlled manner. The pharmaceutical administration form enables controlled release, e.g. for oral, transdermal or another route of parenteral administration.
摘要翻译： Deoxypeganine和/或其药学上可接受的酸加成盐可用于药物成瘾或药物成瘾的治疗。这些物质优选以连续的和受控的方式施用。该药物剂型提供了一种用于例如控制释放口服，通过其他手段经皮或肠胃外给药。

7. 发明申请

WO2007144081A3 SMOKING WITHDRAWAL COMBINATION WAFER 审中-公开
标题翻译：戒烟组合晶片
公开(公告)号：WO2007144081A3
公开(公告)日：2008-04-10
申请号：PCT/EP2007004937
申请日：2007-06-04
申请人： LOHMANN THERAPIE SYST LTS , HOFFMANN HANS-RAINER , BRAENDLI RETO , THEOBALD FRANK
发明人： HOFFMANN HANS-RAINER , BRAENDLI RETO , THEOBALD FRANK
IPC分类号： A61K9/00
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/7007
摘要： The present invention relates to a quickly decomposing oral drug preparation, for the application of active ingredient combinations for smoking withdrawal, which contains nicotine, a nicotine salt, a nicotine derivative, or a substance that reacts to nicotine, in combination with another active ingredient, and the use of such a drug preparation for the treatment of smoking withdrawal, and the use of nicotine, and/or nicotine salts or derivatives, for the production of medications for the treatment of smoking withdrawal. The active ingredient that is to be administered, in combination, for this purpose is a centrally active ingredient, preferably an antidepressant for the fighting of psychic dependency in terms of a smoking withdrawal therapy. The administration of the active ingredient combination to the patient should be handled in a simple and reliable way and should exclude side effects to a large extent.
摘要翻译：本发明涉及一种快速崩解用于戒烟与尼古丁的含量，烟碱盐，烟碱衍生物或具有烟碱作用的织物的活性物质组合的施用口服剂型，与另一种活性成分和尼古丁成瘾的治疗中使用这样的制剂的组合，对尼古丁替代或戒烟和用于制备剂型尼古丁依赖的治疗中的用途尼古丁或其盐或衍生物。在组合给药的活性成分是一种中枢作用的物质，优选的抗抑郁药物打击心理依赖作为戒烟治疗的一部分。联合用药的管理才能够对其进行简单和可靠的方式，患者并在很大程度上排除副作用。

8. 发明申请

WO2007144085A8 OPIOID COMBINATION WAFER 审中-公开
标题翻译：阿片组合晶片
公开(公告)号：WO2007144085A8
公开(公告)日：2008-02-21
申请号：PCT/EP2007004954
申请日：2007-06-04
申请人： LOHMANN THERAPIE SYST LTS , HOFFMANN HANS-RAINER , BRAENDLI RETO , THEOBALD FRANK
发明人： HOFFMANN HANS-RAINER , BRAENDLI RETO , THEOBALD FRANK
IPC分类号： A61K9/00 , A61K9/20 , A61K9/70 , A61K31/19 , A61K31/196 , A61K31/515 , A61K31/5513
CPC分类号： A61K9/006 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0056 , A61K31/19 , A61K31/196 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K45/06 , A61K2300/00
摘要： Illnesses or injuries are usually accompanied by pain, with pain itself now being regarded as an illness and increasingly occurring as an independent symptom. The present invention relates to wafer-like presentations for pain therapy, based on hydrophilic polymers, which rapidly dissolve or disintegrate in a watery environment and which release active agent combinations when placed into a body orifice or body cavity, and which are preferably orally administered, with the presentation containing an active agent combination consisting of an opioid and a second substance, wherein the second active agent is a non-steroidal anti-rheumatic (NSAR) or an antidepressant.
摘要翻译：疼痛通常伴随疾病或损伤，但现在甚至理解为一种疾病和随频率增加作为一个独立的症状发生。本发明涉及成形的基础上，在活性物质结合的在体腔或体腔中的释放的亲水性聚合物，优选用于口服给药的，其中所述剂型阿片类药的活性成分组合和第二物质在含水环境或腐蚀性Darreichungs形式用于疼痛治疗快速溶解的表面包括，其中所述第二活性成分是一种非甾体抗炎（NSAID）或抗抑郁药。

9. 发明申请

WO2007144084A8 TYPE-2 DIABETES COMBINATION WAFER 审中-公开
标题翻译： 2型糖尿病组合晶片
公开(公告)号：WO2007144084A8
公开(公告)日：2008-02-14
申请号：PCT/EP2007004953
申请日：2007-06-04
申请人： LOHMANN THERAPIE SYST LTS , HOFFMANN HANS-RAINER , BRAENDLI RETO , THEOBALD FRANK
发明人： HOFFMANN HANS-RAINER , BRAENDLI RETO , THEOBALD FRANK
IPC分类号： A61K9/70
CPC分类号： A61K45/06 , A61K9/0056 , A61K9/006 , A61K31/155 , A61K31/198 , A61K31/64 , A61K2300/00
摘要： The present invention relates to rapidly disintegrating oral drug preparations for the application of active agent combinations for diabetes therapy, wherein the drug preparations contain at least two active agents suitable for treating type-2 diabetes, and where the antidiabetic active agents are selected from the group comprising sulfonylureas, glitazones, glinides, biguanides, and resorption inhibitors. The present invention is further aimed at the use of the active agent combination in accordance with the invention to produce an oral drug preparation for the treatment of diabetes, at a method for the therapeutic treatment of diabetes, and at a method for the production of a wafer-like drug preparation.
摘要翻译：本发明涉及迅速崩解的口服剂型用于治疗糖尿病的活性化合物fkombinationen的给药，所述剂型含有至少两个选自磺酰脲类所述的组被选择，其是适用于治疗2型糖尿病的，而抗糖尿病Wirksoffe活性化合物，格列酮类，格列奈类，双胍类和吸收抑制剂。本发明还涉及使用根据本发明用于制备的口服剂型用于治疗糖尿病的治疗中，一种用于糖尿病的治疗性治疗和用于制造片状剂型的方法的活性成分的组合。

10. 发明申请

WO2006081994A3 ISOLATION OF N-BUTYLBENZENESULFONAMIDE, SYNTHESIS OF BENZENESULFONAMIDE DERIVATIVES, AND USE OF N-BUTYLBENZENESULFONAMIDE AND BENZENESULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BENIGN PROSTATE HYPERPLASIA AND/OR PROSTATE CARCINOMA 审中-公开
标题翻译： N-丁基苯，衍生物和苯磺酰胺N-丁基苯的使用和苯磺酰胺衍生物的合成良性前列腺的治疗和/或前列腺癌的隔离
公开(公告)号：WO2006081994A3
公开(公告)日：2007-03-22
申请号：PCT/EP2006000746
申请日：2006-01-28
申请人： LOHMANN THERAPIE SYST LTS , HOFFMANN HANS-RAINER , MATUSCH RUDOLF , BANIAHMAD ARIA
发明人： HOFFMANN HANS-RAINER , MATUSCH RUDOLF , BANIAHMAD ARIA
IPC分类号： A61K31/18 , A61K36/00 , A61P13/08 , A61P35/00
CPC分类号： A61K36/736 , A61K31/18
摘要： The invention relates to a method for isolating N-butylbenzenesulfonamide (NBBS) from biological material, especially prunus africana, the chemical synthesis of benzenesulfonamide derivatives, and the use of NBBS and benzenesulfonamide derivatives for the treatment of or producing medicaments for the treatment of benign prostate hyperplasia and/or prostate carcinoma and as a basic substance for the development of agents used for treating said diseases.
摘要翻译：本发明涉及用于从生物材料的N-苯磺酰胺（NBBS）的分离的方法，特别是从非洲臀果木，苯磺酰胺衍生物的化学合成，以及使用NBBS和苯磺酰胺衍生物用于治疗或用于制备药物的用于治疗良性前列腺增生症和/或前列腺癌，以及用于发展代理商用于上述疾病的治疗的引线物质。

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