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1. 发明申请

WO2011133143A1 MULTI-PILLAR STRUCTURE FOR MOLECULAR ANALYSIS 审中-公开
标题翻译：用于分子分析的多支架结构
公开(公告)号：WO2011133143A1
公开(公告)日：2011-10-27
申请号：PCT/US2010/031790
申请日：2010-04-20
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , LI, Zhiyong , HU, Min , OU, Fung Suong , WU, Wei , WILLIAMS, R. Stanley
发明人： LI, Zhiyong , HU, Min , OU, Fung Suong , WU, Wei , WILLIAMS, R. Stanley
IPC分类号： G01N21/65 , G01N33/483 , B82B1/00 , G01J3/44
CPC分类号： G01N21/658
摘要： A multi-pillar structure for molecular analysis is provided. The structure comprises at least two nanopoles, each nanopole attached at one end to a substrate and freely movable along its length. The opposite ends of the at least two nanopoles are each capable of movement toward each other to trap at least one analyte molecule at their opposite ends. Each nanopole is coated with a metal coating. An array of such multi-pillar structures is also provided. A method for preparing the multi-pillar structure is further provided.
摘要翻译：提供了一种用于分子分析的多支柱结构。该结构包括至少两个纳米微粒，每个纳米孔一端连接到基底上，并可沿其长度自由移动。至少两个纳米球的相对端各自能够相互移动以在其相对端捕获至少一种分析物分子。每个纳米孔涂有金属涂层。还提供了这种多支柱结构的阵列。还提供了一种制备多支柱结构的方法。

2. 发明申请

WO2010104520A1 BROAD BAND STRUCTURES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY 审中-公开
标题翻译：表面增强拉曼光谱的宽带结构
公开(公告)号：WO2010104520A1
公开(公告)日：2010-09-16
申请号：PCT/US2009/037167
申请日：2009-03-13
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , LI, Zhiyong , HU, Min
发明人： LI, Zhiyong , HU, Min
IPC分类号： G01J3/44
CPC分类号： G01N21/554 , B82Y30/00 , G01N21/553 , G01N21/658
摘要： Broad band structures (10, 10', 10") for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure (10, 10', 10") is made up of a metal layer, and a dielectric layer (16A, 16S, 16P) established on at least a portion of the metal layer. The dielectric layer (16A, 16S, 16P) has a controlled thickness that varies from at least one portion of the dielectric layer (16A, 16s, 16p) to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer (16A, 16S, 16P) at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances.
摘要翻译：本文公开了用于表面增强拉曼光谱的宽带结构（10,10'，10“）。结构（10,10'，10”）的每个实施例由金属层和电介质层（16A， 16S，16P）建立在金属层的至少一部分上。电介质层（16A，16S，16P）具有从电介质层（16A，16s，16p）的至少一部分至电介质层的至少另一部分变化的受控厚度。至少在部分和另一部分，在介电层（16A，16S，16P）上建立纳米结构，因此纳米结构被配置为展现可变的等离子体共振。

3. 发明申请

WO2011093876A1 ENVIRONMENT SENSITIVE DEVICES 审中-公开
标题翻译：环境敏感装置
公开(公告)号：WO2011093876A1
公开(公告)日：2011-08-04
申请号：PCT/US2010/022562
申请日：2010-01-29
申请人： HEWLETT PACKARD DEVELOPMENT COMPANY, L.P. , OU, Fung, Suong , LI, Zhiyong , KUO, Huei, Pei , HU, Min
发明人： OU, Fung, Suong , LI, Zhiyong , KUO, Huei, Pei , HU, Min
IPC分类号： B82B3/00 , G01N21/65 , H01L21/02
CPC分类号： B82Y15/00 , G01N21/658 , H01L29/0665
摘要： An environment sensitive device (10, 10', 10'') is disclosed. The device (10, 10', 10'') includes a substrate, a three-dimensional structure (24, 24', 24'') established on the substrate, a first coating (28) established on a first portion (P 1 ) of the three-dimensional structure (24, 24', 24''), and a second coating (30) established on a second portion (P 2 ) of the three-dimensional structure (24, 24', 24''). The first and second coatings (28, 30) contain different materials that are configured to respond differently when exposed to a predetermined external stimulus.
摘要翻译：公开了一种环境敏感设备（10,10'，10“）。设备（10,10'，10“）包括基板，在基板上建立的三维结构（24,24'，24”），建立在第一部分（P1）上的第一涂层（28）的三维结构（24,24'，24“），以及第二涂层（30），其建立在三维结构（24,24'，24”）的第二部分（P2）上。第一和第二涂层（28,30）包含不同的材料，其被配置为当暴露于预定的外部刺激时不同地响应。

4. 发明申请

WO2013158114A1 INTEGRATED SENSORS 审中-公开
标题翻译：集成传感器
公开(公告)号：WO2013158114A1
公开(公告)日：2013-10-24
申请号：PCT/US2012/034448
申请日：2012-04-20
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , BRATKOVSKI, Alexandre M. , LI, Zhiyong , WU, Wei , HU, Min , WILLIAMS, R. Stanley , KIM, Ansoon
发明人： BRATKOVSKI, Alexandre M. , LI, Zhiyong , WU, Wei , HU, Min , WILLIAMS, R. Stanley , KIM, Ansoon
IPC分类号： G01N35/00 , G01N21/00
CPC分类号： G01N21/658 , B01L3/5088 , B01L2300/0627 , B01L2300/0819 , B01L2300/161 , G01N21/648 , G01N35/00009 , G01N2035/00019
摘要： Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a substrate and a sensing member formed on a surface of the substrate. The sensing member includes collapsible signal amplifying structures and an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures.
摘要翻译：本文公开了集成传感器的示例。集成传感器的示例包括形成在基板的表面上的基板和感测构件。感测构件包括可折叠信号放大结构和围绕可折叠信号放大结构的区域，其使得能够将暴露于其的液滴自动定位到可折叠信号放大结构。

5. 发明申请

WO2011133144A1 A SELF-ARRANGING, LUMINESCENCE-ENHANCEMENT DEVICE FOR SURFACE-ENHANCED LUMINESCENCE 审中-公开
标题翻译：表面增强发光的自亮装置，增亮装置
公开(公告)号：WO2011133144A1
公开(公告)日：2011-10-27
申请号：PCT/US2010/031809
申请日：2010-04-20
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , LI, Zhiyong , HU, Min , OU, Fung Suong , WU, Wei
发明人： LI, Zhiyong , HU, Min , OU, Fung Suong , WU, Wei
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658 , G01N21/648
摘要： A self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence. The self-arranging, luminescence-enhancement device 101 for surface-enhanced luminescence includes a substrate 110, and a plurality 120 of flexible columnar structures. A flexible columnar structure 120-1 of the plurality 120 includes a flexible column 120-1A, and a metallic cap 120-1B coupled to the apex 120-1C of the flexible column 120-1A. At least the flexible columnar structure 120-1 and a second flexible columnar structure 120-2 are configured to self-arrange into a close-packed configuration with at least one molecule 220-1 disposed between at least the metallic cap 120-1B and a second metallic cap 120-2B of respective flexible columnar structure 120-1 and second flexible columnar structure 120-2.
摘要翻译：用于表面增强发光的自配置发光增强装置101。用于表面增强发光的自配置发光增强装置101包括基板110和多个120个柔性柱状结构。多个120的柔性柱状结构120-1包括柔性柱120-1A以及耦合到柔性柱120-1A的顶点120-1C的金属盖120-1B。至少柔性柱状结构120-1和第二柔性柱状结构120-2构造成自配置成紧密堆积构造，其中至少一个分子220-1设置在至少金属盖120-1B和各个柔性柱状结构120-1的第二金属盖120-2B和第二柔性柱状结构120-2。

6. 发明申请

WO2012015443A1 OPTICAL FIBER SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) PROBE 审中-公开
标题翻译：光纤表面增强拉曼光谱（SERS）探头
公开(公告)号：WO2012015443A1
公开(公告)日：2012-02-02
申请号：PCT/US2010/044039
申请日：2010-07-30
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , LI, Zhiyong , HU, Min , WU, Wei
发明人： LI, Zhiyong , HU, Min , WU, Wei
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658
摘要： A surface enhanced Raman spectroscopy (SERS) probe apparatus (100) and a method (300) of SERS probing employ Raman-active surfaces of a plurality of nanoscale field concentrator (NFC) structures (130) at a terminal end (114) of an optical fiber (110). The SERS probe apparatus (100) includes an optical fiber (110) having an optical path (112) and a terminal end (114) that terminates the optical path (112). The SERS probe apparatus (100) further includes a plurality of NFC structures (130) and nanoparticles (140) on surfaces (120) of the plurality of NFC structures (130). First ends of the NFC structures (130) are adjacent to the terminal end (114) of optical fiber (110). The nanoparticles (140) are Raman active to an analyte (102).
摘要翻译：在SERS探测的表面增强拉曼光谱（SERS）探针装置（100）和方法（300）中，在多个纳米尺度场集中器（NFC）结构（130）的末端（114）处使用拉曼活性表面光纤（110）。 SERS探针装置（100）包括具有光路（112）的光纤（110）和终止光路（112）的终端（114）。 SERS探针装置（100）还包括在多个NFC结构（130）的表面（120）上的多个NFC结构（130）和纳米颗粒（140）。 NFC结构（130）的第一端与光纤（110）的终端（114）相邻。纳米颗粒（140）是对分析物（102）有活性的拉曼。

7. 发明申请

WO2011093871A1 SENSING DEVICES 审中-公开
标题翻译：感应装置
公开(公告)号：WO2011093871A1
公开(公告)日：2011-08-04
申请号：PCT/US2010/022549
申请日：2010-01-29
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , OU, Fung Suong , KUO, Huei Pei , LI, Zhiyong , HU, Min
发明人： OU, Fung Suong , KUO, Huei Pei , LI, Zhiyong , HU, Min
IPC分类号： G01N27/00
CPC分类号： G01N21/658 , B82Y15/00 , G01J3/44 , G01N27/12
摘要： A sensing device (10, 10') includes a substrate (14), and first and second electrodes (E IC , E ICs , E O ) established on the substrate (14). The first electrode (E IC , E ICS ) has a three-dimensional shape, and the second electrode (E 0 ) is electrically isolated from and surrounds a perimeter of the first electrode (E IC , E ICS ).
摘要翻译：感测装置（10,10'）包括衬底（14）以及在衬底（14）上建立的第一和第二电极（EIC，EIC，EO）。第一电极（EIC，EICS）具有三维形状，并且第二电极（E0）与第一电极（EIC，EICS）的周边电隔离并围绕第一电极的周边。

8. 发明申请

WO2011034533A1 ELECTRICALLY DRIVEN DEVICES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY 审中-公开
标题翻译：用于表面增强拉曼光谱的电驱动装置
公开(公告)号：WO2011034533A1
公开(公告)日：2011-03-24
申请号：PCT/US2009/057327
申请日：2009-09-17
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , KUO, Huei Pei , WANG, Shih-Yuan , HU, Min , LI, Zhiyong , BRATKOVSKI, Alexandre M.
发明人： KUO, Huei Pei , WANG, Shih-Yuan , HU, Min , LI, Zhiyong , BRATKOVSKI, Alexandre M.
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y15/00 , B82Y30/00
摘要： An electrically driven device (10) for surface enhanced Raman spectroscopy includes a first electrode (16), a substrate (12) positioned proximate to the first electrode (16), a plurality of cone shaped protrusions (12') formed integrally with or on a substrate surface (S), a Raman signal-enhancing material (14) coated on each protrusion (12'), and a second electrode (18) positioned relative to the first electrode (16) at a predetermined distance, D. Each of the protrusions (12') has a tip (22) with a radius of curvature, r, ranging from about 0.1 nm to about 100 nm. The second electrode (18) is positioned relative to the first electrode (16) such that the electrodes (16, 18) together produce an electric field (EF) when a voltage bias is applied therebetween. The electric field (EF) has a field distribution that creates a stronger field gradient at a region proximate to the tips (22) than at other portions of the substrate (12).
摘要翻译：用于表面增强拉曼光谱的电驱动装置（10）包括第一电极（16），靠近第一电极（16）定位的衬底（12），与该第一电极（16）一体形成或多个形成的多个锥形突起涂覆在每个突起（12'）上的衬底表面（S），拉曼信号增强材料（14）和相对于第一电极（16）以预定距离D定位的第二电极（D）。突起（12'）具有从约0.1nm至约100nm范围内的具有曲率半径r的尖端（22）。第二电极（18）相对于第一电极（16）定位，使得当施加电压时，电极（16,18）一起产生电场（EF）。电场（EF）具有在靠近尖端（22）的区域处比在衬底（12）的其它部分处产生更强的场梯度的场分布。

9. 发明申请

WO2013048446A1 DEVICES TO DETECT A SUBSTANCE AND METHODS OF PRODUCING SUCH A DEVICE 审中-公开
标题翻译：检测物质的装置和生产这种装置的方法
公开(公告)号：WO2013048446A1
公开(公告)日：2013-04-04
申请号：PCT/US2011/054283
申请日：2011-09-30
申请人： HEWLET-PACKARD DEVELOPMENT COMPANY, L.P. , WU, Wei , LI, Zhiyong , KIM, Ansoon , HU, Min , STUKE, Michael Josef
发明人： WU, Wei , LI, Zhiyong , KIM, Ansoon , HU, Min , STUKE, Michael Josef
IPC分类号： G01N1/36 , G01N21/64 , G01N21/65 , G01N33/00
CPC分类号： G01N31/22 , B01L3/5085 , B01L3/50853 , B01L2200/141 , B01L2300/0636 , B01L2300/069 , B01L2300/0819 , B82Y15/00 , G01N21/648 , G01N21/658 , G01N2201/0227 , G01N2201/023 , Y10T436/25
摘要： Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining an externally accessible chamber and a seal to enclose at least a portion of the chamber. The example device also includes a substrate includes nanoparticles positioned within the chamber. The nanoparticles to react to the substance when exposed thereto. The example device also includes a non-analytic solution within the chamber to protect the nanoparticles from premature exposure.
摘要翻译：公开了检测物质的装置和制造这种装置的方法。用于检测物质的示例性装置包括限定外部可触及室的壳体和用于封闭室的至少一部分的密封件。该示例性装置还包括基底，其包括位于腔室内的纳米颗粒。纳米颗粒暴露于物质时与物质反应。该示例性装置还包括室内的非分析溶液以保护纳米颗粒免于过早暴露。

10. 发明公开

EP2528858A1 ENVIRONMENT SENSITIVE DEVICES 审中-公开
标题翻译：环境检测装置
公开(公告)号：EP2528858A1
公开(公告)日：2012-12-05
申请号：EP10844877.0
申请日：2010-01-29
申请人： Hewlett Packard Development Company, L.P.
发明人： OU, Fung, Suong , LI, Zhiyong , KUO, Huei, Pei , HU, Min
IPC分类号： B82B3/00 , G01N21/65 , H01L21/02
CPC分类号： B82Y15/00 , G01N21/658 , H01L29/0665
摘要： An environment sensitive device (10, 10', 10'') is disclosed. The device (10, 10', 10'') includes a substrate, a three-dimensional structure (24, 24', 24'') established on the substrate, a first coating (28) established on a first portion (P
1 ) of the three-dimensional structure (24, 24', 24''), and a second coating (30) established on a second portion (P
2 ) of the three-dimensional structure (24, 24', 24''). The first and second coatings (28, 30) contain different materials that are configured to respond differently when exposed to a predetermined external stimulus.

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