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1. 发明申请

WO2006081994A3 ISOLATION OF N-BUTYLBENZENESULFONAMIDE, SYNTHESIS OF BENZENESULFONAMIDE DERIVATIVES, AND USE OF N-BUTYLBENZENESULFONAMIDE AND BENZENESULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BENIGN PROSTATE HYPERPLASIA AND/OR PROSTATE CARCINOMA 审中-公开
标题翻译： N-丁基苯，衍生物和苯磺酰胺N-丁基苯的使用和苯磺酰胺衍生物的合成良性前列腺的治疗和/或前列腺癌的隔离
公开(公告)号：WO2006081994A3
公开(公告)日：2007-03-22
申请号：PCT/EP2006000746
申请日：2006-01-28
申请人： LOHMANN THERAPIE SYST LTS , HOFFMANN HANS-RAINER , MATUSCH RUDOLF , BANIAHMAD ARIA
发明人： HOFFMANN HANS-RAINER , MATUSCH RUDOLF , BANIAHMAD ARIA
IPC分类号： A61K31/18 , A61K36/00 , A61P13/08 , A61P35/00
CPC分类号： A61K36/736 , A61K31/18
摘要： The invention relates to a method for isolating N-butylbenzenesulfonamide (NBBS) from biological material, especially prunus africana, the chemical synthesis of benzenesulfonamide derivatives, and the use of NBBS and benzenesulfonamide derivatives for the treatment of or producing medicaments for the treatment of benign prostate hyperplasia and/or prostate carcinoma and as a basic substance for the development of agents used for treating said diseases.
摘要翻译：本发明涉及用于从生物材料的N-苯磺酰胺（NBBS）的分离的方法，特别是从非洲臀果木，苯磺酰胺衍生物的化学合成，以及使用NBBS和苯磺酰胺衍生物用于治疗或用于制备药物的用于治疗良性前列腺增生症和/或前列腺癌，以及用于发展代理商用于上述疾病的治疗的引线物质。

2. 发明申请

WO2010091822A8 N-HYDROXYLATED AMIDINE-, GUANIDINE- AND/OR AMINOHYDRAZONE-TYPE PRODRUGS FOR APPLICATION ON THE SKIN 审中-公开
标题翻译：前体药物类型N-羟基脒，胍和/或AMINOHYDRAZONE通过皮肤施用
公开(公告)号：WO2010091822A8
公开(公告)日：2011-08-11
申请号：PCT/EP2010000715
申请日：2010-02-05
申请人： LOHMANN THERAPIE SYST LTS , MATUSCH RUDOLF , HOFFMANN HANS-RAINER , ASMUSSEN BODO , KOCH ANDREAS
发明人： MATUSCH RUDOLF , HOFFMANN HANS-RAINER , ASMUSSEN BODO , KOCH ANDREAS
IPC分类号： A61K9/00 , A61K9/70 , A61K31/155 , A61K31/4245 , A61K47/48
CPC分类号： A61K9/0014
摘要： The invention relates to N-hydroxylated amidines, guanidines and aminohydrazones for application on the skin. In particular, the invention relates to transdermal therapeutic systems, containing N-hydroxylated amidines, guanidines and aminohydrazones as a prodrug, and to methods for producing and using such systems.
摘要翻译：本发明涉及N-羟基化脒，胍，和Aminohydrazone用于皮肤上的应用程序。特别地，本发明涉及一种透皮治疗系统使用N-羟基脒，胍，和Aminohydrazone包含作为前药，以及制造和使用这种系统的方法。

3. 发明申请

WO2010091822A3 N-HYDROXYLATED AMIDINE-, GUANIDINE- AND/OR AMINOHYDRAZONE-TYPE PRODRUGS FOR APPLICATION ON THE SKIN 审中-公开
标题翻译：用于皮肤应用的N-羟基脒，胍和/或氨基腙类
公开(公告)号：WO2010091822A3
公开(公告)日：2011-10-13
申请号：PCT/EP2010000715
申请日：2010-02-05
申请人： LOHMANN THERAPIE SYST LTS , MATUSCH RUDOLF , HOFFMANN HANS-RAINER , ASMUSSEN BODO , KOCH ANDREAS
发明人： MATUSCH RUDOLF , HOFFMANN HANS-RAINER , ASMUSSEN BODO , KOCH ANDREAS
IPC分类号： A61K9/00 , A61K9/70 , A61K31/155 , A61K31/4245 , A61K47/48
CPC分类号： A61K9/0014
摘要： The invention relates to N-hydroxylated amidines, guanidines and aminohydrazones for application on the skin. In particular, the invention relates to transdermal therapeutic systems, containing N-hydroxylated amidines, guanidines and aminohydrazones as a prodrug, and to methods for producing and using such systems.
摘要翻译：本发明涉及用于通过皮肤给药的N-羟基化脒，胍和氨基腙。具体而言，本发明涉及含有N-羟基化脒，胍和氨基腙作为前药的透皮治疗系统，以及制造和使用此类系统的方法。

4. 发明申请

WO0071125A3 PHARMACEUTICAL PREPARATION CONTAINING THE ACTIVE SUBSTANCE DIAMORPHINE AND ITS UTILIZATION IN A METHOD FOR TREATING OPIATE ADDICTION 审中-公开
标题翻译：与ACTIVE海洛因药物制备及其用途的方法，阿片类药物治疗网瘾
公开(公告)号：WO0071125A3
公开(公告)日：2001-03-15
申请号：PCT/EP0004458
申请日：2000-05-17
申请人： LOHMANN THERAPIE SYST LTS , MATUSCH RUDOLF , ADAM BERND , KOCH ANDREAS , HOFFMANN HANS RAINER , ASMUSSEN BODO
发明人： MATUSCH RUDOLF , ADAM BERND , KOCH ANDREAS , HOFFMANN HANS-RAINER , ASMUSSEN BODO
IPC分类号： A61K9/70 , A61K31/485 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/22 , A61K47/32 , A61K47/34 , A61P25/04 , A61P25/36
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/485
摘要： The invention relates to pharmaceutical preparations that are used in a method for treating opiate addiction or opiate dependence, especially heroin dependence. The active substance used is preferably diamorphine and/or one of the pharmaceutically acceptable acid addition salts thereof. The invention also relates to a method for treating opiate dependence.
摘要翻译：本发明涉及一种用于在一个方法中使用阿片类药物成瘾或阿片成瘾，特别是Heroinabhäbhängigkeit的治疗的药物制剂。使用的活性成分，优选为二乙酰吗啡和/或它的药学上可接受的酸加成盐中的一种。阿片类依赖的治疗的方法也被描述。

5. 发明专利

IL199731A SINGLE-USE INJECTOR WITH AT LEAST ONE DRAW HOOK 未知
公开(公告)号：IL199731A
公开(公告)日：2012-12-31
申请号：IL19973109
申请日：2009-07-07
申请人： LOHMANN THERAPIE SYST LTS , MATUSCH RUDOLF , ASMUSSEN BODO , HOFFMANN HANS-RAINER , WORTMANN UWE
发明人： MATUSCH RUDOLF , ASMUSSEN BODO , HOFFMANN HANS-RAINER , WORTMANN UWE
摘要： A single-use injector is disclosed comprising a housing (10), arranged in which are at least one mechanical spring energy store (50), at least one piston-cylinder unit (100), which can be effectively filled at least for a certain time, at least one piston-actuating ram (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram (60) has at least one retaining rod or hook (62), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit (80) releases the supporting portion to allow it to move away from the resting surface.

6. 发明专利

IL146277A PHARMACEUTICAL PRODUCT COMPRISING THE ACTIVE SUBSTANCE DIAMORPHINE AND ITS USE IN A PROCESS FOR TREATING OPIATE ADDICTION 未知
公开(公告)号：IL146277A
公开(公告)日：2006-12-10
申请号：IL14627701
申请日：2001-11-01
申请人： LOHMANN THERAPIE SYST LTS , MATUSCH RUDOLF , ADAM BERND , KOCH ANDREAS , HOFFMANN HANS-RAINER , ASMUSSEN BODO
发明人： MATUSCH RUDOLF , ADAM BERND , KOCH ANDREAS , HOFFMANN HANS-RAINER , ASMUSSEN BODO
IPC分类号： A61K9/70 , A61K31/485 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/22 , A61K47/32 , A61K47/34 , A61P25/04 , A61P25/36
摘要： The invention relates to pharmaceutical preparations that are used in a method for treating opiate addiction or opiate dependence, especially heroin dependence. The active substance used is preferably diamorphine and/or one of the pharmaceutically acceptable acid addition salts thereof. The invention also relates to a method for treating opiate dependence.

7. 发明申请

WO2010136132A2 DUAL-CHAMBER CYLINDER-PISTON UNIT FOR THE LYOPHILISATION, STORAGE, RECONSTITUTION AND APPLICATION OF INJECTION SOLUTIONS FOR AN INJECTOR, AND METHOD FOR FILLING THE CYLINDER-PISTON UNIT 审中-公开
标题翻译：二室气缸活塞装置于冻干储存，准备和注射液用于灌装缸柱塞单元一个注射器和法中的应用
公开(公告)号：WO2010136132A2
公开(公告)日：2010-12-02
申请号：PCT/EP2010002974
申请日：2010-05-14
申请人： LOHMANN THERAPIE SYST LTS , MATUSCH RUDOLF
发明人： MATUSCH RUDOLF
IPC分类号： A61M5/30
CPC分类号： A61M5/1782 , A61M5/30 , A61M5/3007 , A61M5/3129 , A61M5/31596 , A61M2005/3118 , B65B3/003
摘要： The invention relates to a piston-cylinder unit (1) for a needle-free injector, for example for providing a sterile injection solution, said unit comprising a chamber (3) arranged in a cylinder (2), for receiving an injection solution (4), a front wall (5) having at least one nozzle borehole or an outlet element (6), and a second piston (7) arranged in such a way that it can move in the chamber. Said unit is characterised in that the chamber (3) is made from two parts with a first chamber (8) and a concentric second chamber (9), the cross-section of the first chamber (8) being larger than the cross-section of the second chamber (9), the first chamber (8) is closed by a first piston (10) and the second chamber (9) is closed by the second piston, the first chamber (8) being separated from the second chamber (9), and the second piston comprises at least one flow channel (16) or the first chamber comprises at least one closable, axially oriented freeze-drying channel (34), and the second chamber (9) comprises at least one axially oriented flow channel (36), on the respective rear ends of the chambers (8, 9). The invention also relates to a method for filling the cylinder-piston unit (11).
摘要翻译：（1）设置用于无针注射器，例如甲活塞 - 缸单元，其用于接收注射溶液（4），一个端壁提供在气缸（2）腔室（3），用于注射的无菌溶液，与（5）具有至少一个喷嘴孔和出口元件在所述腔室（3）的第二活塞（7），其特征在于在（6）和可移动地布置一个 - 所述室（3）（以两个部分的第一腔室（8）和一个同心第二室9 形成），第一腔室的横截面（8）比所述第二腔室（9）的横截面更大， - 所述第一腔室（8）（由第一活塞10）和第二室（9）通过第二活塞（7）关闭时，其特征在于，从所述第二腔室（9）的第一腔室（8）分离，以及 - 所述第二活塞（7）具有至少一个输送管道（16）或 - 所述第一腔室（8）具有至少一个可关闭的 n个位于轴向排列的冷冻干燥通道（34）和第二室（9）与至少一个轴向取向的传输管（36）到所述腔室的相应的后端部（8,9）形成。本发明还涉及一种用于填充所述气缸 - 活塞装置（1）。

8. 发明申请

WO2010136133A3 CYLINDER-PISTON UNIT SUITABLE FOR STORING INJECTION SOLUTIONS FOR A NEEDLE-FREE INJECTOR AND METHOD FOR THE BUBBLE-FREE AUTOMATIC OR MANUAL FILLING OF THE CYLINDER-PISTON UNIT, ALSO UNDER ATMOSPHERIC PRESSURE 审中-公开
标题翻译：储存注射液的缸活塞单元，用于自动无气泡填充或MANELLEN缸活塞UNIT A无针注射器和方法，即使在大气压力下
公开(公告)号：WO2010136133A3
公开(公告)日：2011-02-24
申请号：PCT/EP2010002975
申请日：2010-05-14
申请人： LOHMANN THERAPIE SYST LTS , MATUSCH RUDOLF
发明人： MATUSCH RUDOLF
IPC分类号： A61M5/30 , A61M5/178
CPC分类号： A61J1/2096 , A61M5/1782 , A61M5/286 , A61M5/30 , A61M2005/3128 , B65B3/003
摘要： The invention relates to a cylinder-piston unit (1) which is resistant to pressure, vapour and oxygen for a needle-free injector. Said unit comprises a chamber (3) which is arranged in a cylinder (2) and is used to accommodate an injection solution (4) in a durable and sterile manner, a front wall (5) having at least one nozzle bore or an outlet element (6), a pressure-stable exterior cylinder (13) and a piston (7) which is pressure, vapour and oxygen resistant and which is arranged in a displaceable manner in the chamber (3). According to the invention, the chamber (3) consists of a first chamber (8) and a second concentric chamber (9), the cross-section of the first chamber (8) being greater than the cross-section of the second chamber (9) and each nozzle bore or each outlet element (6) is sealed in a sterile manner by a membrane (26, 27) which is vapour and oxygen resistant and which opens when subjected to excess pressure. The invention also relates to a method for automatically or manually filling the cylinder-piston unit (1), also under atmospheric pressure.
摘要翻译：在水蒸汽和氧气阻隔性，耐压力缸 - 活塞装置（1）一种无针注射器，其被布置在一个在气缸（2）腔室（3），用于永久和无菌接受注射溶液（4），一个端壁（5）（7），所述室（3），其具有第一腔室具有至少一个喷嘴孔和出口元件（6），耐压外筒（13）和一个在所述腔室（3）可移动地布置，阻断水蒸气和氧气，耐压烧瓶（ 8）和第二同心腔室（9），其中，所述第一腔室的横截面（8）比所述第二腔室（9）的横截面，并且每个喷嘴孔或每个出口元件（6）由水蒸汽和氧气阻隔时，在过压开口形成以无菌的方式将膜（26，27）。本发明还涉及一种用于自动或手动填充所述气缸 - 活塞装置（1），即使在大气压下的方法。

9. 发明申请

WO0041683A3 TRANSDERMAL THERAPEUTIC SYSTEM WITH SELF-ADHESIVE MATRIX, CONTAINING ORGANIC ACID ADDITION SALTS OF MORPHINE- OR MORPHINAN-TYPE ALKALOIDS 审中-公开
标题翻译：用粘合剂MATRIX含生物碱吗啡有机酸盐或透皮治疗系统 MORPHINANTYPS
公开(公告)号：WO0041683A3
公开(公告)日：2001-11-08
申请号：PCT/EP0000198
申请日：2000-01-13
申请人： LOHMANN THERAPIE SYST LTS , KOCH ANDREAS , ADAM BERND , MATUSCH RUDOLF , ASMUSSEN BODO
发明人： KOCH ANDREAS , ADAM BERND , MATUSCH RUDOLF , ASMUSSEN BODO
IPC分类号： A61K9/70 , A61K31/485 , A61K47/12 , A61K47/32 , A61K47/34 , A61P25/04 , A61P25/30
CPC分类号： A61K9/7061 , A61K31/485
摘要： The invention relates to a transdermal therapeutic system (TTS) comprising a support layer which is impermeable to the active ingredient, a self-adhesive matrix consisting of a cationic base polymer and a detachable protective film on the side facing the skin. As active ingredient the matrix contains organic acid addition salts of morphine alkaloids on the basis of a water-soluble polyaminomethacrylate salt containing fatty acids. The invention is characterized in that a sparingly water-soluble copolymer of acrylic and methacrylic acid esters with a comparatively low quaternary content of ammonium groups which form a salt with inorganic acids is admixed to the cationic base polymer.
摘要翻译：的透皮治疗系统（TTS），其包括一个活性物质不可渗透的背层，阳离子基础聚合物和所述面向皮肤侧上的可取下的保护片的自粘性基质，所述基于脂肪酸的含酸含吗啡生物碱的作为活性物质的有机酸加成盐基质，水溶性Polyaminomethacrylatsalzes是其特征在于，所述阳离子基础聚合物是丙烯酸和甲基丙烯酸酯的具有相对小的内容的有限的水溶性共聚物，其中加入了形成与无机酸盐的季铵基团。

10. 发明专利

IL202956A DISPOSABLE INJECTOR WITH AT LEAST ONE COMPRESSION BAR AND A CLOSURE CAP 未知
公开(公告)号：IL202956A
公开(公告)日：2013-01-31
申请号：IL20295609
申请日：2009-12-24
申请人： MATUSCH RUDOLF , LOHMANN THERAPIE SYST LTS
发明人： MATUSCH RUDOLF

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